Vol. 107 No. 6 (2022): June, 2022

Daniela Kuzilková, Cristina Bugarin, Katerina Rejlova, Axel R. Schulz, Henrik E. Mei, Maddalena Paganin, Alessandra Biffi, Andrea Biondi, Tomas Kalina, Giuseppe Gaipa

https://doi.org/10.3324/haematol.2021.278796

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia (3764 Online Views)

Sean M. Post, Huaxian Ma, Prerna Malaney, Xiaorui Zhang, Marisa J.L. Aitken, Po Yee Mak, Vivian R. Ruvolo, Tomoko Yasuhiro, Ryohei Kozaki, Lauren E. Chan, Lauren B. Ostermann, Marina Konopleva, Bing Z. Carter, Courtney DiNardo, Michael D. Andreeff, Joseph D. Khoury, Peter P. Ruvolo

https://doi.org/10.3324/haematol.2021.278369

Transforming growth factor-β signaling modifies the hematopoietic acute inflammatory response to drive bone marrow failure (2116 Online Views)

Jose Javier, Ashwini Hinge, James Bartram, Juying Xu, Marie-Dominique Filippi

https://doi.org/10.3324/haematol.2020.273292

Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients (6266 Online Views)

Jennifer R. Brown, John C. Byrd, Paolo Ghia, Jeff P. Sharman, Peter Hillmen, Deborah M. Stephens, Clare Sun, Wojciech Jurczak, John M. Pagel, Alessandra Ferrajoli, Priti Patel, Lin Tao, Nataliya Kuptsova-Clarkson, Javid Moslehi, Richard R. Furman

https://doi.org/10.3324/haematol.2021.278901

Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim-Chester disease in 78 patients from a single center (2641 Online Views)

Fleur Cohen Aubart, Lucie Poupel, Flora Saint-Charles, Frederic Charlotte, Youssef Arsafi, Eric Frisdal, Damien Roos-Weil, Jean-Francois Emile, Zahir Amoura, Maryse Guerin, Philippe Lesnik, Julien Haroche, Wilfried Le Goff

https://doi.org/10.3324/haematol.2021.279118

Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia (2657 Online Views)

Li Li, Jiawei Zhou, Shuai Wang, Lei Jiang, Xiaoyan Chen, Yangfan Zhou, Jingke Li, Jingqi Shi, Pu Liu, Zheyue Shu, Frank J. Gonzalez, Aiming Liu, Hu Hu

https://doi.org/10.3324/haematol.2021.279770

Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis (1832 Online Views)

Stefania Momi, Jessica Canino, Mauro Vismara, Luca Galgano, Emanuela Falcinelli, Giuseppe Guglielmini, Giulia Ciarrocca Taranta, Gianni Francesco Guidetti, Paolo Gresele, Mauro Torti, Ilaria Canobbio

https://doi.org/10.3324/haematol.2021.279703

CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development (1436 Online Views)

Boguslawa Korona, Dagmara Korona, Wanfeng Zhao, Andrew C. Wotherspoon, Ming-Qing Du

https://doi.org/10.3324/haematol.2021.280067

Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in relapsed multiple myeloma patients with renal impairment: IKEMA subgroup analysis (5482 Online Views)

Marcelo Capra, Thomas Martin, Philippe Moreau, Ross Baker, Ludek Pour, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Marta Reinoso Segura, Mehmet Turgut, Richard LeBlanc, Marie-Laure Risse, Laure Malinge, Sandrine Schwab, Meletios Dimopoulos

https://doi.org/10.3324/haematol.2021.279229

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment (2291 Online Views)

Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea

https://doi.org/10.3324/haematol.2021.279276

Correction of RNA splicing defect in β⁶⁵⁴-thalassemia mice using CRISPR/Cas9 gene-editing technology (1942 Online Views)

Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng

https://doi.org/10.3324/haematol.2020.278238

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease (1588 Online Views)

Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood

https://doi.org/10.3324/haematol.2021.278666

Direct and indirect anti-leukemic properties of activity-on-target interferons for the treatment of T-cell acute lymphoblastic leukemia (1693 Online Views)

Steven Goossens, Anje Cauwels, Tim Pieters, Renate De Smedt, Sara T’Sas, André Almeida, Willem Daneels, Pieter Van Vlierberghe, Jan Tavernier

https://doi.org/10.3324/haematol.2021.278913

A third anti-SARS-CoV-2 mRNA dose does not overcome the pejorative impact of anti-CD20 therapy and/or low immunoglobulin levels in patients with lymphoma or chronic lymphocytic leukemia (2951 Online Views)

Milena Kohn, Marc Delord, Maureen Chbat, Amina Guemriche, Fatiha Merabet, Anne-Laure Roupie, Naelle Lombion, Hassan Farhat, Thomas Longval, Aurélie Cabannes-Hamy, Juliette Lambert, Stéphanie Marque-Juillet, Victoria Raggueneau, Jennifer Osman, Marc Spentchian, Sophie Rigaudeau, Philippe Rousselot, Caroline Besson

https://doi.org/10.3324/haematol.2021.280026

The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact (1702 Online Views)

Jonathan J. Pinney, Sara K. Blick-Nitko, Andrea M. Baran, Derick R. Peterson, Hannah E. Whitehead, Raquel Izumi, Veerendra Munugalavadla, Karl R. Van DerMeid, Paul M. Barr, Clive S. Zent, Michael R. Elliott, Charles C. Chu

https://doi.org/10.3324/haematol.2021.279560

Diagnosis of acute promyelocytic leukemia based on routine biological parameters using machine learning (2160 Online Views)

Estelle Cheli, Simon Chevalier, Olivier Kosmider, Marion Eveillard, Nicolas Chapuis, Adriana Plesa, Maël Heiblig, Lydie Andre, Jenny Pouget, Pascal Mossuz, Olivier Theisen, Vincent Alcazer, Dan Gugenheim, Nicolas Autexier, Pierre Sujobert

https://doi.org/10.3324/haematol.2022.280406

Risk of hepatitis B virus reactivation in chronic lymphocytic leukemia patients receiving ibrutinib with or without antiviral prophylaxis. A retrospective multicentric GIMEMA study (2162 Online Views)

Idanna Innocenti, Gianluigi Reda, Andrea Visentin, Marta Coscia, Marina Motta, Roberta Murru, Riccardo Moia, Massimo Gentile, Elsa Pennese, Francesca Maria Quaglia, Francesco Albano, Ramona Cassin, Marina Deodato, Claudia Ielo, Anna Maria Frustaci, Alfonso Piciocchi, Arianna Rughini, Valentina Arena, Daniela Di Sevo, Annamaria Tomasso, Francesco Autore, Giovanni Del Poeta, Lydia Scarfò, Francesca Romana Mauro, Alessandra Tedeschi, Livio Trentin, Maurizio Pompili, Robin Foà, Paolo Ghia, Antonio Cuneo, Luca Laurenti

https://doi.org/10.3324/haematol.2021.280325

Do liberal thresholds for red cell transfusion result in improved quality of life for patients undergoing intensive chemotherapy for acute myeloid leukemia? A randomized crossover feasibility study (1429 Online Views)

Suzy Morton, Mallika Sekhar, Heather Smethurst, Ana Mora, Renate L. Hodge, Cara L. Hudson, Joseph Parsons, Valerie Hopkins, Simon J. Stanworth

https://doi.org/10.3324/haematol.2021.279867

Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic hematopoietic stem cell transplantation (1628 Online Views)

Sigrun Einarsdottir, Anna Martner, Malin Nicklasson, Hanna Grauers Wiktorin, Mohammad Arabpour, Andreas Törnell, Krista Vaht, Jesper Waldenström, Johan Ringlander, Tomas Bergström, Mats Brune, Kristoffer Hellstrand, Per Ljungman, Martin Lagging

https://doi.org/10.3324/haematol.2021.280494

Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria (1924 Online Views)

Jun-ichi Nishimura, Kiyoshi Ando, Masayoshi Masuko, Hideyoshi Noji, Yoshikazu Ito, Jiri Mayer, Laimonas Griskevicius, Christoph Bucher, Florian Müllershausen, Peter Gergely, Izabela Rozenberg, Anna Schubart, Raghav Chawla, Jean-Michel Rondeau, Michael Roguska, Igor Splawski, Mark T. Keating, Leslie Johnson, Rambabu Danekula, Morten Bagger, Yoko Watanabe, Börje Haraldsson, Yuzuru Kanakura

https://doi.org/10.3324/haematol.2020.265868