October, 2018
No. 103 (10)

Editorials

Review Articles

Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts (4927 Online Views)

Peter Valent, Guntram Büsche, Igor Theurl, Iris Z. Uras, Ulrich Germing, Reinhard Stauder, Karl Sotlar, Wolfgang Füreder, Peter Bettelheim, Michael Pfeilstöcker, Rainer Oberbauer, Wolfgang R. Sperr, Klaus Geissler, Jürg Schwaller, Richard Moriggl, Marie C. Béné, Ulrich Jäger, Hans-Peter Horny, Olivier Hermine

https://doi.org/10.3324/haematol.2018.192518

Articles

Hematopoiesis

Repopulating hematopoietic stem cells from steady-state blood before and after ex vivo culture are enriched in the CD34+CD133+CXCR4low fraction (395 Online Views)

Véronique Lapostolle, Jean Chevaleyre, Pascale Duchez, Laura Rodriguez, Marija Vlaski-Lafarge, Ioanna Sandvig, Philippe Brunet de la Grange, Zoran Ivanovic

https://doi.org/10.3324/haematol.2017.183962

Iron Metabolism & its Disorders

Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis (310 Online Views)

Cornel S.G. Mirciov, Sarah J. Wilkins, Grace C. C. Hung, Sheridan L. Helman, Gregory J. Anderson, David M. Frazer

https://doi.org/10.3324/haematol.2017.187245


Acute Myeloid Leukemia

Addition of the mammalian target of rapamycin inhibitor, everolimus, to consolidation therapy in acute myeloid leukemia: experience from the UK NCRI AML17 trial (353 Online Views)

Alan K Burnett, Emma Das Gupta, Steve Knapper, Asim Khwaja, Marion Sweeney, Lars Kjeldsen, Timothy Hawkins, Sophie E Betteridge, Paul Cahalin, Richard E Clark, Robert K Hills, Nigel H Russell

https://doi.org/10.3324/haematol.2018.189514

Acute Lymphoblastic Leukemia

Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients (546 Online Views)

Ibrahim Aldoss, Tracey Stiller, Ni-Chun Tsai, Joo Y. Song, Thai Cao, N. Achini Bandara, Amandeep Salhotra, Samer Khaled, Ahmed Aribi, Monzr M. Al Malki, Matthew Mei, Haris Ali, Ricardo Spielberger, Margaret O’Donnell, David Snyder, Thomas Slavin, Ryotaro Nakamura, Anthony S. Stein, Stephen J. Forman, Guido Marcucci, Vinod Pullarkat

https://doi.org/10.3324/haematol.2018.193599

Non-Hodgkin Lymphoma

CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth (333 Online Views)

Raúl Jiménez-P, Carla Martín-Cortázar, Omar Kourani, Yuri Chiodo, Raul Cordoba, María Purificación Domínguez-Franjo, Juan Miguel Redondo, Teresa Iglesias, Miguel R. Campanero

https://doi.org/10.3324/haematol.2018.188961

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies (326 Online Views)

Mara M. Epstein, Bernard Rosner, Elizabeth C. Breen, Julie L. Batista, Edward L. Giovannucci, Larry Magpantay, Jon C. Aster, Scott J. Rodig, Kimberly A. Bertrand, Francine Laden, Otoniel Martínez-Maza, Brenda M. Birmann

https://doi.org/10.3324/haematol.2017.183236

Plasma Cell Disorders

Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation (359 Online Views)

Ailing Liu, Shirong Li, Vera Donnenberg, Jing Fu, Susanne M. Gollin, Huihui Ma, Caisheng Lu, Donna B. Stolz, Markus Y. Mapara, Sara A. Monaghan, Suzanne Lentzsch

https://doi.org/10.3324/haematol.2018.188227

Stem Cell Transplantation

The eGVHD App has the potential to improve the accuracy of graft-versus-host disease assessment: a multicenter randomized controlled trial (367 Online Views)

Helene M. Schoemans, Kathy Goris, Raf Van Durm, Steffen Fieuws, Sabina De Geest, Steven Z. Pavletic, Annie Im, Daniel Wolff, Stephanie J. Lee, Hildegard Greinix, Rafael F. Duarte, Xavier Poiré, Dominik Selleslag, Philippe Lewalle, Tessa Kerre, Carlos Graux, Frédéric Baron, Johan A. Maertens, Fabienne Dobbels

https://doi.org/10.3324/haematol.2018.190777

Upper gastrointestinal acute graft-versus-host disease adds minimal prognostic value in isolation or with other graft-versus-host disease symptoms as currently diagnosed and treated (462 Online Views)

Sarah Nikiforow, Tao Wang, Michael Hemmer, Stephen Spellman, Görgün Akpek, Joseph H. Antin, Sung Won Choi, Yoshihiro Inamoto, Hanna J. Khoury, Margaret MacMillan, David I. Marks, Ken Meehan, Hideki Nakasone, Taiga Nishihori, Richard Olsson, Sophie Paczesny, Donna Przepiorka, Vijay Reddy, Ran Reshef, Hélène Schoemans, Ned Waller, Daniel Weisdorf, Baldeep Wirk, Mary Horowitz, Amin Alousi, Daniel Couriel, Joseph Pidala, Mukta Arora, Corey Cutler

https://doi.org/10.3324/haematol.2017.182550

Cell Therapy & Immunotherapy

CD16+NK-92 and anti-CD123 monoclonal antibody prolongs survival in primary human acute myeloid leukemia xenografted mice (834 Online Views)

Brent A. Williams, Xing-Hua Wang, Jeffrey V. Leyton, Sonam Maghera, Bishoy Deif, Raymond M. Reilly, Mark D. Minden, Armand Keating

https://doi.org/10.3324/haematol.2017.187385

Coagulation & its Disorders

Blood Transfusion

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation (541 Online Views)

Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas

https://doi.org/10.3324/haematol.2018.189365

Online Only Articles

Stability of fetal hemoglobin levels in patients receiving metformin therapy (225 Online Views)

Mohamed-Rachid Boulassel, Abdal-Aziz Issa El-Hussain, Moataz Mohamed Hassan, Mohamed-Lamine Toumi, Sameha Merzoug, Zahra Al-Qarni, Hammad Khan, Zied Gaifer, Khalil Al-Farsi, Murtadha Al-Khabori, Mohamed Al Huneini, Salam Al-Kindi

https://doi.org/10.3324/haematol.2018.190967

Genomic characterization of spleens in patients with myelofibrosis (176 Online Views)

Eran Zimran, Joseph Tripodi, Raajit Rampal, Franck Rappoport, Sharon Zirkiev, Ronald Hoffman, Vesna Najfeld

https://doi.org/10.3324/haematol.2018.193763

NPM1 mutation is not associated with prolonged complete remission in acute myeloid leukemia patients treated with hypomethylating agents (415 Online Views)

Pedro Henrique Prata, Cécile Bally, Thomas Prebet, Christian Recher, Geoffroy Venton, Xavier Thomas, Emmanuel Raffoux, Arnaud Pigneux, Thomas Cluzeau, Judith Desoutter, Julie Gay, Claude Preudhomme, Pierre Fenaux, Lionel Adès

https://doi.org/10.3324/haematol.2018.189886

Autologous T-cell activation fosters ABT-199 resistance in chronic lymphocytic leukemia: rationale for a combined therapy with SYK inhibitors and anti-CD20 monoclonal antibodies (178 Online Views)

Esteban Enrique Elías, María Belén Almejún, Ana Colado, Gregorio Cordini, Maricef Vergara-Rubio, Enrique Podaza, Denise Risnik, María Cabrejo, Horacio Fernández-Grecco, Raimundo Fernando Bezares, María del Rosario Custidiano, Julio César Sánchez-Ávalos, Ángeles Vicente, Gonzalo Martín Garate, Mercedes Borge, Mirta Giordano, Romina Gamberale

https://doi.org/10.3324/haematol.2018.188680

Real-world treatment and outcomes among older adults with chronic lymphocytic leukemia before the novel agents era (232 Online Views)

Anthony Mato, Jordan Jahnke, Pengxiang Li, Maneesha Mehra, Vrushabh P. Ladage, Michelle Mahler, Scott Huntington, Jalpa A. Doshi

https://doi.org/10.3324/haematol.2017.185868

Impact of ibrutinib dose intensity on patient outcomes in previously treated Waldenström macroglobulinemia (198 Online Views)

Jorge J. Castillo, Joshua N. Gustine, Kirsten Meid, Toni E. Dubeau, Lian Xu, Guang Yang, Zachary R. Hunter, Ranjana Advani, Lia Palomba, Steven P. Treon

https://doi.org/10.3324/haematol.2018.191999

Phase I study of the heparanase inhibitor roneparstat: an innovative approach for ultiple myeloma therapy (298 Online Views)

Monica Galli, Manik Chatterjee, Mariella Grasso, Giorgina Specchia, Hila Magen, Hermann Einsele, Ivana Celeghini, Paola Barbieri, David Paoletti, Silvia Pace, Ralph D. Sanderson, Alessandro Rambaldi, Arnon Nagler

https://doi.org/10.3324/haematol.2017.182865

Safety and efficacy of vorinostat, bortezomib, doxorubicin and dexamethasone in a phase I/II study for relapsed or refractory multiple myeloma (VERUMM study: vorinostat in elderly, relapsed and unfit multiple myeloma) (274 Online Views)

Johannes M. Waldschmidt, Alexander Keller, Gabriele Ihorst, Olga Grishina, Stefan Müller, Dagmar Wider, Anna V. Frey, Kristina King, Roman Simon, Annette May, Pierfrancesco Tassone, Justus Duyster, Manfred Jung, Noopur Raje, Ralph Wäsch, Monika Engelhardt

https://doi.org/10.3324/haematol.2018.189969

Interleukin-22 levels are increased in gastrointestinal graft-versus-host disease in children (169 Online Views)

Dana T. Lounder, Pooja Khandelwal, Nicholas J. Gloude, Christopher E. Dandoy, Sonata Jodele, Mario Medvedovic, Lee A. Denson, Adam Lane, Kelly Lake, Bridget Litts, Alyss Wilkey, Stella M. Davies

https://doi.org/10.3324/haematol.2017.174771

Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease (237 Online Views)

Satheesh Chonat, Maa-Ohui Quarmyne, Caroline M. Bennett, Christina L. Dean, Clinton H. Joiner, Ross M. Fasano, Sean R. Stowell

https://doi.org/10.3324/haematol.2018.194670

Pitfalls in the molecular follow up of NPM1 mutant acute myeloid leukemia (346 Online Views)

Ulrike Bacher, Naomi Porret, Raphael Joncourt, Javier Sanz, Nijas Aliu, Gertrud Wiedemann, Barbara Jeker, Yara Banz, Thomas Pabst

https://doi.org/10.3324/haematol.2018.192104

Comment

Infection prevention in patients with hereditary hemorrhagic telangiectasia (135 Online Views)

Juan Rodríguez-García, Roberto Zarrabeitia-Puente, Rafael Fernández-Santos, José Antonio García-Erce

https://doi.org/10.3324/haematol.2018.200873