The interleukin-1 receptor accessory protein (IL1RAP) is upregulated in plasma membranes of stem/progenitor cells from acute myeloid leukemia patients. This study suggests that blocking the IL1-IL1RAP signaling axis might reduce inflammation in the bone marrow niche and thereby promote normal hematopoietic recovery over leukemic proliferation after chemotherapy.

The prognosis of patients with Richter’s transformation (RT) of chronic lymphocytic leukemia remains poor. This retrospective analysis investigated 28 patients with such a condition who underwent allogeneic hematopoietic cell transplantation (alloHCT). It was concluded that a sizeable proportion of patients with RT in remission can achieve durable remissions, and that alloHCT should be considered as a treatment option for patients who are fit and have controlled disease.