Vol. 109 No. 10 (2024): October, 2024

Xiaoyuan Gong, Qiuyun Fang, Runxia Gu, Shaowei Qiu, Kaiqi Liu, Dong Lin, Chunlin Zhou, Guangji Zhang, Benfa Gong, Yuntao Liu, Yan Li, Bingcheng Liu, Ying Wang, Hui Wei, Yingchang Mi, Jianxiang Wang

https://doi.org/10.3324/haematol.2023.284228

Inotuzumab ozogamicin combined with chemotherapy in pediatric B-cell precursor CD22⁺ acute lymphoblastic leukemia: results of the phase IB ITCC-059 trial (2087 Online Views)

Edoardo Pennesi, Erica Brivio, Anneke C. J. Ammerlaan, Yilin Jiang, Vincent H. J. van der Velden, H. Berna Beverloo, Barbara Sleight, Franco Locatelli, Benoit Brethon, Claudia Rossig, Gernot Engstler, Anna Nilsson, Benedicte Bruno, Arnaud Petit, Bella Bielorai, Carmelo Rizzari, Fanny Rialland, Alba Rubio-San-Simón, Francisco J. Bautista Sirvent, Cristina Diaz-de-Heredia, Susana Rives, Christian M. Zwaan

https://doi.org/10.3324/haematol.2023.284409

Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia (1344 Online Views)

Sarah Meyers, Olga Gielen, Jan Cools, Sofie Demeyer

https://doi.org/10.3324/haematol.2023.284901

CD74 is expressed in a subset of pediatric acute myeloid leukemia patients and is a promising target for therapy: a report from the Children’s Oncology Group (1505 Online Views)

Andrew J. Menssen, Chad A. Hudson, Todd Alonzo, Robert Gerbing, Laura Pardo, Amanda Leonti, Jacqueline A. Cook, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Collette Fearing, Keely Ghirardelli, Tiffany Hylkema, Katherine Tarlock, Keith R. Loeb, Edward A. Kolb, Todd Cooper, Jessica Pollard, Denise A. Wells, Michael R. Loken, Richard Aplenc, Soheil Meshinchi, Lisa Eidenschink Brodersen

https://doi.org/10.3324/haematol.2023.283757

Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia (1740 Online Views)

Sarah A. Pötgens, Violaine Havelange, Sophie Lecop, Fuyong Li, Audrey M. Neyrinck, Florence Bindels, Nathalie Neveux, Jean-Baptiste Demoulin, Ine Moors, Tessa Kerre, Johan Maertens, Jens Walter, Hélène Schoemans, Nathalie M. Delzenne, Laure B. Bindels

https://doi.org/10.3324/haematol.2023.284138

Small extracellular vesicles derived from acute myeloid leukemia cells promote leukemogenesis by transferring miR-221-3p (1574 Online Views)

Mengyu Li, Guohuan Sun, Jinlian Zhao, Shuangshuang Pu, Yanling Lv, Yifei Wang, Yapu Li, Xiangnan Zhao, Yajie Wang, Shangda Yang, Tao Cheng, Hui Cheng

https://doi.org/10.3324/haematol.2023.284145

Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes (1414 Online Views)

Federica Galaverna, Sara Flamini, Carmen Dolores De Luca, Ilaria Pili, Emilia Boccieri, Francesca Benini, Francesco Quagliarella, Chiara Rosignoli, Marco Rosichini, Shirley Genah, Marialuigia Catanoso, Antonella Cardinale, Gabriele Volpe, Marianna Coccetti, Angela Pitisci, Giuseppina Li Pira, Roberto Carta, Barbarella Lucarelli, Francesca Del Bufalo, Valentina Bertaina, Marco Becilli, Daria Pagliara, Mattia Algeri, Pietro Merli, Franco Locatelli, Enrico Velardi

https://doi.org/10.3324/haematol.2023.284649

The diversity of the microbiome impacts chronic lymphocytic leukemia development in mice and humans (1429 Online Views)

Tereza Faitova, Mariana Coelho, Caspar da Cunha-Bang, Selcen Ozturk, Ece Kartal, Peer Bork, Martina Seiffert, Carsten U. Niemann

https://doi.org/10.3324/haematol.2023.284693

Treatment of chronic-phase chronic myeloid leukemia in patients randomized to dasatinib or imatinib after suboptimal responses to 3 months of imatinib therapy: final 5-year results from DASCERN (1693 Online Views)

Jorge E. Cortes, Qian Jiang, Jianxiang Wang, Jianyu Weng, Huanling Zhu, Xiaoli Liu, Andreas Hochhaus, Dong-Wook Kim, Jerald Radich, Michael Savona, Patricia Martin-Regueira, Oumar Sy, Giuseppe Saglio

https://doi.org/10.3324/haematol.2023.283428

Use of defibrotide in COVID-19 pneumonia: comparison of a phase II study and a matched real-world cohort control (1035 Online Views)

Annalisa Ruggeri, Francesco Corrado, Antonio Voza, Lee-Jen Wei, Gloria Catalano, Carmine Liberatore, Rosamaria Nitti, Carlo Fedeli, Alessandro Bruno, Eleonora Calabretta, Fabio Giglio, Fabio Sciutti, Francesca Lunghi, Giovanni Landoni, Alessio Aghemo, Massimo Iacobelli, Patrizia Rovere Querini, Paul G. Richardson, Andrea Assanelli, Jacopo Peccatori, Fabio Ciceri, Carmelo Carlo-Stella

https://doi.org/10.3324/haematol.2024.285345

Cell-free DNA from nail clippings as source of normal control for genomic studies in hematologic malignancies (1826 Online Views)

Melissa Krystel-Whittemore, Kseniya Petrova-Drus, Ryan N. Ptashkin, Mark D. Ewalt, JinJuan Yao, Ying Liu, Menglei Zhu, Jamal Benhamida, Benjamin Durham, Jyoti Kumar, Khedoudja Nafa, Iwona Kiecka, Anita S. Bowman, Erika Gedvilaite, Jacklyn Casanova, Yun-Te Lin, Abhinita S. Mohanty, Satshil Rana, Anoop Balakrishnan Rema, Ivelise Rijo, Nelio Chaves, Paulo Salazar, Anita Yun, Sean Lachhander, Wei Wang, Mohammad S. Haque, Wenbin Xiao, Mikhail Roshal, Sergio Giralt, Gilles Salles, Raajit Rampal, Eytan M. Stein, Miguel-Angel Perales, Steven Horwitz, Ann Jakubowski, Doris Ponce, Alina Markova, Ozge Birsoy, Diana Mandelker, Simon Mantha, Ahmet Dogan, Ryma Benayed, Marc Ladanyi, Michael F. Berger, A. Rose Brannon, Ahmet Zehir, Chad Vanderbilt, Maria E. Arcila

https://doi.org/10.3324/haematol.2024.285054

Continuous and differential improvement in worldwide access to hematopoietic cell transplantation: activity has doubled in a decade with a notable increase in unrelated and non-identical related donors (1854 Online Views)

Yoshiko Atsuta, Helen Baldomero, Daniel Neumann, Anna Sureda, Jakob D. DeVos, Minako Iida, Amado Karduss, Duncan Purtill, Alaa M. Elhaddad, Nosa G. Bazuaye, Carmem Bonfim, Rafael de la Camara, Naeem A. Chaudhri, Fabio Ciceri, Cinthya Correa, Cristobal Frutos, Sebastian Galeano, Laurent Garderet, Oscar Gonzalez-Ramella, Raffaella Greco, Nada Hamad, Mette D. Hazenberg, Mary M. Horowitz, Krzysztof Kalwak, Bor-Sheng Ko, Yoshihisa Kodera, Mickey B.C. Koh, Kaiyan Liu, Donal P. McLornan, Joon Ho Moon, Benedicte Neven, Shinichiro Okamoto, Marcelo C. Pasquini, Jakob R. Passweg, Kristjan Paulson, Damiano Rondelli, Annalisa Ruggeri, Adriana Seber, John A. Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Hildegard Greinix, Wael Saber, Mahmoud Aljurf, Dietger Niederwieser

https://doi.org/10.3324/haematol.2024.285002

Checkpoint inhibition enhances cell contacts between CD4⁺ T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma (879 Online Views)

Kübra Yadigaroglu, Sonja Scharf, Steffen Gretser, Hendrik Schäfer, Aresu Sadeghi Shoreh Deli, Andreas G. Loth, Hasmik Yegoryan, Roland Schmitz, Emmanuel Donnadieu, Martin-Leo Hansmann, Sylvia Hartmann

https://doi.org/10.3324/haematol.2023.284512

Pilot study of lung cancer screening for survivors of Hodgkin lymphoma (1032 Online Views)

Rachel Broadbent, Philip Crosbie, Christopher J. Armitage, Ben Taylor, Sean Tenant, Joseph Mercer, John Radford, Kim Linton

https://doi.org/10.3324/haematol.2023.283287

Targeting CD19-positive lymphomas with the antibodydrug conjugate loncastuximab tesirine: preclinical evidence of activity as a single agent and in combination therapy (1622 Online Views)

Chiara Tarantelli, David Wald, Nicolas Munz, Filippo Spriano, Alessio Bruscaggin, Eleonora Cannas, Luciano Cascione, Eugenio Gaudio, Alberto J. Arribas, Shivaprasad Manjappa, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Giorgio Inghirami, Patrick H. van Berkel, Davide Rossi, Paolo F. Caimi, Francesca Zammarchi, Francesco Bertoni

https://doi.org/10.3324/haematol.2023.284197

Efficacy of intravenous high-dose methotrexate in preventing relapse to the central nervous system in R-CHOP(-like)-treated, high-risk, diffuse large B-cell lymphoma patients and its effect on mortality: a systematic review and meta-analysis (2726 Online Views)

Elisabeth R. Tolley, Christian Lewinter, Lars M. Pedersen, Torsten Holm Nielsen

https://doi.org/10.3324/haematol.2023.284281

Impact and utility of follicular lymphoma GELF criteria in routine care: an Australasian Lymphoma Alliance study (2168 Online Views)

Allison Barraclough, Shivam Agrawal, Dipti Talaulikar, Geoffrey Chong, Edward Yoo, Chan Y. Cheah, Nunzio Franco, Bianca Nguyen, Howard Mutsando, Fatima Tahir, Judith Trotman, Jing Huang, Colm Keane, Mitchel Lincoln, Tara Cochrane, Anna M. Johnston, Michael Dickinson, Stephen Opat, Zoe K. McQuilten, Erica M. Wood, Gayathri St George, Eliza A. Hawkes

https://doi.org/10.3324/haematol.2023.284538

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment (1134 Online Views)

Sarah Liane Linguet, Suzanne Verlhac, Florence Missud, Laurent Holvoet-Vermaut, Valentine Brousse, Ghislaine Ithier, Alexandra Ntorkou, Emmanuelle Lesprit, Malika Benkerrou, Manoëlle Kossorotoff, Berengere Koehl

https://doi.org/10.3324/haematol.2023.283773

Long-term efficacy and safety of tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: final analysis of phase IIb results (1765 Online Views)

Shinya Rai, Won Seog Kim, Kiyoshi Ando, Ilseung Choi, Koji Izutsu, Norifumi Tsukamoto, Dai Maruyama, Kunihiro Tsukasaki, Junya Kuroda, Jun Ando, Michihiro Hidaka, Youngil Koh, Hisashi Kato, Toshiki Uchida, Deok Hwan Yang, Kenji Ishitsuka, Kenichi Ishizawa, Jin Seok Kim, Hong Ghi Lee, Hironobu Minami, Hyeon Seok Eom, Mitsutoshi Kurosawa, Jae Hoon Lee, Jong Seok Lee, Won Sik Lee, Hirokazu Nagai, Takero Shindo, Dok Hyun Yoon, Shinichiro Yoshida, Mireille Gillings, Hiroshi Onogi, Kensei Tobinai

https://doi.org/10.3324/haematol.2023.283992

An investigation of germline variants of HAVCR2 in subcutaneous panniculitis-like T-cell lymphoma and related lesions in a North American population (732 Online Views)

Jinjun Cheng, Liqiang Xi, Yoon Jang, Jung Kim, Hao-Wei Wang, Stefania Pittaluga, Elaine S. Jaffe, Mark Raffeld

https://doi.org/10.3324/haematol.2023.284738

Soluble urokinase plasminogen activator receptor is associated with kidney disease and its progression in sickle cell anemia (780 Online Views)

Rima S. Zahr, Sara R. Rashkin, Maria Armila Ruiz, Laila Elsherif, Guohui Ren, Guadalupe Salas, Kenneth I. Ataga, Victor R. Gordeuk, Jeffrey Lebensburger, Xu Zhang, Santosh L. Saraf

https://doi.org/10.3324/haematol.2023.284920

PD-1 blockade and allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma, a matter of time: a national study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (801 Online Views)

Eleonore Kaphan, Francois Bettega, Nicolas Vallet, Nathalie Fegueux, Marie Robin, Ali Bazarbachi, Stephanie Nguyen, David Beauvais, Edouard Forcade, Maria Carolina Montes De Oca, Raynier Devillier, Patrice Chevallier, Michael Loschi, Anne Huynh, Jacques-Olivier Bay, Marie-Therese Rubio, Felipe Suarez, Sylvie Francois, Xavier Poire, Nathalie Contentin, Deborah Desmier, Amandine Charbonnier, Jerome Cornillon, Sylvain Chantepie, Pascal Turlure, Claude-Eric Bulabois, David Michonneau, Alban Villate; SFGM-TC (Collaborative Group)

https://doi.org/10.3324/haematol.2024.284968

The phase III DUO trial of PI3K inhibitor duvelisib versus ofatumumab in relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma: final analysis including overall survival (1020 Online Views)

Alexey V. Danilov, Ian W. Flinn, Matthew S. Davids, Beth Gregory, Ohad Bentur, David Sidransky, Jennifer R. Brown

https://doi.org/10.3324/haematol.2024.285043

Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings (1282 Online Views)

Ozge Ceyhan-Birsoy, Elise Fiala, Satshil Rana, Margaret Sheehan, Jennifer Kennedy, Zarina Yelskaya, Vikas Rai, Yirong Li, Ciyu Yang, Donna Wong, Ivelise Rijo, Jacklyn Casanova, Joshua Somar, Nikita Mehta, Hyeonjin Park, Silvana Ostafi, Kanika Arora, Angelika Padunan, Mark D. Ewalt, Umut Aypar, Panieh Terraf, Maksym Misyura, Sofia Haque, Gerald G. Behr, Tamanna Haque, Maria Sulis, Mark B. Geyer, Christopher Forlenza, Meghan C. Thompson, Maria Carlo, Alicia Latham, Ying Liu, Ahmet Zehir, Rose Brannon, Michael Berger, Luis A Diaz Jr, Ahmet Dogan, Marc Ladanyi, Kseniya Petrova-Drus, Khedoudja Nafa, Kenneth Offit, Maria Arcila, Zsofia K. Stadler, Michael F. Walsh, Diana Mandelker

https://doi.org/10.3324/haematol.2024.285055

Factor VIII promotes angiogenesis and vessel stability regulating extracellular matrix proteins (914 Online Views)

Cristina Olgasi, Alessia Cucci, Ivan Molineris, Simone Assanelli, Francesca Anselmi, Chiara Borsotti, Chiara Sgromo, Andrea Lauria, Simone Merlin, Gillian E. Walker, Salvatore Oliviero, Antonia Follenzi

https://doi.org/10.3324/haematol.2024.285089

Validation and molecular integration of the RR6 model to predict survival after 6 months of therapy with ruxolitinib (876 Online Views)

Giacomo Coltro, Giulio Capecchi, Margherita Maffioli, Francesco Mannelli, Barbara Mora, Alessandro Atanasio, Alessandra Iurlo, Chiara Maccari, Mirko Farina, Elena Nacca, Marianna Caramella, Leonardo Signori, Miriam Borella, Lorenza Bertù, Maria Esposito, Paola Guglielmelli, Francesco Passamonti, Alessandro Maria Vannucchi

https://doi.org/10.3324/haematol.2024.285098

Reduced toxicity conditioning for hematopoietic stem cell transplantation in children with Diamond-Blackfan anemia (780 Online Views)

Amr Qudeimat, Shruthi Suryaprakash, Renee Madden, Ashok Srinivasan, Marcin W. Wlodarski, Senthil Velan Bhoopalan

https://doi.org/10.3324/haematol.2024.285147

Changes in sex-specific incidence of lymphoid neoplasms across the lifespan (577 Online Views)

Bryan Valcarcel, Sara J. Schonfeld, Sarah S. Jackson, Graça M. Dores, Martha S. Linet, Lindsay M. Morton

https://doi.org/10.3324/haematol.2024.285281

Soluble SLAMF7 is generated by alternative splicing in multiple myeloma cells (956 Online Views)

Jiro Kikuchi, Mitsuo Hori, Naoki Osada, Sae Matsuoka, Atsushi Suzuki, Satoshi Kakugawa, Hiroshi Yasui, Takeshi Harada, Hirofumi Tenshin, Masahiro Abe, Hideki Nakasone, Yusuke Furukawa

https://doi.org/10.3324/haematol.2024.285368

ASXL1/TET2 genotype-based risk stratification outperforms ASXL1 mutational impact and is independent of mutant variant allele fractions in chronic myelomonocytic leukemia (892 Online Views)

Clifford M. Csizmar, Mark Gurney, Rashmi Kanagal-Shamanna, Kelly Chien, Danielle Hammond, Terra L. Lasho, Christy M. Finke, Christopher Dean, Anuya Natu, Abhishek A. Mangaonkar, Aref Al-Kali, Naseema Gangat, Ayalew Tefferi, Hassan Alkhateeb, Guillermo Garcia-Manero, Rami S. Komrokji, Najla A. Ali, Eric Padron, Guillermo Montalban-Bravo, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2024.285410

Ethnic diversity in presentation and outcome of Waldenström macroglobulinemia and IgM monoclonal gammopathy of clinical significance in the United Kingdom (1716 Online Views)

Jahanzaib Khwaja, Nicole Japzon, Maria Gabriel, Oliver Tomkins, Jindriska Lindsay, Charalampia Kyriakou, Ashutosh Wechalekar, Shirley D’Sa

https://doi.org/10.3324/haematol.2024.285420

De-escalation of corticosteroids and clonal remission in UBA1 mutation-driven VEXAS syndrome with 5-azacytidine (1215 Online Views)

Roochi Trikha, Kar Lok Kong, James Galloway, Tanya N. Basu, Lynn Quek, Jamie Wilson, Louise Gamble, Henna Wong, Steven Best, Austin Kulasekararaj

https://doi.org/10.3324/haematol.2024.285519

Infrequent fractures and resilient bone mineral density: bone health in patients with Fanconi anemia (602 Online Views)

Jane Koo, Jonathan C. Howell, Lindsey Hornung, Anthony Sabulski, Parinda A. Mehta, Stella M. Davies, Kasiani C. Myers

https://doi.org/10.3324/haematol.2024.285612

Treatment strategies for progressive immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome: case series (1274 Online Views)

Jack J. Scala, Michael J. Eckrich, Keagan Lipak, Bonnie Yates, Constance Yuan, Hao-Wei Wang, Saurabh Dahiya, Jan-Inge Henter, Jeffrey S. Huo, Matthew J. Frank, Nirali N. Shah

https://doi.org/10.3324/haematol.2023.284784

A case of familial donor-derived acute myeloid leukemia with underlying pre-leukemic mutations (1147 Online Views)

Luca Vincenzo Cappelli, Clara Minotti, Manja Meggendorfer, Marietta Truger, Torsten Haferlach, Cristina Mecucci, Caterina Matteucci, Caterina Alati, Anna Paola Iori, Maurizio Martelli, Robin Foà

https://doi.org/10.3324/haematol.2024.285156