April, 2021
No. 106 (4)

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Editorials

Review Articles

Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets ex vivo (979 Online Views)

Christian A. Di Buduo, Alicia Aguilar, Paolo M. Soprano, Alberto Bocconi, Carolina P. Miguel, Giovanna Mantica, Alessandra Balduini

https://doi.org/10.3324/haematol.2020.262485

Articles

Hematologic Cancers

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers (879 Online Views)

Thomas Lewis, David B. Corcoran, David E. Thurston, Peter J. Giles, Kevin Ashelford, Elisabeth J. Walsby, Christopher D. Fegan, Andrea G.S. Pepper, Khondaker Miraz Rahman, Chris Pepper

https://doi.org/10.3324/haematol.2019.238584

Chronic Lymphocytic Leukemia

Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice (899 Online Views)

Bola S. Hanna, Haniyeh Yazdanparast, Yasmin Demerdash, Philipp M. Roessner, Ralph Schulz, Peter Lichter, Stephan Stilgenbauer, Martina Seiffert

https://doi.org/10.3324/haematol.2019.238154

Cell Therapy & Immunotherapy

Immune reconstitution and associated infections following axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma (1476 Online Views)

Jennifer M. Logue, Elisa Zucchetti, Christina A. Bachmeier, Gabriel S. Krivenko, Victoria Larson, Daniel Ninh, Giovanni Grillo, Biwei Cao, Jongphil Kim, Julio C. Chavez, Aliyah Baluch, Farhad Khimani, Aleksandr Lazaryan, Taiga Nishihori, Hien D. Liu, Javier Pinilla-Ibarz, Bijal D. Shah, Rawan Faramand, Anna E. Coghill, Marco L. Davila, Bhagirathbhai R. Dholaria, Michael D. Jain, Frederick L. Locke

https://doi.org/10.3324/haematol.2019.238634

CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T-cells (838 Online Views)

Marika Guercio, Domenico Orlando, Stefano Di Cecca, Matilde Sinibaldi, Iolanda Boffa, Simona Caruso, Zeinab Abbaszadeh, Antonio Camera, Biancamaria Cembrola, Katia Bovetti, Simona Manni, Ignazio Caruana, Roselia Ciccone, Francesca Del Bufalo, Pietro Merli, Luciana Vinti, Katia Girardi, Annalisa Ruggeri, Cristiano De Stefanis, Marco Pezzullo, Ezio Giorda, Marco Scarsella, Rita De Vito, Sabina Barresi, Andrea Ciolfi, Marco Tartaglia, Lorenzo Moretta, Franco Locatelli, Concetta Quintarelli, Biagio De Angelis

https://doi.org/10.3324/haematol.2019.231183

Acute Myeloid Leukemia

The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia (647 Online Views)

Teresa D'Altri, Anna S. Wilhelmson, Mikkel B. Schuster, Anne Wenzel, Adrija Kalvisa, Sachin Pundhir, Anne Meldgaard Hansen, Bo T. Porse

https://doi.org/10.3324/haematol.2019.235150

Endogenous and combination retinoids are active in myelomonocytic leukemias (536 Online Views)

Orsola di Martino, Haixia Niu, Gayla Hadwiger, Heikki Kuusanmaki, Margaret A. Ferris, Anh Vu, Jeremy Beales, Carl Wagner, María P. Menéndez-Gutiérrez, Mercedes Ricote, Caroline Heckman, John S. Welch

https://doi.org/10.3324/haematol.2020.264432

A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia (782 Online Views)

Lauren Lee, Yoshiyuki Hizukuri, Paul Severson, Benjamin Powell, Chao Zhang, Yan Ma, Maiko Narahara, Hiroyuki Sumi, Daniela Hernandez, Trivikram Rajkhowa, Gideon Bollag, Mark Levis

https://doi.org/10.3324/haematol.2020.247346

Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models (1461 Online Views)

Raghuveer Singh Mali, Qi Zhang, RosaAnna DeFilippis, Antonio Cavazos, Vinitha Mary Kuruvilla, Jayant Raman, Vidhi Mody, Edna F. Choo, Monique Dail, Neil P. Shah, Marina Konopleva, Deepak Sampath, Elisabeth A. Lasater

https://doi.org/10.3324/haematol.2019.244020

Acute Lymphoblastic Leukemia

Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia (951 Online Views)

Yuzhe Shi, Melanie C. Beckett, Helen J. Blair, Ricky Tirtakusuma, Sirintra Nakjang, Amir Enshaei, Christina Halsey, Josef Vormoor, Olaf Heidenreich, Anja Krippner-Heidenreich, Frederik W. van Delft

https://doi.org/10.3324/haematol.2019.241026

Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia (742 Online Views)

Joseph P. Loftus, Anella Yahiaoui, Patrick A. Brown, Lisa M. Niswander, Asen Bagashev, Min Wang, Allyson Schauf, Stacey Tannheimer, Sarah K. Tasian

https://doi.org/10.3324/haematol.2019.241729

Plasma Cell Disorders

Carfilzomib, cyclophosphamide and dexamethasone for newly diagnosed, high-risk myeloma patients not eligible for transplant: a pooled analysis of two studies (1462 Online Views)

Roberto Mina, Francesca Bonello, Maria Teresa Petrucci, Anna Marina Liberati, Concetta Conticello, Stelvio Ballanti, Pellegrino Musto, Attilio Olivieri, Giulia Benevolo, Andrea Capra, Milena Gilestro, Piero Galieni, Michele Cavo, Agostina Siniscalchi, Antonio Palumbo, Vittorio Montefusco, Gianluca Gaidano, Paola Omedé, Mario Boccadoro, Sara Bringhen

https://doi.org/10.3324/haematol.2019.243428

Blood Transfusion

Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial (512 Online Views)

Veronika Brixner, Gesine Bug, Petra Pohler, Doris Krämer, Bernd Metzner, Andreas Voss, Jochen Casper, Ulrich Ritter, Stefan Klein, Nael Alakel, Rudolf Peceny, Hans G. Derigs, Frank Stegelmann, Martin Wolf, Hubert Schrezenmeier, Thomas Thiele, Erhard Seifried, Hans-Hermann Kapels, Andrea Döscher, Eduard K. Petershofen, Thomas H. Müller, Axel Seltsam

https://doi.org/10.3324/haematol.2020.260430

Hematopoiesis

Impact of luteinizing hormone suppression on hematopoietic recovery after intensive chemotherapy in patients with leukemia (652 Online Views)

Iman Abou Dalle, Ronald Paranal, Jabra Zarka, Shilpa Paul, Koji Sasaki, Wen Li, Jing Ning, Nicholas J. Short, Maro Ohanian, Jorge E. Cortes, Elias J. Jabbour, Ghayas C. Issa

https://doi.org/10.3324/haematol.2020.256453

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay (663 Online Views)

Gaëtan Juban, Nathalie Sakakini, Hedia Chagraoui, David Cruz Hernandez, Qian Cheng, Kelly Soady, Bilyana Stoilova, Catherine Garnett, Dominic Waithe, Georg Otto, Jessica Doondeea, Batchimeg Usukhbayar, Elena Karkoulia, Maria Alexiou, John Strouboulis, Edward Morrissey, Irene Roberts, Catherine Porcher, Paresh Vyas

https://doi.org/10.3324/haematol.2019.244541

Non-Hodgkin Lymphoma

Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma (747 Online Views)

Julia Garcia-Reyero, Nerea Martinez Magunacelaya, Sonia Gonzalez de Villambrosia, Sanam Loghavi, Angela Gomez Mediavilla, Raul Tonda, Sergi Beltran, Marta Gut, Ainara Pereña Gonzalez, Emanuele d'Ámore, Carlo Visco, Joseph D. Khoury, Santiago Montes-Moreno

https://doi.org/10.3324/haematol.2020.251579

Hodgkin Lymphoma

Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study (1367 Online Views)

Marie José Kersten, Julia Driessen, Josée M. Zijlstra, Wouter J. Plattel, Franck Morschhauser, Pieternella J. Lugtenburg, Pauline Brice, Martin Hutchings, Thomas Gastinne, Roberto Liu, Coreline N. Burggraaff, Marcel Nijland, Sanne H. Tonino, Anne I.J. Arens, Roelf Valkema, Harm van Tinteren, Marta Lopez-Yurda, Arjan Diepstra, Daphne De Jong, Anton Hagenbeek

https://doi.org/10.3324/haematol.2019.243238

Hemostasis

Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport (599 Online Views)

Ellie Karampini, Petra E. Bürgisser, Jenny Olins, Aat A. Mulder, Carolina R. Jost, Dirk Geerts, Jan Voorberg, Ruben Bierings

https://doi.org/10.3324/haematol.2019.242727

Platelet Biology & its Disorders

Letters to the Editor

Concomitant constitutive LNK and NFE2 mutation with loss of sumoylation in a case of hereditary thrombocythemia (425 Online Views)

Lukas Clemens Böckelmann, Titiksha Basu, Albert Gründer, Wei Wang, Jan Breucker, Sandra Kaiser, Andrea Pichler, Heike Luise Pahl

https://doi.org/10.3324/haematol.2020.246587

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance. (856 Online Views)

Hannah Åbacka, Jesper S. Hansen, Peng Huang, Raminta Venskutonytė, Axel Hyrenius-Wittsten, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Filippo Minutolo, Anna K. Hagström-Andersson, Karin Lindkvist-Petersson

https://doi.org/10.3324/haematol.2020.246843

Anemia and hemodilution: analysis of a single center cohort based on 2,858 red cell mass measurements (181 Online Views)

Louis Drevon, Nabih Maslah, Juliette Soret-Dulphy, Christine Dosquet, Odno Ravdan, Laetitia Vercellino, Celia Belkhodja, Nathalie Parquet, Anne C. Brignier, Marie-Helene Schlageter, Bruno Cassinat, Jean-Jacques Kiladjian, Christine Chomienne, Stéphane Giraudier

https://doi.org/10.3324/haematol.2020.249409

Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma. (535 Online Views)

Keiichiro Watanabe, Ariunzaya Bat-Erdene, Hirofumi Tenshin, Qu Cui, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Takeshi Harada, Hirokazu Miki, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Yukari Mitsui, Itsuro Endo, Eiji Tanaka, Makoto Kawatani, Hiroyuki Osada, Toshio Matsumoto, Masahiro Abe

https://doi.org/10.3324/haematol.2019.244418

Infrequent “chronic lymphocytic leukemia-specific” immunoglobulin stereotypes in aged individuals with or without low-count monoclonal B-cell lymphocytosis (427 Online Views)

Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfò, Theodoros Moysiadis, Alessandra Rovida, Maria Gounari, Fotis Psomopoulos, Pamela Ranghetti, Alex Galanis, Frederic Davi, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Paolo Ghia

https://doi.org/10.3324/haematol.2020.247908

Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis (1773 Online Views)

Fredrik H. Schjesvold, Paul G. Richardson, Thierry Facon, Adrián Alegre, Andrew Spencer, Artur Jurczyszyn, Kazutaka Sunami, Laurent Frenzel, Chang-Ki Min, Sophie Guillonneau, Peggy L. Lin, Solenn Le-Guennec, Frank Campana, Helgi van de Velde, Samira Bensfia, Sara Bringhen

https://doi.org/10.3324/haematol.2020.253450

A homozygous missense variant in UBE2T is associated with a mild Fanconi anemia phenotype (599 Online Views)

Laura Schultz-Rogers, Francis P. Lach, Kimberly A. Rickman, Alejandro Ferrer, Abhishek A. Mangaonkar, Tanya L. Schwab, Christopher T. Schmitz, Karl J. Clark, Nikita R. Dsouza, Michael T. Zimmermann, Mark Litzow, Nicole Jacobi, Eric W. Klee, Agata Smogorzewska, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2020.259275

Bi38-3 is a novel CD38/CD3 bispecific T-cell engager with low toxicity for the treatment of multiple myeloma (677 Online Views)

Maxime Fayon, Carolina Martinez-Cingolani, Audrey Abecassis, Nathalie Roders, Elisabeth Nelson, Caroline Choisy, Alexis Talbot, Armand Bensussan, Jean-Paul Fermand, Bertrand Arnulf, Jean-Christophe Bories

https://doi.org/10.3324/haematol.2019.242453

Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols (505 Online Views)

Jenneke E. van Atteveld, Hester A. de Groot-Kruseman, Marta Fiocco, Maarten H. Lequin, Sebastian J.C.M.M. Neggers, Saskia M.F. Pluijm, Inge M. van der Sluis, Rob Pieters, Marry M. van den Heuvel-Eibrink

https://doi.org/10.3324/haematol.2020.257550

Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR (509 Online Views)

Audrey Belot, Ophélie Gourbeyre, Anais Palin, Aude Rubio, Amélie Largounez, Céline Besson-Fournier, Chloé Latour, Megane Lorgouilloux, Inka Gallitz, Alexandra Montagner, Arnaud Polizzi, Marion Régnier, Sarra Smati, An-Sheng Zhang, Manuel D. Diaz-Munoz, Andrea U. Steinbicker, Hervé Guillou, Marie-Paule Roth, Hélène Coppin, Delphine Meynard

https://doi.org/10.3324/haematol.2019.237321

Sex-specific transcriptional profiles identified in β-thalassemia patients (689 Online Views)

Aikaterini Nanou, Chrisavgi Toumpeki, Pavlos Fanis, Nicoletta Bianchi, Lucia Carmela Cosenza, Cristina Zuccato, George Sentis, Giorgos Giagkas, Coralea Stephanou, Marios Phylactides, Soteroula Christou, Michalis Hadjigavriel, Maria Sitarou, Carsten W. Lederer, Roberto Gambari, Marina Kleanthous, Eleni Katsantoni

https://doi.org/10.3324/haematol.2020.248013

Case Reports

Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia (512 Online Views)

Barbara Schmaltz-Panneau, Anne Pagnier, Séverine Clauin, Julien Buratti, Caroline Marty, Odile Fenneteau, Klaus Dieterich, Blandine Beaupain, Jean Donadieu, Isabelle Plo, Christine Bellanné-Chantelot

https://doi.org/10.3324/haematol.2020.247825

Biallelic IARS2 mutations presenting as sideroblastic anemia (454 Online Views)

Giulia Barcia, Dinusha Pandithan, Benedetta Ruzzenente, Zahra Assouline, Alessandra Pennisi, Clothilde Ormieres, Claude Besmond, Charles-Joris Roux, Nathalie Boddaert, Isabelle Desguerre, David R. Thorburn, Drago Bratkovic, Arnold Munnich, Jean-Paul Bonnefont, Agnès Rötig, Julie Steffann

https://doi.org/10.3324/haematol.2020.270710

Comments

Errata Corrige

A real world multicenter retrospective study on extramedullary disease from Balkan Myeloma Study Group and Barcelona University: analysis of parameters that improve outcome (229 Online Views)

Meral Beksac, Guldane Cengiz Seval, Nicholas Kanellias, Daniel Coriu, Laura Rosiñol, Gulsum Ozet, Vesselina Goranova-Marinova, Ali Unal, Jelena Bila, Hayri Ozsan, Arben Ivanaj, Lejla Ibricevic Balić, Efstathios Kastritis, Joan Bladé, Meletios Athanasios Dimopoulos

https://doi.org/10.3324/haematol.2020.278272