CURRENT ISSUE
December, 2024
No. 109 (12)

Landmark papers in Hematology

Editorials

Review Series

Perspective Articles

Guidelines

Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukemia in children and young adults (1063 Online Views)

Tobias Feuchtinger, Peter Bader, Marion Subklewe, Maike Breidenbach, Semjon Willier, Markus Metzler, Nicola Gökbuget, Julia Hauer, Fabian Müller, Paul-Gerhardt Schlegel, Michael Frühwald, Christoph Schmid, Anja Troeger, Claudia Baldus, Roland Meisel, Annette Künkele, Max Topp, Jean-Pierre Bourquin, Gunnar Cario, Arend von Stackelberg, Christina Peters

https://doi.org/10.3324/haematol.2023.283780

Articles

Acute Lymphoblastic Leukemia

IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia (765 Online Views)

Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen

https://doi.org/10.3324/haematol.2023.284357

Azacitidine as epigenetic priming for chemotherapy is safe and well-tolerated in infants with newly diagnosed KMT2A-rearranged acute lymphoblastic leukemia: Children’s Oncology Group trial AALL15P1 (637 Online Views)

Erin M. Guest, John A. Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown

https://doi.org/10.3324/haematol.2024.285158

Cell Therapy & Immunotherapy

Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab (976 Online Views)

Alexander Biedermann, Maria Patra-Kneuer, Dimitrios Mougiakakos, Maike Büttner-Herold, Doris Mangelberger-Eberl, Johannes Berges, Christian Kellner, Sarah Altmeyer, Jörg Thomas Bittenbring, Christian Augsberger, Kristina Ilieva-Babinsky, Stefan Haskamp, Fabian Beier, Christopher Lischer, Julio Vera, Anja Lührmann, Simone Bertz, Simon Völkl, Benedikt Jacobs, Stefan Steidl, Andreas Mackensen, Heiko Bruns

https://doi.org/10.3324/haematol.2023.284795

Umbilical cord blood T cells can be isolated and enriched by CD62L selection for use in ‘off the shelf’ chimeric antigen receptor T-cell therapies to widen transplant options (809 Online Views)

Christos Georgiadis, Lauren Nickolay, Farhatullah Syed, Hong Zhan, Soragia Athina Gkazi, Annie Etuk, Ulrike Abramowski-Mock, Roland Preece, Piotr Cuber, Stuart Adams, Giorgio Ottaviano, Waseem Qasim

https://doi.org/10.3324/haematol.2024.285101

Chronic Myeloid Leukemia

Safety and efficacy of flumatinib as later-line therapy in patients with chronic myeloid leukemia (672 Online Views)

Yunfan Yang, Yuntao Liu, Hui Sun, Li Meng, Hai Lin, Chunyan Chen, Jianda Hu, Xuliang Shen, Minghui Duan, Yanli Zhang, Dilinazi Abulaiti, Jinghua Wang, Hongqian Zhu, Luoming Hua, Qing Leng, Chun Zhang, Lili Sun, Weiming Li, Huanling Zhu, Bingcheng Liu, Jianxiang Wang

https://doi.org/10.3324/haematol.2023.284892

Hematopoiesis

LSD1/KDM1A and GFI1B repress endothelial fate and induce hematopoietic fate in induced pluripotent stem cell-derived hemogenic endothelium (818 Online Views)

Huan Zhang, Marten Hansen, Franca di Summa, Marieke von Lindern, Nynke Gillemans, Wilfred F.J. van IJcken, Arthur Flohr Svendsen, Sjaak Philipsen, Bert van der Reijden, Eszter Varga, Emile van den Akker

https://doi.org/10.3324/haematol.2024.285214

Non-Hodgkin Lymphoma

Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma (1015 Online Views)

Nicholas Davies, Tegan Francis, Ceri Oldreive, Maria Azam, Jordan Wilson, Philip J. Byrd, Megan Burley, Archana Sharma-Oates, Peter Keane, Sael Alatawi, Martin R. Higgs, Zbigniew Rudzki, Maha Ibrahim, Tracey Perry, Angelo Agathanggelou, Anne-Marie Hewitt, Edward Smith, Constanze Bonifer, Mark O’Connor, Josep V. Forment, Paul G. Murray, Eanna Fennell, Gemma Kelly, Catherine Chang, Grant S. Stewart, Tatjana Stankovic, Marwan Kwok, Alexander Malcolm Taylor

https://doi.org/10.3324/haematol.2023.284404

Core regions in immunoglobulin heavy chain enhancers essential for survival of non-Hodgkin lymphoma cells are identified by a CRISPR interference screen (693 Online Views)

Marta Elżbieta Kasprzyk, Weronika Sura, Marta Podralska, Marta Kazimierska, Annika Seitz, Wojciech Łosiewski, Tomasz Woźniak, Jeroen E. J. Guikema, Arjan Diepstra, Joost Kluiver, Anke van den Berg, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk

https://doi.org/10.3324/haematol.2023.284672

Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations (825 Online Views)

Caroline S. Myers, Eli Williams, Carlos Barrionuevo Cornejo, Georgios Pongas, Ngoc L. Toomey, Jose A. Sanches, Maxime Battistella, Samuel Mo, Melissa Pulitzer, Cristopher A. Moskaluk, Govind Bhagat, Kenneth Ofori, Jonathan J. Davick, Octavio Servitje, Denis Miyashiro, Fina Climent, Kimberley Ringbloom, Daniela Duenas, Calvin Law, Sandro Casavilca Zambrano, Luis Malpica, Brady E. Beltran, Denisse Castro, Luciana Barreto, Carlos Brites, Jennifer R. Chapman, Jaehyuk Choi, Alejandro A. Gru, Juan C. Ramos

https://doi.org/10.3324/haematol.2024.285233

Plasma Cell Disorders

Combinatorial strategies targeting NEAT1 and AURKA as new potential therapeutic options for multiple myeloma (762 Online Views)

Noemi Puccio, Gloria Manzotti, Elisabetta Mereu, Federica Torricelli, Domenica Ronchetti, Michela Cumerlato, Ilaria Craparotta, Laura Di Rito, Marco Bolis, Valentina Traini, Veronica Manicardi, Valentina Fragliasso, Yvan Torrente, Nicola Amodio, Niccolò Bolli, Elisa Taiana, Alessia Ciarrocchi, Roberto Piva, Antonino Neri

https://doi.org/10.3324/haematol.2024.285470

Single-point and kinetics of peripheral residual disease by mass spectrometry to predict outcome in patients with high-risk smoldering multiple myeloma included in the GEM-CESAR trial (1101 Online Views)

Noemí Puig, Cristina Agulló, Teresa Contreras, José-Juan Pérez, Irene Aires, María-José Calasanz, Ramón García-Sanz, Sergio Castro, Joaquín Martínez-López, Paula Rodríguez-Otero, Verónica González-Calle, Marta S González, Albert Oriol, Norma C Gutiérrez, Rafael Ríos-Tamayo, Laura Rosiñol, Miguel-Ángel Álvarez, Joan Bargay, Ana-Pilar González-Rodríguez, Adrián Alegre, Fernando Escalante, María-Belén Iñigo, Javier de la Rubia, Ana-Isabel Teruel, Felipe de Arriba, Luis Palomera, Miguel T Hernández, Javier López-Jiménez, Marta Reinoso, Aránzazu García-Mateo, Enrique M Ocio, Joan Bladé, Juan-José Lahuerta, María-Teresa Cedena, Bruno Paiva, Jesús F San Miguel, María-Victoria Mateos

https://doi.org/10.3324/haematol.2024.285742

Letters to the Editor

Co-shared genomic alterations within tumors from patients with both myeloproliferative neoplasms and lymphoma (388 Online Views)

Johanne M. Holst, Martin B. Pedersen, Marie B. Enemark, Marcus C. Hansen, Patrick R. Noerhave, Trine L. Plesner, Henrik Frederiksen, Michael B. Moeller, Stephen J. Hamilton-Dutoit, Peter Noergaard, Bo K. Mortensen, Hans B. Ommen, Jesper Stentoft, Wayne Tam, Maja Ludvigsen, Wing C. Chan, Nicolai J. Birkbak, Giorgio Inghirami, Francesco d’Amore

https://doi.org/10.3324/haematol.2023.283798

A multicenter, phase Ib study of subcutaneous administration of isatuximab in combination with pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma (1049 Online Views)

Hang Quach, Gurdeep Parmar, Enrique M. Ocio, H. Miles Prince, Albert Oriol, Helen Crowther, Nobuhiro Tsukada, Pierre Bories, Sumit Madan, Nitya Nathwani, Kazutaka Sunami, Dorothee Semiond, Disa Yu, Paul Cordero, Sandrine Macé, Florence Suzan, Philippe Moreau

https://doi.org/10.3324/haematol.2023.284730

A transgenic mouse model of Down syndrome acute lymphoblastic leukemia identifies targetable vulnerabilities (379 Online Views)

Jacob J. Junco, Max Rochette, Michelle Alozie, Raushan Rashid, Maci Terrell, Barry Zorman, Pavel Sumazin, Lauren Rowland, Gino Dettorre, Reid T. Powell, Clifford C. Stephan, Peter J. Davies, Margarita Martinez-Moczygemba, Jun J. Yang, Karen R. Rabin

https://doi.org/10.3324/haematol.2023.284761

Ponatinib alone or with chemo-immunotherapy in heavily pre treated Philadelphia-like acute lymphoblastic leukemia: a CAMPUS ALL real-life study (601 Online Views)

Francesca Kaiser, Monia Lunghi, Deborah Cardinali, Vittorio Bellomarino, Marco Beldinanzi, Irene Della Starza, Francesco Malfona, Claudia M. Basilico, Marzia Defina, Sara Mastaglio, Fabio Giglio, Davide Lazzarotto, Prassede Salutari, Matteo Piccini, Valeria Cardinali, Antonio Pierini, Nicola S. Fracchiolla, Federica Di Biase, Mario Annunziata, Mariangela Di Trani, Robin Foa, Sabina Chiaretti

https://doi.org/10.3324/haematol.2024.285258

A phase II study of post-remission therapy with pembrolizumab in older patients with acute myeloid leukemia (395 Online Views)

Kevin Quann, Konstantinos Lontos, Alison Sehgal, Anastasios Raptis, Annie Im, Robert L. Redner, Kathleen A. Dorritie, Mounzer Agha, Jing-Zhou Hou, Rafic Farah, James Rossetti, Daniel P. Normolle, Theresa L. Whiteside, Yen-Michael Sheng Hsu, Michael Boyiadzis

https://doi.org/10.3324/haematol.2024.285313

Infection by Helicobacter pylori cytotoxin-A-associated antigen-positive strains is associated with iron deficiency anemia in a longitudinal birth cohort in Brazil (296 Online Views)

Dulciene M. M. Queiroz, Lucia L. C. Braga, Gifone A. Rocha, Sérgio A. Batista, Andreia M. C. Rocha, Mayuko Saito, William Checkley, Robert H. Gilman, Jean E. Crabtree

https://doi.org/10.3324/haematol.2024.285446

Superior survival with allogeneic hematopoietic stem cell transplantation versus chemotherapy for high-risk adult acute lymphoblastic leukemia in a PDT-ALL-2016 pediatric-inspired cohort (426 Online Views)

Junjie Chen, Zihong Cai, Zicong Huang, Jieping Lin, Zhixiang Wang, Jiawang Ou, Xiuli Xu, Bingqing Tang, Chenhao Ding, Jia Li, Ren Lin, Ting Zhang, Li Xuan, Qifa Liu, Hongsheng Zhou

https://doi.org/10.3324/haematol.2024.285590

Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia (641 Online Views)

Farnaz Barneh, Joost B. Koedijk, Noa E. Wijnen, Tom Meulendijks, Minoo Ashtiani, Ester Dunnebach, Noël Dautzenberg, Annelisa M. Cornel, Anja Krippner-Heidenreich, Kim Klein, Michel C. Zwaan, Jürgen Kuball, Stefan Nierkens, Jacqueline Cloos, Gertjan J.L. Kaspers, Olaf Heidenreich

https://doi.org/10.3324/haematol.2024.285707

Case Reports

Expanding the genetic landscape of congenital neutropenia: CXCR2 mutations in three families revealed through whole exome sequencing (477 Online Views)

Maksim Klimiankou, Ivan Tesakov, Grigorios Tsaknakis, Erasmia Boutakoglou, Irene Mavroudi, Malte Ritter, Marc Sturm, Julia Skokowa, Helen A. Papadaki

https://doi.org/10.3324/haematol.2024.285569

Comments

Errata Corrige

Erratum to: Breast implant-associated Epstein-Barr virus-positive large B-cell lymphomas: a report of three cases (1 Online View)

Socorro María Rodríguez-Pinilla, Francisco Javier Sánchez García, Olga Balagué, Manuel Rodríguez-Justo, Miguel Ángel Piris

https://doi.org/10.3324/haematol.2024.285012