September, 2018
No. 103 (9)

Editorials

Review Articles

Cardiovascular adverse events in modern myeloma therapy – Incidence and risks. A review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA)

Sara Bringhen, Alberto Milan, Claudio Ferri, Ralph Wäsch, Francesca Gay, Alessandra Larocca, Marco Salvini, Evangelos Terpos, Hartmut Goldschmidt, Michele Cavo, Maria Teresa Petrucci, Heinz Ludwig, Holger W. Auner, Jo Caers, Martin Gramatzki, Mario Boccadoro, Hermann Einsele, Pieter Sonneveld, Monika Engelhardt

https://doi.org/10.3324/haematol.2018.191288

Articles

Hematopoiesis

Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells

Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, Mattias Magnusson, Praveen Kumar, Jonas Larsson, Aurélie Baudet

https://doi.org/10.3324/haematol.2018.188466

Bone Marrow Failure

Myelodysplastic Syndromes

Transforming growth factor β1-mediated functional inhibition of mesenchymal stromal cells in myelodysplastic syndromes and acute myeloid leukemia

Stefanie Geyh, Manuel Rodríguez-Paredes, Paul Jäger, Annemarie Koch, Felix Bormann, Julian Gutekunst, Christoph Zilkens, Ulrich Germing, Guido Kobbe, Frank Lyko, Rainer Haas, Thomas Schroeder

https://doi.org/10.3324/haematol.2017.186734

Acute Myeloid Leukemia

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Weiqiang Lu, Jin Huang

https://doi.org/10.3324/haematol.2018.188185

Clofarabine, high-dose cytarabine and liposomal daunorubicin in pediatric relapsed/refractory acute myeloid leukemia: a phase IB study

Natasha K.A. van Eijkelenburg, Mareike Rasche, Essam Ghazaly, Michael N. Dworzak, Thomas Klingebiel, Claudia Rossig, Guy Leverger, Jan Stary, Eveline S.J.M. De Bont, Dana A. Chitu, Yves Bertrand, Benoit Brethon, Brigitte Strahm, Inge M. van der Sluis, Gertjan J.L. Kaspers, Dirk Reinhardt, C. Michel Zwaan

https://doi.org/10.3324/haematol.2017.187153

Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2

Paul M. Barr, Tadeusz Robak, Carolyn Owen, Alessandra Tedeschi, Osnat Bairey, Nancy L. Bartlett, Jan A. Burger, Peter Hillmen, Steven Coutre, Stephen Devereux, Sebastian Grosicki, Helen McCarthy, Jianyong Li, David Simpson, Fritz Offner, Carol Moreno, Cathy Zhou, Lori Styles, Danelle James, Thomas J. Kipps, Paolo Ghia

https://doi.org/10.3324/haematol.2018.192328

Real-world outcomes and management strategies for venetoclax-treated chronic lymphocytic leukemia patients in the United States

Anthony R. Mato, Meghan Thompson, John N. Allan, Danielle M. Brander, John M. Pagel, Chaitra S. Ujjani, Brian T. Hill, Nicole Lamanna, Frederick Lansigan, Ryan Jacobs, Mazyar Shadman, Alan P. Skarbnik, Jeffrey J. Pu, Paul M. Barr, Alison R. Sehgal, Bruce D. Cheson, Clive S. Zent, Hande H. Tuncer, Stephen J. Schuster, Peter V. Pickens, Nirav N. Shah, Andre Goy, Allison M. Winter, Christine Garcia, Kaitlin Kennard, Krista Isaac, Colleen Dorsey, Lisa M. Gashonia, Arun K. Singavi, Lindsey E. Roeker, Andrew Zelenetz, Annalynn Williams, Christina Howlett, Hanna Weissbrot, Naveed Ali, Sirin Khajavian, Andrea Sitlinger, Eve Tranchito, Joanna Rhodes, Joshua Felsenfeld, Neil Bailey, Bhavisha Patel, Timothy F. Burns, Melissa Yacur, Mansi Malhotra, Jakub Svoboda, Richard R. Furman, Chadi Nabhan

https://doi.org/10.3324/haematol.2018.193615

Plasma Cell Disorders

A phase I/II dose-escalation study investigating all-oral ixazomib-melphalan-prednisone induction followed by single-agent ixazomib maintenance in transplant-ineligible newly diagnosed multiple myeloma

Jesús F. San-Miguel, Maria-Asunción Echeveste Gutierrez, Ivan Špicka, María-Victoria Mateos, Kevin Song, Michael D. Craig, Joan Bladé, Roman Hájek, Christine Chen, Alessandra Di Bacco, Jose Estevam, Neeraj Gupta, Catriona Byrne, Vickie Lu, Helgi van de Velde, Sagar Lonial

https://doi.org/10.3324/haematol.2017.185991

Stem Cell Transplantation

Competing-risk outcomes after hematopoietic stem cell transplantation from the perspective of time-dependent effects

Daniel Fuerst, Sandra Frank, Carlheinz Mueller, Dietrich W Beelen, Johannes Schetelig, Dietger Niederwieser, Jürgen Finke, Donald Bunjes, Nicolaus Kröger, Christine Neuchel, Chrysanthi Tsamadou, Hubert Schrezenmeier, Jan Beyersmann, Joannis Mytilineos

https://doi.org/10.3324/haematol.2017.183012

Quality of Life

Patient-reported outcomes and health status associated with chronic graft-versus-host disease

Stephanie J. Lee, Lynn Onstad, Eric J. Chow, Bronwen E. Shaw, Heather S.L. Jim, Karen L. Syrjala, K. Scott Baker, Sarah Buckley, Mary E. Flowers

https://doi.org/10.3324/haematol.2018.192930

Blood Transfusion

Coagulation & Its Disorders

Frequency, risk factors, and impact on mortality of arterial thromboembolism in patients with cancer

Ella Grilz, Oliver Königsbrügge, Florian Posch, Manuela Schmidinger, Robert Pirker, Irene M. Lang, Ingrid Pabinger, Cihan Ay

https://doi.org/10.3324/haematol.2018.192419

Platelet Biology & its Disorders

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy

Constance C. F. M. J. Baaten, Floor C. J. I. Moenen, Yvonne M. C. Henskens, Frauke Swieringa, Rick J. H. Wetzels, René van Oerle, Harry F. G. Heijnen, Hugo ten Cate, Graham P. Holloway, Erik A. M. Beckers, Johan W. M. Heemskerk, Paola E. J. van der Meijden

https://doi.org/10.3324/haematol.2017.185165

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

Jianlin Qiao, Xiaoqing Wu, Qi Luo, Guangyu Wei, Mengdi Xu, Yulu Wu, Yun Liu, Xiaoqian Li, Jie Zi, Wen Ju, Lin Fu, Chong Chen, Qingyun Wu, Shengyun Zhu, Kunming Qi, Depeng Li, Zhenyu Li, Robert K. Andrews, Lingyu Zeng, Elizabeth E. Gardiner, Kailin Xu

https://doi.org/10.3324/haematol.2018.191700

Errata Corrige

Safety and efficacy of plerixafor dose escalation for the mobilization of CD34+ hematopoietic progenitor cells in patients with sickle cell disease: interim results

Farid Boulad, Tsiporah Shore, Koen van Besien, Caterina Minniti, Mihaela Barbu-Stevanovic, Sylvie Wiener Fedus, Fabiana Perna, June Greenberg, Danielle Guarneri, Vijay Nandi, Audrey Mauguen, Karina Yazdanbakhsh, Michel Sadelain, Patricia A. Shi

https://doi.org/10.3324/haematol.2018.199414

Online Only Articles

Value of cytogenetic abnormalities in post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a study of the MYSEC project

Barbara Mora, Toni Giorgino, Paola Guglielmelli, Elisa Rumi, Margherita Maffioli, Alessandro Rambaldi, Marianna Caramella, Rami Komrokji, Jason Gotlib, Jean Jacques Kiladjian, Francisco Cervantes, Timothy Devos, Francesca Palandri, Valerio De Stefano, Marco Ruggeri, Richard T. Silver, Giulia Benevolo, Francesco Albano, Chiara Cavalloni, Daniela Barraco, Michele Merli, Daniela Pietra, Rosario Casalone, Tiziano Barbui, Giada Rotunno, Mario Cazzola, Alessandro Maria Vannucchi, Francesco Passamonti

https://doi.org/10.3324/haematol.2017.185751

GFI1 is required for RUNX1/ETO positive acute myeloid leukemia

Anna E. Marneth, Lacramioara Botezatu, Judith M. Hönes, Jimmy C.L. Israël, Judith Schütte, Lothar Vassen, Robert F. Lams, Saskia M. Bergevoet, Laura Groothuis, Amit Mandoli, Joost H.A. Martens, Gerwin Huls, Joop H. Jansen, Ulrich Dührsen, Tobias Berg, Tarik Möröy, Christian Wichmann, Mia-Chia Lo, Dong-Er Zhang, Bert A. van der Reijden, Cyrus Khandanpour

https://doi.org/10.3324/haematol.2017.180844

Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes

Carmen Martínez-Losada, Juana Serrano-López, Josefina Serrano-López, Nelida I. Noguera, Eduardo Garza, Liliana Piredda, Serena Lavorgna, María Antonietta Irno Consalvo, Tiziana Ottone, Valentina Alfonso, Juan Ramón Peinado, María Victoria Garcia-Ortiz, Teresa Morales-Ruiz, Andrés Jérez, Ana María Hurtado, Pau Montesinos, José Cervera, Esperanza Such, Marian Ibañez, Amparo Sempere, Miguel Ángel Sanz, Francesco Lo-Coco, Joaquín Sánchez-García

https://doi.org/10.3324/haematol.2018.188433

Efficacy of the combination of venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

Ibrahim Aldoss, Dongyun Yang, Ahmed Aribi, Haris Ali, Karamjeet Sandhu, Monzr M. Al Malki, Matthew Mei, Amandeep Salhotra, Samer Khaled, Ryotaro Nakamura, David Snyder, Margaret O’Donnell, Anthony S. Stein, Stephen J. Forman, Guido Marcucci, Vinod Pullarkat

https://doi.org/10.3324/haematol.2018.188094

MYD88 mutated and wild-type Waldenström’s Macroglobulinemia: characterization of chromosome 6q gene losses and their mutual exclusivity with mutations in CXCR4

Maria Luisa Guerrera, Nickolas Tsakmaklis, Lian Xu, Guang Yang, Maria Demos, Amanda Kofides, Gloria G. Chan, Robert J. Manning, Xia Liu, Jiaji G. Chen, Manit Munshi, Christopher J. Patterson, Jorge J. Castillo, Toni Dubeau, Joshua Gustine, Ruben D. Carrasco, Luca Arcaini, Marzia Varettoni, Mario Cazzola, Steven P. Treon, Zachary R. Hunter

https://doi.org/10.3324/haematol.2018.190181

Dramatically improved survival in multiple myeloma patients in the recent decade: results from a Swedish population-based study

Sigrun Thorsteinsdottir, Paul W. Dickman, Ola Landgren, Cecilie Blimark, Malin Hultcrantz, Ingemar Turesson, Magnus Björkholm, Sigurdur Y. Kristinsson

https://doi.org/10.3324/haematol.2017.183475

A phase I study of romidepsin and ifosfamide, carboplatin, etoposide for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma

Paolo Strati, Dai Chihara, Yasuhiro Oki, Luis E Fayad, Nathan Fowler, Loretta Nastoupil, Jorge E Romaguera, Felipe Samaniego, Naveen Garg, Lei Feng, Emily T. Wesson, Charnelle E. Ruben, Mildred D. Stafford, Yago Nieto, Issa F Khouri, Chitra Hosing, Sandra B. Horowitz, Rammurti T-. Kamble, Michelle A. Fanale

https://doi.org/10.3324/haematol.2018.187617

NKG2D-based chimeric antigen receptor therapy induced remission in a relapsed/refractory acute myeloid leukemia patient

David A. Sallman, Jason Brayer, Elizabeth M. Sagatys, Caroline Lonez, Eytan Breman, Sophie Agaugué, Bikash Verma, David E. Gilham, Frédéric F. Lehmann, Marco L Davila

https://doi.org/10.3324/haematol.2017.186742

Clinical efficacy of ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure

Yang Y. Ding, Julie W. Stern, Tracey F. Jubelirer, Gerald B. Wertheim, Fumin Lin, Fengqi Chang, Zhaohui Gu, Charles G. Mullighan, Yong Li, Richard C. Harvey, I-Ming Chen, Cheryl L. Willman, Stephen P. Hunger, Marilyn M. Li, Sarah K. Tasian

https://doi.org/10.3324/haematol.2018.192088