CURRENT ISSUE
May, 2022
No. 107 (5)

About the Cover

Landmark papers in Hematology

Editorials

Articles

Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia (858 Online Views)

Dimitrios Papaioannou, Hatice G. Ozer, Deedra Nicolet, Amog P. Urs, Tobias Herold, Krzysztof Mrózek, Aarif M.N. Batcha, Klaus H. Metzeler, Ayse S. Yilmaz, Stefano Volinia, Marius Bill, Jessica Kohlschmidt, Maciej Pietrzak, Christopher J. Walker, Andrew J. Carroll, Jan Braess, Bayard L. Powell, Ann-Kathrin Eisfeld, Geoffrey L. Uy, Eunice S. Wang, Jonathan E. Kolitz, Richard M. Stone, Wolfgang Hiddemann, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon

https://doi.org/10.3324/haematol.2021.266643

Bone Marrow Transplantation

One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors (1688 Online Views)

Dietger Niederwieser, Helen Baldomero, Nosa Bazuaye, Caitrin Bupp, Naeem Chaudhri, Selim Corbacioglu, Alaa Elhaddad, Cristóbal Frutos, Sebastian Galeano, Nada Hamad, Amir Ali Hamidieh, Shahrukh Hashmi, Aloysius Ho, Mary M. Horowitz, Minako Iida, Gregorio Jaimovich, Amado Karduss, Yoshihisa Kodera, Nicolaus Kröger, Regis Péffault de Latour, Jong Wook Lee, Juliana Martínez-Rolón, Marcelo C. Pasquini, Jakob Passweg, Kristjan Paulson, Adriana Seber, John A. Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Mickey B.C. Koh, Mahmoud Aljurf, Hildegard Greinix, Yoshiko Atsuta, Wael Saber

https://doi.org/10.3324/haematol.2021.279189

Cell Therapy & Immunotherapy

Improved outcome of patients with graft-versus-host disease after allogeneic hematopoietic cell transplantation for hematologic malignancies over time: an EBMT mega-file study (1001 Online Views)

Hildegard T. Greinix, Dirk-Jan Eikema, Linda Koster, Olaf Penack, Ibrahim Yakoub-Agha, Silvia Montoto, Christian Chabannon, Jan Styczynski, Arnon Nagler, Marie Robin, Stephen Robinson, Yves Chalandon, Malgorzata Mikulska, Stefan Schönland, Zinaida Peric, Annalisa Ruggeri, Francesco Lanza, Liesbeth C. de Wreede, Mohamad Mohty, Grzegorz W. Basak, Nicolaus Kröger

https://doi.org/10.3324/haematol.2020.265769

Coagulation & its Disorders

A homozygous duplication of the FGG exon 8-intron 8 junction causes congenital afibrinogenemia. Lessons learned from the study of a large consanguineous Turkish family (802 Online Views)

Michel Guipponi, Frédéric Masclaux, Frédérique Sloan-Béna, Corinne Di Sanza, Namik Özbek, Flora Peyvandi, Marzia Menegatti, Alessandro Casini, Baris Malbora, Marguerite Neerman-Arbez

https://doi.org/10.3324/haematol.2021.278945

Hemostasis

Germline GATA2 variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation (1066 Online Views)

Giulio Purgatorio, Elisa Piselli, Giuseppe Guglielmini, Emanuela Falcinelli, Loredana Bury, Valeria Di Battista, Fabrizia Pellanera, Francesca Milano, Caterina Matteucci, Cristina Mecucci, Paolo Gresele

https://doi.org/10.3324/haematol.2021.278450

Hodgkin Lymphoma

Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study (2011 Online Views)

Andrew M. Evens, Joseph M. Connors, Anas Younes, Stephen M. Ansell, Won Seog Kim, John Radford, Tatyana Feldman, Joseph Tuscano, Kerry J. Savage, Yasuhiro Oki, Andrew Grigg, Christopher Pocock, Monika Dlugosz-Danecka, Keenan Fenton, Andres Forero-Torres, Rachael Liu, Hina Jolin, Ashish Gautam, Andrea Gallamini

https://doi.org/10.3324/haematol.2021.278438

Immunologic Dysregulation

Complement dysregulation is associated with severe COVID-19 illness (1558 Online Views)

Jia Yu, Gloria F. Gerber, Hang Chen, Xuan Yuan, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky

https://doi.org/10.3324/haematol.2021.279155

Myeloproliferative Disorders

Non-Hodgkin Lymphoma

Toxicity and efficacy of chimeric antigen receptor T-cell therapy in patients with diffuse large B-cell lymphoma above the age of 70 years compared to younger patients – a matched control multicenter cohort study (1841 Online Views)

Ron Ram, Sigal Grisariu, Liat Shargian-Alon, Odelia Amit, Yaeli Bar-On, Polina Stepensky, Moshe Yeshurun, Batia Avni, David Hagin, Chava Perry, Ronit Gurion, Nadav Sarid, Yair Herishanu, Ronit Gold, Chen Glait-Santar, Sigi Kay, Irit Avivi

https://doi.org/10.3324/haematol.2021.278288

Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas (1198 Online Views)

Jing Gao, Michelle Y. Wang, Yuan Ren, Tint Lwin, Tao Li, Joy C. Yan, Eduardo M. Sotomayor, Derek R. Duckett, Bijal D. Shah, Kenneth H. Shain, Xiaohong Zhao, Jianguo Tao

https://doi.org/10.3324/haematol.2021.278743

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma (1092 Online Views)

Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni

https://doi.org/10.3324/haematol.2020.267096

Prephase rituximab/prednisone therapy and aging-related, proinflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma (1470 Online Views)

Richard J. Lin, Colette N. Owens, Esther Drill, Augustine Iannotta, Mayan Oliveros, Dylan L. Schick, Ariela Noy, John F. Gerecitano, Pamela R. Drullinsky, Philip C. Caron, Anita Kumar, Matthew J. Matasar, Craig Moskowitz, Beatriz Korc-Grodzicki, Andrew D. Zelenetz, Gilles A. Salles, Paul A. Hamlin

https://doi.org/10.3324/haematol.2021.278719

Dose-adjusted EPOCH and rituximab for the treatment of double expressor and double-hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome (1679 Online Views)

Anna Dodero, Anna Guidetti, Fabrizio Marino, Alessandra Tucci, Francesco Barretta, Alessandro Re, Monica Balzarotti, Cristiana Carniti, Chiara Monfrini, Annalisa Chiappella, Antonello Cabras, Fabio Facchetti, Martina Pennisi, Daoud Rahal, Valentina Monti, Liliana Devizzi, Rosalba Miceli, Federica Cocito, Lucia Farina, Francesca Ricci, Giuseppe Rossi, Carmelo Carlo-Stella, Paolo Corradini

https://doi.org/10.3324/haematol.2021.278638

Plasma Cell Disorders

Natural history of Waldenström macroglobulinemia following acquired resistance to ibrutinib monotherapy (983 Online Views)

Joshua N. Gustine, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Carly Leventoff, Timothy White, Maria Luisa Guerrera, Lian Xu, Amanda Kofides, Nicholas Tsakmaklis, Manit Munshi, Maria Demos, Christopher J. Patterson, Xia Liu, Guang Yang, Zachary R. Hunter, Andrew R. Branagan, Steven P. Treon, Jorge J. Castillo

https://doi.org/10.3324/haematol.2021.279112

Quality of Life

Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies (1376 Online Views)

Clark DuMontier, Hajime Uno, Tammy Hshieh, Guohai Zhou, Richard Chen, Emily S. Magnavita, Lee Mozessohn, Houman Javedan, Richard M. Stone, Robert J. Soiffer, Jane A. Driver, Gregory A. Abel

https://doi.org/10.3324/haematol.2021.278802

Letters to the Editor

BNT162b2 COVID-19 and ChAdOx1 nCoV-19 vaccination in patients with myelodysplastic syndromes (576 Online Views)

Sultan Abdul-Jawad, Richard Beatson, Thomas Lechmere, Rosalind Graham, Thanussuyah Alaguthurai, Carl Graham, Jennifer Vidler, Austin Kulasekararaj, Piers E.M. Patten, Katie J. Doores, Sheeba Irshad

https://doi.org/10.3324/haematol.2021.280337

A report from the Leukemia Electronic Abstraction of Records Network on risk of hepatotoxicity during pediatric acute lymphoblastic leukemia treatment (371 Online Views)

Joanna S. Yi, Tiffany M. Chambers, Kelly D. Getz, Tamara P. Miller, Evanette Burrows, Marla H. Daves, Philip J. Lupo, Michael E. Scheurer, Richard Aplenc, Karen R. Rabin, Maria M. Gramatges

https://doi.org/10.3324/haematol.2021.279805

SF3B1-mutant myelodysplastic syndrome/myeloproliferative neoplasms: a unique molecular and prognostic entity (596 Online Views)

Abhishek A. Mangaonkar, Terra L. Lasho, Christy Finke, Rhett P. Ketterling, Kaaren K. Reichard, Kristen McCullough, Naseema Gangat, Aref Al-Kali, Kebede H. Begna, William H. Hogan, Mark R. Litzow, Hassan Alkhateeb, Mithun Shah, Animesh Pardanani, Ayalew Tefferi, Najla H. Al Ali, Chetasi Talati, David Sallman, Eric Padron, Rami Komrokji, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2021.280463

Immune thrombocytopenia following vaccination during the COVID-19 pandemic (1260 Online Views)

Philip Young-Ill Choi, Danny Hsu, Huyen Anh Tran, Chee Wee Tan, Anoop Enjeti, Vivien Mun Yee Chen, Beng Hock Chong, Jennifer Curnow, Dominic Pepperell, Robert Bird

https://doi.org/10.3324/haematol.2021.279442

Erythrocytosis associated with EPAS1(HIF2A), EGLN1(PHD2), VHL, EPOR or BPGM mutations: The Mayo Clinic experience (511 Online Views)

Naseema Gangat, Jennifer L. Oliveira, Tavanna R Porter, James D. Hoyer, Aref Al-Kali, Mrinal M. Patnaik, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2021.280516

Outstanding outcomes in infants with KMT2A-germline acute lymphoblastic leukemia treated with chemotherapy alone: results of the Children’s Oncology Group AALL0631 trial (706 Online Views)

Erin M. Guest, John A. Kairalla, Joanne M. Hilden, ZoAnn E. Dreyer, Andrew J. Carroll, Nyla A. Heerema, Cindy Y. Wang, Meenakshi Devidas, Lia Gore, Wanda L. Salzer, Naomi J. Winick, William L. Carroll, Elizabeth A. Raetz, Michael Borowitz, Mignon L. Loh, Stephen P. Hunger, Patrick A. Brown

https://doi.org/10.3324/haematol.2021.280146

Comments

Case Reports

Platelet-activating anti-PF4 antibodies mimic VITT antibodies in an unvaccinated patient with monoclonal gammopathy (579 Online Views)

Andreas Greinacher, Florian Langer, Linda Schonborn, Thomas Thiele, Munif Haddad, Thomas Renne, Jerome Rollin, Yves Gruel, Theodore E. Warkentin

https://doi.org/10.3324/haematol.2021.280366

Kikuchi-Fujimoto disease associated with hemophagocytic lymphohistiocytosis following the BNT162b2 mRNA COVID-19 vaccination (665 Online Views)

Giovanni Caocci, Daniela Fanni, Mariagrazia Porru, Marianna Greco, Sonia Nemolato, Davide Firinu, Gavino Faa, Angelo Scuteri, Giorgio La Nasa

https://doi.org/10.3324/haematol.2021.280239