P104 | Soluble BCMA mirrors bone marrow disease burden and predicts outcome in multiple myeloma patients (147 Online Views)

D. Soncini^1|2, I. Traverso¹, G. Giorgetti², A.E. Laserra¹, E. Catini¹, F. Guolo^1|2, M. Garibotto², A. Cagnetta², R.M. Lemoli^1|2, M. Cea^1|2 | ¹Clinic of Hematology, Department of Internal Medicine and Medical Specialties ^DiMI, University of Genoa; ²IRCCS Ospedale Policlinico San Martino

CO32 | ARQ531 targets MAPK–S6K1 signaling and synergizes with lenalidomide in RAS-mutant and wild-type multiple myeloma (107 Online Views)

D. Soncini^1|2, P. Becherini D.², E. Gelli³, M. Chen⁴, A. Carreira⁵, Provenzani A.⁵, F. Ladisa², M. Squillario¹, I. Traverso², G. Giorgetti¹, M. Garibotto¹, F. Guolo^1|2, M. Piana¹, R.M. Lemoli^1|2, M. Cea^1|2 | ¹IRCCS Ospedale Policlinico San Martino; ²Clinic of Hematology, Department of Internal Medicine and Medical Specialties DiMI, University of Genoa; ³Genetics and Epigenetics of Behavior Laboratory, Fondazione Istituto Italiano di Tecnologia IIT; ⁴Harvard University; ⁵Department of Cellular, Computational and Integrative Biology CIBIO, University of Trento, Italy

A02 | Role of metabolic alterations in the marrow microenvironment in the response to immunotherapy in multiple myeloma (139 Online Views)

Michele Cea | Chair of Hematology, Department of Internal Medicine and Medical Specialties - DiMI, University of Genoa; IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment (3577 Online Views)

Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea

The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs (3042 Online Views)

Debora Soncini, Stefania Orecchioni, Samantha Ruberti, Paola Minetto, Claudia Martinuzzi, Luca Agnelli, Katia Todoerti, Antonia Cagnetta, Maurizio Miglino, Marino Clavio, Paola Contini, Riccardo Varaldo, Micaela Bergamaschi, Fabio Guolo, Mario Passalacqua, Alessio Nencioni, Fiammetta Monacelli, Marco Gobbi, Antonino Neri, Giovanni Abbadessa, Sudharshan Eathiraj, Brian Schwartz, Francesco Bertolini, Roberto M. Lemoli, Michele Cea

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents (3137 Online Views)

Antonia Cagnetta, Debora Soncini, Stefania Orecchioni, Giovanna Talarico, Paola Minetto, Fabio Guolo, Veronica Retali, Nicoletta Colombo, Enrico Carminati, Marino Clavio, Maurizio Miglino, Micaela Bergamaschi, Aimable Nahimana, Michel Duchosal, Katia Todoerti, Antonino Neri, Mario Passalacqua, Santina Bruzzone, Alessio Nencioni, Francesco Bertolini, Marco Gobbi, Roberto M. Lemoli, Michele Cea