May, 2021
No. 106 (5)

About the Cover

Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia (1126 Online Views)

Xinyu Li, Yongwei Su, Katie Hege, Gerard Madlambayan, Holly Edwards, Tristan Knight, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jay Yang, Regan Miller, Guan Wang, Lijing Zhao, Yue Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge

https://doi.org/10.3324/haematol.2019.233445

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3 (1049 Online Views)

Wenli Feng, Xiao Yang, Lina Wang, Rong Wang, Feifei Yang, Hao Wang, Xiaoli Liu, Qian Ren, Yingchi Zhang, Xiaofan Zhu, Guoguang Zheng

https://doi.org/10.3324/haematol.2019.243360

Blood Transfusion

Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity (1013 Online Views)

Angelo D'Alessandro, Xiaoyun Fu, Tamir Kanias, Julie A. Reisz, Rachel Culp-Hill, Yuelong Guo, Mark T. Gladwin, Grier Page, Steven Kleinman, Marion Lanteri, Mars Stone; Michael P. Busch, James C. Zimring

https://doi.org/10.3324/haematol.2020.246603

Bone Marrow Failure

Genotype-phenotype association and variant characterization in Diamond-Blackfan anemia caused by pathogenic variants in RPL35A (1107 Online Views)

D. Matthew Gianferante, Marcin W. Wlodarski, Evangelia Atsidaftos, Lydie Da Costa, Polyxeni Delaporta, Jason E. Farrar, Frederick D. Goldman, Maryam Hussain, Antonis Kattamis, Thierry Leblanc, Jeffrey M. Lipton, Charlotte M. Niemeyer, Dagmar Pospisilova, Paola Quarello, Ugo Ramenghi, Vijay G. Sankaran, Adrianna Vlachos, Jana Volejnikova, Blanche P. Alter, Sharon A. Savage, Neelam Giri

https://doi.org/10.3324/haematol.2020.246629

A zebrafish model for HAX1-associated congenital neutropenia (950 Online Views)

Larissa Doll, Narges Aghaallaei, Advaita M. Dick, Karl Welte, Julia Skokowa, Baubak Bajoghli

https://doi.org/10.3324/haematol.2019.240200

Cell Therapy & Immunotherapy

Endothelial injury, F-actin and vitamin-D binding protein after hematopoietic stem cell transplant and association with clinical outcomes (1129 Online Views)

Nathan Luebbering, Sheyar Abdullah, Dana Lounder, Adam Lane, Nikhil Dole, Jeremy Rubinstein, Martin Hewison, Nicholas Gloude, Sonata Jodele, Kitty M.R. Perentesis, Kelly Lake, Bridget Litts, Alexandra Duell, Christopher E. Dandoy, Stella M. Davies

https://doi.org/10.3324/haematol.2019.233478

Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model (1100 Online Views)

Dina Stroopinsky, Jessica Liegel, Manoj Bhasin, Giulia Cheloni, Beena Thomas, Swati Bhasin, Ruchit Panchal, Haider Ghiasuddin, Maryam Rahimian, Myrna Nahas, Shira Orr, Marzia Capelletti, Daniela Torres, Cansu Tacettin, Matthew Weinstock, Lina Bisharat, Adam Morin, Kathleen M. Mahoney, Benjamin Ebert, Richard Stone, Donald Kufe, Gordon J. Freeman, Jacalyn Rosenblatt, David Avigan

https://doi.org/10.3324/haematol.2020.259457

Chronic Lymphocytic Leukemia

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia (1021 Online Views)

Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio

https://doi.org/10.3324/haematol.2019.242016

Hematopoiesis

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification (1399 Online Views)

Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann

https://doi.org/10.3324/haematol.2019.228064

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation (1078 Online Views)

Alicia Bornert, Julie Boscher, Fabien Pertuy, Anita Eckly, David Stegner, Catherine Strassel, Christian Gachet, François Lanza, Catherine Léon

https://doi.org/10.3324/haematol.2019.239111

Non-Hodgkin Lymphoma

MYC rearrangement but not extra MYC copies is an independent prognostic factor in patients with mantle cell lymphoma (1278 Online Views)

Lifu Wang, Guilin Tang, L. Jeffrey Medeiros, Jie Xu, Wenting Huang, C. Cameron Yin, Michael Wang, Preetesh Jain, Pei Lin, Shaoying Li

https://doi.org/10.3324/haematol.2019.243071

Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group (1034 Online Views)

Olga Moser, Martin Zimmermann, Ulrike Meyer, Wolfram Klapper, Ilske Oschlies, Martin Schrappe, Andishe Attarbaschi, Georg Mann, Felix Niggli, Claudia Spix, Udo Kontny, Thomas Klingebiel, Alfred Reiter, Birgit Burkhardt, Wilhelm Woessmann

https://doi.org/10.3324/haematol.2019.244780

Plasma Cell Disorders

TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma (1175 Online Views)

Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Asuka Oda, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Mohannad Ashtar, So Shimizu, Masami Iwasa, Kimiko Sogabe, Masahiro Oura, Shiro Fujii, Kumiko Kagawa, Hirokazu Miki, Itsuro Endo, Tatsuji Haneji, Toshio Matsumoto, Masahiro Abe

https://doi.org/10.3324/haematol.2019.234476

Platelet Biology & its Disorders

Clinical spectrum, outcome and management of immune thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia (1692 Online Views)

Vincent Jachiet, Guillaume Moulis, Jérome Hadjadj, Julie Seguier, Kamel Laribi, Nicolas Schleinitz, Norbert Vey, Karim Sacre, Bertrand Godeau, Odile Beyne-Rauzy, Romain Bouvet, Jonathan Broner, Natacha Brun, Thibault Comont, Clément Gaudin, Olivier Lambotte, Lenaïg Le Clech, Pierre Peterlin, Frédérique Roy-Peaud, Clémentine Salvado, Mathilde Versini, Françoise Isnard, Jean Emmanuel Kahn, Delphine Gobert, Lionel Adès, Pierre Fenaux, Olivier Fain, Arsène Mekinian

https://doi.org/10.3324/haematol.2020.272559

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function (880 Online Views)

Melissa V. Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O'Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, NIHR BioResource, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner

https://doi.org/10.3324/haematol.2019.235895

Red Cell Biology & its Disorders

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance (776 Online Views)

Alisa Dong, Valentina Ghiaccio, Irene Motta, Shuling Guo, Raechel Peralta, Susan M. Freier, Andy Watt, Sagar Damle, Yasuhiro Ikawa, Danuta Jarocha, Maxwell Chappell, Coralea Stephanou, Paola Delbini, Connie Chen, Soteroula Christou, Marina Kleanthous, Kim Smith-Whitley, Deepa Manwani, Carla Casu, Osheiza Abdulmalik, Maria Domenica Cappellini, Stefano Rivella, Laura Breda

https://doi.org/10.3324/haematol.2019.226852

T-cell Leukemia

Loss of interleukin-10 activates innate immunity to eradicate adult T-cell leukemia-initiating cells (669 Online Views)

Hiba El Hajj, Rita Hleihel, Marwan El Sabban, Julie Bruneau, Ghazi Zaatari, Morgane Cheminant, Ambroise Marçais, Abdou Akkouche, Hideki Hasegawa, William Hall, Hugues De Thé, Olivier Hermine, Ali Bazarbachi

https://doi.org/10.3324/haematol.2020.264523

Letters to the Editor

Immunologic characterization of COVID-19 patients with hematological cancer (1561 Online Views)

Catarina Maia, Esperanza Martín-Sánchez, Juan José Garcés, Ascensión López-Díaz de Cerio, Susana Inogés, Manuel F. Landecho, Belén Gil-Alzugaray, Cristina Perez, Cirino Botta, Aintzane Zabaleta, Félix Alegre, César Rincón, Laura Blanco, Sarai Sarvide, Amaia Vilas-Zornoza, Diego Alignani, Cristina Moreno, Artur Paiva, António Martinho, Rui Alves, Enrique Colado, Covadonga Quirós, Mónica Olid, Andrés Blanco, Josepmaria Argemi, Bruno Paiva, José Ramón Yuste

https://doi.org/10.3324/haematol.2020.269878

The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia (779 Online Views)

Yun Zhou, Haiwei Lian, Ning Shen, Sovannarith Korm, Andrew Kwok Ping Lam, Olivia Layton, Leah N. Huiting, Dun Li, Kelly Miao, Aozhuo Zeng, Esther Landesman-Bollag, David C. Seldin, Hui Fu, Li Hong, Hui Feng

https://doi.org/10.3324/haematol.2020.246918

Molecular attributes underlying central nervous system and systemic relapse in diffuse large B-cell lymphoma (1272 Online Views)

Keren Isaev, Daisuke Ennishi, Laura Hilton, Brian Skinnider, Karen L. Mungall, Andrew J. Mungall, Mehran Bakhtiari, Rosemarie Tremblay-LeMay, Anjali Silva, Susana Ben-Neriah, Merrill Boyle, Diego Villa, Marco A. Marra, Christian Steidl, Randy D. Gascoyne, Ryan Morin, Kerry J. Savage, David W. Scott, Robert Kridel

https://doi.org/10.3324/haematol.2020.255950

Hemostatic alterations in COVID-19 (1952 Online Views)

Flora Peyvandi, Andrea Artoni, Cristina Novembrino, Stefano Aliberti, Mauro Panigada, Marco Boscarino, Roberta Gualtierotti, Federica Rossi, Roberta Palla, Ida Martinelli, Giacomo Grasselli, Francesco Blasi, Armando Tripodi

https://doi.org/10.3324/haematol.2020.262634

How to implement endurance exercise training in sickle cell disease (663 Online Views)

Laurent A. Messonnier, Manon Riccetti, Benjamin Chatel, Frédéric Galactéros, Barnabas Gellen, Thomas Rupp, Léonard Féasson, Pablo Bartolucci

https://doi.org/10.3324/haematol.2020.267047

Quantitative polymerase chain reaction-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: results from the KIM-PB prospective study (694 Online Views)

Valentina Gambacorta, Riccardo Parolini, Elisabetta Xue, Raffaella Greco, Evelien E. Bouwmans, Cristina Toffalori, Fabio Giglio, Andrea Assanelli, Maria Teresa Lupo Stanghellini, Alessandro Ambrosi, Benedetta Mazzi, Wietse Mulder, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Luca Vago

https://doi.org/10.3324/haematol.2019.238543

Exosome-driven lipolysis and bone marrow niche remodeling support leukemia expansion (829 Online Views)

Bijender Kumar, Marvin Orellana, Jamison Brooks, Srideshikan Sargur Madabushi, Paresh Vishwasrao, Liliana E. Parra, James Sanchez, Amandeep Salhotra, Anthony Stein, Ching-Cheng Chen, Guido Marcucci, Susanta Kumar Hui

https://doi.org/10.3324/haematol.2019.246058

Very low incidence of Clostridioides difficile infection in pediatric sickle cell disease patients (579 Online Views)

Philip Lee, Arpan A. Sinha, Vijaya L. Soma, Carlos Cruz, Tao Wang, Olga Aroniadis, Betsy C. Herold, Paul S. Frenette, David L. Goldman, Deepa Manwani

https://doi.org/10.3324/haematol.2019.244582

Benefit of intermediate-dose cytarabine-containing induction in molecular subgroups of acute myeloid leukemia (760 Online Views)

Hui Wei, Chunlin Zhou, Dong Lin, Bingcheng Liu, Yan Li, Xingli Zhao, Shuning Wei, Benfa Gong, Kaiqi Liu, Xiaoyuan Gong, Yuntao Liu, Guangji Zhang, Jiayuan Chen, Junping Zhang, Jingjing Jin, Shaowei Qiu, Runxia Gu, Ying Wang, Yingchang Mi, Jianxiang Wang

https://doi.org/10.3324/haematol.2020.267526

Standardization of flow cytometric minimal residual disease assessment in international clinical trials. A feasibility study from the European Myeloma Network (1227 Online Views)

Davine Hofste op Bruinink, Stefania Oliva, Lucie Rihova, Alexander Schmitz, Milena Gilestro, Jeroen te Marvelde, Romana Kralova, Helle Høholt, Annemiek Broijl, Hans Erik Johnsen, Roman Hajek, Mario Boccadoro, Pieter Sonneveld, Paola Omedè, Vincent H.J. van der Velden

https://doi.org/10.3324/haematol.2020.267831

Modulated expression of adhesion, migration and activation molecules may predict the degree of response in chronic lymphocytic leukemia patients treated with ibrutinib plus rituximab (629 Online Views)

Nadia Peragine, Maria Stefania De Propris, Stefania Intoppa, Maria Laura Milani, Paola Mariglia, Francesca Romana Mauro, Sara Raponi, Stefano Soddu, Antonio Cuneo, Gian Matteo Rigolin, Ilaria Del Giudice, Robin Foà, Anna Guarini

https://doi.org/10.3324/haematol.2020.262071

Case Reports

Acute leucoencephalomyelopathy and quadriparesis after CAR T-cell therapy (1418 Online Views)

Ranjit Nair, Gaëlle Drillet, Faustine Lhomme, Anthony Le Bras, Laure Michel, John Rossi, Marika Sherman, Allen Xue, Anne Kerber, Nutchawan Jittapiromsak, Linda Chi, Sudhakar Tummala, Sattva S. Neelapu, Roch Houot

https://doi.org/10.3324/haematol.2020.259952

Unusual survival of a twin with homozygous α0-thalassemia due to chimerism (873 Online Views)

Dejian Pang, Xuan Shang, Decheng Cai, Fang Yang, Huijie Lu, Yi Cheng, Xiaofeng Wei, Fei He, Xiangmin Xu

https://doi.org/10.3324/haematol.2020.262600