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Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients

Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands
Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands
Department of Exploratory Toxicology, Celgene, San Diego, CA, USA
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands
Department of Hematology, Maastricht University Medical Center, the Netherlands
Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Internal Medicine, Meander Medical Center, Amersfoort, the Netherlands
Department of Exploratory Toxicology, Celgene, San Diego, CA, USA
Department of Exploratory Toxicology, Celgene, San Diego, CA, USA
Department of Hematology, St. Antonius Hospital, Nieuwegein, the Netherlands
Laboratory for Translational Immunology, University Medical Center Utrecht, the Netherlands
Department of Internal Medicine, Spaarne Hospital, Hoofddorp, the Netherlands
Department of Internal Medicine, Rode Kruis Hospital, Beverwijk, the Netherlands
Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands
Department of Hematology, University Medical Center Utrecht Cancer Center, the Netherlands
Department of Pathology, University Medical Center Utrecht, the Netherlands
Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands
Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands
Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands
Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands
Department of Translational Development, Celgene Corporation, Summit, NJ, USA
Department of Translational Development, Celgene Corporation, Summit, NJ, USA
Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands
Vol. 103 No. 8 (2018): August, 2018 https://doi.org/10.3324/haematol.2017.186601