February, 2018
No. 103 (2)

Editorials

Review Articles

From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives

Francesca Gay, Monika Engelhardt, Evangelos Terpos, Ralph Wäsch, Luisa Giaccone, Holger W. Auner, Jo Caers, Martin Gramatzki, Niels van de Donk, Stefania Oliva, Elena Zamagni, Laurent Garderet, Christian Straka, Roman Hajek, Heinz Ludwig, Herman Einsele, Meletios Dimopoulos, Mario Boccadoro, Nicolaus Kröger, Michele Cavo, Hartmut Goldschmidt, Benedetto Bruno, Pieter Sonneveld

https://doi.org/10.3324/haematol.2017.174573

Articles

Bone Marrow Failure

Nationwide survey on the use of eltrombopag in patients with severe aplastic anemia: a report on behalf of the French Reference Center for Aplastic Anemia

Etienne Lengline, Bernard Drenou, Pierre Peterlin, Olivier Tournilhac, Julie Abraham, Ana Berceanu, Brigitte Dupriez, Gaelle Guillerm, Emmanuel Raffoux, Flore Sicre de Fontbrune, Lionel Ades, Marie Balsat, Driss Chaoui, Paul Coppo, Selim Corm, Thierry Leblanc, Natacha Maillard, Louis Terriou, Gerard Socié, Regis Peffault de Latour

https://doi.org/10.3324/haematol.2017.176339

Rational management approach to pure red cell aplasia

Suresh Kumar Balasubramanian, Meena Sadaps, Swapna Thota, Mai Aly, Bartlomiej P. Przychodzen, Cassandra M. Hirsch, Valeria Visconte, Tomas Radivoyevitch, Jaroslaw P. Maciejewski

https://doi.org/10.3324/haematol.2017.175810

Phagocyte Biology and its disorders

Myelodysplastic Syndrome

Outcome after relapse of myelodysplastic syndrome and secondary acute myeloid leukemia following allogeneic stem cell transplantation: a retrospective registry analysis on 698 patients by the Chronic Malignancies Working Party of the European Society of Blood and Marrow Transplantation

Christoph Schmid, Liesbeth C. de Wreede, Anja van Biezen, Jürgen Finke, Gerhard Ehninger, Arnold Ganser, Liisa Volin, Dietger Niederwieser, Dietrich Beelen, Paolo Alessandrino, Lothar Kanz, Michael Schleuning, Jakob Passweg, Hendrik Veelken, Johan Maertens, Jan J. Cornelissen, Didier Blaise, Martin Gramatzki, Noel Milpied, Ibrahim Yakoub-Agha, Ghulam Mufti, Montserrat Rovira, Renate Arnold, Theo de Witte, Marie Robin, Nikolaus Kröger

https://doi.org/10.3324/haematol.2017.168716

Acute Myeloid Leukemia

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia

Edith Schneider, Anna Staffas, Linda Röhner, Erik D. Malmberg, Arghavan Ashouri, Kathrin Krowiorz, Nicole Pochert, Christina Miller, Stella Yuan Wei, Laleh Arabanian, Christian Buske, Hartmut Döhner, Lars Bullinger, Linda Fogelstrand, Michael Heuser, Konstanze Döhner, Ping Xiang, Jens Ruschmann, Oleh I. Petriv, Alireza Heravi-Moussavi, Carl L. Hansen, Martin Hirst, R. Keith Humphries, Arefeh Rouhi, Lars Palmqvist, Florian Kuchenbauer

https://doi.org/10.3324/haematol.2017.177485

Allogeneic stem cell transplantation benefits for patients ≥ 60 years with acute myeloid leukemia and FLT3 internal tandem duplication: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Xavier Poiré, Myriam Labopin, Emmanuelle Polge, Jakob Passweg, Charles Craddock, Didier Blaise, Jan J. Cornelissen, Liisa Volin, Nigel H. Russell, Gérard Socié, Mauricette Michallet, Nathalie Fegueux, Patrice Chevallier, Arne Brecht, Mathilde Hunault-Berger, Mohamad Mohty, Jordi Esteve, Arnon Nagler

https://doi.org/10.3324/haematol.2017.178251

Acute Lymphoblastic Leukemia

WT1 loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia

Fulvio Bordin, Erich Piovan, Elena Masiero, Alberto Ambesi-Impiombato, Sonia Minuzzo, Roberta Bertorelle, Valeria Sacchetto, Giorgia Pilotto, Giuseppe Basso, Paola Zanovello, Alberto Amadori, Valeria Tosello

https://doi.org/10.3324/haematol.2017.170431

Non-Hodgkin Lymphoma

Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes

Siok-Bian Ng, Tae-Hoon Chung, Seiichi Kato, Shigeo Nakamura, Emiko Takahashi, Young-Hyeh Ko, Joseph D. Khoury, C. Cameron Yin, Richie Soong, Anand D. Jeyasekharan, Michal Marek Hoppe, Viknesvaran Selvarajan, Soo-Yong Tan, Soon-Thye Lim, Choon-Kiat Ong, Maarja-Liisa Nairismägi, Priyanka Maheshwari, Shoa-Nian Choo, Shuangyi Fan, Chi-Kuen Lee, Shih-Sung Chuang, Wee-Joo Chng

https://doi.org/10.3324/haematol.2017.180430

A bioclinical prognostic model using MYC and BCL2 predicts outcome in relapsed/refractory diffuse large B-cell lymphoma

Mark Bosch, Ariz Akhter, Bingshu E. Chen, Adnan Mansoor, David Lebrun, David Good, Michael Crump, Lois Shepherd, David W. Scott, Douglas A. Stewart

https://doi.org/10.3324/haematol.2017.179309

Outcomes among North American patients with diffuse large B-cell lymphoma are independent of tumor Epstein-Barr virus positivity or immunosuppression

Sean I. Tracy, Thomas M. Habermann, Andrew L. Feldman, Matthew J. Maurer, Ahmet Dogan, Usha S. Perepu, Sergei Syrbu, Stephen M. Ansell, Carrie A. Thompson, George J. Weiner, Grzegorz S. Nowakowski, Cristine Allmer, Susan L. Slager, Thomas E. Witzig, James R. Cerhan, Brian K. Link

https://doi.org/10.3324/haematol.2017.176511

Lymphoproliferative Disorders

Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia

Paula Savola, Oscar Brück, Thomas Olson, Tiina Kelkka, Markku J. Kauppi, Panu E. Kovanen, Soili Kytölä, Tuulikki Sokka-Isler, Thomas P. Loughran, Marjatta Leirisalo-Repo, Satu Mustjoki

https://doi.org/10.3324/haematol.2017.175729

Chronic Lymphocytic Leukemia

Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia

Hana Plešingerová, Pavlína Janovská, Archana Mishra, Lucie Smyčková, Lucie Poppová, Antonín Libra, Karla Plevová, Petra Ovesná, Lenka Radová, Michael Doubek, Šárka Pavlová, Šárka Pospíšilová, Vítězslav Bryja

https://doi.org/10.3324/haematol.2017.178699

Plasma Cell Disorders

Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma

Arnold Bolomsky, Roy Heusschen, Karin Schlangen, Kathrin Stangelberger, Joséphine Muller, Wolfgang Schreiner, Niklas Zojer, Jo Caers, Heinz Ludwig

https://doi.org/10.3324/haematol.2017.172973

Prognostic significance of tumor burden assessed by whole-body magnetic resonance imaging in multiple myeloma patients treated with allogeneic stem cell transplantation

Jennifer Mosebach, Sofia Shah, Stefan Delorme, Thomas Hielscher, Hartmut Goldschmidt, Heinz-Peter Schlemmer, Stefan Schönland, Ute Hegenbart, Jens Hillengass

https://doi.org/10.3324/haematol.2017.176073

Coagulation & Its Disorders

Clustered F8 missense mutations cause hemophilia A by combined alteration of splicing and protein biosynthesis and activity

Irving Donadon, John H. McVey, Isabella Garagiola, Alessio Branchini, Mimosa Mortarino, Flora Peyvandi, Francesco Bernardi, Mirko Pinotti

https://doi.org/10.3324/haematol.2017.178327

Complement C3 is a novel modulator of the anti-factor VIII immune response

Julie Rayes, Mathieu Ing, Sandrine Delignat, Ivan Peyron, Laurent Gilardin, Carl-Wilhelm Vogel, David C. Fritzinger, Véronique Frémeaux-Bacchi, Srinivas V. Kaveri, Lubka T. Roumenina, Sébastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2017.165720

Blood Transfusion

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

Travis Nemkov, Kaiqi Sun, Julie A. Reisz, Anren Song, Tatsuro Yoshida, Andrew Dunham, Matthew J. Wither, Richard O. Francis, Robert C. Roach, Monika Dzieciatkowska, Stephen C. Rogers, Allan Doctor, Anastasios Kriebardis, Marianna Antonelou, Issidora Papassideri, Carolyn T. Young, Tiffany A. Thomas, Kirk C. Hansen, Steven L. Spitalnik, Yang Xia, James C. Zimring, Eldad A. Hod, Angelo D’Alessandro

https://doi.org/10.3324/haematol.2017.178608

Online Only Articles

Letters to the Editor

Alternatively spliced fibronectin extra domain A is required for hemangiogenic recovery upon bone marrow chemotherapy

Alessandro Malara, Cristian Gruppi, Giuseppe Celesti, Vittorio Abbonante, Gianluca Viarengo, Luigi Laghi, Luigi De Marco, Andrés F. Muro, Alessandra Balduini

https://doi.org/10.3324/haematol.2017.173070

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

Carla Casu, Vania Lo Presti, Paraskevi Rea Oikonomidou, Luca Melchiori, Osheiza Abdulmalik, Pedro Ramos, Stefano Rivella

https://doi.org/10.3324/haematol.2017.181511

Inflammatory molecule reduction with hydroxyurea therapy in children with sickle cell anemia

Rhiannon R. Penkert, Julia L. Hurwitz, Paul Thomas, Jason Rosch, Jola Dowdy, Yilun Sun, Li Tang, Jane S. Hankins

https://doi.org/10.3324/haematol.2017.177360

MDS1 and EVI1 complex locus (MECOM): a novel candidate gene for hereditary hematological malignancies

Tim Ripperger, Winfried Hofmann, Jan C. Koch, Katayoon Shirneshan, Detlef Haase, Gerald Wulf, Peter R. Issing, Matthias Karnebogen, Gunnar Schmidt, Bernd Auber, Brigitte Schlegelberger, Thomas Illig, Birgit Zirn, Doris Steinemann

https://doi.org/10.3324/haematol.2017.178723

Outcomes after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia harboring t(7;11)(p15;p15)

Kaito Harada, Noriko Doki, Jun Aoki, Jinichi Mori, Shinichiro Machida, Masayoshi Masuko, Naoyuki Uchida, Yuho Najima, Takahiro Fukuda, Heiwa Kanamori, Hiroyasu Ogawa, Shuichi Ota, Kazuei Ogawa, Satoshi Takahashi, Masanobu Kasai, Akio Maeda, Koji Nagafuji, Toshiro Kawakita, Tatsuo Ichinohe, Yoshiko Atsuta

https://doi.org/10.3324/haematol.2017.179804

High PDGFRA expression does not serve as an effective therapeutic target in ERG-deleted B-cell precursor acute lymphoblastic leukemia

Isabel S. Jerchel, Danai Chatzivasileiou, Alex Q. Hoogkamer, Judith M. Boer, H. Berna Beverloo, Rob Pieters, Monique L. den Boer

https://doi.org/10.3324/haematol.2017.171702

GA101 P329GLALA, a variant of obinutuzumab with abolished ADCC, ADCP and CDC function but retained cell death induction, is as efficient as rituximab in B-cell depletion and antitumor activity

Sylvia Herter, Frank Herting, Gunter Muth, Erwin van Puijenbroek, Tilman Schlothauer, Claudia Ferrara, Kevin Brady, Sabine Lang, Marina Bacac, Ekkehard Mössner, Pablo Umana, Christian Klein

https://doi.org/10.3324/haematol.2017.178996

Case Report

Worldwide study of hematopoietic allogeneic stem cell transplantation in pyruvate kinase deficiency

Stephanie van Straaten, Marc Bierings, Paola Bianchi, Kensuke Akiyoshi, Hitoshi Kanno, Isabel Badell Serra, Jing Chen, Xiaohang Huang, Eduard van Beers, Supachai Ekwattanakit, Tayfun Güngör, Wijnanda Adriana Kors, Frans Smiers, Reinier Raymakers, Lucrecia Yanez, Julian Sevilla, Wouter van Solinge, Jose Carlos Segovia, Richard van Wijk

https://doi.org/10.3324/haematol.2017.177857

A novel AGGF1-PDGFRb fusion in pediatric T-cell acute lymphoblastic leukemia

Matthew S. Zabriskie, Orlando Antelope, Anupam R. Verma, Lauren R. Draper, Christopher A. Eide, Anthony D. Pomicter, Thai Hoa Tran, Brian J. Druker, Jeffrey W. Tyner, Rodney R. Miles, James M. Graham, Jae-Yeon Hwang, Katherine E. Varley, Reha M. Toydemir, Michael W. Deininger, Elizabeth A. Raetz, Thomas O’Hare

https://doi.org/10.3324/haematol.2017.165282

Letters to the Editor

Obituary