January, 2018
No. 103 (1)

Editorials

Review Articles

The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source

Barnaby Peacock-Young, Fraser L. Macrae, Darren J. Newton, Anita Hill, Robert A S Ariëns

https://doi.org/10.3324/haematol.2017.177618

Articles

Acute Myeloid Leukemia

Randomized study of continuous high-dose lenalidomide, sequential azacitidine and lenalidomide, or azacitidine in persons 65 years and over with newly-diagnosed acute myeloid leukemia

Bruno C. Medeiros, Kelly McCaul, Suman Kambhampati, Daniel A. Pollyea, Rajat Kumar, Lewis R. Silverman, Andrea Kew, Lalit Saini, CL Beach, Ravi Vij, Xiwei Wang, Jim Zhong, Robert Peter Gale

https://doi.org/10.3324/haematol.2017.172353

Acute Lymphoblastic Leukemia

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies

Giovanni Cazzaniga, Paola De Lorenzo, Julia Alten, Silja Röttgers, Jeremy Hancock, Vaskar Saha, Anders Castor, Hans O. Madsen, Virginie Gandemer, Hélène Cavé, Veronica Leoni, Rolf Köhler, Giulia M. Ferrari, Kirsten Bleckmann, Rob Pieters, Vincent van der Velden, Jan Stary, Jan Zuna, Gabriele Escherich, Udo zur Stadt, Maurizio Aricò, Valentino Conter, Martin Schrappe, Maria Grazia Valsecchi, Andrea Biondi

https://doi.org/10.3324/haematol.2017.176917

Non-Hodgkin Lymphoma

Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment

Martina Rudelius, Mathias Tillmann Rosenfeldt, Ellen Leich, Hilka Rauert-Wunderlich, Antonio Giovanni Solimando, Andreas Beilhack, German Ott, Andreas Rosenwald

https://doi.org/10.3324/haematol.2017.177162

Chronic Lymphocytic Leukemia

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia

Carl Philipp Simon-Gabriel, Katharina Foerster, Shifa Saleem, Dorothee Bleckmann, Marco Benkisser-Petersen, Nicolas Thornton, Kazuo Umezawa, Sarah Decker, Meike Burger, Hendrik Veelken, Rainer Claus, Christine Dierks, Justus Duyster, Katja Zirlik

https://doi.org/10.3324/haematol.2017.165381

Platelet Biology & its Disorders

Introducing high-throughput sequencing into mainstream genetic diagnosis practice in inherited platelet disorders

José M. Bastida, María L. Lozano, Rocío Benito, Kamila Janusz, Verónica Palma-Barqueros, Mónica Del Rey, Jesús M. Hernández-Sánchez, Susana Riesco, Nuria Bermejo, Hermenegildo González-García, Agustín Rodriguez-Alén, Carlos Aguilar, Teresa Sevivas, María F. López-Fernández, Anna E. Marneth, Bert A. van der Reijden, Neil V. Morgan, Steve P. Watson, Vicente Vicente, Jesús M. Hernández-Rivas, José Rivera, José R. González-Porras

https://doi.org/10.3324/haematol.2017.171132

Coagulation & Its Disorders

Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells

Ivan Peyron, Robin B. Hartholt, Laura Pedró-Cos, Floris van Alphen, Anja ten Brinke, Neubury Lardy, Alexander B. Meijer, Jan Voorberg

https://doi.org/10.3324/haematol.2017.175083

Analyses of the FranceCoag cohort support differences in immunogenicity among one plasma-derived and two recombinant factor VIII brands in boys with severe hemophilia A

Thierry Calvez, Hervé Chambost, Roseline d’Oiron, Vincent Dalibard, Virginie Demiguel, Alexandra Doncarli, Yves Gruel, Yoann Huguenin, Patrice Lutz, Chantal Rothschild, Christine Vinciguerra, Jenny Goudemand, for FranceCoag Collaborators

https://doi.org/10.3324/haematol.2017.174706

Hematopoiesis

Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells

Stefanie C. Herkt, Olga N. Kuvardina, Julia Herglotz, Lucas Schneider, Annekarin Meyer, Claudia Pommerenke, Gabriela Salinas-Riester, Erhard Seifried, Halvard Bonig, Jörn Lausen

https://doi.org/10.3324/haematol.2017.174516

Bone Marrow Failure

Myeloproliferative Disorders

Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models

Jieyu Wang, Yoshihiro Hayashi, Asumi Yokota, Zefeng Xu, Yue Zhang, Rui Huang, Xiaomei Yan, Hongyun Liu, Liping Ma, Mohammad Azam, James P. Bridges, Jose A. Cancelas, Theodosia A. Kalfa, Xiuli An, Zhijian Xiao, Gang Huang

https://doi.org/10.3324/haematol.2017.172775

Treatment of essential thrombocythemia in Europe: a prospective long-term observational study of 3649 high-risk patients in the Evaluation of Anagrelide Efficacy and Long-term Safety study

Gunnar Birgegård, Carlos Besses, Martin Griesshammer, Luigi Gugliotta, Claire N. Harrison, Mohamed Hamdani, Jingyang Wu, Heinrich Achenbach, Jean-Jacques Kiladjian

https://doi.org/10.3324/haematol.2017.174672

Myelodysplastic Syndromes

Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway

Ekaterina Balaian, Manja Wobus, Heike Weidner, Ulrike Baschant, Maik Stiehler, Gerhard Ehninger, Martin Bornhäuser, Lorenz C Hofbauer, Martina Rauner, Uwe Platzbecker

https://doi.org/10.3324/haematol.2017.172726

Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes

Louise de Swart, Chloé Reiniers, Timothy Bagguley, Corine van Marrewijk, David Bowen, Eva Hellström-Lindberg, Aurelia Tatic, Argiris Symeonidis, Gerwin Huls, Jaroslav Cermak, Arjan A. van de Loosdrecht, Hege Garelius, Dominic Culligan, Mac Macheta, Michail Spanoudakis, Panagiotis Panagiotidis, Marta Krejci, Nicole Blijlevens, Saskia Langemeijer, Jackie Droste, Dorine W. Swinkels, Alex Smith, Theo de Witte

https://doi.org/10.3324/haematol.2017.171884

Acute Myeloid Leukemia

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

Antonia Cagnetta, Debora Soncini, Stefania Orecchioni, Giovanna Talarico, Paola Minetto, Fabio Guolo, Veronica Retali, Nicoletta Colombo, Enrico Carminati, Marino Clavio, Maurizio Miglino, Micaela Bergamaschi, Aimable Nahimana, Michel Duchosal, Katia Todoerti, Antonino Neri, Mario Passalacqua, Santina Bruzzone, Alessio Nencioni, Francesco Bertolini, Marco Gobbi, Roberto M. Lemoli, Michele Cea

https://doi.org/10.3324/haematol.2017.176248

Online Only Articles

Long-term safety of deferiprone treatment in children from the Mediterranean region with beta-thalassemia major: the DEEP-3 multi-center observational safety study

Sebastian Botzenhardt, Mariagrazia Felisi, Donato Bonifazi, Giovanni C. Del Vecchio, Maria C. Putti, Antonis Kattamis, Adriana Ceci, Ian C.K. Wong, Antje Neubert

https://doi.org/10.3324/haematol.2017.176065

Single-molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple TP53 alterations

Laurence Lodé, Adam Ameur, Thibault Coste, Audrey Ménard, Steven Richebourg, Jean-Baptiste Gaillard, Yannick Le Bris, Marie-Christine Béné, Thierry Lavabre-Bertrand, Thierry Soussi

https://doi.org/10.3324/haematol.2017.176719

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype

Frank G. Rücker, Anna Dolnik, Tamara J. Blätte, Veronica Teleanu, Aurélie Ernst, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner, Lars Bullinger

https://doi.org/10.3324/haematol.2017.180497

Small bone marrow adipocytes predict poor prognosis in acute myeloid leukemia

Wei Lu, Wei Weng, Qi Zhu, Yuanmei Zhai, Yun Wan, Haiyan Liu, Shaoxin Yang, Yehua Yu, Yanyu Wei, Jun Shi

https://doi.org/10.3324/haematol.2017.173492

Panobinostat monotherapy and combination therapy in patients with acute myeloid leukemia: results from two clinical trials

Richard F. Schlenk, Jürgen Krauter, Emmanuel Raffoux, Karl-Anton Kreuzer, Markus Schaich, Lucien Noens, Thomas Pabst, Madhuri Vusirikala, Didier Bouscary, Andrew Spencer, Anna Candoni, Jorge Sierra Gil, Noah Berkowitz, Hans-Jochen Weber, Oliver Ottmann

https://doi.org/10.3324/haematol.2017.172411

A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology

Amelia D. Wallace, Stephen S. Francis, Xiaorong Shao, Adam J. de Smith, Kyle M. Walsh, Roberta Mckean-Cowdin, Xiaomei Ma, Gary Dahl, Lisa F. Barcellos, Joseph L. Wiemels, Catherine Metayer

https://doi.org/10.3324/haematol.2017.179317

Treat or palliate: outcomes of very elderly myeloma patients

Fotios Panitsas, Jaimal Kothari, Grant Vallance, Faouzi Djebbari, Lisa Ferguson, Manuela Sultanova, Karthik Ramasamy

https://doi.org/10.3324/haematol.2017.173617

Clinical severity in adult warm autoimmune hemolytic anemia and its relationship to antibody specificity

Philippe Chadebech, Valentine Loustau, Daniel Janvier, Laetitia Languille, Julie Ripa, Marie Tamagne, Philippe Bierling, Rachid Djoudi, Bertrand Godeau, Marc Michel, France Pirenne, Matthieu Mahévas

https://doi.org/10.3324/haematol.2017.175976

Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma

Sophie Voruz, Anne Cairoli, Olaia Naveiras, Laurence de Leval, Edoardo Missiaglia, Krisztian Homicsko, Olivier Michielin, Sabine Blum

https://doi.org/10.3324/haematol.2017.179150

Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms

Gabriela S. Hobbs, Amritha Varshini Hanasoge Somasundara, Maria Kleppe, Rivka Litvin, Maria Arcila, Jihae Ahn, Anna Sophia McKenney, Kristina Knapp, Ryan Ptashkin, Howard Weinstein, Murk-Hein Heinemann, Jasmine Francis, Suzanne Chanel, Ellin Berman, Michael Mauro, Martin S. Tallman, Mark L. Heaney, Ross L. Levine, Raajit K. Rampal

https://doi.org/10.3324/haematol.2017.177600