March, 2016
No. 101 (3)

Editorials

Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?

Sarka Pospisilova, Lesley-Ann Sutton, Jitka Malcikova, Eugen Tausch, Davide Rossi, Emili Montserrat, Carol Moreno, Kostas Stamatopoulos, Gianluca Gaidano, Richard Rosenquist, Paolo Ghia

https://doi.org/10.3324/haematol.2015.139246

Securing reimbursement for patient centered haemophilia care: major collaborative efforts are needed

Karin C. Berger, Brian M. Feldman, Joan Wasserman, Wolfgang Schramm, Victor Blanchette, Kathelijn Fischer

https://doi.org/10.3324/haematol.2015.139931

Review Articles

Articles

Hematopoiesis

Iron Metabolism & Its Disorders

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

Huiyong Chen, Tenzin Choesang, Huihui Li, Shuming Sun, Petra Pham, Weili Bao, Maria Feola, Mark Westerman, Guiyuan Li, Antonia Follenzi, Lionel Blanc, Stefano Rivella, Robert E. Fleming, Yelena Z. Ginzburg

https://doi.org/10.3324/haematol.2015.127902

Coagulation & Its Disorders

von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII

Nicoletta Sorvillo, Robin B. Hartholt, Esther Bloem, Magdalena Sedek, Anja ten Brinke, Carmen van der Zwaan, Floris P. van Alphen, Alexander B. Meijer, Jan Voorberg

https://doi.org/10.3324/haematol.2015.137067


Acute Myeloid Leukemia

Prospective long-term minimal residual disease monitoring using RQ-PCR in RUNX1-RUNX1T1-positive acute myeloid leukemia: results of the French CBF-2006 trial

Christophe Willekens, Odile Blanchet, Aline Renneville, Pascale Cornillet-Lefebvre, Cécile Pautas, Romain Guieze, Norbert Ifrah, Hervé Dombret, Eric Jourdan, Claude Preudhomme, Nicolas Boissel

https://doi.org/10.3324/haematol.2015.131946

Acute Lymphoblastic Leukemia

Minimal residual disease monitoring by 8-color flow cytometry in mantle cell lymphoma: an EU-MCL and LYSA study

Morgane Cheminant, Coralie Derrieux, Aurore Touzart, Stéphanie Schmit, Adrien Grenier, Amélie Trinquand, Marie-Hélène Delfau-Larue, Ludovic Lhermitte, Catherine Thieblemont, Vincent Ribrag, Stéphane Cheze, Laurence Sanhes, Fabrice Jardin, François Lefrère, Richard Delarue, Eva Hoster, Martin Dreyling, Vahid Asnafi, Olivier Hermine, Elizabeth Macintyre

https://doi.org/10.3324/haematol.2015.134957

Plasma Cell Disorders

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Christoph Driessen, Marianne Kraus, Markus Joerger, Hilde Rosing, Jürgen Bader, Felicitas Hitz, Catherine Berset, Alexandros Xyrafas, Hanne Hawle, Gregoire Berthod, Hermann S. Overkleeft, Christiana Sessa, Alwin Huitema, Thomas Pabst, Roger von Moos, Dagmar Hess, Ulrich J.M. Mey

https://doi.org/10.3324/haematol.2015.135780

Impact of renal impairment on outcomes with lenalidomide and dexamethasone treatment in the FIRST trial, a randomized, open-label phase 3 trial in transplant-ineligible patients with multiple myeloma

Meletios A. Dimopoulos, Matthew C. Cheung, Murielle Roussel, Ting Liu, Barbara Gamberi, Brigitte Kolb, H. Guenter Derigs, HyeonSeok Eom, Karim Belhadj, Pascal Lenain, Richard Van der Jagt, Sophie Rigaudeau, Mamoun Dib, Rachel Hall, Henry Jardel, Arnaud Jaccard, Axel Tosikyan, Lionel Karlin, William Bensinger, Rik Schots, Nicolas Leupin, Guang Chen, Jennifer Marek, Annette Ervin-Haynes, Thierry Facon

https://doi.org/10.3324/haematol.2015.133629

Stem Cell Transplantation

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

Letizia Muccio, Alice Bertaina, Michela Falco, Daniela Pende, Raffaella Meazza, Miguel Lopez-Botet, Lorenzo Moretta, Franco Locatelli, Alessandro Moretta, Mariella Della Chiesa

https://doi.org/10.3324/haematol.2015.134155

Polymorphism in TGFB1 is associated with worse non-relapse mortality and overall survival after stem cell transplantation with unrelated donors

Esteban Arrieta-Bolaños, Neema P. Mayor, Steven G.E. Marsh, J. Alejandro Madrigal, Jane F. Apperley, Keiren Kirkland, Stephen Mackinnon, David I. Marks, Grant McQuaker, Julia Perry, Michael N. Potter, Nigel H. Russell, Kirsty Thomson, Bronwen E. Shaw

https://doi.org/10.3324/haematol.2015.134999

Guidelines

Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation

Inge M. van der Sluis, Lynda M. Vrooman, Rob Pieters, Andre Baruchel, Gabriele Escherich, Nicholas Goulden, Veerle Mondelaers, Jose Sanchez de Toledo, Carmelo Rizzari, Lewis B. Silverman, James A. Whitlock

https://doi.org/10.3324/haematol.2015.137380

Online Only Articles

Brentuximab vedotin in refractory or relapsed peripheral T-cell lymphomas: the French named patient program experience in 56 patients

Mathilde Lamarque, Céline Bossard, Adrien Contejean, Pauline Brice, Marie Parrens, Steven Le Gouill, Josette Brière, Reda Bouabdallah, Danielle Canioni, Hervé Tilly, Brigitte Bouchindhomme, Emmanuel Bachy, Richard Delarue, Corinne Haioun, Philippe Gaulard

https://doi.org/10.3324/haematol.2015.135400

The anti-tumoral effect of lenalidomide is increased in vivo by hypoxia-inducible factor (HIF)-1α inhibition in myeloma cells

Paola Storti, Denise Toscani, Irma Airoldi, Valentina Marchica, Sophie Maiga, Marina Bolzoni, Elena Fiorini, Nicoletta Campanini, Eugenia Martella, Cristina Mancini, Daniela Guasco, Valentina Ferri, Gaetano Donofrio, Franco Aversa, Martine Amiot, Nicola Giuliani

https://doi.org/10.3324/haematol.2015.133736

Concomitant gain of 1q21 and MYC translocation define a poor prognostic subgroup of hyperdiploid multiple myeloma

Niels Weinhold, Desiree Kirn, Anja Seckinger, Thomas Hielscher, Martin Granzow, Uta Bertsch, Gerlinde Egerer, Hans Salwender, Igor W. Blau, Katja Weisel, Jens Hillengass, Marc S. Raab, Dirk Hose, Hartmut Goldschmidt, Anna Jauch

https://doi.org/10.3324/haematol.2015.136929

Response to: Dietary and pharmacological factors affecting iron absorption in mice and man

Carine Fillebeen, Konstantinos Gkouvatsos, Gabriela Fragoso, Annie Calvé, Daniel Garcia-Santos, Marzell Buffler, Christiane Becker, Klaus Schümann, Prem Ponka, Manuela M. Santos, Kostas Pantopoulos

https://doi.org/10.3324/haematol.2015.139741

The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation

Adam Ceroi, Fanny Angelot Delettre, Charline Marotel, Thierry Gauthier, Afag Asgarova, Sabéha Biichlé, Anne Duperrier, Guillaume Mourey, Sylvain Perruche, Laurent Lagrost, David Masson, Philippe Saas

https://doi.org/10.3324/haematol.2015.135459

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling

Therese Vu, Rebecca Austin, Catherine Paine Kuhn, Claudia Bruedigam, Axia Song, Solene Guignes, Sebastien Jacquelin, Hayley S. Ramshaw, Geoffrey R. Hill, Angel F. Lopez, Steven W. Lane

https://doi.org/10.3324/haematol.2015.136705

Hyperhomocysteinemia and high doses of nilotinib favor cardiovascular events in chronic phase Chronic Myelogenous Leukemia patients

Gaëlle Fossard, Emilie Blond, Marie Balsat, Stéphane Morisset, Stéphane Giraudier, Martine Escoffre-Barbe, Hélène Labussière-Wallet, Maël Heiblig, Arthur Bert, Madeleine Etienne, Jocelyne Drai, Mohamad Sobh, Isabelle Redonnet-Vernhet, Jean-Christophe Lega, François-Xavier Mahon, Gabriel Etienne, Franck Emmanuel Nicolini

https://doi.org/10.3324/haematol.2015.135103

Clinical and molecular genetic characterization of wild-type MLL infant acute lymphoblastic leukemia identifies few recurrent abnormalities

Marieke H. van der Linden, Judith M. Boer, Pauline Schneider, Merel Willekes, Lidija Seslija, Paola De Lorenzo, Maria Grazia Valsecchi, Giovanni Cazzaniga, Andrea Biondi, Monique L. den Boer, Rob Pieters, Ronald W. Stam

https://doi.org/10.3324/haematol.2014.122119

Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors

Sylvia Ganghammer, Julia Gutjahr, Evelyn Hutterer, Peter W. Krenn, Susanne Pucher, Claudia Zelle-Rieser, Karin Jöhrer, Maikel Wijtmans, Rob Leurs, Martine J. Smit, Valter Gattei, Richard Greil, Tanja N. Hartmann

https://doi.org/10.3324/haematol.2015.133470