November, 2025
No. 110 (11)

Landmark papers in Hematology

1

Editorials

4

Review Series

4
Histiocytic Disorders

Articles

13
Acute Lymphoblastic Leukemia

S-adenosylmethionine addiction confers sensitivity to methionine restriction in KMT2A-rearranged acute lymphoblastic leukemia (2468 Online Views)

Trisha Tee, Titine J.J. Ruiter, Shuiyan Wu, Weiya Zhang, Dorette van Ingen Schenau, Maria Rodionova, Danique Wajon, Britt M.T. Vervoort, Kari J.T. Grunewald, Marjolein Bosma, Rico Hagelaar, John Baker-Hernandez, Ahmed Dahaoui, Pauline Schneider, Nanda M. Verhoeven-Duif, Laurens T. van der Meer, Frank N. van Leeuwen

https://doi.org/10.3324/haematol.2023.284869

Improved outcomes of acute lymphoblastic leukemia after allogeneic blood or marrow transplantation with highdose post-transplantation cyclophosphamide in the era of more effective pre-transplant therapy (2961 Online Views)

Jonathan A. Webster, Madison Reed, Hua-Ling Tsai, Philip H. Imus, Douglas B. Smith, Alexander J. Ambinder, Mark J. Levis, Amy E. DeZern, Gabrielle T. Prince, Tania Jain, Javier Bolaños-Meade, Lukasz P. Gondek, Gabriel Ghiaur, William Brian Dalton, Theodoros Karantanos, Suman Paul, Ephraim J. Fuchs, Cole Sterling, Lode J. Swinnen, Nina Wagner-Johnston, Richard F. Ambinder, Christian B. Gocke, Syed Abbas Ali, Carol Ann Huff, Leo Luznik, Ravi Varadhan, Richard J. Jones, Ivana Gojo

https://doi.org/10.3324/haematol.2025.287433

Acute Myeloid Leukemia

Metabolic reprogramming by PRDM16 drives cytarabine resistance in acute myeloid leukemia (2847 Online Views)

Junji Ikeda, Hiroyoshi Kunimoto, Yusuke Saito, Shin-Ichi Tsujimoto, Masanobu Takeuchi, Ayaka Miura, Takayuki Kurosawa, Koichi Murakami, Ikuma Kato, Megumi Funakoshi-Tago, Akihiko Yokoyama, Norio Shiba, Souichi Adachi, Daisuke Tomizawa, Tomohiko Tamura, Shuichi Ito, Hideaki Nakajima

https://doi.org/10.3324/haematol.2024.287265

Cell Therapy & Immunotherapy

CAR T expansion and systemic inflammation: diverging impacts on large B-cell lymphoma therapy in the multicenter CART SIE study (3239 Online Views)

Martina Magni, Sadhana Jonnalagadda, Francesca Bonifazi, Massimiliano Bonafe, Silva Ljevar, Giada Zanirato, Serena De Matteis, Federico Stella, Angelica Barone, Giulia Bertolini, Anisa Bermema, Annalisa Chiappella, Maria Chiara Tisi, Ilaria Cutini, Mattia Novo, Giovanni Grillo, Mirko Farina, Massimo Martino, Mauro Krampera, Massimo Massaia, Luca Arcaini, Stefania Bramanti, Pier Luigi Zinzani, Anna Dodero, Paolo Corradini, Cristiana Carniti

https://doi.org/10.3324/haematol.2025.287528

Chronic Lymphocytic Leukemia

Hematopoiesis

Contribution of genetics to hematopoietic stem cell mobilization: a genome-wide association study of 564 healthy donors mobilized with granulocyte colony-stimulating factor (1877 Online Views)

Miriam Stenzinger, Susanne Beck, Iordanis Ourailidis, Anna-Lena Volckmar, Nagarajan Paramasivam, Aysel Ahadova, Aitzkoa Lopez de Lapuente Portilla, Phuong La Yen, Bjorn Nilsson, Justo Lorenzo Bermejo, Halvard Bonig, Jan Budczies

https://doi.org/10.3324/haematol.2025.287637

Myeloproliferative Disorders

Artificial intelligence-based quantitative bone marrow pathology analysis for myeloproliferative neoplasms (2944 Online Views)

Dandan Yu, Hongju Zhang, Yanyan Song, Yuan Tao, Fengyuan Zhou, Ziyi Wang, Rongfeng Fu, Ting Sun, Huan Dong, Wenjing Gu, Renchi Yang, Zhijian Xiao, Qi Sun, Lei Zhang

https://doi.org/10.3324/haematol.2024.286123

Non-Hodgkin Lymphoma

Dynamic change in Epstein-Barr virus DNA predicts prognosis in early stage natural killer/T-cell lymphoma with pegaspargase-based treatment: long-term follow-up and biomarker analysis from the NHL-004 multicenter randomized study (3722 Online Views)

Huijuan Zhong, Shu Cheng, Jie Xiong, Jiayi Chen, Rongji Mu, Haoxu Yang, Hongmei Yi, Qi Song, Hao Zhang, Yu Hu, Guohui Cui, Juying Wei, Xi Zhang, Bing Xu, Wenbin Qian, Xiaobing Huang, Ming Hou, Feng Yan, Xin Wang, Yongping Song, Yuanhua Liu, Xuejun Ma, Jianda Hu, Fei Li, Chongyang Wu, Junmin Chen, Li Yu, Ou Bai, Jingyan Xu, Zunmin Zhu, Li Liu, Xin Zhou, Li Huang, Yin Tong, Ting Niu, Depei Wu, Xufeng Jiang, Chaofu Wang, Binshen Ouyang, Gang Cai, Biao Li, Jia Liu, Zhifeng Li, Rong Xiao, Luqun Wang, Yujie Jiang, Yanyan Liu, Xiaoyun Zheng, Pengpeng Xu, Li Wang, Saijuan Chen, Wei-Li Zhao

https://doi.org/10.3324/haematol.2025.287513

Plasma Cell Disorders

Improving predictive accuracy in multiple myeloma using a plasma cell profile derived from single-cell RNA sequencing (2768 Online Views)

Lanting Liu, Hao Sun, Fangshuo Feng, Xiyue Sun, Jingyuan Ma, Rui Lv, Tengteng Yu, Linhai Ye, Xiuchun Li, Zhen Yu, Xiaoyu Zhang, Huaqing Jing, Yao Yao, Fengxia Ma, Lugui Qiu, Mu Hao

https://doi.org/10.3324/haematol.2025.287586

Clonal plasma cell features in light chain amyloidosis are associated with depth and timing of cardiac response independent of hematologic response (2549 Online Views)

Matthew J. Rees, Susan Geyer, Binoy Yohannan, Nadia Toumeh, Suheil Albert Atallah-Yunes, Morie A. Gertz, Angela Dispenzieri, Suzanne R. Hayman, Francis Buadi, David Dingli, Rahma Warsame, Prashant Kapoor, Martha Grogan, Joselle Cook, Moritz Binder, Nelson Leung, Taxiarchis Kourelis, Wilson Gonsalves, Vincent S. Rajkumar, Shaji Kumar, Eli Muchtar

https://doi.org/10.3324/haematol.2025.287848

Platelet Biology & its Disorders

Risk of cancer in adults with primary immune thrombocytopenia: a binational population-based realworld cohort study from Denmark and France (2879 Online Views)

Nikolaj Mannering, Yoann Zadro, Dennis Lund Hansen, Julien Maquet, Margaux Lafaurie, Anton Pottegård, Guillaume Moulis, Henrik Frederiksen

https://doi.org/10.3324/haematol.2025.287330

Letters to the Editor

13

LDHAL6B is a novel prognostic marker and promotes disease progression in multiple myeloma (1799 Online Views)

Liping Zuo, Zhixin Li, Linyu Cai, Qun Li, Fengjuan Fan, Bo Zhang, Fei Zhao, Shanshan Luo, Yuhuan Zheng, Yu Hu, Chunyan Sun

https://doi.org/10.3324/haematol.2024.286835

Characterization of a novel FLI1 mutation in a family with thrombocytopenia and other congenital malformations (1712 Online Views)

Daniele Ammeti, Serena Barozzi, Alessandro Pecci, Melania Eva Zanchetta, Edward Cesnik, Alessandra Ferlini, Mariabeatrice Sanchini, Laura Verga, Valeria Bozzi, Fabio Corsolini, Michela Faleschini, Anna Savoia, Stefania Bigoni

https://doi.org/10.3324/haematol.2024.287120

T-cell and antibody responses in immunocompromised patients with hematologic malignancies indicate strong potential of SARS-CoV-2 mRNA vaccines (2160 Online Views)

Cilia R. Pothast, Quincy Hofsink, Sabine Haggenburg, Romy C. Dijkland, Marian van de Meent, Kayleigh van Dijk, Michel S. Bhoekhan, Nienke J.E. Haverkate, Johan van Meerloo, J.H. Frederik Falkenburg, Ruben A.L. de Groen, Annoek E.C. Broers, Jaap A. van Doesum, Rob S. van Binnendijk, Gerco den Hartog, Birgit I. Lissenberg-Witte, Arnon P. Kater, Gaby P. Smits, Dorine Wouters, Ester M.M. van Leeuwen, Hetty J. Bontkes, Neeltje A. Kootstra, Sandra Vogels-Nooijen, Debbie van Baarle, Rory D. de Vries, Tom van Meerten, Pim G.N.J. Mutsaers, Abraham Goorhuis, Inger S. Nijhof, Mette D. Hazenberg, Mirjam H.M. Heemskerk, Caroline E. Rutten; COBRA KAI study team (Collaborative Group)

https://doi.org/10.3324/haematol.2024.287136

Clonal evolution and the risk of secondary myeloid neoplasia following chimeric antigen receptor T-cell therapy (2396 Online Views)

Francesca Sillito, Alexandros Rampotas, Kathleen Cheok, Sabine Pomplun, Robert Baker, Teresa Marafioti, Maeve O'Reilly, Rajeev Gupta, Amy A. Kirkwood, Claire Roddie

https://doi.org/10.3324/haematol.2025.287341

Outcomes for unselected, newly diagnosed multiple myeloma patients (3663 Online Views)

Jonathan T. Moore, Sarah M. Mettias, Jamie Cheung, Regina Swift, Benjamin Eades, Shahrooz Eshaghian, Gary Schwartz, James R. Berenson

https://doi.org/10.3324/haematol.2025.287458

MATRix and HD-MTX/IFO/DEP treatment and autologous stem cell transplantation in secondary central nervous system lymphoma: a Dutch retrospective analysis (1789 Online Views)

Fleur A. de Groot, Floriske G. Stedema, Esther J. Kret, Lorraine M. de Haan, Patty M. Jansen, Stefan Böhringer, Arjan Diepstra, Marjolein W.M. van der Poel, Myrurgia Abdul Hamid, Liane C.J. te Boome, Valeska Terpstra, Mirian Brink, Hendrik Veelken, Ruben A.L. de Groen, Tim J.A. Dekker, Marcel Nijland, Joost S.P. Vermaat

https://doi.org/10.3324/haematol.2025.287485

Comprehensive characterization of human bone marrow microenvironment shows age-related changes (2193 Online Views)

Mareike Peters, Patric Teodorescu, Sergiu Pasca, Xuan Zhang, Rulin Wang, Srinivasan Yegnasubramanian, Leighton H. Grimes, Nathan Salomonis, Lukasz P. Gondek, Gabriel Ghiaur

https://doi.org/10.3324/haematol.2025.287536

Case Reports

3

An aggressive hematolymphoid neoplasm with homozygous SMARCB1 loss shows response to EZH2 inhibition (1727 Online Views)

Iman Sarami, Amy S. Duffield, Suchitra Sundaram, Douglas I. Lin, Christian Salib, Shafinaz Hussein, Siraj El Jamal, Nasrin Ghesani, Busra Cangut, Bruce E. Petersen

https://doi.org/10.3324/haematol.2024.285776

Comments

3

Response to Comment on: “A simplified frailty score predicts outcome in curatively treated older patients with classical Hodgkin lymphoma” (1531 Online Views)

Kjersti Lia, Rasmus Rask Kragh Jørgensen, Per Wikman, Bente L. Wold, Ninja Övergaard, Øystein Fluge, Unn-Merete Fagerli, Hanne Bersvendsen, Idun B. Bø, Sameer Bhargava, Daniel Molin, Alexander Fosså

https://doi.org/10.3324/haematol.2025.288284

Erratum

1

Erratum to: “Donor cytomegalovirus serology impacts overall survival in children receiving first unrelated hematopoietic stem cell transplant for acute leukemia: European Society of Bone Marrow Transplantation Pediatric Diseases Working Party Study” (480 Online Views)

Elif Ince, Jaques-Emmanuel Galimard, Marianne Ifversen, Arnaud Dalissier, Zofia Szmit, Oana Mirci-Danicar, Franco Locatelli, Petr Sedlacek, Jan Styczynski, Jean-Hugues Dalle, Cecile Renard, Adriana Balduzzi, Arjan Lankester, Marc Bierings, Franca Fagioli, Katrine Kielsen, Fanny Rialland, Jochen Buechner, Mervi Taskinen, Robert Wynn, Charlotte Jubert, Gérard Michel, Herbert Pichler, Gergely Krivan, Simone Cesaro, Selim Corbacioglu, Roland Meisel, Krzysztof Kalwak

https://doi.org/10.3324/haematol.2025.288047