CURRENT ISSUE
September, 2021
No. 106 (9)

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Editorials

Review Articles

Articles

Acute Myeloid Leukemia

Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse (1481 Online Views)

Esther Onecha, Inmaculada Rapado, María Luz Morales, Gonzalo Carreño-Tarragona, Pilar Martinez-Sanchez, Xabier Gutierrez, José María Sáchez Pina, María Linares, Miguel Gallardo, Joaquín Martinez-López, Rosa Ayala

https://doi.org/10.3324/haematol.2020.254623

Chronic Lymphocytic Leukemia

Three-dimensional co-culture model of chronic lymphocytic leukemia bone marrow microenvironment predicts patient-specific response to mobilizing agents (1163 Online Views)

Federica Barbaglio, Daniela Belloni, Lydia Scarfò, Francesca Vittoria Sbrana, Maurilio Ponzoni, Lucia Bongiovanni, Luca Pavesi, Desiree Zambroni, Kostas Stamatopoulos, Valeria R. Caiolfa, Elisabetta Ferrero, Paolo Ghia, Cristina Scielzo

https://doi.org/10.3324/haematol.2020.248112

Impaired nodal shrinkage and apoptosis define the independent adverse outcome of NOTCH1 mutated patients under ibrutinib therapy in chronic lymphocytic leukaemia (634 Online Views)

Giovanni Del Poeta, Annalisa Biagi, Luca Laurenti, Annalisa Chiarenza, Federico Pozzo, Idanna Innocenti, Massimiliano Postorino, Francesca Maria Rossi, Maria Ilaria Del Principe, Riccardo Bomben, Paolo de Fabritiis, Antonio Bruno, Maria Cantonetti, Francesco Di Raimondo, Antonella Zucchetto, Valter Gattei

https://doi.org/10.3324/haematol.2020.251488

Zanubrutinib monotherapy for patients with treatment-naïve chronic lymphocytic leukemia and 17p deletion (4181 Online Views)

Constantine S. Tam, Tadeusz Robak, Paolo Ghia, Brad S. Kahl, Patricia Walker, Wojciech Janowski, David Simpson, Mazyar Shadman, Peter S. Ganly, Luca Laurenti, Stephen Opat, Monica Tani, Hanna Ciepluch, Emma Verner, Martin Šimkovič, Anders Österborg, Marek Trněný, Alessandra Tedeschi, Jason C. Paik, Sowmya B. Kuwahara, Shibao Feng, Vanitha Ramakrishnan, Aileen Cohen, Jane Huang, Peter Hillmen, Jennifer R. Brown

https://doi.org/10.3324/haematol.2020.259432

Phase II study of acalabrutinib in ibrutinib-intolerant patients with relapsed/refractory chronic lymphocytic leukemia (3190 Online Views)

Kerry A. Rogers, Philip A. Thompson, John N. Allan, Morton Coleman, Jeff P. Sharman, Bruce D. Cheson, Daniel Jones, Raquel Izumi, Melanie M. Frigault, Cheng Quah, Rakesh K. Raman, Priti Patel, Min Hui Wang, Thomas J. Kipps

https://doi.org/10.3324/haematol.2020.272500

Complications in Hematology

Elastography improves accuracy of early hepato-biliary complications diagnosis after allogeneic stem cell transplantation (882 Online Views)

Pierre-Edouard Debureaux, Pierre Bourrier, Pierre-Emmanuel Rautou, Anne-Marie Zagdanski, Morgane De Boutiny, Simona Pagliuca, Aurélien Sutra Del Galy, Marie Robin, Régis Peffault de Latour, Aurélie Plessier, Flore Sicre de Fontbrune, Aliénor Xhaard, Pedro Henrique de Lima Prata, Dominique Valla, Gérard Socié, David Michonneau

https://doi.org/10.3324/haematol.2019.245407

Myeloproliferative Disorders

Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis (606 Online Views)

Ivo Veletic, Sanja Prijic, Taghi Manshouri, Graciela M. Nogueras-Gonzalez, Srdan Verstovsek, Zeev Estrov

https://doi.org/10.3324/haematol.2020.249441

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat (978 Online Views)

Elisabeth Oppliger Leibundgut, Monika Haubitz, Bart Burington, Oliver G. Ottmann, Gary Spitzer, Olatoyosi Odenike, Michael A. McDevitt, Alexander Röth, David S. Snyder, Gabriela M. Baerlocher

https://doi.org/10.3324/haematol.2020.252817

Non-Hodgkin Lymphoma

A three-gene signature based on MYC, BCL-2 and NFKBIA improves risk stratification in diffuse large B-cell lymphoma (1042 Online Views)

Enrico Derenzini, Saveria Mazzara, Federica Melle, Giovanna Motta, Marco Fabbri, Riccardo Bruna, Claudio Agostinelli, Alessandra Cesano, Chiara Antonia Corsini, Ning Chen, Simona Righi, Elena Sabattini, Annalisa Chiappella, Angelica Calleri, Stefano Fiori, Valentina Tabanelli, Antonello Cabras, Giancarlo Pruneri, Umberto Vitolo, Alessandro Massimo Gianni, Alessandro Rambaldi, Paolo Corradini, Pier Luigi Zinzani, Corrado Tarella, Stefano Pileri

https://doi.org/10.3324/haematol.2019.236455

Long-term outcomes from the Phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (1935 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2020.275958

Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1 (968 Online Views)

Gehong Dong, Yuping Li, Logan Lee, Xuxiang Liu, Yunfei Shi, Xiaoqian Liu, Alyssa Bouska, Qiang Gong, Lingbo Kong, Jinhui Wang, Chih-Hong Lou, Timothy W. McKeithan, Javeed Iqbal, Wing C. Chan

https://doi.org/10.3324/haematol.2020.254276

Platelet Biology & its Disorders

Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial (1300 Online Views)

Matthieu Mahévas, Imane Azzaoui, Etienne Crickx, Florence Canoui-Poitrine, Delphine Gobert, Laetitia Languille, Nicolas Limal, Constance Guillaud, Laure Croisille, Mohamed Jeljeli, Fréderic Batteux, Samia Baloul, Olivier Fain, France Pirenne, Jean-Claude Weill, Claude-Agnès Reynaud, Bertrand Godeau, Marc Michel

https://doi.org/10.3324/haematol.2020.259481

Red Cell Biology & its Disorders

Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus (596 Online Views)

Petros Kountouris, Kyriaki Michailidou, Soteroula Christou, Michael Hadjigavriel, Maria Sitarou, Anita Kolnagou, Marina Kleanthous, Paul Telfer

https://doi.org/10.3324/haematol.2020.260224

Oxidative stress activates red cell adhesion to laminin in sickle cell disease (1072 Online Views)

Maria Alejandra Lizarralde-Iragorri, Sophie D. Lefevre, Sylvie Cochet, Sara El Hoss, Valentine Brousse, Anne Filipe, Michael Dussiot, Slim Azouzi, Caroline Le Van Kim, Fernando Rodrigues-Lima, Olivier Français, Bruno Le Pioufle, Thomas Klei, Robin van Bruggen, Wassim El Nemer

https://doi.org/10.3324/haematol.2020.261586

Letters to the Editor

Survival and causes of death in 2,033 patients with non-transfusion-dependent β-thalassemia (917 Online Views)

Khaled M. Musallam, Angela Vitrano, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio

https://doi.org/10.3324/haematol.2021.278684

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (894 Online Views)

Rebecca J. Shaw, Simon T. Abrams, James Austin, Joseph M. Taylor, Steven Lane, Tina Dutt, Colin Downey, Min Du, Lance Turtle, J. Kenneth Baillie, Peter J.M. Openshaw, Guozheng Wang, Malcolm G. Semple, Cheng-Hock Toh

https://doi.org/10.3324/haematol.2021.278492

Heritability and association with distinct genetic loci of erythropoietin levels in the general population (674 Online Views)

Tanguy Corre, Belen Ponte, Edward Pivin, Menno Pruijm, Daniel Ackermann, Georg Ehret, Katharina Spanaus, Murielle Bochud, Roland H. Wenger

https://doi.org/10.3324/haematol.2021.278389

Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma (749 Online Views)

Heli Vajavaara, Frida Ekeblad, Harald Holte, Judit Jorgensen, Suvi-Katri Leivonen, Mattias Berglund, Peter Kamper, Holger J. Moller, Francesco d’Amore, Daniel Molin, Gunilla Enblad, Maja Ludvigsen, Ingrid Glimelius, Sirpa Leppa

https://doi.org/10.3324/haematol.2020.278182

Clinical diagnostic value of telomere length measurement in inherited bone marrow failure syndromes (672 Online Views)

Shunsuke Miwata, Atsushi Narita, Yusuke Okuno, Kyogo Suzuki, Motoharu Hamada, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Kotaro Narita, Hironobu Kitazawa, Daisuke Ichikawa, Rieko Taniguchi, Nozomu Kawashima, Eri Nishikawa, Nobuhiro Nishio, Seiji Kojima, Hideki Muramatsu, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2021.278334

Myeloma natural killer cells are exhausted and have impaired regulation of activation (610 Online Views)

Criselle D’Souza, Simon P. Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K. Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S. Ritchie, Simon J. Harrison, Joseph A. Trapani, H. Miles Prince, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson

https://doi.org/10.3324/haematol.2020.277525

Targeting BRD4 in acute myeloid leukemia with partial tandem duplication of the MLL gene (503 Online Views)

Marius Bill, Chinmayee Goda, Felice Pepe, Hatice Gulcin Ozer, Betina McNeil, Xiaoli Zhang, Malith Karunasiri, Rohan Kulkarni, Sonu Kalyan, Dimitrios Papaioannou, Gregory Ferenchak, Ramiro Garzon, James E. Bradner, Guido Marcucci, Michael A. Caligiuri, Adrienne M. Dorrance

https://doi.org/10.3324/haematol.2020.271627

Case Reports