September, 2020
No. 105 (9)

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Editorials

Perspective Article

Acute Lymphoblastic Leukemia

BCR-ABL1-like acute lymphoblastic leukemia in childhood and targeted therapy

Gunnar Cario, Veronica Leoni, Valentino Conter, André Baruchel, Martin Schrappe, Andrea Biondi

https://doi.org/10.3324/haematol.2018.207019

Centenary Review

Review Articles

The variable manifestations of disease in pyruvate kinase deficiency and their management

Hanny Al-Samkari, Eduard J. van Beers, Kevin H.M. Kuo, Wilma Barcellini, Paola Bianchi, Andreas Glenthøj, María del Mar Mañú Pereira, Richard van Wijk, Bertil Glader, Rachael F. Grace

https://doi.org/10.3324/haematol.2019.240846

Articles

Red Cell Biology & Its Disorders

XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia

Flavia Guillem, Michaël Dussiot, Elia Colin, Thunwarat Suriyun, Jean Benoit Arlet, Nicolas Goudin, Guillaume Marcion, Renaud Seigneuric, Sebastien Causse, Patrick Gonin, Marc Gastou, Marc Deloger, Julien Rossignol, Mathilde Lamarque, Zakia Belaid Choucair, Emilie Fleur Gautier, Sarah Ducamp, Julie Vandekerckhove, Ivan C. Moura, Thiago Trovati Maciel, Carmen Garrido, Xiuli An, Patrick Mayeux, Narla Mohandas, Geneviève Courtois, Olivier Hermine

https://doi.org/10.3324/haematol.2018.210054

Granulocyte Biology & its Disorders

Impaired microRNA processing in neutrophils from rheumatoid arthritis patients confers their pathogenic profile. Modulation by biological therapies

Ivan Arias de la Rosa, Carlos Perez-Sanchez, Patricia Ruiz-Limon, Alejandra Patiño-Trives, Carmen Torres-Granados, Yolanda Jimenez-Gomez, Maria del Carmen Abalos-Aguilera, Irene Cecchi, Rafaela Ortega, Miguel Angel Caracuel, Jerusalem Calvo-Gutierrez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Chary Lopez-Pedrera, Nuria Barbarroja

https://doi.org/10.3324/haematol.2018.205047

Myeloproliferative Neoplasms

Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis: a phase II study

Anders Lindholm Sørensen, Stine Ulrik Mikkelsen, Trine Alma Knudsen, Mads Emil Bjørn, Christen Lykkegaard Andersen, Ole Weis Bjerrum, Nana Brochmann, Dustin Andersen Patel, Lise Mette Rahbek Gjerdrum, Daniel El Fassi, Torben A. Kruse, Thomas Stauffer Larsen, Hans Torben Mourits-Andersen, Claus Henrik Nielsen, Christina Ellervik, Niels Pallisgaard, Mads Thomassen, Lasse Kjær, Vibe Skov, Hans Carl Hasselbalch

https://doi.org/10.3324/haematol.2019.235648

Acute Myeloid Leukemia

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng

https://doi.org/10.3324/haematol.2019.230482

Non-Hodgkin Lymphoma

Prognostic impact of somatic mutations in diffuse large B-cell lymphoma and relationship to cell-of-origin: data from the phase III GOYA study

Christopher R. Bolen, Magdalena Klanova, Marek Trneny, Laurie H. Sehn, Jie He, Jing Tong, Joseph N. Paulson, Eugene Kim, Umberto Vitolo, Alice Di Rocco, Günter Fingerle-Rowson, Tina Nielsen, Georg Lenz, Mikkel Z. Oestergaard

https://doi.org/10.3324/haematol.2019.227892

DA-EPOCH-R combined with high-dose methotrexate in patients with newly diagnosed stage II-IV CD5-positive diffuse large B-cell lymphoma: a single-arm, open-label, phase II study

Kana Miyazaki, Naoko Asano, Tomomi Yamada, Kohta Miyawaki, Rika Sakai, Tadahiko Igarashi, Momoko Nishikori, Kinya Ohata, Kazutaka Sunami, Isao Yoshida, Go Yamamoto, Naoki Takahashi, Masataka Okamoto, Hiroki Yano, Yuki Nishimura, Satoshi Tamaru, Masakatsu Nishikawa, Koji Izutsu, Tomohiro Kinoshita, Junji Suzumiya, Koichi Ohshima, Koji Kato, Naoyuki Katayama, Motoko Yamaguchi

https://doi.org/10.3324/haematol.2019.231076

Plasma Cell Disorders

RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS

Marcel Seibold, Thorsten Stühmer, Nadine Kremer, Anja Mottok, Claus-Jürgen Scholz, Andreas Schlosser, Ellen Leich, Ulrike Holzgrabe, Daniela Brünnert, Santiago Barrio, K. Martin Kortüm, Antonio G. Solimando, Manik Chatterjee, Hermann Einsele, Andreas Rosenwald, Ralf C. Bargou, Torsten Steinbrunn

https://doi.org/10.3324/haematol.2019.223024

Hemostasis

Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study

Pauline C.S. van Paridon, Marina Panova-Noeva, Rene van Oerle, Andreas Schultz, Iris M. Hermanns, Jürgen H. Prochaska, Nathalie Arnold, Harald Binder, Irene Schmidtmann, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Hugo ten Cate, Philipp S. Wild, Henri M.H. Spronk

https://doi.org/10.3324/haematol.2019.221655

Hemostasis - Coagulation and its Disorders

A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A

Toufik Abache, Alexandre Fontayne, Dominique Grenier, Emilie Jacque, Alain Longue, Anne-Sophie Dezetter, Béatrice Souilliart, Guillaume Chevreux, Damien Bataille, Sami Chtourou, Jean-Luc Plantier

https://doi.org/10.3324/haematol.2019.219865

Letters to the Editor

Mortality in children with sickle cell disease in mainland France from 2000 to 2015

Emilie Desselas, Isabelle Thuret, Florentia Kaguelidou, Malika Benkerrou, Mariane de Montalembert, Marie-Hélène Odièvre, Emmanuelle Lesprit, Eva Rumpler, Arnaud Fontanet, Corinne Pondarre, Valentine Brousse

https://doi.org/10.3324/haematol.2019.237602

Circulating cell-free BRAF V600E during chemotherapy is associated with prognosis of children with Langerhans cell histiocytosis

Lei Cui, Li Zhang, Hong-Hao Ma, Chan-Juan Wang, Dong Wang, Hong-Yun Lian, Wei-Jing Li, Qing Zhang, Na Li, Tian-You Wang, Zhi-Gang Li, Rui Zhang

https://doi.org/10.3324/haematol.2019.229187

The long non-coding RNA Cancer Susceptibility 15 (CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia

Sarah Grasedieck, Christoph Ruess, Kathrin Krowiorz, Susanne Lux, Nicole Pochert, Adrian Schwarzer, Jan-Henning Klusmann, Mojca Jongen-Lavrencic, Tobias Herold, Lars Bullinger, Jonathan R. Pollack, Arefeh Rouhi, Florian Kuchenbauer

https://doi.org/10.3324/haematol.2019.235291

Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia

Florentien E.M. in't Hout, Mylène Gerritsen, Lars Bullinger, Bert A. van der Reijden, Gerwin Huls, Edo Vellenga, Joop H. Jansen

https://doi.org/10.3324/haematol.2019.232827

Whole exome sequencing identifies mutational signatures of vitreoretinal lymphoma

Junwon Lee, Borahm Kim, Hyeonah Lee, Heejung Park, Suk Ho Byeon, Jong Rak Choi, Sung Chul Lee, Seung-Tae Lee, Christopher Seungkyu Lee

https://doi.org/10.3324/haematol.2019.233783

Safety and efficacy of brentuximab vedotin as a treatment for lymphoproliferative disorders in primary immunodeficiencies

Thomas Pincez, Julie Bruneau, Laureline Berteloot, Eve Piekarski, Caroline Thomas, Ambroise Marçais, Amélie Trinquand, Martin Castelle, Nicolas Garcelon, Dominique Plantaz, Morgane Cheminant, Despina Moshous, Thierry Jo Molina, Olivier Hermine, Elizabeth Macintyre, Alain Fischer, Stéphane Blanche, Felipe Suarez, Bénédicte Neven

https://doi.org/10.3324/haematol.2019.230276

Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia

Enrique Podaza, Florencia Palacios, Diego O. Croci, Denise Risnik, Xiao J. Yan, María Belén Almejún, Ana Colado, Esteban E. Elías, Mercedes Borge, Pablo E. Morande, Raimundo Bezares, Horacio Fernández-Grecco, Gabriel A. Rabinovich, Romina Gamberale, Nicholas Chiorazzi, Mirta Giordano

https://doi.org/10.3324/haematol.2019.227975

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment

Daniel Alameda, Borja Saez, David Lara-Astiaso, Sarai Sarvide, Marta Lasa, Diego Alignani, Idoia Rodriguez, Sonia Garate, Amaia Vilas, Bruno Paiva, Matias Alfonso-Olmos, Jose Maria Lamo de Espinosa, Felipe Prosper, Jesus F. San Miguel, Patricia Maiso

https://doi.org/10.3324/haematol.2019.235135

Infection-related morbidity in a large study of transplant non-eligible newly diagnosed myeloma patients treated with UK standard of care

Faouzi Djebbari, Fotios Panitsas, Toby A. Eyre, Catherine Prodger, Fearn Davies, Kieran Burton, Akhil Khera, Grant Vallance, Sally Moore, Jaimal Kothari, Andy Peniket, Karthik Ramasamy

https://doi.org/10.3324/haematol.2019.240762

Early relapse after autologous transplant for myeloma is associated with poor survival regardless of cytogenetic risk

Jill Corre, Lydia Montes, Elodie Martin, Aurore Perrot, Denis Caillot, Xavier Leleu, Karim Belhadj, Thierry Facon, Cyrille Hulin, Mohamad Mohty, Jean Fontan, Margaret Macro, Sabine Brechignac, Arnaud Jaccard, Anne-Marie Stoppa, Frederique Orsini-Piocelle, Didier Adiko, Laurent Voillat, Faiza Keddar, Marly Barry, Helene Demarquette, Marie-Noelle Certain, Isabelle Plantier, Murielle Roussel, Benjamin Hébraud, Thomas Filleron, Michel Attal, Hervé Avet-Loiseau

https://doi.org/10.3324/haematol.2019.236588

Case Reports

Chronic Lymphocytic Leukemia

Chronic lymphocytic leukaemia and prolymphocytic leukaemia. Two coins or two sides of the same coin?

Laura Magnano, Alba Navarro, Mónica López-Guerra, Guillem Clot, Sílvia Beà, Gabriela Bastidas, Dolors Costa, Andrea Rivero, Marta Garrote, Eva Giné, María Rozman, Marta Aymerich, Dolors Colomer, Armando López-Guillermo, Elías Campo, Neus Villamor, Estella Matutes

https://doi.org/10.3324/haematol.2020.253062