May, 2020
No. 105 (5)

About the cover

Editorials

Perspective Article

Structured assessment of frailty in multiple myeloma as a paradigm of individualized treatment algorithms in cancer patients at advanced age

Monika Engelhardt, Gabriele Ihorst, Jesus Duque-Afonso, Ulrich Wedding, Ernst Spät-Schwalbe, Valentin Goede, Gerald Kolb, Reinhard Stauder, Ralph Wäsch

https://doi.org/10.3324/haematol.2019.242958

Review Articles

Articles

Hematopoiesis

Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells

Hongzhe Li, Hooi-Ching Lim, Dimitra Zacharaki, Xiaojie Xian, Keane J.G. Kenswil, Sandro Bräunig, Marc H.G.P. Raaijmakers, Niels-Bjarne Woods, Jenny Hansson, Stefan Scheding

https://doi.org/10.3324/haematol.2019.216648

Prion protein deficiency impairs hematopoietic stem cell determination and sensitizes myeloid progenitors to irradiation

Capucine Siberchicot, Nathalie Gault, Nathalie Déchamps, Vilma Barroca, Adriano Aguzzi, Paul-Henri Roméo, J. Pablo Radicella, Anne Bravard, Jacqueline Bernardino-Sgherri

https://doi.org/10.3324/haematol.2018.205716

Bone Marrow Failure

Long-term outcome of a randomized controlled study in patients with newly diagnosed severe aplastic anemia treated with antithymocyte globulin and cyclosporine, with or without granulocyte colony-stimulating factor: a Severe Aplastic Anemia Working Party Trial from the European Group of Blood and Marrow Transplantation

André Tichelli, Régis Peffault de Latour, Jakob Passweg, Cora Knol-Bout, Gérard Socié, Judith Marsh, Hubert Schrezenmeier, Britta Höchsmann, Andrea Bacigalupo, Sujith Samarasinghe, Alicia Rovó, Austin Kulasekararaj, Alexander Röth, Dirk-Jan Eikema, Paul Bosman, Peter Bader, Antonio Risitano, Carlo Dufour

https://doi.org/10.3324/haematol.2019.222562

Iron Metabolism & Its Disorders

Red Cell Biology & Its Disorders

Extensive multilineage analysis in patients with mixed chimerism after allogeneic transplantation for sickle cell disease: insight into hematopoiesis and engraftment thresholds for gene therapy

Alessandra Magnani, Corinne Pondarré, Naïm Bouazza, Jeremy Magalon, Annarita Miccio, Emmanuelle Six, Cecile Roudaut, Cécile Arnaud, Annie Kamdem, Fabien Touzot, Aurélie Gabrion, Elisa Magrin, Chloé Couzin, Mathieu Fusaro, Isabelle André, Jean-Paul Vernant, Eliane Gluckman, Françoise Bernaudin, Dominique Bories, Marina Cavazzana

https://doi.org/10.3324/haematol.2019.227561

Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation

Myriam Chimen, Aigli Evryviadou, Clare L. Box, Matthew J. Harrison, Jon Hazeldine, Lea H. Dib, Sahithi J. Kuravi, Holly Payne, Joshua M.J. Price, Dean Kavanagh, Asif J. Iqbal, Sian Lax, Neena Kalia, Alex Brill, Steve G. Thomas, Antonio Belli, Nicholas Crombie, Rachel A. Adams, Shelley-Ann Evans, Hans Deckmyn, Janet M. Lord, Paul Harrison, Steve P. Watson, Gerard B. Nash, G. Ed Rainger

https://doi.org/10.3324/haematol.2018.215145

Chronic Myeloid Leukemia

Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model

Bing Z. Carter, Po Yee Mak, Hong Mu, Xiangmeng Wang, Wenjing Tao, Duncan H. Mak, Elisha J. Dettman, Michael Cardone, Oleg Zernovak, Takahiko Seki, Michael Andreeff

https://doi.org/10.3324/haematol.2019.219261

Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

Chuanjiang Yu, Sivahari P. Gorantla, Alina Müller-Rudorf, Tony A. Müller, Stefanie Kreutmair, Corinna Albers, Lena Jakob, Lena J. Lippert, Zhenyu Yue, Monika Engelhardt, Marie Follo, Robert Zeiser, Tobias B. Huber, Justus Duyster, Anna L. Illert

https://doi.org/10.3324/haematol.2018.212027

Acute Myeloid Leukemia

Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia

Amit Sharma, Nidhi Jyotsana, Razif Gabdoulline, Dirk Heckl, Florian Kuchenbauer, Robert K. Slany, Arnold Ganser, Michael Heuser

https://doi.org/10.3324/haematol.2018.211201

Acute Lymphoblastic Leukemia

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Barbara Depreter, Karin E. Weening, Karl Vandepoele, Magnus Essand, Barbara De Moerloose, Maria Themeli, Jacqueline Cloos, Diana Hanekamp, Ine Moors, Inge D’hont, Barbara Denys, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Sylvia Snauwaert, Glenn Goetgeluk, Stijn De Munter, Tessa Kerre, Bart Vandekerckhove, Tim Lammens, Jan Philippé

https://doi.org/10.3324/haematol.2019.222612

Dissecting molecular mechanisms of resistance to NOTCH1-targeted therapy in T-cell acute lymphoblastic leukemia xenografts

Valentina Agnusdei, Sonia Minuzzo, Marica Pinazza, Alessandra Gasparini, Laura Pezzè, Adriana Agnese Amaro, Lorenza Pasqualini, Paola Del Bianco, Martina Tognon, Chiara Frasson, Pietro Palumbo, Yari Ciribilli, Ulrich Pfeffer, Massimo Carella, Alberto Amadori, Stefano Indraccolo

https://doi.org/10.3324/haematol.2019.217687

Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research

Aleksandr Lazaryan, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A. Kharfan-Dabaja, David I. Marks, Nelli Bejanyan, Edward Copelan, Navneet S. Majhail, Edmund K. Waller, Nelson Chao, Tim Prestidge, Taiga Nishihori, Partow Kebriaei, Yoshihiro Inamoto, Betty Hamilton, Shahrukh K. Hashmi, Rammurti T. Kamble, Ulrike Bacher, Gerhard C. Hildebrandt, Patrick J. Stiff, Joseph McGuirk, Ibrahim Aldoss, Amer M. Beitinjaneh, Lori Muffly, Ravi Vij, Richard F. Olsson, Michael Byrne, Kirk R. Schultz, Mahmoud Aljurf, Matthew Seftel, Mary Lynn Savoie, Bipin N. Savani, Leo F. Verdonck, Mitchell S. Cairo, Nasheed Hossain, Vijaya Raj Bhatt, Haydar A. Frangoul, Hisham Abdel-Azim, Monzr Al Malki, Reinhold Munker, David Rizzieri, Nandita Khera, Ryotaro Nakamura, Olle Ringdén, Marjolein van der Poel, Hemant S. Murthy, Hongtao Liu, Shahram Mori, Satiro De Oliveira, Javier Bolaños-Meade, Mahmoud Elsawy, Pere Barba, Sunita Nathan, Biju George, Attaphol Pawarode, Michael Grunwald, Vaibhav Agrawal, Youjin Wang, Amer Assal, Paul Castillo Caro, Yachiyo Kuwatsuka, Sachiko Seo, Celalettin Ustun, Ioannis Politikos, Hillard M. Lazarus, Wael Saber, Brenda M. Sandmaier, Marcos De Lima, Mark Litzow, Veronika Bachanova, Daniel Weisdorf, Acute Leukemia Committee of the CIBMTR

https://doi.org/10.3324/haematol.2019.220756

Hodgkin Lymphoma

An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma

Julien Record, Anton Sendel, Joanna S. Kritikou, Nikolai V. Kuznetsov, Hanna Brauner, Minghui He, Noemi Nagy, Mariana M.S. Oliveira, Elena Griseti, Christoph B. Haase, Jenny Dahlström, Sanjaykumar Boddul, Fredrik Wermeling, Adrian J. Thrasher, Chaohong Liu, John Andersson, Hans-Erik Claesson, Ola Winqvist, Siobhan O. Burns, Magnus Björkholm, Lisa S. Westerberg

https://doi.org/10.3324/haematol.2019.216317

Non-Hodgkin Lymphoma

Identification of a miR-146b-Fas ligand axis in the development of neutropenia in T large granular lymphocyte leukemia

Barbara Mariotti, Giulia Calabretto, Marzia Rossato, Antonella Teramo, Monica Castellucci, Gregorio Barilà, Matteo Leoncin, Cristina Vicenzetto, Monica Facco, Gianpietro Semenzato, Flavia Bazzoni, Renato Zambello

https://doi.org/10.3324/haematol.2019.225060

CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas

Linfeng Chen, Jing Ouyang, Kirsty Wienand, Kamil Bojarczuk, Yansheng Hao, Bjoern Chapuy, Donna Neuberg, Przemyslaw Juszczynski, Lee N. Lawton, Scott J. Rodig, Stefano Monti, Margaret A. Shipp

https://doi.org/10.3324/haematol.2019.216218

An increase in MYC copy number has a progressive negative prognostic impact in patients with diffuse large B-cell and high-grade lymphoma, who may benefit from intensified treatment regimens

Francesca Schieppati, Piera Balzarini, Simona Fisogni, Alessandro Re, Chiara Pagani, Nicola Bianchetti, Lorenzo Micheli, Angela Passi, Samantha Ferrari, Adriana Maifredi, Chiara Bottelli, Rossella Leopaldo, Vilma Pellegrini, Fabio Facchetti, Giuseppe Rossi, Alessandra Tucci

https://doi.org/10.3324/haematol.2019.223891

Chronic Lymphocytic Leukemia

Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription

Jennifer Edelmann, Karlheinz Holzmann, Eugen Tausch, Emily A. Saunderson, Billy M. C. Jebaraj, Daniela Steinbrecher, Anna Dolnik, Tamara J. Blätte, Dan A. Landau, Jenny Saub, Sven Estenfelder, Stefan Ibach, Florence Cymbalista, Veronique Leblond, Alain Delmer, Jasmin Bahlo, Sandra Robrecht, Kirsten Fischer, Valentin Goede, Lars Bullinger, Catherine J. Wu, Daniel Mertens, Gabriella Ficz, John G. Gribben, Michael Hallek, Hartmut Döhner, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2019.217307

Plasma Cell Disorders

Cardiac biomarkers are prognostic in systemic light chain amyloidosis with no cardiac involvement by standard criteria

Faye A. Sharpley, Marianna Fontana, Ana Martinez-Naharro, Richa Manwani, Shameem Mahmood, Sajitha Sachchithanantham, Helen J. Lachmann, Julian D. Gillmore, Carol J. Whelan, Philip N. Hawkins, Ashutosh D. Wechalekar

https://doi.org/10.3324/haematol.2019.217695

Platelet Biology & its Disorders

Hemostasis

The contact system proteases play disparate roles in streptococcal sepsis

Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Carolin Trepesch, Alexey S. Revenko, Jeffrey R. Crosby, A. Robert Macleod, Stefan Mikkat, Sonja Oehmcke-Hecht

https://doi.org/10.3324/haematol.2019.223545

Coagulation & Its Disorders

Accuracy of the Ottawa score in risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism: a systematic review and meta-analysis

Aurélien Delluc, Sébastien Miranda, Paul den Exter, Martha Louzada, Adriano Alatri, Shin Ahn, Manuel Monreal, Alok Khorana, Menno V. Huisman, Philip S. Wells, Marc Carrier

https://doi.org/10.3324/haematol.2019.222828

Stem Cell Transplantation

Pre-transplant testosterone and outcome of men after allogeneic stem cell transplantation

Aleksandar Radujkovic, Lambros Kordelas, Julia Krzykalla, Axel Benner, David Schult, Joshua Majer-Lauterbach, Dietrich W. Beelen, Carsten Müller-Tidow, Christian Kasperk, Peter Dreger, Thomas Luft

https://doi.org/10.3324/haematol.2019.220293

Errata Corrige

Non-Hodgkin Lymphoma

Association of early disease progression and very poor survival in the GALLIUM study in follicular lymphoma: benefit of obinutuzumab in reducing the rate of early progression

John F. Seymour, Robert Marcus, Andrew Davies, Eve Gallop-Evans, Andrew Grigg, Andrew Haynes, Michael Herold, Thomas Illmer, Herman Nilsson-Ehle, Martin Sökler, Ulrich Dünzinger, Tina Nielsen, Aino Launonen, Wolfgang Hiddemann

https://doi.org/10.3324/haematol.2020.246991

Online Only Articles

Letters to the Editor

Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification

Natalie J. Welsh, Christina A. Gewinner, Kavita Mistry, Mumta Koglin, Juniebel Cooke, Matthew Butler, Ben Powney, Malcolm Roberts, James M. Staddon, Anthony H. V. Schapira

https://doi.org/10.3324/haematol.2019.224717

5-formylcytosine and 5-hydroxymethyluracil as surrogate markers of TET2 and SF3B1 mutations in myelodysplastic syndrome, respectively

Daniel Gackowski, Maciej Gawronski, Cassandra Kerr, Tomas Radivoyevitch, Ewelina Zarakowska, Marta Starczak, Abdulkadir Abakir, Alexey Ruzov, Jaroslaw P. Maciejewski, Ryszard Olinski

https://doi.org/10.3324/haematol.2019.224030

Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells

Koji Takaishi, Masahiro Takeuchi, Shokichi Tsukamoto, Naoya Takayama, Motohiko Oshima, Kenji Kimura, Yusuke Isshiki, Kensuke Kayamori, Yutaro Hino, Nagisa Oshima-Hasegawa, Shio Mitsukawa, Yusuke Takeda, Naoya Mimura, Chikako Ohwada, Tohru Iseki, Sou Nakamura, Koji Eto, Atsushi Iwama, Koutaro Yokote, Chiaki Nakaseko, Emiko Sakaida

https://doi.org/10.3324/haematol.2018.214841

Disease progression in myeloproliferative neoplasms: comparing patients in accelerated phase with those in chronic phase with increased blasts (<10%) or with other types of disease progression

Julia T. Geyer, Elizabeth Margolskee, Spencer A. Krichevsky, Daniele Cattaneo, Leonardo Boiocchi, Paola Ronchi, Francesca Lunghi, Joseph M. Scandura, Maurilio Ponzoni, Robert P. Hasserjian, Umberto Gianelli, Alessandra Iurlo, Attilio Orazi

https://doi.org/10.3324/haematol.2019.230193

EZH2 mutations and impact on clinical outcome: an analysis in 1,604 patients with newly diagnosed acute myeloid leukemia

Sebastian Stasik, Jan M. Middeke, Michael Kramer, Christoph Röllig, Alwin Krämer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Volker Kunzmann, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan Krause, Regina Herbst, Mathias Hänel, Norbert Frickhofen, Richard Noppeney, Ulrich Kaiser, Claudia D. Baldus, Martin Kaufmann, Zdenek Rácil, Uwe Platzbecker, Wolfgang E. Berdel, Jiri Mayer, Hubert Serve, Carsten Müller-Tidow, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Christian Thiede

https://doi.org/10.3324/haematol.2019.222323

IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma

Santiago Barrio, Umair Munawar, Yuan Xiao Zhu, Nicola Giesen, Chang-Xin Shi, Matteo Da Viá, Ricardo Sanchez, Laura Bruins, Theresa Demler, Nicole Müller, Larissa Haertle, Andoni Garitano, Torsten Steinbrunn, Sophia Danhof, Isabel Cuenca, Clara Barrio-Garcia, Esteban Braggio, Andreas Rosenwald, Joaquin Martinez-Lopez, Leo Rasche, Marc S. Raab, A. Keith Stewart, Hermann Einsele, Thorsten Stühmer, K. Martin Kortüm

https://doi.org/10.3324/haematol.2019.217943

Phase I/Ib study of carfilzomib and panobinostat with or without dexamethasone in patients with relapsed/refractory multiple myeloma

Elisabet E. Manasanch, Jatin J. Shah, Hans C. Lee, Donna M. Weber, Sheeba K. Thomas, Behrang Amini, Jasper Olsem, Brandon Crumpton, Ashley Morphey, Zuzana Berkova, Lei Feng, Robert Z. Orlowski

https://doi.org/10.3324/haematol.2019.225375

Revisiting the link between platelets and depression through genetic epidemiology: new insights from platelet distribution width

Alessandro Gialluisi, Benedetta Izzi, Augusto Di Castelnuovo, Chiara Cerletti, Maria Bendetta Donati, Giovanni de Gaetano, Licia Iacoviello

https://doi.org/10.3324/haematol.2019.222513

Case Reports

Severe treatment-refractory T-cell-mediated immune skin toxicities observed with obinutuzumab/rituximab-atezo-pola in two patients with follicular lymphoma

Max S. Topp, Johannes Duell, Ana Maria Abajo Guijarro, Marielle Odin, Tina Nielsen, Anand Rajeswaran, Michael Wenger, Christelle Zundel, Aleksandra Bogucka-Fedorczuk, Tomasz Wrobel

https://doi.org/10.3324/haematol.2019.233189