April, 2022
No. 107 (4)

About the Cover

Landmark papers in Hematology

Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for mixed lineage leukemia-rearranged acute leukemia (2143 Online Views)

Gabriel Gracia-Maldonado, Jason Clark, Matthew Burwinkel, Brenay Greenslade, Mark Wunderlich, Nathan Salomonis, Dario Leone, Evelina Gatti, Philippe Pierre, Ashish R. Kumar, Lynn H. Lee

https://doi.org/10.3324/haematol.2020.257451

Acute Myeloid Leukemia

Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation (1633 Online Views)

Pablo Peña-Martínez, Ramprasad Ramakrishnan, Carl Högberg, Caroline Jansson, David Gisselsson Nord, Marcus Järås

https://doi.org/10.3324/haematol.2020.270421

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia (2249 Online Views)

Dan Cojocari, Brianna N. Smith, Julie J. Purkal, Maria P. Arrate, Jason D. Huska, Yu Xiao, Agnieszka Gorska, Leah J. Hogdal, Haley E. Ramsey, Erwin R. Boghaert, Darren C. Phillips, Michael R. Savona

https://doi.org/10.3324/haematol.2020.272609

Characteristics and outcome of patients with core-binding factor acute myeloid leukemia and FLT3-ITD: results from an international collaborative study (1895 Online Views)

Sabine Kayser, Michael Kramer, David Martínez-Cuadrón, Justin Grenet, Klaus H. Metzeler, Zuzana Sustkova, Marlise R. Luskin, Andrew M. Brunner, Michelle A. Elliott, Cristina Gil, Sandra Casal Marini, Zdeněk Ráčil, Petr Cetkovsky, Jan Novak, Alexander E. Perl, Uwe Platzbecker, Friedrich Stölzel, Anthony D. Ho, Christian Thiede, Richard M. Stone, Christoph Röllig, Pau Montesinos, Richard F. Schlenk, Mark J. Levis

https://doi.org/10.3324/haematol.2021.278645

Bone Marrow Transplantation

Refined HLA-DPB1 mismatch with molecular algorithms predicts outcomes in hematopoietic stem cell transplantation (1379 Online Views)

Jun Zou, Piyanuch Kongtim, Betül Oran, Vasilis Kosmoliaptsis, Yudith Carmazzi, Junsheng Ma, Liang Li, Gabriela Rondon, Samer Srour, Hannah C. Copley, David Partlow, Stefan O. Ciurea, Uri Greenbaum, Qing Ma, Elizabeth J. Shpall, Richard E. Champlin, Kai Cao

https://doi.org/10.3324/haematol.2021.278993

Cell Therapy & Immunotherapy

Chronic Lymphocytic Leukemia

The complex karyotype landscape in chronic lymphocytic leukemia allows the refinement of the risk of Richter syndrome transformation (1424 Online Views)

Andrea Visentin, Laura Bonaldi, Gian Matteo Rigolin, Francesca Romana Mauro, Annalisa Martines, Federica Frezzato, Stefano Pravato, Leila Romano Gargarella, Maria Antonella Bardi, Maurizio Cavallari, Eleonora Volta, Francesco Cavazzini, Mauro Nanni, Monica Facco, Francesco Piazza, Anna Guarini, Robin Foà, Gianpietro Semenzato, Antonio Cuneo, Livio Trentin

https://doi.org/10.3324/haematol.2021.278304

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load (1184 Online Views)

Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Astrid Thomsen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Karina Dalsgaard Johansen, Maja Ludvigsen, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz

https://doi.org/10.3324/haematol.2021.278477

Hematopoiesis

Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome (1731 Online Views)

Ayala Tovy, Carina Rosas, Amos S. Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M. Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E. Conneely, Anna G. Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J. Kim, Melissa T. Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M. John Hicks, Andrea N. Marcogliese, Margaret A. Goodell, Rachel E. Rau

https://doi.org/10.3324/haematol.2021.278990

Hodgkin Lymphoma

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis (2243 Online Views)

Yago Nieto, Stephen Gruschkus, Benigno C. Valdez, Roy B. Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J. Shpall, Borje S. Andersson

https://doi.org/10.3324/haematol.2021.278311

Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect (1480 Online Views)

Roberta Pece, Sara Tavella, Delfina Costa, Serena Varesano, Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello, Massimo Alfano, Cristina D’Arrigo, Denise Galante, Jean-Louis Ravetti, Marco Gobbi, Francesca Tosetti, Alessandro Poggi, Maria Raffaella Zocchi

https://doi.org/10.3324/haematol.2021.278469

Plasma Cell Disorders

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome (1741 Online Views)

Katia Todoerti, Domenica Ronchetti, Vanessa Favasuli, Francesco Maura, Fortunato Morabito, Niccolò Bolli, Elisa Taiana, Antonino Neri

https://doi.org/10.3324/haematol.2021.278342

Platelet Biology & its Disorders

The GPIbα intracellular tail - role in transducing VWF- and collagen/GPVI-mediated signaling (1244 Online Views)

Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley

https://doi.org/10.3324/haematol.2020.278242

Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines (2325 Online Views)

Stephan Michalik, Florian Siegerist, Raghavendra Palankar, Kati Franzke, Maximilian Schindler, Alexander Reder, Ulrike Seifert, Clemens Cammann, Jan Wesche, Leif Steil, Christian Hentschker, Manuela Gesell-Salazar, Emil Reisinger, Martin Beer, Nicole Endlich, Andreas Greinacher, Uwe Völker

https://doi.org/10.3324/haematol.2021.280154

Red Cell Biology & its Disorders

Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy (1159 Online Views)

Valentine Brousse, Corinne Pondarre, Manoelle Kossorotoff, Cecile Arnaud, Annie Kamdem, Mariane de Montalembert, Benedicte Boutonnat-Faucher, Slimane Allali, Hélène Bourdeau, Keyne Charlot, Sebastien Bertil, Lydie da Costa, Philippe Connes, David Grévent, Suzanne Verlhac

https://doi.org/10.3324/haematol.2020.278226

Letters to the Editor

Loss of 5-hydroxymethylcytosine expression is near-universal in B-cell lymphomas with variable mutations in epigenetic regulators (649 Online Views)

Kevin S. Tanager, Jovian Yu, Brian C-H Chiu, Timothy C. Carll, Alexandra H. Tatarian, Peter Riedell, Sonali Smith, Justin Kline, Girish Venkataraman

https://doi.org/10.3324/haematol.2021.279648

Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease (797 Online Views)

Klara M. Benninghoven-Frey, Nina Neuhaus, Atte K. Lahtinen, Claudia Krallmann, Joana M.D. Portela, Andrea Jarisch, Verena Nordhoff, Armin Soave, Hajar A.M. Ba Omar, Mikael Sundin, Cecilia Langenskiöld, Sabine Kliesch, Jan-Bernd Stukenborg, Kirsi Jahnukainen

https://doi.org/10.3324/haematol.2021.279253

Phase Ib dose-escalation study of the selective, non-covalent, reversible Bruton’s tyrosine kinase inhibitor vecabrutinib in B-cell malignancies (902 Online Views)

John N. Allan, Javier Pinilla-Ibarz, Douglas E. Gladstone, Krish Patel, Jeff P. Sharman, William G. Wierda, Michael Y. Choi, Susan M. O’Brien, Mazyar Shadman, Matthew S. Davids, John M. Pagel, Habte A. Yimer, Renee Ward, Gary Acton, Pietro Taverna, Daniel L. Combs, Judith A. Fox, Richard R. Furman, Jennifer R. Brown

https://doi.org/10.3324/haematol.2021.280061

In vitro and in vivo effects of short-term cold storage of platelets in PAS-C (574 Online Views)

S. Lawrence Bailey, Lydia Y. Fang, Lynda Fitzpatrick, Daire Byrne, Esther Pellham, Moritz Stolla

https://doi.org/10.3324/haematol.2021.279865

Conventional interferon-α 2b versus hydroxyurea for newly-diagnosed patients with polycythemia vera in a real world setting: a retrospective study based on 286 patients from a single center (1150 Online Views)

Dan Liu, Zefeng Xu, Peihong Zhang, Tiejun Qin, Xiujuan Sun, Shiqiang Qu, Lijuan Pan, Jiao Ma, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Zhongxun Shi, Huijun Huang, Gang Huang, Robert Peter Gale, Bing Li, Raajit K. Rampal, Zhijian Xiao

https://doi.org/10.3324/haematol.2021.280080

Daratumumab with or without chemotherapy in relapsed and refractory acute lymphoblastic leukemia. A retrospective observational Campus ALL study (1342 Online Views)

Marco Cerrano, Massimiliano Bonifacio, Matteo Olivi, Antonio Curti, Michele Malagola, Michelina Dargenio, Anna Maria Scattolin, Cristina Papayannidis, Fabio Forghieri, Carmela Gurrieri, Ilaria Tanasi, Patrizia Zappasodi, Roberta La Starza, Nicola Stefano Fracchiolla, Patrizia Chiusolo, Luisa Giaccone, Maria Ilaria Del Principe, Fabio Giglio, Marzia Defina, Claudio Favre, Carmelo Rizzari, Barbara Castella, Giovanni Pizzolo, Felicetto Ferrara, Sabina Chiaretti, Robin Foà

https://doi.org/10.3324/haematol.2021.279851

T-cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial (1176 Online Views)

Lisa Blixt, David Wullimann, Soo Aleman, Jeanette Lundin, Puran Chen, Yu Gao, Angelica Cuapio, Mira Akber, Joshua Lange, Olga Rivera-Ballesteros, Marcus Buggert, Hans-Gustaf Ljunggren, Lotta Hansson, Anders Österborg

https://doi.org/10.3324/haematol.2021.280300

Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis (775 Online Views)

Lidia M. Fernández-Sevilla, Germán Belenguer, Beatriz Martí-Prado, Paula Ortiz-Sánchez, Manuel Ramírez, Alberto Varas, Isabel Fariñas, Ángeles Vicente

https://doi.org/10.3324/haematol.2021.279383

Case Reports

Immune-mediated thrombotic thrombocytopenic purpura following administration of Pfizer-BioNTech COVID-19 vaccine (1134 Online Views)

Gaetano Giuffrida, Annalisa Condorelli, Mary Ann Di Giorgio, Uros Markovic, Roberta Sciortino, Daniela Nicolosi, Francesco Di Raimondo

https://doi.org/10.3324/haematol.2021.279535

VEXAS syndrome in a female patient with constitutional 45,X (Turner syndrome) (1489 Online Views)

Ryan J. Stubbins, Eric McGinnis, Bhupinder Johal, Luke YC Chen, Lorena Wilson, Daniela Ospina Cardona, Thomas J. Nevill

https://doi.org/10.3324/haematol.2021.280238