August, 2017
No. 102 (8)

Editorials

Articles

Red Cell Biology & its Disorders

Hemostasis

Patient-derived anti-β2GP1 antibodies recognize a peptide motif pattern and not a specific sequence of residues (202 Online Views)

Philippe de Moerloose, Céline Fickentscher, Françoise Boehlen, Jean-Marie Tiercy, Egbert K.O. Kruithof, Karim J. Brandt

https://doi.org/10.3324/haematol.2017.170381

Platelet Biology & its Disorders

Safety and efficacy of romiplostim in splenectomized and nonsplenectomized patients with primary immune thrombocytopenia (381 Online Views)

Douglas B. Cines, Jeffrey Wasser, Francesco Rodeghiero, Beng H. Chong, Michael Steurer, Drew Provan, Roger Lyons, Jaime Garcia-Chavez, Nancy Carpenter, Xuena Wang, Melissa Eisen

https://doi.org/10.3324/haematol.2016.161968

Myeloproliferative Disorders

Bone marrow morphology is a strong discriminator between chronic eosinophilic leukemia, not otherwise specified and reactive idiopathic hypereosinophilic syndrome (649 Online Views)

Sa A. Wang, Robert P. Hasserjian, Wayne Tam, Albert G. Tsai, Julia T. Geyer, Tracy I. George, Kathryn Foucar, Heesun J. Rogers, Eric D. Hsi, Bryan A. Rea, Adam Bagg, Carlos E. Bueso-Ramos, Daniel A. Arber, Srdan Verstovsek, Attilio Orazi

https://doi.org/10.3324/haematol.2017.165340

Chronic Myeloid Leukemia

Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib (464 Online Views)

Stein-Erik Gullaksen, Jørn Skavland, Sonia Gavasso, Vinko Tosevski, Krzysztof Warzocha, Claudia Dumrese, Augustin Ferrant, Tobias Gedde-Dahl, Andrzej Hellmann, Jeroen Janssen, Boris Labar, Alois Lang, Waleed Majeed, Georgi Mihaylov, Jesper Stentoft, Leif Stenke, Josef Thaler, Noortje Thielen, Gregor Verhoef, Jaroslava Voglova, Gert Ossenkoppele, Andreas Hochhaus, Henrik Hjorth-Hansen, Satu Mustjoki, Sieghart Sopper, Francis Giles, Kimmo Porkka, Dominik Wolf, Bjørn Tore Gjertsen

https://doi.org/10.3324/haematol.2017.167080

Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study (363 Online Views)

Delphine Rea, Guylaine Henry, Zena Khaznadar, Gabriel Etienne, François Guilhot, Franck Nicolini, Joelle Guilhot, Philippe Rousselot, Françoise Huguet, Laurence Legros, Martine Gardembas, Viviane Dubruille, Agnès Guerci-Bresler, Aude Charbonnier, Frédéric Maloisel, Jean-Christophe Ianotto, Bruno Villemagne, François-Xavier Mahon, Hélène Moins-Teisserenc, Nicolas Dulphy, Antoine Toubert

https://doi.org/10.3324/haematol.2017.165001

Acute Myeloid Leukemia

FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia (364 Online Views)

Ines Peschel, Silvio R. Podmirseg, Martin Taschler, Justus Duyster, Katharina S. Götze, Heinz Sill, David Nachbaur, Heidelinde Jäkel, Ludger Hengst

https://doi.org/10.3324/haematol.2016.160101

Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia (405 Online Views)

Dimitrios Papaioannou, Deedra Nicolet, Stefano Volinia, Krzysztof Mrózek, Pearlly Yan, Ralf Bundschuh, Andrew J. Carroll, Jessica Kohlschmidt, William Blum, Bayard L. Powell, Geoffrey L. Uy, Jonathan E. Kolitz, Eunice S. Wang, Ann-Kathrin Eisfeld, Shelley J. Orwick, David M. Lucas, Michael A. Caligiuri, Richard M. Stone, John C. Byrd, Ramiro Garzon, Clara D. Bloomfield

https://doi.org/10.3324/haematol.2017.166215

Chronic Lymphocytic Leukemia

Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells (276 Online Views)

Elena Tibaldi, Mario Angelo Pagano, Federica Frezzato, Valentina Trimarco, Monica Facco, Giuseppe Zagotto, Giovanni Ribaudo, Valeria Pavan, Luciana Bordin, Andrea Visentin, Francesca Zonta, Gianpietro Semenzato, Anna Maria Brunati, Livio Trentin

https://doi.org/10.3324/haematol.2016.155747

Non-Hodgkin Lymphoma

Prognostic relevance of CD163 and CD8 combined with EZH2 and gain of chromosome 18 in follicular lymphoma: a study by the Lunenburg Lymphoma Biomarker Consortium (357 Online Views)

Wendy B.C. Stevens, Matias Mendeville, Robert Redd, Andrew J. Clear, Reno Bladergroen, Maria Calaminici, Andreas Rosenwald, Eva Hoster, Wolfgang Hiddemann, Philippe Gaulard, Luc Xerri, Gilles Salles, Wolfram Klapper, Michael Pfreundschuh, Andrew Jack, Randy D. Gascoyne, Yasodha Natkunam, Ranjana Advani, Eva Kimby, Birgitta Sander, Laurie H. Sehn, Anton Hagenbeek, John Raemaekers, John Gribben, Marie José Kersten, Bauke Ylstra, Edie Weller, Daphne de Jong

https://doi.org/10.3324/haematol.2017.165415

Plasma Cell Disorders

Lenalidomide/melphalan/dexamethasone in newly diagnosed patients with immunoglobulin light chain amyloidosis: results of a prospective phase 2 study with long-term follow up (322 Online Views)

Ute Hegenbart, Tilmann Bochtler, Axel Benner, Natalia Becker, Christoph Kimmich, Arnt V. Kristen, Jörg Beimler, Ernst Hund, Markus Zorn, Anja Freiberger, Marianne Gawlik, Hartmut Goldschmidt, Dirk Hose, Anna Jauch, Anthony D. Ho, Stefan O. Schönland

https://doi.org/10.3324/haematol.2016.163246

Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation (285 Online Views)

Maximilian Merz, Anna Jauch, Thomas Hielscher, Elias K. Mai, Anja Seckinger, Dirk Hose, Uta Bertsch, Kai Neben, Marc S. Raab, Hans Salwender, Igor W. Blau, Hans-Walter Lindemann, Ingo Schmidt-Wolf, Christof Scheid, Mathias Haenel, Katja Weisel, Hartmut Goldschmidt, Jens Hillengass

https://doi.org/10.3324/haematol.2017.168005

Serial measurements of circulating plasma cells before and after induction therapy have an independent prognostic impact in patients with multiple myeloma undergoing upfront autologous transplantation (174 Online Views)

Rajshekhar Chakraborty, Eli Muchtar, Shaji K. Kumar, Dragan Jevremovic, Francis K. Buadi, David Dingli, Angela Dispenzieri, Suzanne R. Hayman, William J. Hogan, Prashant Kapoor, Martha Q. Lacy, Nelson Leung, Morie A. Gertz

https://doi.org/10.3324/haematol.2017.166629

Cell Therapy & Immunotherapy

Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease (160 Online Views)

Shoba Amarnath, Arian Laurence, Nathaniel Zhu, Renato Cunha, Michael A. Eckhaus, Samuel Taylor, Jason E. Foley, Monalisa Ghosh, Tania C. Felizardo, Daniel H. Fowler

https://doi.org/10.3324/haematol.2016.155879

Guidelines

Recommendations regarding splenectomy in hereditary hemolytic anemias (1603 Online Views)

Achille Iolascon, Immacolata Andolfo, Wilma Barcellini, Francesco Corcione, Loïc Garçon, Lucia De Franceschi, Claudio Pignata, Giovanna Graziadei, Dagmar Pospisilova, David C. Rees, Mariane de Montalembert, Stefano Rivella, Antonella Gambale, Roberta Russo, Leticia Ribeiro, Jules Vives-Corrons, Patricia Aguilar Martinez, Antonis Kattamis, Beatrice Gulbis, Maria Domenica Cappellini, Irene Roberts, Hannah Tamary

https://doi.org/10.3324/haematol.2016.161166

Online Only Articles

Increased vancomycin dosing requirements in sickle cell disease due to hyperfiltration-dependent and independent pathways (193 Online Views)

Jin Han, Xu Zhang, Jennifer Oderinde, Santosh L. Saraf, Michel Gowhari, Joharah Hassan, Shivi Jain, Victor R. Gordeuk, Robert E. Molokie

https://doi.org/10.3324/haematol.2017.169128

Absence of the spleen and the occurrence of primary red cell alloimmunization in humans (181 Online Views)

Dorothea Evers, Johanna G. van der Bom, Janneke Tijmensen, Masja de Haas, Rutger A. Middelburg, Karen M.K. de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C.V. Péquériaux, Francisca Hudig, Jaap Jan Zwaginga

https://doi.org/10.3324/haematol.2016.162685

Myelodysplasia and liver disease extend the spectrum of RTEL1 related telomeropathies (299 Online Views)

Shirleny R. Cardoso, Alicia C.M. Ellison, Amanda J. Walne, David Cassiman, Manoj Raghavan, Bhuvan Kishore, Philip Ancliff, Carmen Rodríguez-Vigil, Bieke Dobbels, Ana Rio-Machin, Ahad F.H. Al Seraihi, Nikolas Pontikos, Hemanth Tummala, Tom Vulliamy, Inderjeet Dokal

https://doi.org/10.3324/haematol.2017.167056

E14a2 BCR-ABL1 transcript is associated with a higher rate of treatment-free remission in individuals with chronic myeloid leukemia after stopping tyrosine kinase inhibitor therapy (243 Online Views)

Simone Claudiani, Jane F. Apperley, Robert Peter Gale, Richard Clark, Richard Szydlo, Simona Deplano, Renuka Palanicawandar, Jamshid Khorashad, Letizia Foroni, Dragana Milojkovic

https://doi.org/10.3324/haematol.2017.168740

Mutations in the 3′ untranslated region of NOTCH1 are associated with low CD20 expression levels chronic lymphocytic leukemia (155 Online Views)

Tamara Bittolo, Federico Pozzo, Riccardo Bomben, Tiziana D’Agaro, Vanessa Bravin, Pietro Bulian, Francesca Maria Rossi, Antonella Zucchetto, Massimo Degan, Paolo Macor, Giovanni D’Arena, Annalisa Chiarenza, Francesco Zaja, Gabriele Pozzato, Francesco Di Raimondo, Davide Rossi, Gianluca Gaidano, Giovanni Del Poeta, Valter Gattei, Michele Dal Bo

https://doi.org/10.3324/haematol.2016.162594

Clinical and diagnostic relevance of NOTCH2-and KLF2-mutations in splenic marginal zone lymphoma (371 Online Views)

Yolanda Campos-Martín, Nerea Martínez, Azahara Martínez-López, Laura Cereceda, Felipe Casado, Patrocinio Algara, David Oscier, Francisco J. Menarguez, Juan F. García, Miguel A Piris, Manuela Mollejo

https://doi.org/10.3324/haematol.2016.161711

The prognostic value of the depth of response in multiple myeloma depends on the time of assessment, risk status and molecular subtype (203 Online Views)

Carolina Schinke, Antje Hoering, Hongwei Wang, Victoria Carlton, Sharmilan Thanandrarajan, Shayu Deshpande, Purvi Patel, Gabor Molnar, Sandra Susanibar, Meera Mohan, Pankaj Mathur, Muthukumar Radhakrishnan, Shadiqul Hoque, Jorge Jo Kamimoto, Monica Grazziutti, Frits van Rhee, Maurizio Zangari, Giovanni Insuasti-Beltran, Daisy Alapat, Ginell Post, Shmuel Yaccoby, Joshua Epstein, Leo Rasche, Sarah Johnson, Martin Moorhead, Tom Willis, Bart Barlogie, Brian Walker, Niels Weinhold, Faith E Davies, Gareth J. Morgan

https://doi.org/10.3324/haematol.2017.165217

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma (195 Online Views)

Isabel J.F. Hofman, Stephanie Patchett, Mark van Duin, Ellen Geerdens, Jelle Verbeeck, Lucienne Michaux, Michel Delforge, Pieter Sonneveld, Arlen W. Johnson, Kim De Keersmaecker

https://doi.org/10.3324/haematol.2016.162198

Dynamics of epigenetic age following hematopoietic stem cell transplantation (159 Online Views)

Friedrich Stölzel, Mario Brosch, Steve Horvath, Michael Kramer, Christian Thiede, Malte von Bonin, Ole Ammerpohl, Moritz Middeke, Johannes Schetelig, Gerhard Ehninger, Jochen Hampe, Martin Bornhäuser

https://doi.org/10.3324/haematol.2016.160481

JAK1 somatic mutation in a myeloproliferative neoplasm (179 Online Views)

Suzanne O. Arulogun, Hock-Lai Choong, Debbie Taylor, Paula Ambrosoli, Graham Magor, Ian M. Irving, Tee-Beng Keng, Andrew C. Perkins

https://doi.org/10.3324/haematol.2017.170266