April, 2016
No. 101 (4)

Editorials

Review Articles

Articles

Hematopoiesis

A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis

Olivia L. Francis, Terry-Ann M. Milford, Shannalee R. Martinez, Ineavely Baez, Jacqueline S. Coats, Karina Mayagoitia, Katherine R. Concepcion, Elizabeth Ginelli, Cornelia Beldiman, Abigail Benitez, Abby J. Weldon, Keshav Arogyaswamy, Parveen Shiraz, Ross Fisher, Christopher L. Morris, Xiao-Bing Zhang, Valeri Filippov, Ben Van Handel, Zheng Ge, Chunhua Song, Sinisa Dovat, Ruijun Jeanna Su, Kimberly J. Payne

https://doi.org/10.3324/haematol.2015.125336

Platelet Biology & its Disorders

Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII

Nadine J.A. Mattheij, Frauke Swieringa, Tom G. Mastenbroek, Michelle A. Berny-Lang, Frauke May, Constance C.F.M.J. Baaten, Paola E.J. van der Meijden, Yvonne M.C. Henskens, Erik A.M. Beckers, Dennis P.L. Suylen, Marc W. Nolte, Tilman M. Hackeng, Owen J.T. McCarty, Johan W.M. Heemskerk, Judith M.E.M. Cosemans

https://doi.org/10.3324/haematol.2015.131441

Bone Marrow Failure

Extracellular vesicle miR-7977 is involved in hematopoietic dysfunction of mesenchymal stromal cells via poly(rC) binding protein 1 reduction in myeloid neoplasms

Hiroto Horiguchi, Masayoshi Kobune, Shohei Kikuchi, Masahiro Yoshida, Masaki Murata, Kazuyuki Murase, Satoshi Iyama, Kohichi Takada, Tsutomu Sato, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yutaka Kawano, Koji Miyanishi, Norimasa Sawada, Junji Kato

https://doi.org/10.3324/haematol.2015.134932

Acute Myeloid Leukemia

Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia

Chi Keung Cheng, Natalie P. H. Chan, Thomas S. K. Wan, Lai Ying Lam, Coty H. Y. Cheung, Terry H. Y. Wong, Rosalina K. L. Ip, Raymond S. M. Wong, Margaret H. L. Ng

https://doi.org/10.3324/haematol.2015.137125

Chronic Lymphocytic Leukemia

Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia

Paolo Strati, Joon H. Uhm, Timothy J. Kaufmann, Chadi Nabhan, Sameer A. Parikh, Curtis A. Hanson, Kari G. Chaffee, Timothy G. Call, Tait D. Shanafelt

https://doi.org/10.3324/haematol.2015.136556

Hodgkin Lymphoma

Impact of post-brentuximab vedotin consolidation on relapsed/refractory CD30+ Hodgkin lymphomas: a large retrospective study on 240 patients enrolled in the French Named-Patient Program

Aurore Perrot, Hélène Monjanel, Réda Bouabdallah, Philippe Quittet, Clémentine Sarkozy, Marc Bernard, Aspasia Stamatoullas, Cécile Borel, Krimo Bouabdallah, Emmanuelle Nicolas-Virelizier, Marion Fournier, Franck Morschhauser, Pauline Brice

https://doi.org/10.3324/haematol.2015.134213

Single or tandem autologous stem-cell transplantation for first-relapsed or refractory Hodgkin lymphoma: 10-year follow-up of the prospective H96 trial by the LYSA/SFGM-TC study group

David Sibon, Franck Morschhauser, Matthieu Resche-Rigon, David Ghez, Jehan Dupuis, Ambroise Marçais, Bénédicte Deau-Fischer, Reda Bouabdallah, Catherine Sebban, Gilles Salles, Pauline Brice

https://doi.org/10.3324/haematol.2015.136408

Cell Therapy & Immunotherapy

Expression of a dominant T-cell receptor can reduce toxicity and enhance tumor protection of allogeneic T-cell therapy

Angelika Holler, Mathias Zech, Sara Ghorashian, Rebecca Pike, Alastair Hotblack, Pedro Veliça, Shao-An Xue, Ronjon Chakraverty, Emma C. Morris, Hans J. Stauss

https://doi.org/10.3324/haematol.2015.132712

Stem Cell Transplantation

High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation

Satoko Morishima, Koichi Kashiwase, Keitaro Matsuo, Fumihiro Azuma, Toshio Yabe, Aiko Sato-Otsubo, Seishi Ogawa, Takashi Shiina, Masahiro Satake, Hiroh Saji, Shunichi Kato, Yoshihisa Kodera, Takehiko Sasazuki, Yasuo Morishima

https://doi.org/10.3324/haematol.2015.136903

Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation

Paul S. Martin, Shuli Li, Sarah Nikiforow, Edwin P. Alyea, Joseph H. Antin, Philippe Armand, Corey S. Cutler, Vincent T. Ho, Natasha Kekre, John Koreth, C. John Luckey, Jerome Ritz, Robert J. Soiffer

https://doi.org/10.3324/haematol.2015.134841

Multi-state analysis illustrates treatment success after stem cell transplantation for acute myeloid leukemia followed by donor lymphocyte infusion

Matthias Eefting, Liesbeth C. de Wreede, Constantijn J.M. Halkes, Peter A. von dem Borne, Sabina Kersting, Erik W.A. Marijt, Hendrik Veelken, Hein Putter, Johannes Schetelig, J.H. Frederik Falkenburg

https://doi.org/10.3324/haematol.2015.136846

Online Only Articles

The role of Matriptase-2 during the early postnatal development in humans

Luigia De Falco, Mariasole Bruno, Ebru Yilmaz-Keskin, Ertan Sal, Mustafa Büyükavci, Zühre Kaya, Domenico Girelli, Achille Iolascon

https://doi.org/10.3324/haematol.2015.139808

Mutation status of essential thrombocythemia and primary myelofibrosis defines clinical outcome

Julia Asp, Björn Andréasson, Ulrika Hansson, Carina Wasslavik, Johanna Abelsson, Peter Johansson, Lars Palmqvist

https://doi.org/10.3324/haematol.2015.138958

NUP214-ABL1 fusion defines a rare subtype of B-cell precursor acute lymphoblastic leukemia that could benefit from tyrosine kinase inhibitors

Nicolas Duployez, Guillaume Grzych, Benoît Ducourneau, Martin Alarcon Fuentes, Nathalie Grardel, Thomas Boyer, Wadih Abou Chahla, Bénédicte Bruno, Brigitte Nelken, Emmanuelle Clappier, Claude Preudhomme

https://doi.org/10.3324/haematol.2015.136499

Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia

Silvia Rasi, Hossein Khiabanian, Carmela Ciardullo, Lodovico Terzi-di-Bergamo, Sara Monti, Valeria Spina, Alessio Bruscaggin, Michaela Cerri, Clara Deambrogi, Lavinia Martuscelli, Alessandra Biasi, Elisa Spaccarotella, Lorenzo De Paoli, Valter Gattei, Robin Foà, Raul Rabadan, Gianluca Gaidano, Davide Rossi

https://doi.org/10.3324/haematol.2015.136051

Brentuximab vedotin followed by ABVD +/− radiotherapy in patients with previously untreated Hodgkin lymphoma: final results of a pilot phase II study

Massimo Federico, Stefano Luminari, Cinzia Pellegrini, Francesco Merli, Emanuela Anna Pesce, Stephane Chauvie, Letizia Gandolfi, Isabella Capodanno, Massimiliano Salati, Lisa Argnani, Pier Luigi Zinzani

https://doi.org/10.3324/haematol.2015.138388

Survival in multiple myeloma patients who develop second malignancies: a population-based cohort study

Gudbjörg Jonsdottir, Sigrún H. Lund, Magnus Björkholm, Ingemar Turesson, Anders Wahlin, Sham Mailankody, Cecilie Blimark, Malin Hultcrantz, Anna Porwit, Ola Landgren, Sigurdur Y. Kristinsson

https://doi.org/10.3324/haematol.2015.134049

Phase I/II trial of weekly bortezomib with lenalidomide and dexamethasone in first relapse or primary refractory myeloma

Annemiek Broijl, Marie-José Kersten, Wendimagegn Ghidey Alemayehu, Mark-David Levin, Okke de Weerdt, Edo Vellenga, Ellen Meijer, Shulamit Wittebol, Bea C. Tanis, Petra B. Cornelisse, Marian Stevens-Kroef, Gerard M.J. Bos, Pierre W. Wijermans, Henk Lokhorst, Pieter Sonneveld

https://doi.org/10.3324/haematol.2015.132431

Interleukin-15-activated cytokine-induced killer cells may sustain remission in leukemia patients after allogeneic stem cell transplantation: feasibility, safety and first insights on efficacy

Eva Rettinger, Sabine Huenecke, Halvard Bonig, Michael Merker, Andrea Jarisch, Jan Soerensen, Andre Willasch, Gesine Bug, Ansgar Schulz, Thomas Klingebiel, Peter Bader

https://doi.org/10.3324/haematol.2015.138016

Droplet digital polymerase chain reaction for DNMT3A and IDH1/2 mutations to improve early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation

Chiara Brambati, Silvia Galbiati, Elisabetta Xue, Cristina Toffalori, Lara Crucitti, Raffaella Greco, Elisa Sala, Alessandra Crippa, Lorenza Chiesa, Nadia Soriani, Benedetta Mazzi, Cristina Tresoldi, Maria Teresa Lupo Stanghellini, Jacopo Peccatori, Matteo G. Carrabba, Massimo Bernardi, Maurizio Ferrari, Vito Lampasona, Fabio Ciceri, Luca Vago

https://doi.org/10.3324/haematol.2015.135467