March, 2024
No. 109 (3)

Editorials

Spotlight Review

Articles

Acute Myeloid Leukemia

Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation (1465 Online Views)

Ahmed Waraky, Anders Östlund, Tina Nilsson, Dieter Weichenhan, Pavlo Lutsik, Marion Bähr, Joschka Hey, Gürcan Tunali, Jenni Adamsson, Susanna Jacobsson, Mohammad Hamdy Abdelrazak Morsy, Susann Li, Linda Fogelstrand, Christoph Plass, Lars Palmqvist

https://doi.org/10.3324/haematol.2022.282255

Genomic breakpoint-specific monitoring of measurable residual disease in pediatric non-standard-risk acute myeloid leukemia (953 Online Views)

Margarita Maurer-Granofszky, Stefan Kohrer, Susanna Fischer, Angela Schumich, Karin Nebral, Patrizia Larghero, Claus Meyer, Astrid Mecklenbrauker, Nora Muhlegger, Rolf Marschalek, Oskar A. Haas, Renate Panzer-Grumayer, Michael N. Dworzak

https://doi.org/10.3324/haematol.2022.282424

DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response (1218 Online Views)

Minjing Li, Xingli Wu, Meiyang Chen, Shiyu Hao, Yue Yu, Xiang Li, Erdi Zhao, Ming Xu, Zhenhai Yu, Zhiqiang Wang, Ning Xu, Changzhu Jin, Yancun Yin

https://doi.org/10.3324/haematol.2023.282691

Bone Marrow Failure

Current use of androgens in bone marrow failure disorders: a report from the Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (2503 Online Views)

Simona Pagliuca, Austin G. Kulasekararaj, Dirk-Jan Eikema, Brian Piepenbroek, Raheel Iftikhar, Tariq Mahmood Satti, Morag Griffin, Marica Laurino, Alphan Kupesiz, Yves Bertrand, Bruno Fattizzo, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Paola Corti, Erika Massaccesi, Bruno Lioure, Marisa Calabuig, Matthias Klammer, Emel Unal, Depei Wu, Patrice Chevallier, Edouard Forcade, John A. Snowden, Hakan Ozdogu, Antonio Risitano, Régis Peffault de Latour

https://doi.org/10.3324/haematol.2023.282935

Cell Therapy & Immunotherapy

Idecabtagene vicleucel chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma with renal impairment (2553 Online Views)

Surbhi Sidana, Lauren C. Peres, Hamza Hashmi, Hitomi Hosoya, Christopher Ferreri, Jack Khouri, Danai Dima, Shebli Atrash, Peter Voorhees, Gary Simmons, Douglas W. Sborov, Nilesh Kalariya, Vanna Hovanky, Sushma Bharadwaj, David Miklos, Charlotte Wagner, Mehmet H. Kocoglu, Gurbakhash Kaur, James A. Davis, Shonali Midha, Murali Janakiram, Ciara Freeman, Melissa Alsina, Frederick Locke, Rebecca Gonzalez, Yi Lin, Joseph McGuirk, Aimaz Afrough, Leyla Shune, Krina K. Patel, Doris K. Hansen

https://doi.org/10.3324/haematol.2023.283940

Regulatory T cells hamper the efficacy of T-cell-engaging bispecific antibody therapy (1742 Online Views)

Mika Casey, Carol Lee, Wing Yu Kwok, Soi Cheng Law, Dillon Corvino, Maher K Gandhi, Simon J Harrison, Kyohei Nakamura

https://doi.org/10.3324/haematol.2023.283758

Chronic Lymphocytic Leukemia

Lymphocyte migration and retention properties affected by ibrutinib in chronic lymphocytic leukemia (1609 Online Views)

Javier Rey-Barroso, Alice Munaretto, Nelly Rouquié, Aurélie Mougel, Malika Chassan, Sébastien Gadat, Océane Dewingle, Renaud Poincloux, Sarah Cadot, Loïc Ysebaert, Anne Quillet-Mary, Loïc Dupré

https://doi.org/10.3324/haematol.2022.282466

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia (1303 Online Views)

Edwin Quinten, Julieta H. Sepúlveda-Yáñez, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Valeri Nteleah, Ruben A.L. de Groen, Diego Alvarez Saravia, Jeroen Knijnenburg, Hedwig E. Stuivenberg-Bleijswijk, Milena Pantic, Andreas Agathangelidis, Andrea Keppler-Hafkemeyer, Cornelis A. M. van Bergen, Roberto Uribe-Paredes, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo A. Navarrete, Hassan Jumaa, Hendrik Veelken

https://doi.org/10.3324/haematol.2022.282542

Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies (1633 Online Views)

David W. Woolston, Nathan D. Lee, Mazyar Shadman, Elena Latorre-Esteves, Xin Ray Tee, Jeanne Fredrickson, Brendan F. Kohrn, Chaitra Ujjani, Ashley Eckel, Brian Till, Min Fang, Jerald Radich, Ivana Bozic, Rosa Ana Risques, Cecilia C.S. Yeung

https://doi.org/10.3324/haematol.2023.283372

Non-Hodgkin Lymphoma

Lisocabtagene maraleucel for second-line relapsed or refractory large B-cell lymphoma: patient-reported outcomes from the PILOT study (1510 Online Views)

Leo I. Gordon, Fei Fei Liu, Julia Braverman, Daanish Hoda, Nilanjan Ghosh, Mehdi Hamadani, Gerhard C. Hildebrandt, Lily Peng, Shien Guo, Ling Shi, Alison Sehgal

https://doi.org/10.3324/haematol.2023.283162

Plasma Cell Disorders

ANCHOR: melflufen plus dexamethasone and daratumumab or bortezomib in relapsed/refractory multiple myeloma: final results of a phase I/IIa study (1940 Online Views)

Enrique M. Ocio, Yvonne A. Efebera, Roman Hájek, Jan Straub, Vladimir Maisnar, Jean-Richard Eveillard, Lionel Karlin, María-Victoria Mateos, Albert Oriol, Vincent Ribrag, Paul G. Richardson, Stefan Norin, Jakob Obermüller, Nicolaas A. Bakker, Luděk Pour

https://doi.org/10.3324/haematol.2023.283490

Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling (640 Online Views)

Ignacio J. Cardona-Benavides, Irena Misiewicz-Krzeminska, Elizabeta A. Rojas, Cristina De Ramón, Antonio Sanz-Solas, Isabel Isidro, Dalia Quwaider, Aida M. López-Guerrero, Myriam Cuadrado, María-José Calasanz, Laura Rosiñol, Joaquín Martínez-López, Jesús F. San Miguel, María-Victoria Mateos, Luis A. Corchete, Norma C. Gutiérrez

https://doi.org/10.3324/haematol.2023.283445

What is the best treatment strategy before autologous peripheral blood stem cell transplantation in POEMS syndrome? (622 Online Views)

Francesco Autore, Stefania Bramanti, Federica Lessi, Idanna Innocenti, Eugenio Galli, Serena Rocchi, Rossella Ribolla, Daniele Derudas, Stefania Oliva, Paola Stefanoni, Magda Marcatti, Angelo Schenone, Giorgio La Nasa, Claudia Crippa, Elena Zamagni, Marcello Riva, Rita Mazza, Daniele Mannina, Simona Sica, Andrea Bacigalupo, Luca Laurenti

https://doi.org/10.3324/haematol.2023.283719

Efficacy and safety of melflufen plus daratumumab and dexamethasone in relapsed/refractory multiple myeloma: results from the randomized, open-label, phase III LIGHTHOUSE study (2936 Online Views)

Luděk Pour, Monika Szarejko, Jelena Bila, Fredrik H. Schjesvold, Ivan Spicka, Vladimir Maisnar, Artur Jurczyszyn, Zhanet Grudeva-Popova, Roman Hájek, Ganna Usenko, Marcus Thuresson, Stefan Norin, Sara Jarefors, Nicolaas A. Bakker, Paul G. Richardson, Maria-Victoria Mateos

https://doi.org/10.3324/haematol.2023.283509

The changing spectrum of infection with BCMA and GPRC5D targeting bispecific antibody (bsAb) therapy in patients with relapsed refractory multiple myeloma (1676 Online Views)

Lindsay Hammons, Aniko Szabo, Abhishek Janardan, Vineel Bhatlapenumarthi, Evanka Annyapu, Binod Dhakal, Samer Al Hadidi, Sabarinath Venniyil Radhakrishnan, Ravi Narra, Divaya Bhutani, Sharmilan Thanendrarajan, Siegfried Janz, Maurizio Zangari, Suzanne Lentzsch, Frits van Rhee, Juan Carlos Rico Crescencio, Anita D’Souza, Rajshekhar Chakraborty, Meera Mohan, Carolina Schinke

https://doi.org/10.3324/haematol.2023.283590

Platelet Biology & its Disorders

Dynamic actin/septin network in megakaryocytes coordinates proplatelet elaboration (1318 Online Views)

Isabelle C. Becker, Adrian R. Wilkie, Bret A. Unger, Anthony R. Sciaudone, Farheen Fatima, I-Ting Tsai, Ke Xu, Kellie R. Machlus, Joseph E. Italiano

https://doi.org/10.3324/haematol.2023.283369

Letters to the Editor

Phase II trials of zilucoplan in paroxysmal nocturnal hemoglobinuria (1067 Online Views)

Austin G. Kulasekararaj, Anna-Elina Lehtinen, Cecily Forsyth, Shreyans Gandhi, Morag Griffin, Sixten Körper, Gabor Mikala, Petra Muus, Ulrik Overgaard, Christopher J. Patriquin, Humphrey Pullon, Yu-Min Shen, Ruth Spearing, Jeff Szer, Guillemette de la Borderie, Petra W. Duda, Ramin Farzaneh-Far, Sharan Ragunathan, Camil E. Sayegh, Douangsone D. Vadysirisack, Hubert Schrezenmeier

https://doi.org/10.3324/haematol.2022.281780

Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study (687 Online Views)

Maya Schulpen, Auke Beishuizen, Martine E. D. Chamuleau, Avinash G. Dinmohamed, Friederike A. G. Meyer-Wentrup, H. Josef Vormoor, Lotte E. van der Wagen, Monique C. Minnema, Jan L. C. Loeffen, Henrike E. Karim-Kos

https://doi.org/10.3324/haematol.2023.283379

Somatic variant profiling in chronic phase pediatric chronic myeloid leukemia (582 Online Views)

Yvonne Lisa Behrens, Laura Gaschler, Ronny Nienhold, Thea Reinkens, Elke Schirmer, Sabine Knöß, Renate Strasser, Stephanie Sembill, Zofia Wotschofsky, Meinolf Suttorp, Manuela Krumbholz, Brigitte Schlegelberger, Markus Metzler, Gudrun Göhring, Axel Karow

https://doi.org/10.3324/haematol.2023.283800

Outcome heterogeneity of TP53-mutated myeloid neoplasms and the role of allogeneic hematopoietic cell transplantation (698 Online Views)

Sergiu Pasca, Saurav D. Haldar, Alexander Ambinder, Jonathan A. Webster, Tania Jain, W. Brian Dalton, Gabrielle T. Prince, Gabriel Ghiaur, Amy E. DeZern, Ivana Gojo, B. Douglas Smith, Theodoros Karantanos, Cory Schulz, Kristin Stokvis, Mark J. Levis, Richard J. Jones, Lukasz P. Gondek

https://doi.org/10.3324/haematol.2023.283886

A phase II study of interrupted and continuous dose lenalidomide in relapsed/refractory Hodgkin lymphoma (1620 Online Views)

Todd A. Fehniger, Marcus P. Watkins, Nkiruka Ezenwajiaku, Fei Wan, David D. Hurd, Amanda F. Cashen, Kristie A. Blum, Andre Goy, Timothy S. Fenske, Nina D. Wagner-Johnston, Kenneth Carson, Marilyn J. Siegel, David Russler-Germain, Stephanie E. Schneider, Neha Mehta-Shah, Brad Kahl, Nancy L. Bartlett

https://doi.org/10.3324/haematol.2022.282246

Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment (678 Online Views)

Hanny Al-Samkari, Rachael F. Grace, Andreas Glenthøj, Oliver Andres, Wilma Barcellini, Frédéric Galacteros, Kevin H. M. Kuo, D. Mark Layton, Marta Morado, Vip Viprakasit, Feng Tai, Rolandas Urbstonaitis, Jaime Morales, Bryan McGee, Eduard J. van Beers

https://doi.org/10.3324/haematol.2023.282884

Engineering a humanized animal model of polycythemia vera with minimal JAK2V617F mutant allelic burden (1019 Online Views)

Tyler M. Parsons, Aishwarya Krishnan, Wangisa M.B. Dunuwille, Andrew L. Young, Jason Arand, Wentao Han, Grant A. Challen

https://doi.org/10.3324/haematol.2023.283858

Venetoclax salvage therapy in relapsed/refractory multiple myeloma (1094 Online Views)

Maximilian J. Steinhardt, Marietta Truger, Max Bittrich, Xiang Zhou, Julia Noderer, Christine Riedhammer, Xianghui Xiao, Sophia Gawlas, Philipp Weis, Florian Eisele, Claudia Haferlach, Julia Mersi, Johannes Waldschmidt, Hermann Einsele, Leo Rasche, K. Martin Kortüm

https://doi.org/10.3324/haematol.2023.283472

Brentuximab vedotin with chemotherapy in adolescents and young adults with stage III or IV classical Hodgkin lymphoma in ECHELON-1 (1806 Online Views)

Howland E. Crosswell, Ann S. LaCasce, Nancy L. Bartlett, David J. Straus, Kerry J. Savage, Pier Luigi Zinzani, Graham P. Collins, Michelle Fanale, Keenan Fenton, Cassie Dong, Harry Miao, Andrew P. Grigg

https://doi.org/10.3324/haematol.2023.283303

BH3 mimetics in relapsed and refractory adult acute lymphoblastic leukemia: a Campus ALL real-life study (689 Online Views)

Francesco Malfona, Ilaria Tanasi, Matteo Piccini, Cristina Papayannidis, Vincenzo Federico, Valentina Mancini, Elisa Roncoroni, Elisabetta Todisco, Simona Bianchi, Giulia Ciotti, Patrizia Chiusolo, Massimo Gentile, Valentina Gianfelici, Fabio Giglio, Michele Malagola, Antonino Mulé, Francesco Saraceni, Calogero Vetro, Francesco Zallio, Luca Vincenzo Cappelli, Giovanni Pizzolo, Robin Foà, Massimiliano Bonifacio, Sabina Chiaretti

https://doi.org/10.3324/haematol.2023.283684

Case Reports

Concurrent peripheral T-cell lymphoma and T-cell lymphoblastic leukemia/lymphoma with identical STIL::TAL1 fusion events (637 Online Views)

Mahsa Khanlari, Wei Wang, Yen-Chun Liu, Lu Wang, Jeffrey E. Rubnitz, Stephanie Dixon, Brent A. Orr, Obianuju M. Anelo, Zhongshan Cheng, Vidya Balagopal, Jeffery M. Klco

https://doi.org/10.3324/haematol.2023.283585

Tucidinostat restores CCR4 expression in adult T-cell leukemia/lymphoma (1153 Online Views)

Takahito Kawata, Takuya Shimizu, Takero Shindo, Kensuke Fujiwara, Suguru Morimoto, Mitsumasa Watanabe

https://doi.org/10.3324/haematol.2023.283266