July, 2018
No. 103 (7)

Editorials

Review Articles

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers

Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo

https://doi.org/10.3324/haematol.2016.151407

Articles

Hematopoiesis

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

Yile Zhou, Xiaomei Yan, Xiaomin Feng, Jiachen Bu, Yunzhu Dong, Peipei Lin, Yoshihiro Hayashi, Rui Huang, Andre Olsson, Paul R. Andreassen, H. Leighton Grimes, Qian-fei Wang, Tao Cheng, Zhijian Xiao, Jie Jin, Gang Huang

https://doi.org/10.3324/haematol.2018.187708

Red Cell Biology & Its Disorders

Endothelin type A receptors mediate pain in a mouse model of sickle cell disease

Brianna Marie Lutz, Shaogen Wu, Xiyao Gu, Fidelis E. Atianjoh, Zhen Li, Brandon M. Fox, David M. Pollock, Yuan-Xiang Tao

https://doi.org/10.3324/haematol.2017.187013

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction

Sanjay Tewari, George Renney, John Brewin, Kate Gardner, Fenella Kirkham, Baba Inusa, James E Barrett, Stephan Menzel, Swee Lay Thein, Malcolm Ward, David C. Rees

https://doi.org/10.3324/haematol.2018.187815

Complications in Hematology

Late effects after hematopoietic stem cell transplantation for β-thalassemia major: the French national experience

Ilhem Rahal, Claire Galambrun, Yves Bertrand, Nathalie Garnier, Catherine Paillard, Pierre Frange, Corinne Pondarré, Jean Hugues Dalle, Regis Peffault de Latour, Mauricette Michallet, Dominique Steschenko, Despina Moshous, Patrick Lutz, Jean Louis Stephan, Pierre Simon Rohrlich, Ibrahim Yakoub-Agha, Françoise Bernaudin, Christophe Piguet, Nathalie Aladjidi, Catherine Badens, Claire Berger, Gérard Socié, Cécile Dumesnil, Marie Pierre Castex, Marilyne Poirée, Anne Lambilliotte, Caroline Thomas, Pauline Simon, Pascal Auquier, Gérard Michel, Anderson Loundou, Imane Agouti, Isabelle Thuret

https://doi.org/10.3324/haematol.2017.183467

Bone Marrow Failure

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes

Valentina Giudice, Lauren G. Banaszak, Fernanda Gutierrez-Rodrigues, Sachiko Kajigaya, Reema Panjwani, Maria del Pilar Fernandez Ibanez, Olga Rios, Christopher K. Bleck, Erin S. Stempinski, Diego Quinones Raffo, Danielle M. Townsley, Neal S. Young

https://doi.org/10.3324/haematol.2017.182824

Myeloproliferative Disorders

Acute Myeloid Leukemia

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia

Yaser Heshmati, Gözde Türköz, Aditya Harisankar, Shabnam Kharazi, Johan Boström, Esmat Kamali Dolatabadi, Aleksandra Krstic, David Chang, Robert Månsson, Mikael Altun, Hong Qian, Julian Walfridsson

https://doi.org/10.3324/haematol.2017.183970

Non-Hodgkin Lymphoma

Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2

Heike Horn, Christian Kohler, Raphael Witzig, Markus Kreuz, Ellen Leich, Wolfram Klapper, Michael Hummel, Markus Loeffler, Lorenz Trümper, Rainer Spang, Andreas Rosenwald, German Ott, for the Molecular Mechanisms in Malignant Lymphomas (MMML) Network Project

https://doi.org/10.3324/haematol.2017.181024

The outcome of peripheral T-cell lymphoma patients failing first-line therapy: a report from the prospective, International T-Cell Project

Monica Bellei, Francine M. Foss, Andrei R. Shustov, Steven M. Horwitz, Luigi Marcheselli, Won Seog Kim, Maria E. Cabrera, Ivan Dlouhy, Arnon Nagler, Ranjana H. Advani, Emanuela A. Pesce, Young-Hyeh Ko, Virginia Martinez, Silvia Montoto, Carlos Chiattone, Alison Moskowitz, Michele Spina, Irene Biasoli, Martina Manni, Massimo Federico

https://doi.org/10.3324/haematol.2017.186577

Chronic Lymphocytic Leukemia

Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome

Ignacio Criado, Arancha Rodríguez-Caballero, M. Laura Gutiérrez, Carlos E. Pedreira, Miguel Alcoceba, Wendy Nieto, Cristina Teodosio, Paloma Bárcena, Alfonso Romero, Paulino Fernández-Navarro, Marcos González, Julia Almeida, Alberto Orfao, The Primary Health Care Group of Salamanca for the Study of MBL

https://doi.org/10.3324/haematol.2017.183954

Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study

Antonio Cuneo, George Follows, Gian Matteo Rigolin, Alfonso Piciocchi, Alessandra Tedeschi, Livio Trentin, Angeles Medina Perez, Marta Coscia, Luca Laurenti, Gerardo Musuraca, Lucia Farina, Alfredo Rivas Delgado, Ester Maria Orlandi, Piero Galieni, Francesca Romana Mauro, Carlo Visco, Angela Amendola, Atto Billio, Roberto Marasca, Annalisa Chiarenza, Vittorio Meneghini, Fiorella Ilariucci, Monia Marchetti, Stefano Molica, Francesca Re, Gianluca Gaidano, Marcos Gonzalez, Francesco Forconi, Stefania Ciolli, Agostino Cortelezzi, Marco Montillo, Lukas Smolej, Anna Schuh, Toby A. Eyre, Ben Kennedy, Kris M. Bowles, Marco Vignetti, Javier de la Serna, Carol Moreno, Robin Foà, Paolo Ghia

https://doi.org/10.3324/haematol.2018.189837

Plasma Cell Disorders

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment

Christine Lam, Ian D. Ferguson, Margarette C. Mariano, Yu-Hsiu T. Lin, Megan Murnane, Hui Liu, Geoffrey A. Smith, Sandy W. Wong, Jack Taunton, Jun O. Liu, Constantine S. Mitsiades, Byron C. Hann, Blake T. Aftab, Arun P. Wiita

https://doi.org/10.3324/haematol.2017.174482

Plasma cell proliferative index predicts outcome in immunoglobulin light chain amyloidosis treated with stem cell transplantation

M. Hasib Sidiqi, Mohammed A. Aljama, Dragan Jevremovic, William G. Morice, Michael Timm, Francis K. Buadi, Rahma Warsame, Martha Q. Lacy, Angela Dispenzieri, David Dingli, Wilson I. Gonsalves, Shaji Kumar, Prashant Kapoor, Taxiarchis Kourelis, Nelson Leung, William J. Hogan, Morie Gertz

https://doi.org/10.3324/haematol.2018.189985

Platelet Biology & its Disorders

Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation

Eduardo I. Cardenas, Keegan Breaux, Qi Da, Jose R. Flores, Marco A. Ramos, Michael J. Tuvim, Alan R. Burns, Rolando E. Rumbaut, Roberto Adachi

https://doi.org/10.3324/haematol.2017.185637

Coagulation & Its Disorders

C-reactive protein and risk of venous thromboembolism: results from a population-based case-crossover study

Gro Grimnes, Trond Isaksen, Ynse Ieuwe Gerardus Vladimir Tichelaar, Jan Brox, Sigrid Kufaas Brækkan, John-Bjarne Hansen

https://doi.org/10.3324/haematol.2017.186957

Online Only Articles

Letter to the Editor

Improved erythroid differentiation of multiple human pluripotent stem cell lines in microcarrier culture by modulation of Wnt/β-Catenin signaling

Jaichandran Sivalingam, Hong Yu Chen, Bin-Xia Yang, Zhong Ri Lim, Alan Tin Lun Lam, Tsung Liang Woo, Allen Kuan-Liang Chen, Shaul Reuveny, Yuin-Han Loh, Steve Kah-Weng Oh

https://doi.org/10.3324/haematol.2017.180919

Expanding the phenotypic and genetic spectrum of radioulnar synostosis associated hematological disease

Amanda Walne, Hemanth Tummala, Alicia Ellison, Shirleny Cardoso, Jasmin Sidhu, Gabriela Sciuccati, Tom Vulliamy, Inderjeet Dokal

https://doi.org/10.3324/haematol.2017.183855

Prognostic impact of the absence of biallelic deletion at the TRG locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial

Nadine Farah, Amy A Kirkwood, Sunniyat Rahman, Theresa Leon, Sarah Jenkinson, Rosemary E. Gale, Katharine Patrick, Jeremy Hancock, Sujith Samarasinghe, David C. Linch, Anthony V Moorman, Nicholas Goulden, Ajay Vora, Marc R. Mansour

https://doi.org/10.3324/haematol.2017.185801

Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia

Yiping Zhu, Dandan Yin, Yali Su, Xuyang Xia, Takaya Moriyama, Rina Nishii, Fei Liao, Shouyue Zhang, Xia Guo, Qianqian Hou, Yuan Ai, Xueyan Zhou, Shuwen Sun, Duyu Zhang, Yan Zhang, Chao Lin, Yiqi Deng, Xiaoxi Lu, Yuelan Wang, Zhigui Ma, Heyao Wang, Bo Liu, Li Yang, Wei Zhang, Jun J. Yang, Yang Shu, Ju Gao, Heng Xu

https://doi.org/10.3324/haematol.2018.187658

Efficacy and safety of high-dose etoposide cytarabine as consolidation following rituximab methotrexate temozolomide induction in newly diagnosed primary central nervous system lymphoma in immunocompetent patients

Rudy Birsen, Lise Willems, Johan Pallud, Estelle Blanc, Barbara Burroni, Marielle Legoff, Emmanuelle Le Ray, Sylvain Pilorge, Benedicte Deau, Patricia Franchi, Marguerite Vignon, Yioula Kirova, Myriam Edjlali, Caroline Houillier, Carole Soussain, Pascale Varlet, Edouard Dezamis, Diane Damotte, Didier Bouscary, Jerome Tamburini

https://doi.org/10.3324/haematol.2017.185843

Incidence and predictors of infection among patients prior to treatment of chronic lymphocytic leukemia: a Danish nationwide cohort study

Michael Asger Andersen, Casper Tabassum Eriksen, Christian Brieghel, Jorne Lionel Biccler, Caspar da Cunha-Bang, Marie Helleberg, Carsten Utoft Niemann

https://doi.org/10.3324/haematol.2017.182006

Long-term follow up of the CLL2007FMP trial evaluating fludarabine and cyclophosphamide in combination with either rituximab or alemtuzumab in previously untreated patients with chronic lymphocytic leukemia

Pierre Feugier, Thérèse Aurran, Béatrice Mahé, Remi Letestu, Florence Nguyen-Khac, Bruno Cazin, Olivier Tournilhac, Hervé Maisonneuve, Olivier Casasnovas, Alain Delmer, Véronique Leblond, Bruno Royer, Bernadette Corront, Sylvie Chevret, Roselyne Delépine, Sandrine Vaudaux, Eric Van Den Neste, Marie-Christine Béné, Florence Cymbalista, Damien Roos-Weil, Stéphane Leprêtre

https://doi.org/10.3324/haematol.2017.183350

Ibrutinib withdrawal symptoms in patients with Waldenström macroglobulinemia

Jorge J. Castillo, Joshua N. Gustine, Kirsten Meid, Toni Dubeau, Patricia Severns, Steven P. Treon

https://doi.org/10.3324/haematol.2017.186908

The impact of the introduction of bortezomib on dialysis independence in multiple myeloma patients with renal impairment: a nationwide Dutch population-based study

Berdien E. Oortgiesen, Roshna Azad, Marc H. Hemmelder, Robby E. Kibbelaar, Nic J.G.M. Veeger, Joost C. de Vries, Eric N. van Roon, Mels Hoogendoorn

https://doi.org/10.3324/haematol.2017.184754

Recurrent thrombosis in patients with antiphospholipid antibodies treated with vitamin K antagonists or rivaroxaban

Ida Martinelli, Maria Abbattista, Paolo Bucciarelli, Armando Tripodi, Andrea Artoni, Francesca Gianniello, Cristina Novembrino, Flora Peyvandi

https://doi.org/10.3324/haematol.2017.185132

Case Report

Anti-PD1 associated fulminant myocarditis after a single pembrolizumab dose: the role of occult pre-existing autoimmunity

Nicolas Martinez-Calle, Paula Rodriguez-Otero, Sara Villar, Luis Mejías, Ignacio Melero, Felipe Prosper, Patricia Marinello, Bruno Paiva, Miguel Idoate, Jesus San-Miguel

https://doi.org/10.3324/haematol.2017.185777

Successful treatment of disseminated Rosai-Dorfman disease with siltuximab

Hannah Lee, Gentry King, Kavita Garg, Zenggang Pan, Jennifer Tobin, William A. Robinson

https://doi.org/10.3324/haematol.2018.188441

Comment