November, 2018
No. 103 (11)

Editorials

Review Articles

Preclinical human models and emerging therapeutics for advanced systemic mastocytosis

Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent

https://doi.org/10.3324/haematol.2018.195867

Articles

Hematopoiesis

Alas1 is essential for neutrophil maturation in zebrafish

Junwei Lian, Jiakui Chen, Kun Wang, Lingfeng Zhao, Ping Meng, Liting Yang, Jiayi Wei, Ning Ma, Jin Xu, Wenqing Zhang, Yiyue Zhang

https://doi.org/10.3324/haematol.2018.194316

Iron Metabolism & Its Disorders

The SLC40A1 R178Q mutation is a recurrent cause of hemochromatosis and is associated with a novel pathogenic mechanism

Chandran Ka, Julie Guellec, Xavier Pepermans, Caroline Kannengiesser, Cécile Ged, Wim Wuyts, David Cassiman, Victor de Ledinghen, Bruno Varet, Caroline de Kerguenec, Claire Oudin, Isabelle Gourlaouen, Thibaud Lefebvre, Claude Férec, Isabelle Callebaut, Gérald Le Gac

https://doi.org/10.3324/haematol.2018.189845

Bone Marrow Failure

Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A

Jennifer E. Adair, Devikha Chandrasekaran, Gabriella Sghia-Hughes, Kevin G. Haworth, Ann E. Woolfrey, Lauri M. Burroughs, Grace Y. Choi, Pamela S. Becker, Hans-Peter Kiem

https://doi.org/10.3324/haematol.2018.194571

Phagocyte Biology & its Disorders

Prognostic factors of Erdheim–Chester disease: a nationwide survey in Japan

Takashi Toya, Mizuki Ogura, Kazuhiro Toyama, Akihide Yoshimi, Aya Shinozaki-Ushiku, Akira Honda, Kenjiro Honda, Noriko Hosoya, Yukako Murakami, Hiroyuki Kawashima, Yasuhito Nannya, Shunya Arai, Fumihiko Nakamura, Yusuke Shinoda, Masaomi Nangaku, Kiyoshi Miyagawa, Masashi Fukayama, Akiko Moriya-Saito, Ichiro Katayama, Takashi Ogura, Mineo Kurokawa

https://doi.org/10.3324/haematol.2018.190728

Chronic Myeloid Leukemia

Treatment-free remission after two-year consolidation therapy with nilotinib in patients with chronic myeloid leukemia: STAT2 trial in Japan

Naoto Takahashi, Kaichi Nishiwaki, Chiaki Nakaseko, Nobuyuki Aotsuka, Koji Sano, Chikako Ohwada, Jun Kuroki, Hideo Kimura, Michihide Tokuhira, Kinuko Mitani, Kazuhisa Fujikawa, Osamu Iwase, Kohshi Ohishi, Fumihiko Kimura, Tetsuya Fukuda, Sakae Tanosaki, Saori Takahashi, Yoshihiro Kameoka, Hiroyoshi Nishikawa, Hisashi Wakita

https://doi.org/10.3324/haematol.2018.194894

Acute Myeloid Leukemia

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells

Justyna Chlebowska-Tuz, Olga Sokolowska, Pawel Gaj, Michal Lazniewski, Malgorzata Firczuk, Karolina Borowiec, Hanna Sas-Nowosielska, Malgorzata Bajor, Agata Malinowska, Angelika Muchowicz, Kavita Ramji, Piotr Stawinski, Mateusz Sobczak, Zofia Pilch, Anna Rodziewicz-Lurzynska, Malgorzata Zajac, Krzysztof Giannopoulos, Przemyslaw Juszczynski, Grzegorz W. Basak, Dariusz Plewczynski, Rafal Ploski, Jakub Golab, Dominika Nowis

https://doi.org/10.3324/haematol.2018.190231

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older

Victoria V. Prassek, Maja Rothenberg-Thurley, Maria C. Sauerland, Tobias Herold, Hanna Janke, Bianka Ksienzyk, Nikola P. Konstandin, Dennis Goerlich, Utz Krug, Andreas Faldum, Wolfgang E. Berdel, Bernhard Wörmann, Jan Braess, Stephanie Schneider, Marion Subklewe, Stefan K. Bohlander, Wolfgang Hiddemann, Karsten Spiekermann, Klaus H. Metzeler

https://doi.org/10.3324/haematol.2018.191536

Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study

Marta Solans, Adela Castelló, Yolanda Benavente, Rafael Marcos-Gragera, Pilar Amiano, Esther Gracia-Lavedan, Laura Costas, Claudia Robles, Eva Gonzalez-Barca, Esmeralda de la Banda, Esther Alonso, Marta Aymerich, Elias Campo, Trinidad Dierssen-Sotos, Guillermo Fernández-Tardón, Rocio Olmedo-Requena, Eva Gimeno, Gemma Castaño-Vinyals, Nuria Aragonés, Manolis Kogevinas, Silvia de Sanjose, Marina Pollán, Delphine Casabonne

https://doi.org/10.3324/haematol.2018.192526

Safety of obinutuzumab alone or combined with chemotherapy for previously untreated or relapsed/refractory chronic lymphocytic leukemia in the phase IIIb GREEN study

Véronique Leblond, Melih Aktan, Christelle M. Ferra Coll, Caroline Dartigeas, Jens Kisro, Marco Montillo, João Raposo, Jean-Louis Merot, Susan Robson, Ekaterina Gresko, Francesc Bosch, Stephan Stilgenbauer, Robin Foà

https://doi.org/10.3324/haematol.2017.186387

Non-Hodgkin Lymphoma

Inferior survival in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements is not associated with MYC/IG gene rearrangements

Ellen D. McPhail, Matthew J. Maurer, William R. Macon, Andrew L. Feldman, Paul J. Kurtin, Rhett P. Ketterling, Rakhee Vaidya, James R. Cerhan, Stephen M. Ansell, Luis F. Porrata, Grzegorz S. Nowakowski, Thomas E. Witzig, Thomas M. Habermann

https://doi.org/10.3324/haematol.2018.190157

PD-L1+ tumor-associated macrophages and PD-1+ tumor-infiltrating lymphocytes predict survival in primary testicular lymphoma

Marjukka Pollari, Oscar Brück, Teijo Pellinen, Pauli Vähämurto, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Olli Kallioniemi, Pirkko-Liisa Kellokumpu-Lehtinen, Satu Mustjoki, Suvi-Katri Leivonen, Sirpa Leppä

https://doi.org/10.3324/haematol.2018.197194

Stem Cell Transplantation

A phase II/III randomized, multicenter trial of prednisone/sirolimus versus prednisone/ sirolimus/calcineurin inhibitor for the treatment of chronic graft-versus-host disease: BMT CTN 0801

Paul A. Carpenter, Brent R. Logan, Stephanie J. Lee, Daniel J. Weisdorf, Laura Johnston, Luciano J. Costa, Carrie L. Kitko, Javier Bolaños-Meade, Stefanie Sarantopoulos, Amin M. Alousi, Sunil Abhyankar, Edmund K. Waller, Adam Mendizabal, Jiaxi Zhu, Kelly A. O’Brien, Aleksandr Lazaryan, Juan Wu, Eneida R. Nemecek, Steven Z. Pavletic, Corey S. Cutler, Mary M. Horowitz, Mukta Arora

https://doi.org/10.3324/haematol.2018.195123

Coagulation & Its Disorders

N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice

Jesse D. Lai, Laura L. Swystun, Dominique Cartier, Kate Nesbitt, Cunjie Zhang, Christine Hough, James W. Dennis, David Lillicrap

https://doi.org/10.3324/haematol.2018.188219

Guidelines

European Myeloma Network recommendations on tools for the diagnosis and monitoring of multiple myeloma: what to use and when

Jo Caers, Laurent Garderet, K. Martin Kortüm, Michael E. O’Dwyer, Niels W.C.J. van de Donk, Mascha Binder, Sandra Maria Dold, Francesca Gay, Jill Corre, Yves Beguin, Heinz Ludwig, Alessandra Larocca, Christoph Driessen, Meletios A. Dimopoulos, Mario Boccadoro, Martin Gramatzki, Sonja Zweegman, Hermann Einsele, Michele Cavo, Hartmut Goldschmidt, Pieter Sonneveld, Michel Delforge, Holger W. Auner, Evangelos Terpos, Monika Engelhardt

https://doi.org/10.3324/haematol.2018.189159

Online Only Articles

L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients

Erica Bello, Jonathan Kerry, Shalini Singh, Bon Ham Yip, Rajko Kušec, Sally Killick, Sophie Raynaud, Jacqueline Boultwood, Andrea Pellagatti

https://doi.org/10.3324/haematol.2018.190447

The long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias Hofmans, Tim Lammens, Hetty H. Helsmoortel, Silvia Bresolin, Hélène Cavé, Christian Flotho, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Charlotte Niemeyer, Jan Stary, Nadine Van Roy, Pieter Van Vlierberghe, Jan Philippé, Barbara De Moerloose

https://doi.org/10.3324/haematol.2018.189977

Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia

Anne Kresinsky, Reinhard Bauer, Tina M. Schnöder, Tobias Berg, Daria Meyer, Volker Ast, Rainer König, Hubert Serve, Florian H. Heidel, Frank-D. Böhmer, Jörg P. Müller

https://doi.org/10.3324/haematol.2017.185306

Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA

Feng-Ming Tien, Hsin-An Hou, Jih-Luh Tang, Yuan-Yeh Kuo, Chien-Yuan Chen, Cheng-Hong Tsai, Ming Yao, Chien-Ting Lin, Chi-Cheng Li, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Shang-Ju Wu, Jia-Hau Liu, Sheng Chieh Chou, Woei Tsay, Mei-Hsuan Tseng, Ming-Chih Liu, Chia-Wen Liu, Liang-In Lin, Wen-Chien Chou, Hwei-Fang Tien

https://doi.org/10.3324/haematol.2018.189043

Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia

Farhad Ravandi, Ellen K. Ritchie, Hamid Sayar, Jeffrey E. Lancet, Michael D. Craig, Norbert Vey, Stephen A. Strickland, Gary J. Schiller, Elias Jabbour, Arnaud Pigneux, Heinz-August Horst, Christian Récher, Virginia M. Klimek, Jorge E. Cortes, Angelo-Michele Carella, Miklos Egyed, Utz Krug, Judith A. Fox, Adam R. Craig, Renee Ward, Jennifer A. Smith, Gary Acton, Hagop M. Kantarjian, Robert K. Stuart

https://doi.org/10.3324/haematol.2018.191361

Reducing mortality in newly diagnosed standard-risk acute promyelocytic leukemia in elderly patients treated with arsenic trioxide requires major reduction of chemotherapy: a report by the French Belgian Swiss APL group (APL 2006 trial)

Ramy Rahmé, Lionel Ades, Xavier Thomas, Agnès Guerci-Bresler, Arnaud Pigneux, Norbert Vey, Emmanuel Raffoux, Sylvie Castaigne, Olivier Spertini, Sebastian Wittnebel, Jean Pierre Marolleau, Gandhi Damaj, Dominique Bordessoule, Julie Lejeune, Sylvie Chevret, Pierre Fenaux

https://doi.org/10.3324/haematol.2018.193151

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia

Yosuke Tanaka, Masahito Kawazu, Takahiko Yasuda, Miki Tamura, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Hitoshi Kiyoi, Tomoki Naoe, Hiroyuki Mano

https://doi.org/10.3324/haematol.2017.183152

Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy

Anne-Sophie Brunel, Agnieszka Wójtowicz, Frédéric Lamoth, Olivier Spertini, Dionysios Neofytos, Thierry Calandra, Oscar Marchetti, Pierre-Yves Bochud

https://doi.org/10.3324/haematol.2018.195453

A reversible carnitine palmitoyltransferase (CPT1) inhibitor offsets the proliferation of chronic lymphocytic leukemia cells

Elena Gugiatti, Claudya Tenca, Silvia Ravera, Marina Fabbi, Fabio Ghiotto, Andrea N. Mazzarello, Davide Bagnara, Daniele Reverberi, Daniela Zarcone, Giovanna Cutrona, Adalberto Ibatici, Ermanno Ciccone, Zbigniew Darzynkiewicz, Franco Fais, Silvia Bruno

https://doi.org/10.3324/haematol.2017.175414

In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma

Montserrat Pérez-Salvia, Eneko Aldaba, Yosu Vara, Myriam Fabre, Cristina Ferrer, Carme Masdeu, Aizpea Zubia, Eider San Sebastian, Dorleta Otaegui, Pere Llinàs-Arias, Margalida Rosselló-Tortella, Maria Berdasco, Catia Moutinho, Fernando Setien, Alberto Villanueva, Eva González-Barca, Josep Muncunill, José-Tomás Navarro, Miguel A. Piris, Fernando P. Cossio, Manel Esteller

https://doi.org/10.3324/haematol.2018.189241

Lenalidomide plus bendamustine-rituximab does not overcome the adverse impact of TP53 mutations in mantle cell lymphoma

Christian Winther Eskelund, Alexandra Albertsson-Lindblad, Arne Kolstad, Anna Laurell, Riikka Räty, Lone Bredo Pedersen, Christian Hartmann Geisler, Mats Jerkeman, Kirsten Grønbæk

https://doi.org/10.3324/haematol.2018.194399

Mutational screening of newly diagnosed multiple myeloma patients by deep targeted sequencing

Yanira Ruiz-Heredia, Beatriz Sánchez-Vega, Esther Onecha, Santiago Barrio, Rafael Alonso, Jose Carlos Martínez-Ávila, Isabel Cuenca, Xabier Agirre, Esteban Braggio, Miguel-T. Hernández, Rafael Martínez, Laura Rosiñol, Norma Gutierrez, Marisa Martin-Ramos, Enrique M. Ocio, María-Asunción Echeveste, Jaime Pérez de Oteyza, Albert Oriol, Joan Bargay, Mercedes Gironella, Rosa Ayala, Joan Bladé, María-Victoria Mateos, Klaus M. Kortum, Keith Stewart, Ramón García-Sanz, Jesús San Miguel, Juan José Lahuerta, Joaquín Martinez-Lopez

https://doi.org/10.3324/haematol.2018.188839

A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms

Raquel Vinhas, Alexandra Lourenço, Susana Santos, Patrícia Ribeiro, Madalena Silva, Aida Botelho de Sousa, Pedro V. Baptista, Alexandra R. Fernandes

https://doi.org/10.3324/haematol.2018.192534

Clonally related diffuse large B-cell lymphoma and interdigitating dendritic cell sarcoma sharing MYC translocation

Yotaro Ochi, Nobuhiro Hiramoto, Tetsuichi Yoshizato, Yuichiro Ono, June Takeda, Yusuke Shiozawa, Kenichi Yoshida, Nobuyuki Kakiuchi, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Yasuhiro Kazuma, Sumie Tabata, Noboru Yonetani, Keiichiro Uehara, Daisuke Yamashita, Yukihiro Imai, Koji Nagafuji, Mitsunori Yamakawa, Satoru Miyano, Akifumi Takaori-Kondo, Seishi Ogawa, Takayuki Ishikawa

https://doi.org/10.3324/haematol.2018.193490

Comprehensive molecular characterization of a heavy chain deposition disease case

Sébastien Bender, Maria Victoria Ayala, Vincent Javaugue, Amélie Bonaud, Michel Cogné, Guy Touchard, Arnaud Jaccard, Frank Bridoux, Christophe Sirac

https://doi.org/10.3324/haematol.2018.196113