CURRENT ISSUE
August, 2022
No. 107 (8)

About the Cover

Landmark papers in Hematology

Editorials

Articles

Acute Lymphoblastic Leukemia

Rational drug combinations with CDK4/6 inhibitors in acute lymphoblastic leukemia (1170 Online Views)

Karen L. Bride, Hai Hu, Anastasia Tikhonova, Tori J. Fuller, Tiffaney L. Vincent, Rawan Shraim, Marilyn M. Li, William L. Carroll, Elizabeth A. Raetz, Iannis Aifantis, David T. Teachey

https://doi.org/10.3324/haematol.2021.279410

Acute Myeloid Leukemia

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements (767 Online Views)

Sarah Grasedieck, Ariene Cabantog, Liam MacPhee, Junbum Im, Christoph Ruess, Burcu Demir, Nadine Sperb, Frank G. Rücker, Konstanze Döhner, Tobias Herold, Jonathan R. Pollack, Lars Bullinger, Arefeh Rouhi, Florian Kuchenbauer

https://doi.org/10.3324/haematol.2021.276048

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy (926 Online Views)

Jana Ihlow, Sophia Gross, Leonie Busack, Anne Flörcken, Julia Jesse, Michaela Schwarz, Nina Rosa Neuendorff, Ann-Christin von Brünneck, Ioannis Anagnostopoulos, Seval Türkmen, Igor Wolfgang Blau, Thomas Burmeister, David Horst, Lars Bullinger, Jörg Westermann

https://doi.org/10.3324/haematol.2021.279134

A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo (1043 Online Views)

Lucas C. M. Arruda, Arwen Stikvoort, Melanie Lambert, Liqing Jin, Laura Sanchez Rivera, Renato M. P. Alves, Tales Rocha de Moura, Carsten Mim, Sören Lehmann, Rebecca Axelsson-Robertson, John E. Dick, Jonas Mattsson, Björn Önfelt, Mattias Carlsten, Michael Uhlin

https://doi.org/10.3324/haematol.2021.279486

Chronic Lymphocytic Leukemia

Hematopoiesis

Utility of plasma cell-free DNA for de novo detection and quantification of clonal hematopoiesis (1330 Online Views)

Fernanda Gutierrez-Rodrigues, Isabel Beerman, Emma M. Groarke, Bhavisha A. Patel, Nina Spitofsky, Laura W. Dillon, Diego Quinones Raffo, Christopher S. Hourigan, Sachiko Kajigaya, Luigi Ferrucci, Neal S. Young

https://doi.org/10.3324/haematol.2021.279230

Hemostasis

Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture (736 Online Views)

Marije Kat, Ellie Karampini, Arie J. Hoogendijk, Petra E. Bürgisser, Aat A. Mulder, Floris P.J. van Alphen, Jenny Olins, Dirk Geerts, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings

https://doi.org/10.3324/haematol.2021.280121

Immunology

Antibody response after vaccination against SARS-CoV-2 in adults with hematological malignancies: a systematic review and meta-analysis (2761 Online Views)

Nico Gagelmann, Francesco Passamonti, Christine Wolschke, Radwan Massoud, Christian Niederwieser, Raissa Adjallé, Barbara Mora, Francis Ayuk, Nicolaus Kröger

https://doi.org/10.3324/haematol.2021.280163

Non-Hodgkin Lymphoma

Mutational landscape of high-grade B-cell lymphoma with MYC-, BCL2 and/or BCL6 rearrangements characterized by whole-exome sequencing (1498 Online Views)

Axel Künstner, Hanno M. Witte, Jörg Riedl, Veronica Bernard, Stephanie Stölting, Hartmut Merz, Vito Olschewski, Wolfgang Peter, Julius Ketzer, Yannik Busch, Peter Trojok, Nikolas von Bubnoff, Hauke Busch, Alfred C. Feller, Niklas Gebauer

https://doi.org/10.3324/haematol.2021.279631

Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS (1560 Online Views)

Cho Mar Myint Wai, Shangying Chen, The Phyu, Shuangyi Fan, Sai Mun Leong, Wenning Zheng, Louis Ching Yi Low, Shoa-Nian Choo, Chi-Kuen Lee, Tae-Hoon Chung, Kenneth Hon Kim Ban, Soumita Ghosh, Stefanus Lie, Seiichi Kato, Shigeo Nakamura, Emiko Takahashi, Young-Hyeh Ko, Joseph D. Khoury, Shih-Sung Chuang, Rex K.H. Au-Yeung, Soo-Yong Tan, Soon-Thye Lim, Choon-Kiat Ong, Yong-Howe Ho, Li Mei Poon, Sanjay de Mel, Anand D. Jeyasekharan, Wee-Joo Chng, Franziska Otto, Leticia Quintanilla-Martinez, Federica Zanardi, Fabio Iannelli, Claudio Tripodo, Jason J. Pitt, Siok-Bian Ng

https://doi.org/10.3324/haematol.2021.280003

Programmed cell death ligand 1 expression in aggressive pediatric non-Hodgkin lymphomas: frequency, genetic mechanisms, and clinical significance (720 Online Views)

Kevin E. Fisher, Lizmery S. Ferguson, Amy M. Coffey, Brian Y. Merritt, Jonathan L. Curry, Andrea N. Marcogliese, Angela M. Major, Kala Y. Kamdar, Dolores H. Lopez-Terrada, Choladda V. Curry

https://doi.org/10.3324/haematol.2021.280342

Plasma Cell Disorders

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities (1068 Online Views)

Nicola Giesen, Nagarajan Paramasivam, Umut H. Toprak, Daniel Huebschmann, Jing Xu, Sebastian Uhrig, Mehmet Samur, Stella Bähr, Martina Fröhlich, Sadaf S. Mughal, Elias K. Mai, Anna Jauch, Carsten Müller-Tidow, Benedikt Brors, Nikhil Munshi, Hartmut Goldschmidt, Niels Weinhold, Matthias Schlesner, Marc S. Raab

https://doi.org/10.3324/haematol.2021.279360

Platelet Biology & its Disorders

Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes (841 Online Views)

Joanne Lacey, Simon J. Webster, Paul R. Heath, Chris J. Hill, Lucinda Nicholson-Goult, Bart E. Wagner, Abdullah O. Khan, Neil V. Morgan, Michael Makris, Martina E. Daly

https://doi.org/10.3324/haematol.2021.279636

Red Cell Biology & its Disorders

Letters to the Editor

Cell-free DNA sequencing as a potential screening tool for phase I targeted treatment in refractory/relapse diffuse large B-cell lymphoma (620 Online Views)

Cyril Quivoron, Anthony Tarabay, Jean-Marie Michot, Arnaud Pagès, Hélène Lecourt, Anne Aupérin, Alina Danu, Julien Lazarovici, Julien Rossignol, David Ghez, Peggy Dartigues, Véronique Vergé, Christophe Massard, Valérie Camara-Clayette, Vincent Ribrag, Clémentine Sarkozy

https://doi.org/10.3324/haematol.2021.280464

Full versus prophylactic-intermediate doses of anticoagulants in COVID-19: a meta-analysis (461 Online Views)

Lorenzo Loffredo, Augusto Di Castelnuovo, Giovanni Alfonso Chiariello, Pasquale Pignatelli, Francesco Violi

https://doi.org/10.3324/haematol.2022.280652

The use of hydroxyurea pretreatment in chronic myeloid leukemia in the current tyrosine kinase inhibitor era (373 Online Views)

Camille C.B. Kockerols, Inge Geelen, Mark-David Levin, Jeroen J.W.M. Janssen, Avinash G. Dinmohamed, Mels Hoogendoorn, Jan J. Cornelissen, Peter E. Westerweel

https://doi.org/10.3324/haematol.2021.280501

Preclinical evaluation of the preservation of red blood cell concentrates by hypoxic storage technology for transfusion in sickle cell disease (342 Online Views)

Laura Bencheikh, Kim-Anh Nguyen, Philippe Chadebech, Laurent Kiger, Gwellaouen Bodivit, Alicia Jouard, Sadaf Pakdaman, Sandia Adypagavane, Etienne Audureau, Khouloud Tebbakha, Thibaut Bocquet, Blandine Mignen, Nicolas Hebert, Marion Seguin, France Pirenne, Samuel Sowemimo-Coker, Andrew Dunham, Pablo Bartolucci

https://doi.org/10.3324/haematol.2021.279721

Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria (354 Online Views)

Niamh O'Regan, Kristina Gegenbauer, Eimear M. Gleeson, Kenji Fukudome, Jamie M. O'Sullivan, Clive Drakeford, Niall Dalton, Alain Chion, Teresa M. Brophy, Owen P. Smith, Roger J.S. Preston, James S. O'Donnell

https://doi.org/10.3324/haematol.2021.280450

COVID-19 infection in acute lymphoblastic leukemia over 15 months of the pandemic. A Campus ALL report (327 Online Views)

Sabina Chiaretti, Massimiliano Bonifacio, Roberta Agrippino, Fabio Giglio, Mario Annunziata, Antonio Curti, Maria Ilaria Del Principe, Prassede Salutari, Mariarita Sciumè, Mario Delia, Marco Armenio, Valentina Mancini, Antonino Mulè, Francesco Grimaldi, Giovanna Rege-Cambrin, Lidia Santoro, Federico Lussana, Patrizia Chiusolo, Crescenza Pasciolla, Anna Maria Scattolin, Marco Cerrano, Maria Ciccone, Marzia Defina, Fabio Forghieri, Carla Mazzone, Matteo Piccini, Felicetto Ferrara, Giovanni Pizzolo, Robin Foà

https://doi.org/10.3324/haematol.2021.280289

A novel BCMA CAR-T-cell therapy with optimized human scFv for treatment of relapsed/refractory multiple myeloma: results from phase I clinical trials (1281 Online Views)

Min Yang, Wenhao Zhang, Kang Yu, Peng Wang, Hua Jiang, Linjun Chen, Haitao Meng, Yiqin Weng, Rong Tao, Xin Huang, Chongyun Xing, Huamao Wang, Jiangbo Wan, Shasha Wang, Lihui Dai, Amanda Y. Hendrix, Jun Xiao, Wei Wang, Hong Ma, Siguo Hao, Jie Jin, Zonghai Li, Songfu Jiang

https://doi.org/10.3324/haematol.2022.280629

Copy number alterations define outcome in Philadelphia chromosome-positive acute lymphoblastic leukemia (481 Online Views)

Helena Hohtari, Niels Pallisgaard, Matti Kankainen, Pekka Ellonen, Oscar Brück, Timo Siitonen, Marjaana Säily, Marjatta Sinisalo, Marja Pyörälä, Maija Itälä-Remes, Perttu Koskenvesa, Erkki Elonen, Satu Mustjoki, Kimmo Porkka

https://doi.org/10.3324/haematol.2021.280578

Comments

Intricacies of GATA-ca, continued

Christine Lomas-Francis et al.

Intricacies of GATA-ca, continued (356 Online Views)

Christine Lomas-Francis, Elizabeth F. Stone, Connie M. Westhoff, Patricia A. Shi

https://doi.org/10.3324/haematol.2022.280876

Case Reports

Occurrence of a paroxysmal nocturnal hemoglobinuria clone in an essential thrombocythemia: a link between PIGV and MPL (548 Online Views)

Alexej Knaus, François Vergez, Cédric Garcia, Hartmut Engels, Hela Hundertmark, David Ribes, Laetitia Largeaud, Suzanne Tavitian, Bernard Payrastre, Peter Krawitz, Stanislas Faguer, Agnes Ribes

https://doi.org/10.3324/haematol.2021.279804