Vol. 100 No. 9 (2015): September, 2015

Legacy of blood: does prasugrel inhibit megakaryocytes and do juvenile platelets inherit this inhibition? (382 Online Views)

Carlos G. Santos-Gallego

https://doi.org/10.3324/haematol.2015.132134

The FLAM regimen: revisiting time sequential induction therapy for patients with poor-risk acute myeloid leukemia (839 Online Views)

Steven Knapper

https://doi.org/10.3324/haematol.2015.134023

Environmental determinants of severity in sickle cell disease (10268 Online Views)

Sanjay Tewari, Valentine Brousse, Frédéric B. Piel, Stephan Menzel, David C. Rees

https://doi.org/10.3324/haematol.2014.120030

Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication (938 Online Views)

Constance C. F. M. J. Baaten, Leo F. Veenstra, Rick Wetzels, Johanna P. van Geffen, Frauke Swieringa, Susanne M. de Witt, Yvonne M. C. Henskens, Harry Crijns, Sven Nylander, J. J. J. van Giezen, Johan W. M. Heemskerk, Paola E. J. van der Meijden

https://doi.org/10.3324/haematol.2014.122457

A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis (5059 Online Views)

Alessandro M. Vannucchi, Hagop M. Kantarjian, Jean-Jacques Kiladjian, Jason Gotlib, Francisco Cervantes, Ruben A. Mesa, Nicholas J. Sarlis, Wei Peng, Victor Sandor, Prashanth Gopalakrishna, Abdel Hmissi, Viktoriya Stalbovskaya, Vikas Gupta, Claire Harrison, Srdan Verstovsek

https://doi.org/10.3324/haematol.2014.119545

Long-term outcome of a phase 2 trial with nilotinib 400 mg twice daily in first-line treatment of chronic myeloid leukemia (1632 Online Views)

Gabriele Gugliotta, Fausto Castagnetti, Massimo Breccia, Luciano Levato, Mariella D’Adda, Fabio Stagno, Mario Tiribelli, Marzia Salvucci, Carmen Fava, Bruno Martino, Michele Cedrone, Monica Bocchia, Elena Trabacchi, Francesco Cavazzini, Emilio Usala, Antonella Russo Rossi, Maria Teresa Bochicchio, Simona Soverini, Giuliana Alimena, Michele Cavo, Fabrizio Pane, Giovanni Martinelli, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti

https://doi.org/10.3324/haematol.2015.129221

Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia (1769 Online Views)

Jasmijn D.E. de Rooij, Eva Beuling, Marry M. van den Heuvel-Eibrink, Askar Obulkasim, André Baruchel, Jan Trka, Dirk Reinhardt, Edwin Sonneveld, Brenda E.S. Gibson, Rob Pieters, Martin Zimmermann, C. Michel Zwaan, Maarten Fornerod

https://doi.org/10.3324/haematol.2015.124321

Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy (1143 Online Views)

Isabella Spinello, Maria Teresa Quaranta, Rosa Paolillo, Elvira Pelosi, Anna Maria Cerio, Ernestina Saulle, Francesco Lo Coco, Ugo Testa, Catherine Labbaye

https://doi.org/10.3324/haematol.2014.120295

Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia (1943 Online Views)

Joshua F. Zeidner, Matthew C. Foster, Amanda L. Blackford, Mark R. Litzow, Lawrence E. Morris, Stephen A. Strickland, Jeffrey E. Lancet, Prithviraj Bose, M. Yair Levy, Raoul Tibes, Ivana Gojo, Christopher D. Gocke, Gary L. Rosner, Richard F. Little, John J. Wright, L. Austin Doyle, B. Douglas Smith, Judith E. Karp

https://doi.org/10.3324/haematol.2015.125849

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience (8659 Online Views)

Paolo Strati, Samih H. Nasr, Nelson Leung, Curtis A. Hanson, Kari G. Chaffee, Susan M. Schwager, Sara J. Achenbach, Timothy G. Call, Sameer A. Parikh, Wei Ding, Neil E. Kay, Tait D. Shanafelt

https://doi.org/10.3324/haematol.2015.128793

Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease (1519 Online Views)

Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer

https://doi.org/10.3324/haematol.2014.114967

Concomitant systemic and central nervous system non-Hodgkin lymphoma: the role of consolidation in terms of high dose therapy and autologous stem cell transplantation. A 60-case retrospective study from LYSA and the LOC network (1332 Online Views)

Gandhi Damaj, Sarah Ivanoff, Diane Coso, Loïc Ysaebert, Sylvain Choquet, Caroline Houillier, Anne Parcelier, Wajed Abarah, Zora Marjanovic, Rémy Gressin, Reda Garidi, Momar Diouf, Anne-Claire Gac, Jehan Dupuis, Xavier Troussard, Franck Morschhauseur, Hervé Ghesquières, Carole Soussain

https://doi.org/10.3324/haematol.2015.126110

Zoledronic acid as compared with observation in multiple myeloma patients at biochemical relapse: results of the randomized AZABACHE Spanish trial (1629 Online Views)

Ramón García-Sanz, Albert Oriol, María J. Moreno, Javier de la Rubia, Angel R. Payer, Miguel T. Hernández, Luis Palomera, Ana I. Teruel, María J. Blanchard, Mercedes Gironella, Paz Ribas, Joan Bargay, Eugenia Abellá, Miquel Granell, Enrique M. Ocio, Josep M. Ribera, Jesús F. San Miguel, María V. Mateos

https://doi.org/10.3324/haematol.2015.128439

Four genes predict high risk of progression from smoldering to symptomatic multiple myeloma (SWOG S0120) (1594 Online Views)

Rashid Khan, Madhav Dhodapkar, Adam Rosenthal, Christoph Heuck, Xenofon Papanikolaou, Pingping Qu, Frits van Rhee, Maurizio Zangari, Yogesh Jethava, Joshua Epstein, Shmuel Yaccoby, Antje Hoering, John Crowley, Nathan Petty, Clyde Bailey, Gareth Morgan, Bart Barlogie

https://doi.org/10.3324/haematol.2015.124651

Efficacy of immune suppression tapering in treating relapse after reduced intensity allogeneic stem cell transplantation (1090 Online Views)

Natasha Kekre, Haesook T. Kim, Gita Thanarajasingam, Philippe Armand, Joseph H. Antin, Corey Cutler, Sarah Nikiforow, Vincent T. Ho, John Koreth, Edwin P. Alyea, Robert J. Soiffer

https://doi.org/10.3324/haematol.2015.129650

Predictive models for ocular chronic graft-versus-host disease diagnosis and disease activity in transplant clinical practice (1031 Online Views)

Lauren M. Curtis, Manuel B. Datiles, Seth M. Steinberg, Sandra A. Mitchell, Rachel J. Bishop, Edward W. Cowen, Jacqueline Mays, John M. McCarty, Zoya Kuzmina, Filip Pirsl, Daniel H. Fowler, Ronald E. Gress, Steven Z. Pavletic

https://doi.org/10.3324/haematol.2015.124131

An International MDS/MPN Working Group’s perspective and recommendations on molecular pathogenesis, diagnosis and clinical characterization of myelodysplastic/myeloproliferative neoplasms (5133 Online Views)

Tariq I. Mughal, Nicholas C.P. Cross, Eric Padron, Ramon V. Tiu, Michael Savona, Luca Malcovati, Raoul Tibes, Rami S. Komrokji, Jean-Jacques Kiladjian, Guillermo Garcia-Manero, Attilio Orazi, Ruben Mesa, Jaroslaw P. Maciejewski, Pierre Fenaux, Raphael Itzykson, Ghulam Mufti, Eric Solary, Alan F. List

https://doi.org/10.3324/haematol.2014.114660

Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation (1439 Online Views)

Carine Fillebeen, Konstantinos Gkouvatsos, Gabriela Fragoso, Annie Calvé, Daniel Garcia-Santos, Marzell Buffler, Christiane Becker, Klaus Schümann, Prem Ponka, Manuela M. Santos, Kostas Pantopoulos

https://doi.org/10.3324/haematol.2015.126870

Personalized reference intervals for platelet count reduce the number of subjects with unexplained thrombocytopenia (2962 Online Views)

Carlo Zaninetti, Ginevra Biino, Patrizia Noris, Federica Melazzini, Elisa Civaschi, Carlo L. Balduini

https://doi.org/10.3324/haematol.2015.127597

Flow cytometric detection of MPL (CD110) as a diagnostic tool for differentiation of congenital thrombocytopenias (535 Online Views)

Matthias Ballmaier, Wolfgang Holter, Manuela Germeshausen

https://doi.org/10.3324/haematol.2015.125963

Repeat course of rabbit antithymocyte globulin as salvage following initial therapy with rabbit antithymocyte globulin in acquired aplastic anemia (623 Online Views)

Diego V. Clé, Elias H. Atta, Danielle S. P. Dias, Carlos B. L. Lima, Mariana Bonduel, Gabriela Sciuccati, Larissa A. Medeiros, Michel M. de Oliveira, Marco A. Salvino, Marlene Garanito, Sara T. Ollala Saad, Rodrigo T. Calado, Phillip Scheinberg

https://doi.org/10.3324/haematol.2015.123760

The effects of JAK inhibitor therapy upon novel markers of thrombosis In myeloproliferative neoplasms (601 Online Views)

Clodagh Keohane, Donal P. McLornan, Katy Sanchez, Christopher Connor, Deepti Radia, Claire N. Harrison

https://doi.org/10.3324/haematol.2015.128918

Adverse prognostic effect of homozygous TET2 mutation on the relapse risk of acute myeloid leukemia in patients of normal karyotype (828 Online Views)

Jae-Sook Ahn, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Il-Kwon Lee, Nan Young Kim, Mark D Minden, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Namshin Kim, Kenichi Yoshida, Seishi Ogawa, Dennis Dong Hwan Kim

https://doi.org/10.3324/haematol.2015.126227

BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures (1104 Online Views)

Judith M. Boer, João R. M. Marchante, William E. Evans, Martin A. Horstmann, Gabriele Escherich, Rob Pieters, Monique L. Den Boer

https://doi.org/10.3324/haematol.2015.124941

Immunohistochemical differentiation between follicular lymphoma and nodal marginal zone lymphoma – combined performance of multiple markers (1495 Online Views)

Michiel van den Brand, Janneke J.M. Mathijssen, Mar Garcia-Garcia, Konnie M. Hebeda, Patricia J.T.A. Groenen, Brunangelo Falini, Sergio Serrano, J. Han J.M. van Krieken

https://doi.org/10.3324/haematol.2014.120956

Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets (1567 Online Views)

Laurence de Leval, Marie Parrens, Fabien Le Bras, Jean-Philippe Jais, Virginie Fataccioli, Antoine Martin, Laurence Lamant, Richard Delarue, Françoise Berger, Flavie Arbion, Céline Bossard, Marie-Christine Copin, Danielle Canioni, Frédéric Charlotte, Gandhi Damaj, Peggy Dartigues, Bettina Fabiani, Albane Ledoux-Pilon, Karine Montagne, Thierry Molina, Martine Patey, Patrick Tas, Michel Peoch, Barbara Petit, Tony Petrella, Jean-Michel Picquenot, Thérèse Rousset, Marie-Christine Rousselet, Isabelle Soubeyran, Sylvie Thiebault, Olivier Tournilhac, Luc Xerri, Christian Gisselbrecht, Corinne Haioun, Georges Delsol, Philippe Gaulard

https://doi.org/10.3324/haematol.2015.126300

ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2 (660 Online Views)

Saskia A.G.M. Cillessen, Nathalie J. Hijmering, Laura M. Moesbergen, Wim Vos, Sue Ellen Verbrugge, Gerrit Jansen, Otto J. Visser, Joost J. Oudejans, Chris J.L.M. Meijer

https://doi.org/10.3324/haematol.2014.118828

The utility of mRNA analysis in defining SOX11 expression levels in mantle cell lymphoma and reactive lymph nodes (478 Online Views)

Martin Lord, Agata M. Wasik, Birger Christensson, Birgitta Sander

https://doi.org/10.3324/haematol.2015.123885

Management of carbapenem resistant Klebsiella pneumoniae infections in stem cell transplant recipients: an Italian multidisciplinary consensus statement (1040 Online Views)

Corrado Girmenia, Claudio Viscoli, Alfonso Piciocchi, Laura Cudillo, Stefano Botti, Antonio Errico, Loredana Sarmati, Fabio Ciceri, Franco Locatelli, Maddalena Giannella, Matteo Bassetti, Carlo Tascini, Letizia Lombardini, Ignazio Majolino, Claudio Farina, Francesco Luzzaro, Gian Maria Rossolini, Alessandro Rambaldi

https://doi.org/10.3324/haematol.2015.125484