July, 2017
No. 102 (7)

Editorials

Chronic myeloid leukemia: room for improvement?

Michele Baccarani, Fabrizio Pane, Gianantonio Rosti, Domenico Russo, Giuseppe Saglio

https://doi.org/10.3324/haematol.2017.166280

Review Articles

Articles

Hematopoiesis

A new path to platelet production through matrix sensing

Vittorio Abbonante, Christian Andrea Di Buduo, Cristian Gruppi, Carmelo De Maria, Elise Spedden, Aurora De Acutis, Cristian Staii, Mario Raspanti, Giovanni Vozzi, David L. Kaplan, Francesco Moccia, Katya Ravid, Alessandra Balduini

https://doi.org/10.3324/haematol.2016.161562

Red Cell Biology & Its Disorders

The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease

Bérengère Koehl, Pierre Nivoit, Wassim El Nemer, Olivia Lenoir, Patricia Hermand, Catia Pereira, Valentine Brousse, Léa Guyonnet, Giulia Ghinatti, Malika Benkerrou, Yves Colin, Caroline Le Van Kim, Pierre-Louis Tharaux

https://doi.org/10.3324/haematol.2016.156869

Iron Metabolism & Its Disorders

Imatinib and spironolactone suppress hepcidin expression

Katarzyna Mleczko-Sanecka, Ana Rita da Silva, Debora Call, Joana Neves, Nikolai Schmeer, Georg Damm, Daniel Seehofer, Martina U. Muckenthaler

https://doi.org/10.3324/haematol.2016.162917

Coagulation & Its Disorders

Venous thromboembolism is associated with graft-versus-host disease and increased non-relapse mortality after allogeneic hematopoietic stem cell transplantation

Natasha Kekre, Haesook T. Kim, Vincent T. Ho, Corey Cutler, Philippe Armand, Sarah Nikiforow, Edwin P. Alyea, Robert J. Soiffer, Joseph H. Antin, Jean M. Connors, John Koreth

https://doi.org/10.3324/haematol.2017.164012

Platelet Biology & its Disorders

Bleeding risk of surgery and its prevention in patients with inherited platelet disorders

Sara Orsini, Patrizia Noris, Loredana Bury, Paula G. Heller, Cristina Santoro, Rezan A. Kadir, Nora C. Butta, Emanuela Falcinelli, Ana Rosa Cid, Fabrizio Fabris, Marc Fouassier, Koji Miyazaki, Maria Luisa Lozano, Pamela Zúñiga, Claire Flaujac, Gian Marco Podda, Nuria Bermejo, Remi Favier, Yvonne Henskens, Emmanuel De Maistre, Erica De Candia, Andrew D. Mumford, Gul Nihal Ozdemir, Ibrahim Eker, Paquita Nurden, Sophie Bayart, Michele P. Lambert, James Bussel, Barbara Zieger, Alberto Tosetto, Federica Melazzini, Ana C. Glembotsky, Alessandro Pecci, Marco Cattaneo, Nicole Schlegel, Paolo Gresele

https://doi.org/10.3324/haematol.2016.160754

Acute Myeloid Leukemia

Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells

Giulia Daniele, Giorgia Simonetti, Caterina Fusilli, Ilaria Iacobucci, Angelo Lonoce, Antonio Palazzo, Mariana Lomiento, Fabiana Mammoli, Renè Massimiliano Marsano, Elena Marasco, Vilma Mantovani, Hilmar Quentmeier, Hans G Drexler, Jie Ding, Orazio Palumbo, Massimo Carella, Niroshan Nadarajah, Margherita Perricone, Emanuela Ottaviani, Carmen Baldazzi, Nicoletta Testoni, Cristina Papayannidis, Sergio Ferrari, Tommaso Mazza, Giovanni Martinelli, Clelia Tiziana Storlazzi

https://doi.org/10.3324/haematol.2016.163022

Precision and prognostic value of clone-specific minimal residual disease in acute myeloid leukemia

Pierre Hirsch, Ruoping Tang, Nassera Abermil, Pascale Flandrin, Hannah Moatti, Fabrizia Favale, Ludovic Suner, Florence Lorre, Christophe Marzac, Fanny Fava, Anne-Claire Mamez, Simona Lapusan, Françoise Isnard, Mohamad Mohty, Ollivier Legrand, Luc Douay, Chrystele Bilhou-Nabera, François Delhommeau

https://doi.org/10.3324/haematol.2016.159681

Chronic Lymphocytic Leukemia

Host virus and pneumococcus-specific immune responses in high-count monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia: implications for disease progression

Ignacio Criado, Santiago Muñoz-Criado, Arancha Rodríguez-Caballero, Wendy G. Nieto, Alfonso Romero, Paulino Fernández-Navarro, Miguel Alcoceba, Teresa Contreras, Marcos González, Alberto Orfao, Julia Almeida

https://doi.org/10.3324/haematol.2016.159012

Non-Hodgkin Lymphoma

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

Richard A. Noble, Natalie Bell, Helen Blair, Arti Sikka, Huw Thomas, Nicole Phillips, Sirintra Nakjang, Satomi Miwa, Rachel Crossland, Vikki Rand, Despina Televantou, Anna Long, Hector C. Keun, Chris M. Bacon, Simon Bomken, Susan E. Critchlow, Stephen R. Wedge

https://doi.org/10.3324/haematol.2016.163030

Development of a modified prognostic index for patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: possible risk-adapted management strategies including allogeneic transplantation

Shigeo Fuji, Takuhiro Yamaguchi, Yoshitaka Inoue, Atae Utsunomiya, Yukiyoshi Moriuchi, Kaoru Uchimaru, Satsuki Owatari, Takashi Miyagi, Jun Taguchi, Ilseung Choi, Eiichi Otsuka, Sawako Nakachi, Hisashi Yamamoto, Saiko Kurosawa, Kensei Tobinai, Takahiro Fukuda

https://doi.org/10.3324/haematol.2017.164996

Plasma Cell Disorders

Monitoring multiple myeloma by quantification of recurrent mutations in serum

Even Holth Rustad, Eivind Coward, Emilie R Skytøen, Kristine Misund, Toril Holien, Therese Standal, Magne Børset, Vidar Beisvag, Ola Myklebost, Leonardo A Meza-Zepeda, Hong Yan Dai, Anders Sundan, Anders Waage

https://doi.org/10.3324/haematol.2016.160564

Cell Therapy & Immunotherapy

Effect of antithymocyte globulin source on outcomes of bone marrow transplantation for severe aplastic anemia

Natasha Kekre, Ying Zhang, Mei-Jie Zhang, Jeanette Carreras, Parvez Ahmed, Paolo Anderlini, Elias Hallack Atta, Mouhab Ayas, Jaap Jan Boelens, Carmem Bonfim, H. Joachim Deeg, Neena Kapoor, Jong-Wook Lee, Ryotaro Nakamura, Michael A. Pulsipher, Mary Eapen, Joseph H. Antin

https://doi.org/10.3324/haematol.2017.164459

Online Only Articles

Enhanced calreticulin expression in red cells of polycythemia vera patients harboring the JAK2V617F mutation

Mégane Brusson, Sylvie Cochet, Marjorie Leduc, François Guillonneau, Patrick Mayeux, Thierry Peyrard, Christine Chomienne, Caroline Le Van Kim, Bruno Cassinat, Jean-Jacques Kiladjian, Wassim El Nemer

https://doi.org/10.3324/haematol.2016.161604

An extracellular matrix signature in leukemia precursor cells and acute myeloid leukemia

Valerio Izzi, Juho Lakkala, Raman Devarajan, Heli Ruotsalainen, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi

https://doi.org/10.3324/haematol.2017.167304

NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia

Jana Hof, Corinne Kox, Stefanie Groeneveld-Krentz, Obul R. Bandapalli, Leonid Karawajew, Katharina Schedel, Joachim B. Kunz, Cornelia Eckert, Wolf-Dieter Ludwig, Richard Ratei, Peter Rhein, Günter Henze, Martina U. Muckenthaler, Andreas E. Kulozik, Arend von Stackelberg, Renate Kirschner-Schwabe

https://doi.org/10.3324/haematol.2016.157792

Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia

Enrica Rampazzo, Engin Bojnik, Livio Trentin, Laura Bonaldi, Paola Del Bianco, Federica Frezzato, Andrea Visentin, Monica Facco, Gianpietro Semenzato, Anita De Rossi

https://doi.org/10.3324/haematol.2016.157669

Sphingosine kinase 1 participates in the activation, proliferation and survival of chronic lymphocytic leukemia cells

María Belén Almejún, Mercedes Borge, Ana Colado, Esteban Enrique Elías, Enrique Podaza, Denise Risnik, Carlos Daniel De Brasi, Carmen Stanganelli, Irma Slavutsky, María Cabrejo, Horacio Fernández-Grecco, Raimundo Fernando Bezares, Santiago Cranco, Rubén Ángel Burgos, Julio César Sánchez-Ávalos, Pablo Oppezzo, Mirta Giordano, Romina Gamberale

https://doi.org/10.3324/haematol.2017.167353

Double autophagy stimulation using chemotherapy and mTOR inhibition combined with hydroxychloroquine for autophagy modulation in patients with relapsed or refractory multiple myeloma

Emma C. Scott, Richard T. Maziarz, Stephen E. Spurgeon, Eva Medvedova, James Gajewski, Shara Reasor-Heard, Byung Park, Anne Kratz, George V. Thomas, Marc Loriaux, Michael Cascio, Jennifer Podolak, Miranda Gordon, Jennifer Botelho, Edward Stadtmauer, Ravi Amaravadi, Dan T. Vogl

https://doi.org/10.3324/haematol.2016.162321

Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition

Mérédis Favreau, Koen Venken, Sylvia Faict, Ken Maes, Kim De Veirman, Elke De Bruyne, Xavier Leleu, Louis Boon, Dirk Elewaut, Karin Vanderkerken, Eline Menu

https://doi.org/10.3324/haematol.2017.163758

Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the Plasma Cell Disorders subcommittee of the European Group for Blood and Marrow Transplant Chronic Malignancies Working Party

Mohamad Sobh, Mauricette Michallet, Valérie Dubois, Simona Iacobelli, Linda Koster, Anja Van Biezen, Nathalie Fegueux, Reza Tabrizi, Jürgen Finke, Jean El-Cheikh, Martin Schipperus, Ellen Meijer, Peter von dem Borne, Eefke Petersen, Nigel Russell, Eleni Tholouli, Jakob Passweg, Frédéric Garban, Johan Maertens, Patrice Chevalier, Natacha Maillard, Liisa Volin, Sylvie Francois, Bruno Lioure, Yves Beguin, Eliane Gluckman, Annalisa Ruggeri, Laurent Garderet, Nicolaus Kröger

https://doi.org/10.3324/haematol.2017.165399

Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1)

Lucie Heurtier, Hicham Lamrini, Loïc Chentout, Marie-Céline Deau, Amine Bouafia, Jérémie Rosain, Jean-Marc Plaza, Mélanie Parisot, Benoit Dumont, Delphine Turpin, Etienne Merlin, Despina Moshous, Nathalie Aladjidi, Bénédicte Neven, Capucine Picard, Marina Cavazzana, Alain Fischer, Anne Durandy, Jean-Louis Stephan, Sven Kracker

https://doi.org/10.3324/haematol.2017.167601