June, 2019
No. 104 (6)

Editorials

Review Articles

Thrombopoietin receptor agonists: ten years later (34601 Online Views)

Waleed Ghanima, Nichola Cooper, Francesco Rodeghiero, Bertrand Godeau, James B. Bussel

https://doi.org/10.3324/haematol.2018.212845

Articles

Hematopoiesis

Iron Metabolism & its Disorders

The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women (4022 Online Views)

Nicole U. Stoffel, Meryem Lazrak, Souhaila Bellitir, Nissrine El Mir, Asmaa El Hamdouchi, Amina Barkat, Christophe Zeder, Diego Moretti, Hassan Aguenaou, Michael B. Zimmermann

https://doi.org/10.3324/haematol.2018.208645

Chronic Myeloid Leukemia

Poor prognosis of chromosome 7 clonal aberrations in Philadelphia-negative metaphases and relevance of potential underlying myelodysplastic features in chronic myeloid leukemia (1843 Online Views)

Audrey Bidet, Stéphanie Dulucq, Thomas Smol, Alice Marceau-Renaut, Stéphane Morisset, Valérie Coiteux, Marie-Pierre Noël-Walter, Franck-Emmanuel Nicolini, Isabelle Tigaud, Isabelle Luquet, Stéphanie Struski, Baptiste Gaillard, Dominique Penther, Sylvie Tondeur, Nathalie Nadal, Eric Hermet, Lauren Véronèse, Delphine Réa, Carine Gervais, Olivier Theisen, Christine Terré, Pascale Cony-Makhoul, Christine Lefebvre, Jean-Baptiste Gaillard, Isabelle Radford, Anne-Laure Vervaeke, Carole Barin, Elise Chapiro, Florence Nguyen-Khac, Gabriel Etienne, Claude Preudhomme, François Xavier Mahon, Catherine Roche-Lestienne

https://doi.org/10.3324/haematol.2018.208801

Acute Myeloid Leukemia

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes (1925 Online Views)

Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad

https://doi.org/10.3324/haematol.2018.199190

Impact of induction regimen and allogeneic hematopoietic cell transplantation on outcome in younger adults with acute myeloid leukemia with a monosomal karyotype (968 Online Views)

Frédéric Baron, Marian Stevens-Kroef, Michal Kicinski, Giovanna Meloni, Petra Muus, Jean-Pierre Marie, Constantijn J.M. Halkes, Xavier Thomas, Radovan Vrhovac, Francesco Albano, François Lefrère, Simona Sica, Marco Mancini, Adriano Venditti, Anne Hagemeijer, Joop H. Jansen, Sergio Amadori, Theo de Witte, Roelof Willemze, Stefan Suciu

https://doi.org/10.3324/haematol.2018.204826

Acute Lymphoblastic Leukemia

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis (3452 Online Views)

Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam

https://doi.org/10.3324/haematol.2018.206375

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions (2180 Online Views)

Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez

https://doi.org/10.3324/haematol.2018.202044

Non-Hodgkin Lymphoma

Association of early disease progression and very poor survival in the GALLIUM study in follicular lymphoma: benefit of obinutuzumab in reducing the rate of early progression (4576 Online Views)

John F. Seymour, Robert Marcus, Andrew Davies, Eve Gallop-Evans, Andrew Grigg, Andrew Haynes, Michael Herold, Thomas Illmer, Herman Nilsson-Ehle, Martin Sökler, Ulrich Dünzinger, Tina Nielsen, Aino Launonen, Wolfgang Hiddemann

https://doi.org/10.3324/haematol.2018.209015

Plasma Cell Disorders

Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations (2165 Online Views)

Su Lin Lim, Alisa Damnernsawad, Pavithra Shyamsunder, Wee Joo Chng, Bing Chen Han, Liang Xu, Jian Pan, Dakle Pushkar Pravin, Serhan Alkan, Jeffrey W. Tyner, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2018.201483

Stem Cell Transplantation

Total body irradiation dose escalation decreases risk of progression and graft rejection after hematopoietic cell transplantation for myelodysplastic syndromes or myeloproliferative neoplasms (1275 Online Views)

Federico Monaco, Bart L. Scott, Thomas R. Chauncey, Finn B. Petersen, Barry E. Storer, Frederic Baron, Mary E. Flowers, H. Joachim Deeg, David G. Maloney, Rainer Storb, Brenda M. Sandmaier

https://doi.org/10.3324/haematol.2018.199398

Antilymphocyte globulin for matched sibling donor transplantation in patients with myelofibrosis (1172 Online Views)

Marie Robin, Sylvie Chevret, Linda Koster, Christine Wolschke, Ibrahim Yakoub-Agha, Jean Henri Bourhis, Patrice Chevallier, Jan J. Cornelissen, Péter Reményi, Johan Maertens, Xavier Poiré, Charles Craddock, Gérard Socié, Maija Itälä-Remes, Harry C. Schouten, Tony Marchand, Jakob Passweg, Didier Blaise, Gandhi Damaj, Zubeyde Nur Ozkurt, Tsila Zuckerman, Thomas Cluzeau, Hélène Labussière-Wallet, Jörg Cammenga, Donal McLornan, Yves Chalandon, Nicolaus Kröger

https://doi.org/10.3324/haematol.2018.201400

Platelet Biology & its Disorders

Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia (1394 Online Views)

Richard Vollenberg, Rabie Jouni, Peter A. A. Norris, Monika Burg-Roderfeld, Nina Cooper, Mathias J. Rummel, Gregor Bein, Irene Marini, Behnaz Bayat, Richard Burack, Alan H. Lazarus, Tamam Bakchoul, Ulrich J. Sachs

https://doi.org/10.3324/haematol.2018.211086

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia (1507 Online Views)

Ana C. Glembotsky, Dominika Sliwa, Dominique Bluteau, Nathalie Balayn, Cecilia P. Marin Oyarzún, Anna Raimbault, Marie Bordas, Nathalie Droin, Iryna Pirozhkova, Valance Washington, Nora P. Goette, Rosana F. Marta, Rémi Favier, Hana Raslova, Paula G. Heller

https://doi.org/10.3324/haematol.2018.188904

High-throughput elucidation of thrombus formation reveals sources of platelet function variability (1720 Online Views)

Johanna P. van Geffen, Sanne L.N. Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance C.F.M.J. Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke J. E. Kuijpers, Willem H. Ouwehand, Kate Downes, Johan W.M. Heemskerk

https://doi.org/10.3324/haematol.2018.198853

Hemostasis

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients (2209 Online Views)

An-Sofie Schelpe, Elien Roose, Bérangère S. Joly, Inge Pareyn, Ilaria Mancini, Marina Biganzoli, Hans Deckmyn, Jan Voorberg, Rob Fijnheer, Flora Peyvandi, Simon F. De Meyer, Paul Coppo, Agnès Veyradier, Karen Vanhoorelbeke

https://doi.org/10.3324/haematol.2018.205666

Coagulation & its Disorders

The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis (9778 Online Views)

Frits I. Mulder, Matteo Candeloro, Pieter W. Kamphuisen, Marcello Di Nisio, Patrick M. Bossuyt, Noori Guman, Kirsten Smit, Harry R. Büller, Nick van Es

https://doi.org/10.3324/haematol.2018.209114

Online Only Articles

Letters to the Editor

Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia (912 Online Views)

Dorien Kiers, Lucas T. van Eijk, Johannes G. van der Hoeven, Dorine W. Swinkels, Peter Pickkers, Matthijs Kox

https://doi.org/10.3324/haematol.2018.202796

Kinase activity is impaired in neutrophils of sepsis patients (723 Online Views)

Arie J. Hoogendijk, Lonneke A. van Vught, Maryse A. Wiewel, Gwenny M. Fuhler, Hakima Belkasim-Bohoudi, Janneke Horn, Marcus J. Schultz, Brendon P. Scicluna, Maikel P. Peppelenbosch, Cornelis van ’t Veer, Alex F. de Vos, Tom van der Poll

https://doi.org/10.3324/haematol.2018.201913

Clinical correlates, prognostic impact and survival outcomes in chronic myelomonocytic leukemia patients with the JAK2V617F mutation (1346 Online Views)

Mrinal M. Patnaik, Prateek A. Pophali, Terra L. Lasho, Christy M. Finke, Pedro Horna, Rhett P. Ketterling, Naseema Gangat, Abhishek A. Mangaonkar, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2018.208082

FLT3 ligand plasma levels in acute myeloid leukemia (936 Online Views)

Pierre Peterlin, Joelle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Cherel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier

https://doi.org/10.3324/haematol.2018.209460

Durable remissions in TCF3-HLF positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation (2447 Online Views)

Brice Mouttet, Luciana Vinti, Philip Ancliff, Nicole Bodmer, Benoît Brethon, Gunnar Cario, Christiane Chen-Santel, Sarah Elitzur, Volkan Hazar, Joachim Kunz, Anja Möricke, Jerry Stein, Ajay Vora, Yöntem Yaman, Martin Schrappe, Sema Anak, André Baruche, Franco Locatelli, Arend von Stackelberg, Martin Stanulla, Jean-Pierre Bourquin

https://doi.org/10.3324/haematol.2018.210104

False-negative rates for MYC fluorescence in situ hybridization probes in B-cell neoplasms (2374 Online Views)

Rebecca L. King, Ellen D. McPhail, Reid G. Meyer, George Vasmatzis, Kathryn Pearce, James B. Smadbeck, Rhett P. Ketterling, Stephanie A. Smoley, Patricia T. Greipp, Nicole L. Hoppman, Jess F. Peterson, Linda B. Baughn

https://doi.org/10.3324/haematol.2018.207290

Convergence of risk prediction models in follicular lymphoma (1204 Online Views)

Anjali Silva, Sleiman Bassim, Clémentine Sarkozy, Anja Mottok, Tracy Lackraj, Vindi Jurinovic, Marianne Brodtkorb, Ole Christian Lingjaerde, Laurie H. Sehn, Randy D. Gascoyne, Oliver Weigert, Christian Steidl, Robert Kridel

https://doi.org/10.3324/haematol.2018.209031

New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease (3017 Online Views)

Luca Aresu, Serena Ferraresso, Laura Marconato, Luciano Cascione, Sara Napoli, Eugenio Gaudio, Ivo Kwee, Chiara Tarantelli, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Petra Hillmann, Thomas Bohnacker, Matthias P. Wymann, Stefano Comazzi, Massimo Milan, Fulvio Riondato, Giulia Dalla Rovere, Mery Giantin, Diana Giannuzzi, Francesco Bertoni

https://doi.org/10.3324/haematol.2018.207027

Inherited missense variants that affect GFI1B function do not necessarily cause bleeding diatheses (1442 Online Views)

Rinske van Oorschot, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Kathelijne Peerlinck, Claire E. Lentaigne, Carolyn M. Millar, Sarah K. Westbury, Remi Favier, Wendy N. Erber, Ernest Turro, Joop H. Jansen, Willem H. Ouwehand, Harriet L. McKinney, NIHR BioResource Collaborative Group, Kate Downes, Kathleen Freson, Bert A. van der Reijden

https://doi.org/10.3324/haematol.2018.207712

Poor performance of D-dimer in excluding venous thromboembolism among patients with lymphoma and leukemia (1947 Online Views)

Aiham Qdaisat, Rawan Al Soud, Carol C. Wu, Cristhiam M. Rojas Hernandez, Jieli Li, Qing H. Meng, Hikmat Abdel-Razeq, Sai-Ching Jim Yeung

https://doi.org/10.3324/haematol.2018.211466

Role of Epstein-Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature (1675 Online Views)

Massimo Granai, Maria Raffaella Ambrosio, Ayse Akarca, Lucia Mundo, Federica Vergoni, Raffaella Santi, Virginia Mancini, Gioia di Stefano, Teresa Amato, Cristiana Bellan, Benedetta Puccini, Ester Sorrentino, Kikkeri N. Naresh, Lorenzo Leoncini, Teresa Marafioti, Stefano Lazzi

https://doi.org/10.3324/haematol.2018.215053

Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation (865 Online Views)

Lara Zafrani, Charlotte Dekimpe, Bérangère. S. Joly, Elien Roose, Fabienne Fieux, Elie Azoulay, Marie-Noëlle Peraldi, Antoine Durrbach, Paul Coppo, Karen Vanhoorelbeke, Agnès Veyradier

https://doi.org/10.3324/haematol.2019.219063

Perspective Articles