August, 2015
No. 100 (8)

Editorials

Precision medicine in diffuse large B-cell lymphoma: hitting the target

Joost S. Vermaat, Steven T. Pals, Anas Younes, Martin Dreyling, Massimo Federico, Igor Aurer, John Radford, Marie José Kersten

https://doi.org/10.3324/haematol.2015.128371

Articles

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice

Julia Kobuch, Haissi Cui, Barbara Grünwald, Paul Saftig, Percy A. Knolle, Achim Krüger

https://doi.org/10.3324/haematol.2014.121590

Chronic exposure to IFNα drives medullar lymphopoiesis towards T-cell differentiation in mice

Marianna Di Scala, Irene Gil-Fariña, Lucia Vanrell, Rodrigo Sánchez-Bayona, Diego Alignani, Cristina Olagüe, Africa Vales, Pedro Berraondo, Jesús Prieto, Gloria González-Aseguinolaza

https://doi.org/10.3324/haematol.2014.115410

Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy

Cécile Onclinx, Sophie Dogne, Laurence Jadin, Fabienne Andris, Christian Grandfils, François Jouret, François Mullier, Bruno Flamion

https://doi.org/10.3324/haematol.2015.123828

The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention

Man-Chiu Poon, Roseline d’Oiron, Rainer B. Zotz, Niels Bindslev, Matteo Nicola Dario Di Minno, Giovanni Di Minno

https://doi.org/10.3324/haematol.2014.121384

Hospital-associated venous thromboembolism in pediatrics: a systematic review and meta-analysis of risk factors and risk-assessment models

Arash Mahajerin, Brian R. Branchford, Ernest K. Amankwah, Leslie Raffini, Elizabeth Chalmers, C. Heleen van Ommen, Neil A. Goldenberg

https://doi.org/10.3324/haematol.2015.123455

BRCC3 mutations in myeloid neoplasms

Dayong Huang, Yasunobu Nagata, Vera Grossmann, Tomas Radivoyevitch, Yusuke Okuno, Genta Nagae, Naoko Hosono, Susanne Schnittger, Masashi Sanada, Bartlomiej Przychodzen, Ayana Kon, Chantana Polprasert, Wenyi Shen, Michael J. Clemente, James G. Phillips, Tamara Alpermann, Kenichi Yoshida, Niroshan Nadarajah, Mikkael A. Sekeres, Kevin Oakley, Nhu Nguyen, Yuichi Shiraishi, Yusuke Shiozawa, Kenichi Chiba, Hiroko Tanaka, H. Phillip Koeffler, Hans-Ulrich Klein, Martin Dugas, Hiroyuki Aburatani, Satoru Miyano, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, Yang Du, Seishi Ogawa, Hideki Makishima

https://doi.org/10.3324/haematol.2014.111989

Ruxolitinib in combination with lenalidomide as therapy for patients with myelofibrosis

Naval Daver, Jorge Cortes, Kate Newberry, Elias Jabbour, Lingsha Zhou, Xuemei Wang, Sherry Pierce, Tapan Kadia, Koji Sasaki, Gautam Borthakur, Farhad Ravandi, Naveen Pemmaraju, Hagop Kantarjian, Srdan Verstovsek

https://doi.org/10.3324/haematol.2015.126821

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation

Coline Gaillard, Taku A. Tokuyasu, Galit Rosen, Jason Sotzen, Adeline Vitaliano-Prunier, Ritu Roy, Emmanuelle Passegué, Hugues de Thé, Maria E. Figueroa, Scott C. Kogan

https://doi.org/10.3324/haematol.2014.123018

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic

https://doi.org/10.3324/haematol.2014.115170

CD3−CD4+ lymphoid variant of hypereosinophilic syndrome: nodal and extranodal histopathological and immunophenotypic features of a peripheral indolent clonal T-cell lymphoproliferative disorder

Guillaume Lefèvre, Marie-Christine Copin, Christophe Roumier, Hélène Aubert, Martine Avenel-Audran, Nathalie Grardel, Stéphanie Poulain, Delphine Staumont-Sallé, Julien Seneschal, Gilles Salles, Kamel Ghomari, Louis Terriou, Christian Leclech, Chafika Morati-Hafsaoui, Franck Morschhauser, Olivier Lambotte, Félix Ackerman, Jacques Trauet, Sandrine Geffroy, Florent Dumezy, Monique Capron, Catherine Roche-Lestienne, Alain Taieb, Pierre-Yves Hatron, Sylvain Dubucquoi, Eric Hachulla, Lionel Prin, Myriam Labalette, David Launay, Claude Preudhomme, Jean-Emmanuel Kahn

https://doi.org/10.3324/haematol.2014.118042

Bendamustine, bortezomib and prednisone for the treatment of patients with newly diagnosed multiple myeloma: results of a prospective phase 2 Spanish/PETHEMA trial

María-Victoria Mateos, Albert Oriol, Laura Rosiñol, Felipe de Arriba, Noemí Puig, Jesús Martín, Joaquín Martínez-López, María Asunción Echeveste, Josep Sarrá, Enrique Ocio, Gemma Ramírez, Rafael Martínez, Luis Palomera, Angel Payer, Rebeca Iglesias, Javier de la Rubia, Adrian Alegre, Ana Isabel Chinea, Joan Bladé, Juan José Lahuerta, Jesús-F. San Miguel

https://doi.org/10.3324/haematol.2015.124818

Guidelines

Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies

Kai Lehmberg, Kim E. Nichols, Jan-Inge Henter, Michael Girschikofsky, Tatiana Greenwood, Michael Jordan, Ashish Kumar, Milen Minkov, Paul La Rosée, Sheila Weitzman

https://doi.org/10.3324/haematol.2015.123562

Online Only Articles

Statin use and bleeding risk during vitamin K antagonist treatment for venous thromboembolism: a multicenter retrospective cohort study

Nicoletta Riva, Matteo N.D. Di Minno, Nicola Mumoli, Fulvio Pomero, Massimo Franchini, Marta Bellesini, Roberta Lupoli, Silvia Sabatini, Valentina Borretta, Carlo Bonfanti, Walter Ageno, Francesco Dentali

https://doi.org/10.3324/haematol.2015.127183

Imatinib-treated chronic myeloid leukemia patients with discordant response between cytogenetic and molecular tests at 3 and 6 month time-points have a reduced probability of subsequent optimal response

Massimiliano Bonifacio, Gianni Binotto, Elena Maino, Elisabetta Calistri, Luciana Marin, Luigi Scaffidi, Luca Frison, Federico De Marchi, Mauro Krampera, Giampiero Semenzato, Renato Fanin, Achille Ambrosetti, Mario Tiribelli

https://doi.org/10.3324/haematol.2015.124685

Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors

Rachel Thijssen, Erik Slinger, Katinka Weller, Christian R. Geest, Tim Beaumont, Marinus H.J. van Oers, Arnon P. Kater, Eric Eldering

https://doi.org/10.3324/haematol.2015.124560

B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia

Nadja Zaborsky, Claudia Holler, Roland Geisberger, Daniela Asslaber, Franz Josef Gassner, Viktoria Egger, Josephina Piñón-Hofbauer, Thomas Kocher, Tanja Nicole Hartmann, Richard Greil, Alexander Egle

https://doi.org/10.3324/haematol.2015.124719

Ofatumumab monotherapy in fludarabine-refractory chronic lymphocytic leukemia: final results from a pivotal study

Anders Österborg, Roxanne C. Jewell, Swami Padmanabhan-Iyer, Thomas J. Kipps, Jiří Mayer, Stephan Stilgenbauer, Cathy D. Williams, Andrzej Hellmann, Richard R. Furman, Tadeusz Robak, Peter Hillmen, Marek Trnêný, Martin J.S. Dyer, Magdalena Piotrowska, Tomas Kozak, Ira V. Gupta, Jennifer L. Phillips, Nancy Goldstein, Herbert Struemper, Nedjad Losic, Steen Lisby, William G. Wierda

https://doi.org/10.3324/haematol.2014.121459

Proteasome inhibitors block Ikaros degradation by lenalidomide in multiple myeloma

Chang-Xin Shi, Klaus Martin Kortüm, Yuan Xiao Zhu, Patrick Jedlowski, Laura Bruins, Esteban Braggio, A. Keith Stewart

https://doi.org/10.3324/haematol.2015.124297

Impact of maintenance therapy on subsequent treatment in patients with newly diagnosed multiple myeloma: use of “progression-free survival 2” as a clinical trial end-point

Meletios A. Dimopoulos, Maria T. Petrucci, Robin Foà, John Catalano, Martin Kropff, Evangelos Terpos, Jingshan Zhang, Lara Grote, Christian Jacques, Antonio Palumbo

https://doi.org/10.3324/haematol.2014.120790