August, 2020
No. 105 (8)

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Editorials

Perspective Articles

An agenda for future research projects in polycythemia vera and essential thrombocythemia

Tiziano Barbui, Alessandro Maria Vannucchi, Paola Guglielmelli, Valerio De Stefano, Alessandro Rambaldi

https://doi.org/10.3324/haematol.2019.246207

Centenary Review

Review Articles

Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding

Alicia Veninga, Ilaria De Simone, Johan W.M. Heemskerk, Hugo ten Cate, Paola E.J. van der Meijden

https://doi.org/10.3324/haematol.2019.235994

Articles

Hematopoiesis

Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations

Elia Henry, Inès Souissi-Sahraoui, Margaux Deynoux, Andréas Lefèvre, Vilma Barroca, Anna Campalans, Véronique Ménard, Julien Calvo, Françoise Pflumio, Marie-Laure Arcangeli

https://doi.org/10.3324/haematol.2019.226936

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Gijs Kooij*, Claudio Derada Troletti*, Alessandro Leuti, Paul C. Norris, Ian Riley, Maria Albanese, Serena Ruggieri, Stephania Libreros, Susanne M.A. van der Pol, Bert van het Hof, Yoëlle Schell, Gisella Guerrera, Fabio Buttari, Nicola Biagio Mercuri, Diego Centonze, Claudio Gasperini, Luca Battistini, Helga E. de Vries, Charles N. Serhan#, Valerio Chiurchiù#

https://doi.org/10.3324/haematol.2019.219519

Iron Metabolism & Its Disorders

Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis

Shufen Wang, Xuyan He, Qian Wu, Li Jiang, Liyun Chen, Yingying Yu, Pan Zhang, Xin Huang, Jia Wang, Zhenyu Ju, Junxia Min, Fudi Wang

https://doi.org/10.3324/haematol.2019.224899

Myeloproliferative Neoplasms

Chronic Myeloid Leukemia

A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells

Sofia von Palffy, Niklas Landberg, Carl Sandén, Dimitra Zacharaki, Mansi Shah, Naoto Nakamichi, Nils Hansen, Maria Askmyr, Henrik Lilljebjörn, Marianne Rissler, Christine Karlsson, Stefan Scheding, Johan Richter, Connie J. Eaves, Ravi Bhatia, Marcus Järås, Thoas Fioretos

https://doi.org/10.3324/haematol.2019.220434

Acute Myeloid Leukemia

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition

Amal Kamal Abdel-Aziz, Isabella Pallavicini, Elena Ceccacci, Giuseppe Meroni, Mona Kamal Saadeldin, Mario Varasi, Saverio Minucci

https://doi.org/10.3324/haematol.2019.224501

EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase

Yusuke Saito, Daisuke Sawa, Mariko Kinoshita, Ai Yamada, Sachiyo Kamimura, Akira Suekane, Honami Ogoh, Hidemasa Matsuo, Souichi Adachi, Takashi Taga, Daisuke Tomizawa, Motomi Osato, Tomoyoshi Soga, Kazuhiro Morishita, Hiroshi Moritake

https://doi.org/10.3324/haematol.2019.225953

Acute Lymphoblastic Leukemia

Disrupting the leukemia niche in the central nervous system attenuates leukemia chemoresistance

Leslie M. Jonart, Maryam Ebadi, Patrick Basile, Kimberly Johnson, Jessica Makori, Peter M. Gordon

https://doi.org/10.3324/haematol.2019.230334

Non-Hodgkin Lymphoma

Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma

Victoria M. Smith, Anna Dietz, Kristina Henz, Daniela Bruecher, Ross Jackson, Lisa Kowald, Sjoerd J.L. van Wijk, Sandrine Jayne, Salvador Macip, Simone Fulda, Martin J.S. Dyer, Meike Vogler

https://doi.org/10.3324/haematol.2019.220525

Hodgkin Lymphoma

Blood Transfusion

Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage

Davide Stefanoni, Hye Kyung H. Shin, Jin Hyen Baek, Devin P. Champagne, Travis Nemkov, Tiffany Thomas, Richard O. Francis, James C. Zimring, Tatsuro Yoshida, Julie A. Reisz, Steven L. Spitalnik, Paul W. Buehler, Angelo D’Alessandro

https://doi.org/10.3324/haematol.2019.229930

Guidelines

Kreuth V initiative: European consensus proposals for treatment of hemophilia using standard products, extended half-life coagulation factor concentrates and non-replacement therapies

Flora Peyvandi, Karin Berger, Rainer Seitz, Anneliese Hilger, Marie-Laure Hecquet, Michael Wierer, Karl-Heinz Buchheit, Brian O’Mahony, Amanda Bok, Mike Makris, Ulrich Mansmann, Wolfgang Schramm, Pier Mannuccio Mannucci

https://doi.org/10.3324/haematol.2019.242735

Online Only Articles

Letters to the Editor

LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Audrey Belot, Ophélie Gourbeyre, Alexis Fay, Anais Palin, Céline Besson-Fournier, Chloé Latour, Corey R. Hopkins, George F. Tidmarsh, Hélène Coppin, Marie-Paule Roth, Matthew R. Ritter, Charles C. Hong, Delphine Meynard

https://doi.org/10.3324/haematol.2019.236133

Comparing the two leading erythroid lines BEL-A and HUDEP-2

Deborah E. Daniels, Damien J. Downes, Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Belinda K. Singleton, Marieangela C. Wilson, Kongtana Trakarnsanga, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne

https://doi.org/10.3324/haematol.2019.229211

Cloning and characterization of a novel druggable fusion kinase in acute myeloid leukemia

Christian Michel, Elisabeth K.M. Mack, Christopher-Nils Mais, Lea V. Fritz, Ying Wang, Lutz B. Jehn, Sonja K. Hühn, Clara Simon, Sabrina Inselmann, André Marquardt, Jennifer Kremer, Ellen Wollmer, Kristina Sohlbach, Andreas Neubauer, Cornelia A. Brendel, Claudia Haferlach, Gert Bange, Andreas Burchert

https://doi.org/10.3324/haematol.2019.237818

CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax

Katharina Mattes, Mylène Gerritsen, Hendrik Folkerts, Marjan Geugien, Fiona A. van den Heuvel, Arthur Flohr Svendsen, Guoqiang Yi, Joost H.A. Martens, Edo Vellenga

https://doi.org/10.3324/haematol.2019.229997

Selinexor combined with cladribine, cytarabine, and filgrastim in relapsed or refractory acute myeloid leukemia

Ramzi Abboud, Ezhilarasi Chendamarai, Michael P. Rettig, Kathryn M. Trinkaus, Peter A. Riedell, Camille N. Abboud, Armin Ghobadi, Iskra Pusic, Keith Stockerl-Goldstein, Mark A. Schroeder, Ravi Vij, Peter Westervelt, John F. DiPersio, Geoffrey L. Uy

https://doi.org/10.3324/haematol.2019.236810

Cryptic insertions of the immunoglobulin light chain enhancer region near CCND1 in t(11;14)-negative mantle cell lymphoma

Carla Fuster, David Martín-Garcia, Olga Balagué, Alba Navarro, Ferran Nadeu, Dolors Costa, Miriam Prieto, Itziar Salaverria, Blanca Espinet, Alfredo Rivas-Delgado, Maria José Terol, Eva Giné, Pilar Forcada, Margaret Ashton-Key, Xose S. Puente, Steven H. Swerdlow, Sílvia Beà, Elias Campo

https://doi.org/10.3324/haematol.2019.237073

Breast implant-associated Epstein-Barr virus-positive large B-cell lymphomas: a report of three cases

Socorro María Rodríguez-Pinilla, Francisco Javier Sánchez García, Olga Balagué, Manuel Rodríguez-Justo, Miguel Ángel Piris

https://doi.org/10.3324/haematol.2019.232355

Impact of relative dose intensity of standard regimens on survival in elderly patients aged 80 years and older with diffuse large B-cell lymphoma

Shin Lee, Kei Fujita, Eiju Negoro, Tetsuji Morishita, Kana Oiwa, Hikaru Tsukasaki, Keiichi Kinoshita, Yasukazu Kawai, Takanori Ueda, Takahiro Yamauchi

https://doi.org/10.3324/haematol.2019.234435

ASK1 inhibition triggers platelet apoptosis via p38-MAPK-mediated mitochondrial dysfunction

Kurnegala Manikanta, Somanathapura K. Naveen Kumar, Mahadevappa Hemshekhar, Kempaiah Kemparaju, Kesturu S. Girish

https://doi.org/10.3324/haematol.2019.233908

Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin

Mary J. Heeb, José A. Fernández, Atsuki Yamashita, Olivia R. McDowell, Zihan Guo, Laurent O. Mosnier, Hiroshi Deguchi, John H. Griffin

https://doi.org/10.3324/haematol.2019.242982

Case Report

Evolutionary crossroads: morphological heterogeneity reflects divergent intra-clonal evolution in a case of high-grade B-cell lymphoma

Valentina Tabanelli, Federica Melle, Giovanna Motta, Saveria Mazzara, Marco Fabbri, Chiara Corsini, Elvira Gerbino, Angelica Calleri, Maria Rosaria Sapienza, Ignazio Abbene, Viviana Stufano, Massimo Barberis, Stefano A. Pileri

https://doi.org/10.3324/haematol.2020.249664