June, 2022
No. 107 (6)

About the Cover

Landmark papers in Hematology

Editorials

Review Series

Treatment of thrombocytopenias

Articles

Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia (1562 Online Views)

Sean M. Post, Huaxian Ma, Prerna Malaney, Xiaorui Zhang, Marisa J.L. Aitken, Po Yee Mak, Vivian R. Ruvolo, Tomoko Yasuhiro, Ryohei Kozaki, Lauren E. Chan, Lauren B. Ostermann, Marina Konopleva, Bing Z. Carter, Courtney DiNardo, Michael D. Andreeff, Joseph D. Khoury, Peter P. Ruvolo

https://doi.org/10.3324/haematol.2021.278369

Bone Marrow Failure

Chronic Lymphocytic Leukemia

Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients (2665 Online Views)

Jennifer R. Brown, John C. Byrd, Paolo Ghia, Jeff P. Sharman, Peter Hillmen, Deborah M. Stephens, Clare Sun, Wojciech Jurczak, John M. Pagel, Alessandra Ferrajoli, Priti Patel, Lin Tao, Nataliya Kuptsova-Clarkson, Javid Moslehi, Richard R. Furman

https://doi.org/10.3324/haematol.2021.278901

Hematopoiesis

Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim-Chester disease in 78 patients from a single center (886 Online Views)

Fleur Cohen Aubart, Lucie Poupel, Flora Saint-Charles, Frederic Charlotte, Youssef Arsafi, Eric Frisdal, Damien Roos-Weil, Jean-Francois Emile, Zahir Amoura, Maryse Guerin, Philippe Lesnik, Julien Haroche, Wilfried Le Goff

https://doi.org/10.3324/haematol.2021.279118

Hemostasis

Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia (1104 Online Views)

Li Li, Jiawei Zhou, Shuai Wang, Lei Jiang, Xiaoyan Chen, Yangfan Zhou, Jingke Li, Jingqi Shi, Pu Liu, Zheyue Shu, Frank J. Gonzalez, Aiming Liu, Hu Hu

https://doi.org/10.3324/haematol.2021.279770

Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis (804 Online Views)

Stefania Momi, Jessica Canino, Mauro Vismara, Luca Galgano, Emanuela Falcinelli, Giuseppe Guglielmini, Giulia Ciarrocca Taranta, Gianni Francesco Guidetti, Paolo Gresele, Mauro Torti, Ilaria Canobbio

https://doi.org/10.3324/haematol.2021.279703

Non-Hodgkin Lymphoma

Plasma Cell Disorders

Isatuximab plus carfilzomib and dexamethasone versus carfilzomib and dexamethasone in relapsed multiple myeloma patients with renal impairment: IKEMA subgroup analysis (2540 Online Views)

Marcelo Capra, Thomas Martin, Philippe Moreau, Ross Baker, Ludek Pour, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Marta Reinoso Segura, Mehmet Turgut, Richard LeBlanc, Marie-Laure Risse, Laure Malinge, Sandrine Schwab, Meletios Dimopoulos

https://doi.org/10.3324/haematol.2021.279229

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment (1147 Online Views)

Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea

https://doi.org/10.3324/haematol.2021.279276

Red Cell Biology & its Disorders

Correction of RNA splicing defect in β654-thalassemia mice using CRISPR/Cas9 gene-editing technology (853 Online Views)

Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng

https://doi.org/10.3324/haematol.2020.278238

Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease (722 Online Views)

Athena C. Geisness, Melissa Azul, Dillon Williams, Hannah Szafraniec, Daniel C. De Souza, John M. Higgins, David K. Wood

https://doi.org/10.3324/haematol.2021.278666

Letters to the Editor

Direct and indirect anti-leukemic properties of activity-on-target interferons for the treatment of T-cell acute lymphoblastic leukemia (945 Online Views)

Steven Goossens, Anje Cauwels, Tim Pieters, Renate De Smedt, Sara T’Sas, André Almeida, Willem Daneels, Pieter Van Vlierberghe, Jan Tavernier

https://doi.org/10.3324/haematol.2021.278913

A third anti-SARS-CoV-2 mRNA dose does not overcome the pejorative impact of anti-CD20 therapy and/or low immunoglobulin levels in patients with lymphoma or chronic lymphocytic leukemia (1097 Online Views)

Milena Kohn, Marc Delord, Maureen Chbat, Amina Guemriche, Fatiha Merabet, Anne-Laure Roupie, Naelle Lombion, Hassan Farhat, Thomas Longval, Aurélie Cabannes-Hamy, Juliette Lambert, Stéphanie Marque-Juillet, Victoria Raggueneau, Jennifer Osman, Marc Spentchian, Sophie Rigaudeau, Philippe Rousselot, Caroline Besson

https://doi.org/10.3324/haematol.2021.280026

The highly selective Bruton tyrosine kinase inhibitor acalabrutinib leaves macrophage phagocytosis intact (872 Online Views)

Jonathan J. Pinney, Sara K. Blick-Nitko, Andrea M. Baran, Derick R. Peterson, Hannah E. Whitehead, Raquel Izumi, Veerendra Munugalavadla, Karl R. Van DerMeid, Paul M. Barr, Clive S. Zent, Michael R. Elliott, Charles C. Chu

https://doi.org/10.3324/haematol.2021.279560

Diagnosis of acute promyelocytic leukemia based on routine biological parameters using machine learning (667 Online Views)

Estelle Cheli, Simon Chevalier, Olivier Kosmider, Marion Eveillard, Nicolas Chapuis, Adriana Plesa, Maël Heiblig, Lydie Andre, Jenny Pouget, Pascal Mossuz, Olivier Theisen, Vincent Alcazer, Dan Gugenheim, Nicolas Autexier, Pierre Sujobert

https://doi.org/10.3324/haematol.2022.280406

Risk of hepatitis B virus reactivation in chronic lymphocytic leukemia patients receiving ibrutinib with or without antiviral prophylaxis. A retrospective multicentric GIMEMA study (1080 Online Views)

Idanna Innocenti, Gianluigi Reda, Andrea Visentin, Marta Coscia, Marina Motta, Roberta Murru, Riccardo Moia, Massimo Gentile, Elsa Pennese, Francesca Maria Quaglia, Francesco Albano, Ramona Cassin, Marina Deodato, Claudia Ielo, Anna Maria Frustaci, Alfonso Piciocchi, Arianna Rughini, Valentina Arena, Daniela Di Sevo, Annamaria Tomasso, Francesco Autore, Giovanni Del Poeta, Lydia Scarfò, Francesca Romana Mauro, Alessandra Tedeschi, Livio Trentin, Maurizio Pompili, Robin Foà, Paolo Ghia, Antonio Cuneo, Luca Laurenti

https://doi.org/10.3324/haematol.2021.280325

Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic hematopoietic stem cell transplantation (567 Online Views)

Sigrun Einarsdottir, Anna Martner, Malin Nicklasson, Hanna Grauers Wiktorin, Mohammad Arabpour, Andreas Törnell, Krista Vaht, Jesper Waldenström, Johan Ringlander, Tomas Bergström, Mats Brune, Kristoffer Hellstrand, Per Ljungman, Martin Lagging

https://doi.org/10.3324/haematol.2021.280494

Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria (720 Online Views)

Jun-ichi Nishimura, Kiyoshi Ando, Masayoshi Masuko, Hideyoshi Noji, Yoshikazu Ito, Jiri Mayer, Laimonas Griskevicius, Christoph Bucher, Florian Müllershausen, Peter Gergely, Izabela Rozenberg, Anna Schubart, Raghav Chawla, Jean-Michel Rondeau, Michael Roguska, Igor Splawski, Mark T. Keating, Leslie Johnson, Rambabu Danekula, Morten Bagger, Yoko Watanabe, Börje Haraldsson, Yuzuru Kanakura

https://doi.org/10.3324/haematol.2020.265868

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