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Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia

Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pharmaceutical Sciences and Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Department of Pharmaceutical Sciences and Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Precision Medicine, China-Japan Friendship Hospital, Beijing, China
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, China
Department of Pharmaceutical Sciences and Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Department of Pediatric Hematology/Oncology, West China Second Hospital, Sichuan University, Chengdu, China
Department of Laboratory Medicine, Precision Medicine Center, State Key Laboratory of Biotherapy and Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China
Vol. 103 No. 7 (2018): July, 2018 https://doi.org/10.3324/haematol.2018.187658