CURRENT ISSUE
September, 2022
No. 107 (9)

About the Cover

Landmark papers in Hematology

Editorials

Review Articles

IgM monoclonal gammopathies of clinical significance: diagnosis and management (3512 Online Views)

Jahanzaib Khwaja, Shirley D’Sa, Monique C. Minnema, Marie José Kersten, Ashutosh Wechalekar, Josephine M. Vos

https://doi.org/10.3324/haematol.2022.280953

Articles

Acute Lymphoblastic Leukemia

Genetic and genomic analysis of acute lymphoblastic leukemia in older adults reveals a distinct profile of abnormalities: analysis of 210 patients from the UKALL14 and UKALL60+ clinical trials (1986 Online Views)

Thomas Creasey, Emilio Barretta, Sarra L. Ryan, Ellie Butler, Amy A. Kirkwood, Daniel Leongamornlert, Elli Papaemmanuil, Pip Patrick, Laura Clifton-Hadley, Bela Patel, Tobias Menne, Andrew K. McMillan, Christine J. Harrison, Clare J. Rowntree, Nick Morley, David I. Marks, Adele K. Fielding, Anthony V. Moorman

https://doi.org/10.3324/haematol.2021.279177

Outcome of relapsed or refractory acute B-lymphoblastic leukemia patients and BCR-ABL-positive blast cell crisis of B-lymphoid lineage with extramedullary disease receiving inotuzumab ozogamicin (1105 Online Views)

Sabine Kayser, Chiara Sartor, Marlise R. Luskin, Jonathan Webster, Fabio Giglio, Nydia Panitz, Andrew M. Brunner, Matthias Fante, Christoph Lutz, Daniel Wolff, Anthony D. Ho, Mark J. Levis, Richard F. Schlenk, Cristina Papayannidis

https://doi.org/10.3324/haematol.2021.280433

High tumor burden before blinatumomab has a negative impact on the outcome of adult patients with B-cell precursor acute lymphoblastic leukemia. A real-world study by the GRAALL (1080 Online Views)

Aurelie Cabannes-Hamy, Eolia Brissot, Thibaut Leguay, Francoise Huguet, Patrice Chevallier, Mathilde Hunault, Martine Escoffre-Barbe, Thomas Cluzeau, Marie Balsat, Stephanie Nguyen, Florence Pasquier, Magda Alexis, Veronique Lheritier, Cedric Pastoret, Eric Delabesse, Emmanuelle Clappier, Herve Dombret, Nicolas Boissel

https://doi.org/10.3324/haematol.2021.280078

Bone Marrow Failure

Syndromes predisposing to leukemia are a major cause of inherited cytopenias in children (1479 Online Views)

Oded Gilad, Orly Dgany, Sharon Noy-Lotan, Tanya Krasnov, Joanne Yacobovich, Ron Rabinowicz, Tracie Goldberg, Amir A. Kuperman, Abed Abu-Quider, Hagit Miskin, Noa Kapelushnik, Noa Mandel-Shorer, Shai Shimony, Dan Harlev, Tal Ben-Ami, Etai Adam, Carina Levin, Shraga Aviner, Ronit Elhasid, Sivan Berger-Achituv, Lilach Chaitman-Yerushalmi, Yona Kodman, Nino Oniashvilli, Michal Hameiri-Grosman, Shai Izraeli, Hannah Tamary, Orna Steinberg-Shemer

https://doi.org/10.3324/haematol.2021.280116

Cell Therapy and Immunotherapy

Increased visceral fat distribution and body composition impact cytokine release syndrome onset and severity after CD19 chimeric antigen receptor T-cell therapy in advanced B-cell malignancies (1873 Online Views)

David M. Cordas dos Santos, Kai Rejeski, Michael Winkelmann, Lian Liu, Paul Trinkner, Sophie Günther, Veit L. Bücklein, Viktoria Blumenberg, Christian Schmidt, Wolfgang G. Kunz, Michael von Bergwelt-Baildon, Sebastian Theurich, Marion Subklewe

https://doi.org/10.3324/haematol.2021.280189

Chronic Lymphocytic Leukemia

First-line treatment of chronic lymphocytic leukemia with ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab: final analysis of the randomized, phase III iLLUMINATE trial (3019 Online Views)

Carol Moreno, Richard Greil, Fatih Demirkan, Alessandra Tedeschi, Bertrand Anz, Loree Larratt, Martin Simkovic, Jan Novak, Vladimir Strugov, Devinder Gill, John G. Gribben, Kevin Kwei, Sandra Dai, Emily Hsu, James P. Dean, Ian W. Flinn

https://doi.org/10.3324/haematol.2021.279012

Hemostasis

The von Willebrand factor A-1 domain binding aptamer BT200 elevates plasma levels of von Willebrand factor and factor VIII: a first-in-human trial (1083 Online Views)

Katarina D. Kovacevic, Jürgen Grafeneder, Christian Schörgenhofer, Georg Gelbenegger, Gloria Gager, Christa Firbas, Peter Quehenberger, Petra Jilma-Stohlawetz, Andrea Bileck, Shuhao Zhu, James C. Gilbert, Martin Beliveau, Bernd Jilma, Ulla Derhaschnig

https://doi.org/10.3324/haematol.2021.279948

Non-Hodgkin Lymphoma

Humoral immune depression following autologous stem cell transplantation is a marker of prolonged response duration in patients with mantle cell lymphoma (938 Online Views)

Louise Bouard, Benoit Tessoulin, Catherine Thieblemont, Kamal Bouabdallah, Thomas Gastinne, Lucie Oberic, Sylvain Carras, Caroline Delette, Olivier Casasnovas, Caroline Dartigeas, Victoria Cacheux, Sibylle Masse, Olivier Hermine, Steven Le Gouill

https://doi.org/10.3324/haematol.2021.279561

Rituximab in addition to LMB-based chemotherapy regimen in children and adolescents with primary mediastinal large B-cell lymphoma: results of the French LMB2001 prospective study (959 Online Views)

Marie Emilie Dourthe, Aurélie Phulpin, Anne Auperin, Jacques Bosq, Marie-Laure Couec, Peggy Dartigues, Stéphane Ducassou, Nathalie Garnier, Stéphanie Haouy, Thierry Leblanc, Amaury Leruste, Catherine Paillard, Charlotte Rigaud, Mathieu Simonin, Catherine Patte, Véronique Minard-Colin

https://doi.org/10.3324/haematol.2021.280257

Plasma Cell Disorders

Extracellular vesicles mediate the communication between multiple myeloma and bone marrow microenvironment in a NOTCH dependent way (1274 Online Views)

Domenica Giannandrea, Natalia Platonova, Michela Colombo, Mara Mazzola, Valentina Citro, Raffaella Adami, Filippo Maltoni, Silvia Ancona, Vincenza Dolo, Ilaria Giusti, Andrea Basile, Anna Pistocchi, Laura Cantone, Valentina Bollati, Lavinia Casati, Elisabetta Calzavara, Mauro Turrini, Elena Lesma, Raffaella Chiaramonte

https://doi.org/10.3324/haematol.2021.279716

Platelet Biology & its Disorders

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia (1027 Online Views)

Shiying Silvia Zheng, Zohra Ahmadi, Halina Hoi Laam Leung, Rose Wong, Feng Yan, Jose Sail Perdomo, Beng Hock Chong

https://doi.org/10.3324/haematol.2021.279751

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets (788 Online Views)

Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky

https://doi.org/10.3324/haematol.2021.279761

Letters to the Editor

Deregulated JAK3 mediates growth advantage and hemophagocytosis in extranodal nasal-type natural killer/T-cell lymphoma (650 Online Views)

Adrien Picod, Suella Martino, Pascale Cervera, Gregory Manuceau, Marc Arca, Monica Wittner, YanYan Zhang, He Liang, Florian Beghi, Eric Solary, Fawzia Louache, Paul Coppo

https://doi.org/10.3324/haematol.2021.280349

β adrenergic signaling regulates hematopoietic stem and progenitor cell commitment and therapy sensitivity in multiple myeloma (976 Online Views)

Remya Nair, Vimal Subramaniam, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Sagar Lonial, Lawrence H. Boise, Ajay K. Nooka, Kuzhali Muthumalaiappan, Mala Shanmugam

https://doi.org/10.3324/haematol.2022.280907

Pure erythroid leukemia is characterized by biallelic TP53 inactivation and abnormal p53 expression patterns in de novo and secondary cases (1095 Online Views)

Hong Fang, Sa A. Wang, Joseph D. Khoury, Siba El Hussein, Do Hwan Kim, Mehrnoosh Tashakori, Zhenya Tang, Shaoying Li, Zhihong Hu, Fatima Zahra Jelloul, Keyur P. Patel, Timothy J. McDonnell, Tapan Kadia, L. Jeffrey Medeiros, Wei Wang

https://doi.org/10.3324/haematol.2021.280487

The gut microbiome in patients with chronic lymphocytic leukemia (1025 Online Views)

Tereza Faitová, Rebecka Svanberg, Caspar da Cunha-Bang, Emma E. Ilett, Mette Jørgensen, Marc Noguera-Julian, Roger Paredes, Cameron R. MacPherson, Carsten U. Niemann

https://doi.org/10.3324/haematol.2021.280455

A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis (564 Online Views)

José Manuel Soria, Sergi Mojal, Angel Martinez-Perez, Francisco René Acosta, Sonia López, Sara Miqueleiz, Diana Rodriguez, Maria Angeles Quijada, Antonio Cardenas, Francisco Vidal, Angel Remacha, Rosa Maria Antonijoan, Juan Carlos Souto

https://doi.org/10.3324/haematol.2022.281068

ETV6-related thrombocytopenia: dominant negative effect of mutations as common pathogenic mechanism (845 Online Views)

Michela Faleschini, Daniele Ammeti, Nicole Papa, Caterina Alfano, Roberta Bottega, Giorgia Fontana, Valeria Capaci, Melania E. Zanchetta, Federico Pozzani, Francesca Montanari, Valeria Petroni, Paola Giordano, Patrizia Noris, Fiorina Giona, Anna Savoia

https://doi.org/10.3324/haematol.2022.280729

Profound and sustained response with next-generation ALK inhibitors in patients with relapsed or progressive ALK-positive anaplastic large cell lymphoma with central nervous system involvement (580 Online Views)

Charlotte Rigaud, Samuel Abbou, Stephane Ducassou, Mathieu Simonin, Lou Le Mouel, Victor Pereira, Stephanie Gourdon, Anne Lambilliotte, Birgit Geoerger, Veronique Minard-Colin, Laurence Brugieres

https://doi.org/10.3324/haematol.2021.280081

Autologous stem cell transplantation in an older adult population (506 Online Views)

Kateryna Fedorov, Tanim Jain, Kith Pradhan, Jennat Mustafa, Amanda Lombardo, Fariha Khatun, Felisha Joseph, Kailyn Gillick, Anjali Naik, Richard Elkind, Karen Fehn, Alyssa de Castro, Roy Browne, Michelly Abreu, Donika Binakaj, Monika Paroder, Carlo Palesi, Kira Gritsman, R Alejandro Sica, Noah Kornblum, Aditi Shastri, Ioannis Mantzaris, Nishi Shah, Amit Verma, Ira Braunschweig, Mendel Goldfinger

https://doi.org/10.3324/haematol.2022.281020

Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children (419 Online Views)

Joseph L. Wiemels, Rong Wang, Mi Zhou, Helen Hansen, Rachel Gallant, Junghyun Jung, Nicholas Mancuso, Adam J. de Smith, Catherine Metayer, Scott C. Kogan, Xiaomei Ma

https://doi.org/10.3324/haematol.2022.280826

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations (584 Online Views)

Agatheeswaran Subramaniam, Carl Sandén, Larissa Moura-Castro, Kristijonas Žemaitis, Ludwig Schmiderer, Aurelie Baudet, Alexandra Bäckström, Elin Arvidsson, Simon Hultmark, Natsumi Miharada, Mattias Magnusson, Kajsa Paulsson, Thoas Fioretos, Jonas Larsson

https://doi.org/10.3324/haematol.2021.280303

Prolonged remission with pembrolizumab and radiation therapy in a patient with multisystem Langerhans cell sarcoma (514 Online Views)

Saurabh Zanwar, Aishwarya Ravindran, Jithma P. Abeykoon, Jason R. Young, Timothy F. Kozelsky, Karen L. Rech, Gaurav Goyal, Ronald S. Go

https://doi.org/10.3324/haematol.2022.280948