June, 2020
No. 105 (6)

About the Cover

Editorials

Review Articles

Geriatric assessment in older patients with a hematologic malignancy: a systematic review (5258 Online Views)

Ellen R.M. Scheepers, Ariel M. Vondeling, Noortje Thielen, René van der Griend, Reinhard Stauder, Marije E. Hamaker

https://doi.org/10.3324/haematol.2019.245803

Articles

Hematopoiesis

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts (1750 Online Views)

Laura A. Richards, Ashu Kumari, Kathy Knezevic, Julie AI Thoms, Georg von Jonquieres, Christine E. Napier, Zara Ali, Rosemary O’Brien, Jonathon Marks-Bluth, Michelle F. Maritz, Hilda A Pickett, Jonathan Morris, John E. Pimanda, Karen L. MacKenzie

https://doi.org/10.3324/haematol.2018.215699

Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types (2098 Online Views)

Muntasir M. Majumder, Aino-Maija Leppä, Monica Hellesøy, Paul Dowling, Alina Malyutina, Reidun Kopperud, Despina Bazou, Emma Andersson, Alun Parsons, Jing Tang, Olli Kallioniemi, Satu Mustjoki, Peter O’Gorman, Krister Wennerberg, Kimmo Porkka, Bjørn T. Gjertsen, Caroline A. Heckman

https://doi.org/10.3324/haematol.2019.217414

Myelodysplastic Syndromes

Synergistic effects of PRIMA-1Met (APR-246) and 5-azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia (2411 Online Views)

Nabih Maslah, Norman Salomao, Louis Drevon, Emmanuelle Verger, Nicolas Partouche, Pierre Ly, Philippe Aubin, Nadia Naoui, Marie-Helene Schlageter, Cecile Bally, Elsa Miekoutima, Ramy Rahmé, Jacqueline Lehmann-Che, Lionel Ades, Pierre Fenaux, Bruno Cassinat, Stephane Giraudier

https://doi.org/10.3324/haematol.2019.218453

Acute Myeloid Leukemia

The prevalence of extramedullary acute myeloid leukemia detected by 18FDG-PET/CT: final results from the prospective PETAML trial (3507 Online Views)

Friedrich Stölzel, Tors Lüer, Steffen Löck, Stefani Parmentier, Friederike Kuithan, Michael Kramer, Nael S. Alakel, Katja Sockel, Franziska Taube, Jan M. Middeke, Johannes Schetelig, Christoph Röllig, Tobias Paulus, Jörg Kotzerke, Gerhard Ehninger, Martin Bornhäuser, Markus Schaich, Klaus Zoephel

https://doi.org/10.3324/haematol.2019.223032

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism (2498 Online Views)

Luca Mazzarella, Edoardo Botteri, Anthony Matthews, Elena Gatti, Davide Di Salvatore, Vincenzo Bagnardi, Massimo Breccia, Pau Montesinos, Teresa Bernal, Cristina Gil, Timothy J Ley, Miguel Sanz, Krishnan Bhaskaran, Francesco Lo Coco, Pier Giuseppe Pelicci

https://doi.org/10.3324/haematol.2019.223925

Myeloid Neoplasms

Oral arsenic trioxide ORH-2014 pharmacokinetic and safety profile in patients with advanced hematologic disorders (2529 Online Views)

Farhad Ravandi, Iphigenia Koumenis, Anandhi Johri, Martin Tallman, Gail J. Roboz, Stephen Strickland, Guillermo Garcia-Manero, Gautam Borthakur, Kiran Naqvi, Meghan Meyer, Madhu Pudipeddi, Sirish Nidarmarthy, Kris Vaddi, Hagop Kantarjian

https://doi.org/10.3324/haematol.2019.229583

Acute Lymphoblastic Leukemia

Low level CpG island promoter methylation predicts a poor outcome in adult T-cell acute lymphoblastic leukemia (1295 Online Views)

Aurore Touzart, Nicolas Boissel, Mohamed Belhocine, Charlotte Smith, Carlos Graux, Mehdi Latiri, Ludovic Lhermitte, Eve-Lyne Mathieu, Françoise Huguet, Laurence Lamant, Pierre Ferrier, Norbert Ifrah, Elizabeth Macintyre, Hervé Dombret, Vahid Asnafi, Salvatore Spicuglia

https://doi.org/10.3324/haematol.2019.223677

Non-Hodgkin Lymphoma

Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay (2598 Online Views)

Fanny Drieux, Philippe Ruminy, Ahmad Abdel-Sater, François Lemonnier, Pierre-Julien Viailly, Virginie Fataccioli, Vinciane Marchand, Bettina Bisig, Audrey Letourneau, Marie Parrens, Céline Bossard, Julie Bruneau, Pamela Dobay, Liana Veresezan, Aurélie Dupuy, Anaïs Pujals, Cyrielle Robe, Nouhoum Sako, Christiane Copie-Bergman, Marie-Hélène Delfau-Larue, Jean-Michel Picquenot, Hervé Tilly, Richard Delarue, Fabrice Jardin, Laurence de Leval, Philippe Gaulard

https://doi.org/10.3324/haematol.2019.226647

The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T cells (2280 Online Views)

William Townsend, Marta Pasikowska, Deborah Yallop, Elizabeth H. Phillips, Piers E.M. Patten, Jonathan R. Salisbury, Robert Marcus, Andrea Pepper, Stephen Devereux

https://doi.org/10.3324/haematol.2019.220160

KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study (4311 Online Views)

Simone Ferrero, Davide Rossi, Andrea Rinaldi, Alessio Bruscaggin, Valeria Spina, Christian W. Eskelund, Andrea Evangelista, Riccardo Moia, Ivo Kwee, Christina Dahl, Alice Di Rocco, Vittorio Stefoni, Fary Diop, Chiara Favini, Paola Ghione, Abdurraouf Mokhtar Mahmoud, Mattia Schipani, Arne Kolstad, Daniela Barbero, Domenico Novero, Marco Paulli, Alberto Zamò, Mats Jerkeman, Maria Gomes da Silva, Armando Santoro, Annalia Molinari, Andres Ferreri, Kirsten Grønbæk, Andrea Piccin, Sergio Cortelazzo, Francesco Bertoni, Marco Ladetto, Gianluca Gaidano

https://doi.org/10.3324/haematol.2018.214056

Chronic Lymphocytic Leukemia

A laboratory-based scoring system predicts early treatment in Rai 0 chronic lymphocytic leukemia (1743 Online Views)

Jared A. Cohen, Francesca Maria Rossi, Antonella Zucchetto, Riccardo Bomben, Lodovico Terzi-di-Bergamo, Kari G. Rabe, Massimo Degan, Agostino Steffan, Jerry Polesel, Enrico Santinelli, Idanna Innocenti, Giovanna Cutrona, Giovanni D’Arena, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Davide Rossi, Francesco Di Raimondo, Luca Laurenti, Massimo Gentile, Fortunato Morabito, Antonino Neri, Manlio Ferrarini, Christopher D. Fegan, Christopher J. Pepper, Giovanni Del Poeta, Sameer A. Parikh, Neil E. Kay, Valter Gattei

https://doi.org/10.3324/haematol.2019.228171

IGHV mutational status and outcome for patients with chronic lymphocytic leukemia upon treatment: a Danish nationwide population-based study (15231 Online Views)

Emelie Curovic Rotbain, Henrik Frederiksen, Henrik Hjalgrim, Klaus Rostgaard, Gudrun Jakubsdottir Egholm, Banafsheh Zahedi, Christian Bjørn Poulsen, Lisbeth Enggard, Caspar da Cunha-Bang, Carsten Utoft Niemann

https://doi.org/10.3324/haematol.2019.220194

Plasma Cell Disorders

Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy (2024 Online Views)

Jia Tong, Xiaoguang Xu, Zilu Zhang, Chengning Ma, Rufang Xiang, Jia Liu, Wenbin Xu, Chao Wu, Junmin Li, Fenghuang Zhan, Yingli Wu, Hua Yan

https://doi.org/10.3324/haematol.2019.218289

Identification of PIKfyve kinase as a target in multiple myeloma (2765 Online Views)

Cecilia Bonolo de Campos, Yuan Xiao Zhu, Nikolai Sepetov, Sergei Romanov, Laura Ann Bruins, Chang-Xin Shi, Caleb K. Stein, Joachim L. Petit, Alysia N. Polito, Meaghen E. Sharik, Erin W. Meermeier, Gregory J. Ahmann, Ilsel D. Lopez Armenta, Jonas Kruse, P. Leif Bergsagel, Marta Chesi, Nathalie Meurice, Esteban Braggio, A. Keith Stewart

https://doi.org/10.3324/haematol.2019.222729

Health-related quality of life in transplant ineligible newly diagnosed multiple myeloma patients treated with either thalidomide or lenalidomide-based regimen until progression: a prospective, open-label, multicenter, randomized, phase 3 study (1972 Online Views)

Lene Kongsgaard Nielsen, Claudia Stege, Birgit Lissenberg-Witte, Bronno van der Holt, Ulf-Henrik Mellqvist, Morten Salomo, Gerard Bos, Mark-David Levin, Heleen Visser-Wisselaar, Markus Hansson, Annette van der Velden, Wendy Deenik, Juleon Coenen, Maja Hinge, Saskia Klein, Bea Tanis, Damian Szatkowski, Rolf Brouwer, Matthijs Westerman, Rineke Leys, Harm Sinnige, Einar Haukås, Klaas van der Hem, Marc Durian, Peter Gimsing, Niels van de Donk, Pieter Sonneveld, Anders Waage, Niels Abildgaard, Sonja Zweegman

https://doi.org/10.3324/haematol.2019.222299

Platelet Biology & its Disorders

Glycoprotein Ib clustering in platelets can be inhibited by α-linolenic acid as revealed by cryo-electron tomography (1326 Online Views)

Simona Stivala, Simona Sorrentino, Sara Gobbato, Nicole R. Bonetti, Giovanni G. Camici, Thomas F. Lüscher, Ohad Medalia, Jürg H. Beer

https://doi.org/10.3324/haematol.2019.220988

Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets (1274 Online Views)

Inga Scheller, Simon Stritt, Sarah Beck, Bing Peng, Irina Pleines, Katrin G. Heinze, Attila Braun, Oliver Otto, Robert Ahrends, Albert Sickmann, Markus Bender, Bernhard Nieswandt

https://doi.org/10.3324/haematol.2019.225516

Hemostasis

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis (1061 Online Views)

Chantal Kroone, Mariska Vos, Timo Rademakers, Marijke Kuijpers, Mark Hoogenboezem, Jaap van Buul, Johan W.M. Heemskerk, Wolfram Ruf, Astrid van Hylckama Vlieg, Henri H. Versteeg, Marie-José Goumans, Carlie J.M. de Vries, Kondababu Kurakula, INVENT Consortium

https://doi.org/10.3324/haematol.2018.203026

Placenta-derived extracellular vesicles induce preeclampsia in mouse models (3234 Online Views)

Cha Han, Chenyu Wang, Yuanyuan Chen, Jiwei Wang, Xin Xu, Tristan Hilton, Wei Cai, Zilong Zhao, Yingang Wu, Ke Li, Katie Houck, Li Liu, Anil K. Sood, Xiaoping Wu, Fengxia Xue, Min Li, Jing-fei Dong, Jianning Zhang

https://doi.org/10.3324/haematol.2019.226209

Coagulation & its Disorders

D’ domain region Arg782-Cys799 of von Willebrand factor contributes to factor VIII binding (1133 Online Views)

Małgorzata A. Przeradzka, Josse van Galen, Eduard H. T. M. Ebberink, Arie J. Hoogendijk, Carmen van der Zwaan, Koen Mertens, Maartje van den Biggelaar, Alexander B. Meijer

https://doi.org/10.3324/haematol.2019.221994

Thrombotic biomarkers for risk prediction of malignant disease recurrence in patients with early stage breast cancer (1557 Online Views)

Cinzia Giaccherini, Marina Marchetti, Giovanna Masci, Cristina Verzeroli, Laura Russo, Luigi Celio, Roberta Sarmiento, Sara Gamba, Carmen J. Tartari, Erika Diani, Alfonso Vignoli, Paolo Malighetti, Daniele Spinelli, Carlo Tondini, Sandro Barni, Francesco Giuliani, Fausto Petrelli, Andrea D’Alessio, Giampietro Gasparini, Filippo De Braud, Armando Santoro, Roberto Labianca, Anna Falanga, on behalf of the HYPERCAN Investigators

https://doi.org/10.3324/haematol.2019.228981

Stem Cell Transplantation

Allogeneic stem cell transplantation in second complete remission for core binding factor acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (2249 Online Views)

Kazimierz Halaburda, Myriam Labopin, Audrey Mailhol, Gerard Socié, Charles Craddock, Mahmoud Aljurf, Dietrich Beelen, Jan J. Cornelissen, Jean-Henri Bourhis, Hélène Labussière-Wallet, Didier Blaise, Tobias Gedde-Dahl, Maria Gilleece, Ibrahim Yakoub-Agha, Ghulam Mufti, Jordi Esteve, Mohamad Mohty, Arnon Nagler

https://doi.org/10.3324/haematol.2019.222810

Cell Therapy & Immunotherapy

Yttrium-90-labeled anti-CD45 antibody followed by a reduced-intensity hematopoietic cell transplantation for patients with relapsed/refractory leukemia or myelodysplasia (1162 Online Views)

Phuong Vo, Ted A. Gooley, Joseph G. Rajendran, Darrell R. Fisher, Johnnie J. Orozco, Damian J. Green, Ajay K. Gopal, Robyn Haaf, Margaret Nartea, Rainer Storb, Frederick R. Appelbaum, Oliver W. Press, John M. Pagel, Brenda M. Sandmaier

https://doi.org/10.3324/haematol.2019.229492

Genetic platelet depletion is superior in platelet transfusion compared to current models (2428 Online Views)

Manuel Salzmann, Waltraud C. Schrottmaier, Julia B. Kral-Pointner, Marion Mussbacher, Julia Volz, Bastian Hoesel, Bernhard Moser, Sonja Bleichert, Susanne Morava, Bernhard Nieswandt, Johannes A. Schmid, Alice Assinger

https://doi.org/10.3324/haematol.2019.222448

Guidelines

Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (10860 Online Views)

Ali Bazarbachi, Gesine Bug, Frederic Baron, Eolia Brissot, Fabio Ciceri, Iman Abou Dalle, Hartmut Döhner, Jordi Esteve, Yngvar Floisand, Sebastian Giebel, Maria Gilleece, Norbert-Claude Gorin, Elias Jabbour, Mahmoud Aljurf, Hagop Kantarjian, Mohamed Kharfan-Dabaja, Myriam Labopin, Francesco Lanza, Florent Malard, Zinaida Peric, Thomas Prebet, Farhad Ravandi, Annalisa Ruggeri, Jaime Sanz, Christoph Schmid, Roni Shouval, Alexandros Spyridonidis, Jurjen Versluis, Norbert Vey, Bipin N Savani, Arnon Nagler, Mohamad Mohty

https://doi.org/10.3324/haematol.2019.243410

Online Only Articles

Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (2847 Online Views)

Christopher Maximilian Arends, Marlene Weiss, Friederike Christen, Claudia Eulenberg-Gustavus, Anthony Rousselle, Ralph Kettritz, Kai-Uwe Eckardt, Willy Chan, Kaja Hoyer, Mareike Frick, Lars Bullinger, Markus Bieringer, Adrian Schreiber, Frederik Damm

https://doi.org/10.3324/haematol.2019.223305

PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis (1291 Online Views)

Pedro L. Moura, Bethan R. Hawley, Johannes G.G. Dobbe, Geert J. Streekstra, Minke A.E. Rab, Paola Bianchi, Richard van Wijk, Ashley M. Toye, Timothy J. Satchwell

https://doi.org/10.3324/haematol.2019.231159

Hydroxyurea to lower transcranial Doppler velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort (1224 Online Views)

Robert O. Opoka, Heather A. Hume, Teresa S. Latham, Adam Lane, Olatundun Williams, Jennifer Tymon, Maria Nakafeero, Phillip Kasirye, Christopher M. Ndugwa, Chandy C. John, Russell E. Ware

https://doi.org/10.3324/haematol.2019.231407

Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia (1005 Online Views)

Sébastien Chateauvieux, Anthoula Gaigneaux, Déborah Gérard, Marion Orsini, Franck Morceau, Barbora Orlikova-Boyer, Thomas Farge, Christian Récher, Jean-Emmanuel Sarry, Mario Dicato, Marc Diederich

https://doi.org/10.3324/haematol.2019.217281

The microRNA miR-196b acts as a tumor suppressor in Cdx2-driven acute myeloid leukemia (1102 Online Views)

Vijay P. S. Rawat, Maria Götze, Avinash Rasalkar, Naidu M. Vegi, Susann Ihme, Silvia Thoene, Alessandro Pastore, Deepak Bararia, Hartmut Döhner, Konstanze Döhner, Michaela Feuring-Buske, Leticia Quintanilla-Fend, Christian Buske

https://doi.org/10.3324/haematol.2019.223297

RNAmut: robust identification of somatic mutations in acute myeloid leukemia using RNA-sequencing (3670 Online Views)

Muxin Gu, Maximillian Zwiebel, Swee Hoe Ong, Nick Boughton, Josep Nomdedeu, Faisal Basheer, Yasuhito Nannya, Pedro M. Quiros, Seishi Ogawa, Mario Cazzola, Roland Rad, Adam P. Butler, MS Vijayabaskar, George S. Vassiliou

https://doi.org/10.3324/haematol.2019.230821

Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia (3071 Online Views)

Eulàlia Genescà, Mireia Morgades, Pau Montesinos, Pere Barba, Cristina Gil, Ramon Guàrdia, María-José Moreno, Daniel Martínez-Carballeira, Irene García-Cadenas, Susana Vives, Jordi Ribera, José González-Campos, Celia González-Gil, Lurdes Zamora, José-Luís Ramírez, Marina Díaz-Beya, Santiago Mercadal, María-Teresa Artola, Antònia Cladera, Mar Tormo, Arancha Bermúdez, Ferran Vall-Llovera, Pilar Martínez, María-Luz Amigo, Silvia Monsalvo, Andrés Novo, Marta Cervera, Antoni García-Guiñon, Jordi Juncà, Juana Ciudad, Alberto Orfao, Josep-Maria Ribera

https://doi.org/10.3324/haematol.2019.225078

High frequency of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis in Japanese descendants living in Brazil (1086 Online Views)

Mariane de Faria-Moss, Mihoko Yamamoto, Celso Arrais-Rodrigues, Ignacio Criado, Caio Perez Gomes, Maria de Lourdes Chauffaille, Matheus Vescovi Gonçalves, Eliza Kimura, Efstathios Koulieris, Fabio Borges, Guilhermo Dighiero, Joao Bosco Pesquero, Julia Almeida, Alberto Orfao

https://doi.org/10.3324/haematol.2019.230813

Effect of daratumumab on normal plasma cells, polyclonal immunoglobulin levels, and vaccination responses in extensively pre-treated multiple myeloma patients (4275 Online Views)

Kristine A. Frerichs, Patricia W.C. Bosman, Jeroen F. van Velzen, Pieter L.A. Fraaij, Marion P.G. Koopmans, Guus F. Rimmelzwaan, Inger S. Nijhof, Andries C. Bloem, Tuna Mutis, Sonja Zweegman, Niels W.C.J. van de Donk

https://doi.org/10.3324/haematol.2019.231860

Case Reports

IGH rearrangement in myeloid neoplasms (1568 Online Views)

Amy W. Xiao, Yuyan Jia, Linda B. Baughn, Kathryn E. Pearce, Beth A. Pitel, Jon C. Aster, Paola Dal Cin, Sheng Xiao

https://doi.org/10.3324/haematol.2020.246744

Genetic heterogeneity highlighted by differential FDG-PET response in diffuse large B-cell lymphoma (1226 Online Views)

Shamzah Araf, Koorosh Korfi, Findlay Bewicke-Copley, Jun Wang, Sergio Cogliatti, Emil Kumar, Flavio Forrer, Sally F. Barrington, Trevor A. Graham, David W. Scott, Lisa M. Rimsza, Andrew Davies, Peter Johnson, Jessica Okosun, Jude Fitzgibbon, Martin Fehr

https://doi.org/10.3324/haematol.2019.242206

Perspective Articles