July, 2015
No. 100 (7)

Editorials

Review Articles

Articles

Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease

Brian T. Kalish, Alessandro Matte, Immacolata Andolfo, Achille Iolascon, Olga Weinberg, Alessandra Ghigo, James Cimino, Angela Siciliano, Emilio Hirsch, Enrica Federti, Mark Puder, Carlo Brugnara, Lucia De Franceschi

https://doi.org/10.3324/haematol.2015.124586

Extrahepatic sources of factor VIII potentially contribute to the coagulation cascade correcting the bleeding phenotype of mice with hemophilia A

Diego Zanolini, Simone Merlin, Maria Feola, Gabriella Ranaldo, Angela Amoruso, Gianluca Gaidano, Mauro Zaffaroni, Alessandro Ferrero, Sandra Brunelleschi, Guido Valente, Sanjeev Gupta, Maria Prat, Antonia Follenzi

https://doi.org/10.3324/haematol.2014.123117

Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations

Carla Al Assaf, Florence Van Obbergh, Johan Billiet, Els Lierman, Timothy Devos, Carlos Graux, Anne-Sophie Hervent, Jan Emmerechts, Thomas Tousseyn, Pascale De Paepe, Petros Papadopoulos, Lucienne Michaux, Peter Vandenberghe

https://doi.org/10.3324/haematol.2014.118299

A phase I study of danusertib (PHA-739358) in adult patients with accelerated or blastic phase chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant or intolerant to imatinib and/or other second generation c-ABL therapy

Gautam Borthakur, Herve Dombret, Philippe Schafhausen, Tim Henrik Brummendorf, Nicolas Boissel, Elias Jabbour, Mariangela Mariani, Laura Capolongo, Patrizia Carpinelli, Cristina Davite, Hagop Kantarjian, Jorge E. Cortes

https://doi.org/10.3324/haematol.2014.115279

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

Erwin M. Lee, Dean Yee, Samantha J. Busfield, Julie F. McManus, Nik Cummings, Gino Vairo, Andrew Wei, Hayley S. Ramshaw, Jason A. Powell, Angel F. Lopez, Ian D. Lewis, Martin N. McCall, Richard B. Lock

https://doi.org/10.3324/haematol.2014.113092

Acute Myeloid Leukemia

Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia

Marina Konopleva, Peter F. Thall, Cecilia Arana Yi, Gautam Borthakur, Andrew Coveler, Carlos Bueso-Ramos, Juliana Benito, Sergej Konoplev, Yongchuan Gu, Farhad Ravandi, Elias Jabbour, Stefan Faderl, Deborah Thomas, Jorge Cortes, Tapan Kadia, Steven Kornblau, Naval Daver, Naveen Pemmaraju, Hoang Q. Nguyen, Jennie Feliu, Hongbo Lu, Caimiao Wei, William R. Wilson, Teresa J. Melink, John C. Gutheil, Michael Andreeff, Elihu H. Estey, Hagop Kantarjian

https://doi.org/10.3324/haematol.2014.118455

Minimal residual disease analysis by eight-color flow cytometry in relapsed childhood acute lymphoblastic leukemia

Leonid Karawajew, Michael Dworzak, Richard Ratei, Peter Rhein, Giuseppe Gaipa, Barbara Buldini, Giuseppe Basso, Ondrej Hrusak, Wolf-Dieter Ludwig, Günter Henze, Karl Seeger, Arend von Stackelberg, Ester Mejstrikova, Cornelia Eckert

https://doi.org/10.3324/haematol.2014.116707

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B

Manoj K. Kashyap, Deepak Kumar, Reymundo Villa, James J. La Clair, Chris Benner, Roman Sasik, Harrison Jones, Emanuela M. Ghia, Laura Z. Rassenti, Thomas J. Kipps, Michael D. Burkart, Januario E. Castro

https://doi.org/10.3324/haematol.2014.122069

Rituximab maintenance for patients with aggressive B-cell lymphoma in first remission: results of the randomized NHL13 trial

Ulrich Jaeger, Marek Trneny, Helen Melzer, Michael Praxmarer, Weerasak Nawarawong, Dina Ben Yehuda, David Goldstein, Bilijana Mihaljevic, Osman Ilhan, Veronika Ballova, Michael Hedenus, Liang-Tsai Hsiao, Wing-Yan Au, Sonja Burgstaller, Gerhard Weidinger, Felix Keil, Christian Dittrich, Cathrin Skrabs, Anton Klingler, Andreas Chott, Michael A. Fridrik, Richard Greil

https://doi.org/10.3324/haematol.2015.125344

Subcutaneous versus intravenous bortezomib in two different induction therapies for newly diagnosed multiple myeloma: an interim analysis from the prospective GMMG-MM5 trial

Maximilian Merz, Hans Salwender, Mathias Haenel, Elias K. Mai, Uta Bertsch, Christina Kunz, Thomas Hielscher, Igor W. Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Anna Jauch, Jens Hillengass, Marc S. Raab, Baerbel Schurich, Markus Munder, Ingo G.H. Schmidt-Wolf, Christian Gerecke, Hans-Walter Lindemann, Matthias Zeis, Katja Weisel, Jan Duerig, Hartmut Goldschmidt

https://doi.org/10.3324/haematol.2015.124347

Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease

Joseph Pidala, Jongphil Kim, Melissa Alsina, Ernesto Ayala, Brian C. Betts, Hugo F. Fernandez, Teresa Field, Heather Jim, Mohamed A. Kharfan-Dabaja, Frederick L. Locke, Asmita Mishra, Taiga Nishihori, Leonel Ochoa-Bayona, Lia Perez, Marcie Riches, Claudio Anasetti

https://doi.org/10.3324/haematol.2015.123588

The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis

Sebastian FN Bode, Sandra Ammann, Waleed Al-Herz, Mihaela Bataneant, Christopher C Dvorak, Stephan Gehring, Andrew Gennery, Kimberly C Gilmour, Luis I Gonzalez-Granado, Ute Groß-Wieltsch, Marianne Ifversen, Jenny Lingman-Framme, Susanne Matthes-Martin, Rolf Mesters, Isabelle Meyts, Joris M van Montfrans, Jana Pachlopnik Schmid, Sung-Yun Pai, Pere Soler-Palacin, Uta Schuermann, Volker Schuster, Markus G. Seidel, Carsten Speckmann, Polina Stepensky, Karl-Walter Sykora, Bianca Tesi, Thomas Vraetz, Catherine Waruiru, Yenan T. Bryceson, Despina Moshous, Kai Lehmberg, Michael B Jordan, Stephan Ehl

https://doi.org/10.3324/haematol.2014.121608

Online Only Articles

CD127+ innate lymphoid cells are dysregulated in treatment naïve acute myeloid leukemia patients at diagnosis

Sara Trabanelli, Antonio Curti, Mariangela Lecciso, Bérengère Salomé, Carsten Riether, Adrian Ochsenbein, Pedro Romero, Camilla Jandus

https://doi.org/10.3324/haematol.2014.119602

Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates

Judith M. Boer, Jasper E. Koenders, Bronno van der Holt, Carla Exalto, Mathijs A. Sanders, Jan J. Cornelissen, Peter J.M. Valk, Monique L. den Boer, Anita W. Rijneveld

https://doi.org/10.3324/haematol.2014.117424

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia

Adam Linley, Beatriz Valle-Argos, Andrew J. Steele, Freda K. Stevenson, Francesco Forconi, Graham Packham

https://doi.org/10.3324/haematol.2014.120824

Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma

Anne-Sophie Michallet, Yann Guillermin, Benedicte Deau, Laure Lebras, Stephanie Harel, Sandy Amorin, Claire Reynes, Gilles Salles, Fabien Subtil, Pauline Brice

https://doi.org/10.3324/haematol.2015.124784

Experience with HSP90 inhibitor AUY922 in patients with relapsed or refractory non-Hodgkin lymphoma

Yasuhiro Oki, Anas Younes, Javier Knickerbocker, Felipe Samaniego, Loretta Nastoupil, Fredrick Hagemeister, Jorge Romaguera, Nathan Fowler, Larry Kwak, Jason Westin

https://doi.org/10.3324/haematol.2015.126557

Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern

Julio Finalet Ferreiro, Julie Morscio, Daan Dierickx, Lukas Marcelis, Gregor Verhoef, Peter Vandenberghe, Thomas Tousseyn, Iwona Wlodarska

https://doi.org/10.3324/haematol.2015.124305

Somatic mutations of cell-free circulating DNA detected by next-generation sequencing reflect the genetic changes in both germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphomas at the time of diagnosis

Elodie Bohers, Pierre Julien Viailly, Sydney Dubois, Philippe Bertrand, Catherine Maingonnat, Sylvain Mareschal, Philippe Ruminy, Jean-Michel Picquenot, Christian Bastard, Fabienne Desmots, Thierry Fest, Karen Leroy, Hervé Tilly, Fabrice Jardin

https://doi.org/10.3324/haematol.2015.123612

Efficacy of single versus boost vaccination against influenza virus in patients with multiple myeloma

Michael Hahn, Paul Schnitzler, Brunhilde Schweiger, Christina Kunz, Anthony D. Ho, Hartmut Goldschmidt, Michael Schmitt

https://doi.org/10.3324/haematol.2014.116772

Evidence of long-term disease control with panobinostat maintenance in patients with relapsed multiple myeloma

Enrique M. Ocio, Julio Dávila, Juan-Carlos Caballero, Sara Alonso, Verónica González de la Calle, Ramón García-Sanz, Lucien Gazi, Socrates Opio, Mónica Jiménez, Jesús F. San-Miguel, María-Victoria Mateos

https://doi.org/10.3324/haematol.2015.124164