October, 2022
No. 107 (10)

About the Cover

Landmark papers in Hematology

Editorials

Articles

Acute Lymphoblastic Leukemia

Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001) (1334 Online Views)

Sarah K. Tasian, Lewis B. Silverman, James A. Whitlock, Richard Sposto, Joseph P. Loftus, Eric S. Schafer, Kirk R. Schultz, Raymond J. Hutchinson, Paul S. Gaynon, Etan Orgel, Caroline M. Bateman, Todd M. Cooper, Theodore W. Laetsch, Maria Luisa Sulis, Yueh-Yun Chi, Jemily Malvar, Alan S. Wayne, Susan R. Rheingold

https://doi.org/10.3324/haematol.2021.279520

Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes (1411 Online Views)

Stavroula Anastasopoulou, Rikke Linnemann Nielsen, Bodil Als-Nielsen, Joanna Banerjee, Mats A. Eriksson, Marianne Helenius, Mats M. Heyman, Inga Maria Johannsdottir, Olafur Gisli Jonsson, Stuart MacGregor, Marion K. Mateos, Chelsea Mayoh, Sirje Mikkel, Ida Hed Myrberg, Riitta Niinimäki, Kjeld Schmiegelow, Mervi Taskinen, Goda Vaitkeviciene, Anna Warnqvist, Benjamin Wolthers, Arja Harila-Saari, Susanna Ranta

https://doi.org/10.3324/haematol.2021.280016

Acute Myeloid Leukemia

Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study (1740 Online Views)

Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Chenyue W. Hu, Rhonda E. Ries, Andrew Ligeralde, Gaye N. Jenkins, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Amina A. Qutub, Eveline S.J.M. de Bont, Terzah M. Horton, Steven M. Kornblau

https://doi.org/10.3324/haematol.2021.279672

Chronic Myeloid Leukemia

Treatment-free remission in chronic myeloid leukemia patients treated front-line with nilotinib: 10-year followup of the GIMEMA CML 0307 study (1761 Online Views)

Gabriele Gugliotta, Fausto Castagnetti, Massimo Breccia, Luciano Levato, Tamara Intermesoli, Mariella D'Adda, Marzia Salvucci, Fabio Stagno, Giovanna Rege-Cambrin, Mario Tiribelli, Bruno Martino, Monica Bocchia, Michele Cedrone, Elena Trabacchi, Francesco Cavazzini, Ferdinando Porretto, Federica Sorà, Maria Pina Simula, Francesco Albano, Simona Soverini, Robin Foà, Fabrizio Pane, Michele Cavo, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti

https://doi.org/10.3324/haematol.2021.280175

Complications in Hematology

The glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage after chemotherapy and irradiation (1460 Online Views)

Zhong-Shi Lyu, Shu-Qian Tang, Tong Xing, Yang Zhou, Meng Lv, Hai-Xia Fu, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Hsiang-Ying Lee, Yuan Kong, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2021.279756

Hematopoiesis

YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1 (2084 Online Views)

Xiaofei Zhang, Tingting Cong, Lei Wei, Bixi Zhong, Xiaowo Wang, Jin Sun, Shuxia Wang, Meng Michelle Xu, Ping Zhu, Hong Jiang, Jianwei Wang

https://doi.org/10.3324/haematol.2021.279739

Multiple Myeloma

Preclinical evaluation and structural optimization of anti-BCMA CAR to target multiple myeloma (1972 Online Views)

Ortal Harush, Nathalie Asherie, Shlomit Kfir-Erenfeld, Galit Adler, Tilda Barliya, Miri Assayag, Moshe E. Gatt, Polina Stepensky, Cyrille J. Cohen

https://doi.org/10.3324/haematol.2021.280169

Final analysis of the phase III non-inferiority COLUMBA study of subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (2856 Online Views)

Saad Z. Usmani, Hareth Nahi, Wojciech Legiec, Sebastian Grosicki, Vladimir Vorobyev, Ivan Spicka, Vania Hungria, Sibirina Korenkova, Nizar J. Bahlis, Max Flogegard, Joan Bladé, Philippe Moreau, Martin Kaiser, Shinsuke Iida, Jacob Laubach, Hila Magen, Michele Cavo, Cyrille Hulin, Darrell White, Valerio De Stefano, Kristen Lantz, Lisa O’Rourke, Christoph Heuck, Maria Delioukina, Xiang Qin, Ivo Nnane, Ming Qi, Maria-Victoria Mateos

https://doi.org/10.3324/haematol.2021.279459

Non-Hodgkin Lymphoma

Genomic determinants impacting the clinical outcome of mogamulizumab treatment for adult T-cell leukemia/lymphoma (1637 Online Views)

Norio Tanaka, Seiichi Mori, Kazuma Kiyotani, Yuki Ota, Osamu Gotoh, Shigeru Kusumoto, Nobuaki Nakano, Youko Suehiro, Asahi Ito, Ilseung Choi, Eiichi Ohtsuka, Michihiro Hidaka, Kisato Nosaka, Makoto Yoshimitsu, Yoshitaka Imaizumi, Shinsuke Iida, Atae Utsunomiya, Tetsuo Noda, Hiroyoshi Nishikawa, Ryuzo Ueda, Takashi Ishida

https://doi.org/10.3324/haematol.2021.280352

Platelet Biology & its Disorders

Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets (1707 Online Views)

Thijs L.J. van Osch, Janita J. Oosterhoff, Arthur E. H. Bentlage, Jan Nouta, Carolien A. M. Koeleman, Dionne M. Geerdes, Juk Yee Mok, Sebastiaan Heidt, Arend Mulder, Wim J. E. van Esch, Rick Kapur, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Manfred Wuhrer, Jan Voorberg, Gestur Vidarsson

https://doi.org/10.3324/haematol.2021.280493

The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies (1119 Online Views)

Caroline Vayne, Raghavendra Palankar, Sandra Billy, Stefan Handtke, Thomas Thiele, Charlotte Cordonnier, Claire Pouplard, Andreas Greinacher, Yves Gruel, Jérôme Rollin

https://doi.org/10.3324/haematol.2021.280251

Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model (1168 Online Views)

Nuria Fabregas Bregolat, Maja Ruetten, Milene Costa da Silva, Mostafa A. Aboouf, Hyrije Ademi, Nadine von Büren, Julia Armbruster, Martina Stirn, Sandro Altamura, Oriana Marques, Josep M. Monné Rodriguez, Victor J. Samillan, Rashim Pal Singh, Ben Wielockx, Martina U. Muckenthaler, Max Gassmann, Markus Thiersch

https://doi.org/10.3324/haematol.2022.280732

Red Cell Biology & its Disorders

Letters to the Editor

Daunorubicin-60 versus daunorubicin-90 versus idarubicin-12 for induction chemotherapy in acute myeloid leukemia: a retrospective analysis of the Mayo Clinic experience (1621 Online Views)

Ayalew Tefferi, Naseema Gangat, Mithun Shah, Hassan Alkhateeb, Mrinal S. Patnaik, Aref Al-Kali, Michelle A. Elliott, William J. Hogan, Mark R. Litzow, Christopher C. Hook, Abhishek Mangaonkar, David Viswanatha, Dong Chen, Animesh Pardanani, Rhett P. Ketterling, Kebede H. Begna

https://doi.org/10.3324/haematol.2022.281045

SARS-CoV-2-specific cellular response following third COVID-19 vaccination in patients with chronic lymphocytic leukemia (935 Online Views)

Sibylle C. Mellinghoff, Leonie Mayer, Sandra Robrecht, Leonie M. Weskamm, Christine Dahlke, Henning Gruell, Maike Schlotz, Kanika Vanshylla, Hans A. Schloser, Martin Thelen, Anna-Maria Fink, Kirsten Fischer, Florian Klein, Marylyn M. Addo, Barbara Eichhorst, Michael Hallek, Petra Langerbeins

https://doi.org/10.3324/haematol.2022.280982

Primary outcomes by 1q21+ status for isatuximab-treated patients with relapsed/refractory multiple myeloma: subgroup analyses from ICARIA-MM and IKEMA (3809 Online Views)

Tom Martin, Paul G Richardson, Thierry Facon, Philippe Moreau, Aurore Perrot, Ivan Spicka, Kamlesh Bisht, Marlene Inchauspé, France Casca, Sandrine Macé, Helgi van de Velde, Kenshi Suzuki

https://doi.org/10.3324/haematol.2022.280660

COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic hematopoietic stem cell transplantation (747 Online Views)

Hanna Grauers Wiktorin, Sigrun Einarsdottir, Andreas Törnell, Mohammad Arabpour, Nuttida Issdisai, Jesper Waldenström, Johan Ringlander, Magnus Lindh, Martin Lagging, Kristoffer Hellstrand, Anna Martner

https://doi.org/10.3324/haematol.2022.280813

A myeloablative fractionated busulfan conditioning regimen with post-transplant cyclophosphamide in HLA-matched and haploidentical transplantation: results of a phase II study (776 Online Views)

Uday R. Popat, Borje S Andersson, Roland Bassett, Jitesh Kawedia, Ben C. Valdez, Amin M. Alousi, Gheath Al-Atrash, Qaiser Bashir, Chitra M. Hosing, Jin S. Im, Partow Kebriaei, David Marin, Yago Nieto, Betul Oran, Amanda Olson, Muzaffar H. Qazilbash, Samer A. Srour, Elizabeth J. Shpall, Richard E. Champlin, Rohtesh S. Mehta

https://doi.org/10.3324/haematol.2022.280778

Molecular predictors of response to venetoclax plus hypomethylating agent in treatment-naïve acute myeloid leukemia (1540 Online Views)

Naseema Gangat, Isla Johnson, Kristen McCullough, Faiqa Farrukh, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek Mangaonkar, Mark Litzow, William Hogan, Mithun Shah, Mrinal Patnaik, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2022.281214

Association of FLT3-internal tandem duplication length with overall survival in acute myeloid leukemia: a systematic review and meta-analysis (1564 Online Views)

Tobias B. Polak, Joost van Rosmalen, Stijn Dirven, Julia K. Herzig, Jacqueline Cloos, Soheil Meshinchi, Konstanze Döhner, Jeroen J.W.M. Janssen, David G.J. Cucchi

https://doi.org/10.3324/haematol.2022.281218

Platelet functional abnormalities and clinical presentation in pediatric patients with germline RUNX1, ANKRD26, and ETV6 mutations (1842 Online Views)

Galina S. Ovsyannikova, Daria V. Fedorova, Ivan P. Tesakov, Alexey A. Martyanov, Anastasia A. Ignatova, Evgeniya A. Ponomarenko, Pavel A. Zharkov, Anna V. Pavlova, Elena V. Raykina, Michael A. Maschan, Mikhail A. Panteleev, Galina A. Novichkova, Anastasia N. Sveshnikova, Nataliya S. Smetanina

https://doi.org/10.3324/haematol.2022.281340

Case Reports

The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARSCoV2 infection and multisystem inflammatory syndrome in children (983 Online Views)

Tarun Aurora, Noel Joseph, Senthil Velan Bhoopalan, Miguela A. Caniza, Tim Flerlage, Saad Ghafoor, Jane Hankins, Diego R. Hijano, Rohith Jesudas, Justin Kirkham, Hugo Martinez, Gabriela Maron Alfaro, Akshay Sharma, Melissa Hines

https://doi.org/10.3324/haematol.2022.280603