CURRENT ISSUE
November, 2020
No. 105 (11)

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Editorials

Perspective Articles

Novel dynamic outcome indicators and clinical endpoints in myelodysplastic syndrome; the European LeukemiaNet MDS Registry and MDS-RIGHT project perspective

Theo de Witte, Luca Malcovati, Pierre Fenaux, David Bowen, Argiris Symeonidis, Moshe Mittelman, Reinhard Stauder, Guillermo Sanz, Jaroslav Čermák, Saskia Langemeijer, Eva Hellström-Lindberg, Ulrich Germing, Mette Skov Holm, Krzysztof Mądry, Aurelia Tatic, António Medina Almeida, Aleksandar Savic, Inga Mandac Rogulj, Raphael Itzykson, Marlijn Hoeks, Hege Gravdahl Garelius, Dominic Culligan, Ioannis Kotsianidis, Lionel Ades, Arjan A. Van de Loosdrecht, Corine van Marrewijk, Ge Yu, Simon Crouch, Alex Smith

https://doi.org/10.3324/haematol.2020.266817

Centenary Review

Review Articles

Articles

Hematopoiesis

Acute Myeloid Leukemia

Leukemia cells remodel marrow adipocytes via TRPV4-dependent lipolysis

Shaoxin Yang, Wei Lu, Chong Zhao, Yuanmei Zhai, Yanyu Wei, Jiali Liu, Yehua Yu, Zhiqiang Li, Jun Shi

https://doi.org/10.3324/haematol.2019.225763

Non-Hodgkin Lymphoma

Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models

Eugenio Gaudio, Chiara Tarantelli, Filippo Spriano, Francesca Guidetti, Giulio Sartori, Roberta Bordone, Alberto J. Arribas, Luciano Cascione, Mario Bigioni, Giuseppe Merlino, Alessio Fiascarelli, Alessandro Bressan, Afua Adjeiwaa Mensah, Gaetanina Golino, Renzo Lucchini, Elena Bernasconi, Davide Rossi, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Robert S. Boyd, Rachel L. Dusek, Arnima Bisht, Nickolas Attanasio, Christian Rohlff, Andrea Pellacani, Monica Binaschi, Francesco Bertoni

https://doi.org/10.3324/haematol.2019.227215

Early progression of disease predicts shorter survival in MALT lymphoma patients receiving systemic treatment

Annarita Conconi, Catherine Thieblemont, Luciano Cascione, Valter Torri, Barbara Kiesewetter, Gloria Margiotta Casaluci, Gianluca Gaidano, Markus Raderer, Franco Cavalli, Armando Lopez Guillermo, Peter W. Johnson, Emanuele Zucca

https://doi.org/10.3324/haematol.2019.237990

Chronic Lymphocytic Leukemia

Prognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG)

Sonia Jaramillo, Andreas Agathangelidis, Christof Schneider, Jasmin Bahlo, Sandra Robrecht, Eugen Tausch, Johannes Bloehdorn, Manuela Hoechstetter, Kirsten Fischer, Barbara Eichhorst, Valentin Goede, Michael Hallek, Hartmut Döhner, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2019.231027

Platelet Biology & its Disorders

Migfilin supports hemostasis and thrombosis through regulating platelet αIIbβ3 outside-in signaling.

Yangfan Zhou, Mengjiao Hu, Xiaoyan Chen, Shuai Wang, Jingke Li, Lina Sa, Li Li, Jiaqi Huang, Hongqiang Cheng, Hu Hu

https://doi.org/10.3324/haematol.2019.232488

Hemostasis

Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Nuno A.G. Graça, Bogac Ercig, Leydi Carolina Velásquez Pereira, Kadri Kangro, Paul Kaijen, Gerry A.F. Nicolaes, Agnès Veyradier, Paul Coppo, Karen Vanhoorelbeke, Andres Männik, Jan Voorberg

https://doi.org/10.3324/haematol.2019.226068

Coagulation and its Disorders

Stem Cell Transplantation

Predictors of recovery following allogeneic CD34+-selected cell infusion without conditioning to correct poor graft function

Maria M. Cuadrado, Richard M. Szydlo, Mike Watts, Nishil Patel, Hanna Renshaw, Jude Dorman, Mark Lowdell, Stuart Ings, Chloe Anthias, Alejandro Madrigal, Stephen Mackinnon, Panagiotis Kottaridis, Ben Carpenter, Rachael Hough, Emma Morris, Kirsty Thomson, Karl S. Peggs, Ronjon Chakraverty

https://doi.org/10.3324/haematol.2019.226340

Letters to the Editor

Letters to the Editor

Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients

Paul Telfer, Josu de la Fuente, Mamta Sohal, Ralph Brown, Perla Eleftheriou, Noémi Roy, Frédéric B. Piel, Subarna Chakravorty, Kate Gardner, Mark Velangi, Emma Drasar, Farrukh Shah, John B. Porter, Sara Trompeter, Wale Atoyebi, Richard Szydlo, Kofi A. Anie, Kate Ryan, Joseph Sharif, Josh Wright, Emma Astwood, C. Sarah Nicolle, Amy Webster, David J. Roberts, Sanne Lugthart, Banu Kaya, Moji Awogbade, David C. Rees, Rob Hollingsworth, Baba Inusa, Jo Howard, D. Mark Layton

https://doi.org/10.3324/haematol.2020.259440

Exome sequencing reveals heterogeneous clonal dynamics in donor cell myeloid neoplasms after stem cell transplantation

Julia Suárez-González, Juan Carlos Triviño, Guiomar Bautista, José Antonio García-Marco, Ángela Figuera, Antonio Balas, José Luis Vicario, Francisco José Ortuño, Raúl Teruel, José María Álamo, Diego Carbonell, Cristina Andrés-Zayas, Nieves Dorado, Gabriela Rodríguez-Macías, Mi Kwon, José Luis Díez-Martín, Carolina Martínez-Laperche, Ismael Buño, Spanish Group for Hematopoietic Transplantation (GETH)

https://doi.org/10.3324/haematol.2019.234609

Efficacy of anti-PD1 re-treatment in patients with Hodgkin lymphoma who relapsed after anti-PD1 discontinuation

Guillaume Manson, Pauline Brice, Charles Herbaux, Kamal Bouabdallah, Chloé Antier, Florence Poizeau, Laurent Dercle, Roch Houot

https://doi.org/10.3324/haematol.2019.242529

A 70% cut-off for MYC protein expression in diffuse large B cell lymphoma identifies a high-risk group of patients

Marita Ziepert, Stefano Lazzi, Raffaella Santi, Federica Vergoni, Massimo Granai, Virginia Mancini, Annette Staiger, Heike Horn, Markus Löffler, Viola Pöschel, Gerhald Held, Gerald Wulf, Lorenz H. Trümper, Norbert Schmitz, Andreas Rosenwald, Elena Sabattini, Kikkeri N. Naresh, Harald Stein, German Ott, Lorenzo Leoncini

https://doi.org/10.3324/haematol.2019.235556

High rate of MRD-responses in young and fit patients with IGHV mutated chronic lymphocytic leukemia treated with front-line fludarabine, cyclophosphamide, and intensified dose of ofatumumab (FCO2)

Francesca R. Mauro, Stefano Molica, Stefano Soddu, Fiorella Ilariucci, Marta Coscia, Francesco Zaja, Emanuele Angelucci, Francesca Re, Anna Marina Liberati, Alessandra Tedeschi, Gianluigi Reda, Daniela Pietrasanta, Alessandro Gozzetti, Roberta Battistini, Giovanni Del Poeta, Caterina Musolino, Mauro Nanni, Alfonso Piciocchi, Marco Vignetti, Antonino Neri, Francesco Albano, Antonio Cuneo, Ilaria Del Giudice, Irene Della Starza, Maria Stefania De Propris, Sara Raponi, Anna R. Guarini, Robin Foà

https://doi.org/10.3324/haematol.2019.235705

The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor

Yucai Wang, Kari G. Rabe, Michael S. Bold, Min Shi, Curtis A. Hanson, Susan M. Schwager, Timothy G. Call, Saad S. Kenderian, Eli Muchtar, Suzanne R. Hayman, Amber B. Koehler, Amie L. Fonder, Asher A. Chanan-Khan, Daniel L. Van Dyke, Susan L. Slager, Neil E. Kay, Wei Ding, Jose F. Leis, Sameer A. Parikh

https://doi.org/10.3324/haematol.2019.240564

Long-term outcomes after splenectomy in children with immune thrombocytopenia: an update on the registry data from the Intercontinental Cooperative ITP Study Group

Maria L. Avila, Nour Amiri, Eleanor Pullenayegum, Victor Blanchette, Paul Imbach, Thomas Kühne, Intercontinental Cooperative ITP Study Group

https://doi.org/10.3324/haematol.2019.236737

Decolonization of multi-drug resistant bacteria by fecal microbiota transplantation in five pediatric patients before allogeneic hematopoietic stem cell transplantation: gut microbiota profiling, infectious and clinical outcomes.

Pietro Merli, Lorenza Putignani, Annalisa Ruggeri, Federica Del Chierico, Livia Gargiullo, Federica Galaverna, Stefania Gaspari, Daria Pagliara, Alessandra Russo, Stefania Pane, Luisa Strocchio, Mattia Algeri, Francesca Rea, Erminia Francesca Romeo, Paola Bernaschi, Andrea Onetti Muda, Bruno Dallapiccola, Franco Locatelli

https://doi.org/10.3324/haematol.2019.244210

Case Reports

COVID-19 in patients with sickle cell disease - a case series from a UK Tertiary Hospital

Subarna Chakravorty, Giselle Padmore-Payne, Fester Ike, Virginia Tshibangu, Charlotte Graham, David Rees, Sara Stuart-Smith

https://doi.org/10.3324/haematol.2020.254250

Anti-C5 antibody treatment for delayed hemolytic transfusion reactions in sickle cell disease

Aline Floch, Alexandre Morel, Fabian Zanchetta-Balint, Catherine Cordonnier-Jourdin, Slimane Allali, Maximilien Grall, Ghislaine Ithier, Benjamin Carpentier, Sadaf Pakdaman, Jean-Claude Merle, Radjiv Goulabchand, Tackwa Khalifeh, Ana Berceanu, Cécile Helmer, Christelle Chantalat-Auger, Véronique Frémeaux-Bacchi, Marc Michel, Mariane de Montalembert, Armand Mekontso-Dessap, France Pirenne, Anoosha Habibi, Pablo Bartolucci

https://doi.org/10.3324/haematol.2020.253856

Errata Corrige

Genetic platelet depletion is superior in platelet transfusion compared to current models

Manuel Salzmann, Waltraud C. Schrottmaier, Julia B. Kral-Pointner, Marion Mussbacher, Julia Volz, Bastian Hoesel, Bernhard Moser, Sonja Bleichert, Susanne Morava, Bernhard Nieswandt, Johannes A. Schmid, Alice Assinger

https://doi.org/10.3324/haematol.2020.266072