November, 2023
No. 108 (11)

Landmark papers in Hematology

Editorials

Review Articles

Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma (2407 Online Views)

Paul G. Richardson, Brian G. Durie, Laura Rosiñol, Maria-Victoria Mateos, Angela Dispenzieri, Philippe Moreau, Shaji Kumar, Noopur Raje, Nikhil Munshi, Jacob P. Laubach, Peter O’Gorman, Elizabeth O’Donnell, Peter Voorhees, Thierry Facon, Joan Bladé, Sagar Lonial, Aurore Perrot, Kenneth C. Anderson

https://doi.org/10.3324/haematol.2022.282624

Articles

Acute Myeloid Leukemia

Blood Transfusion

Inhibition of GPIb-α-mediated apoptosis signaling enables cold storage of platelets (1153 Online Views)

Irene Marini, Lisann Pelzl, Yoko Tamamushi, Chiara-Tanita Maettler, Andreas Witzemann, Karina Althaus, Stefanie Nowak-Harnau, Erhard Seifried, Tamam Bakchoul

https://doi.org/10.3324/haematol.2022.282572

Cell Therapy & Immunotherapy

Salvage radiotherapy in relapsed/refractory large B-cell lymphoma after failure of CAR T-cell therapy (1557 Online Views)

Hazim S. Ababneh, Andrea K. Ng, Matthew J. Frigault, Jeremy S Abramson, Patrick Connor Johnson, Caron A. Jacobson, Chirayu G. Patel

https://doi.org/10.3324/haematol.2023.282804

Consolidative radiotherapy for residual fluorodeoxyglucose activity on day +30 post CAR T-cell therapy in non-Hodgkin lymphoma (2263 Online Views)

Omran Saifi, William G Breen, Scott C Lester, William G Rule, Bradley J Stish, Allison Rosenthal, Javier Munoz, Yi Lin, Radhika Bansal, Matthew A Hathcock, Patrick B Johnston, Stephen M Ansell, Jonas Paludo, Arushi Khurana, Jose C Villasboas, Yucai Wang, Madiha Iqbal, Muhamad Alhaj Moustafa, Hemant S Murthy, Mohamed A. Kharfan-Dabaja, Jennifer L Peterson, Bradford S Hoppe

https://doi.org/10.3324/haematol.2023.283311

Intestinal IgA-positive plasma cells are highly sensitive indicators of alloreaction early after allogeneic transplantation and associate with both graft-versus-host disease and relapse-related mortality (1268 Online Views)

Lucia Scheidler, Katrin Hippe, Sakhila Ghimire, Daniela Weber, Markus Weber, Elisabeth Meedt, Petra Hoffmann, Petra Lehn, Ralph Burkhardt, Andreas Mamilos, Matthias Edinger, Daniel Wolff, Hendrik Poeck, Matthias Evert, Andre Gessner, Wolfgang Herr, Ernst Holler

https://doi.org/10.3324/haematol.2022.282188

Azacitidine, lenalidomide and donor lymphocyte infusions for relapse of myelodysplastic syndrome, acute myeloid leukemia and chronic myelomonocytic leukemia after allogeneic transplant: the Azalena-Trial (2527 Online Views)

Thomas Schroeder, Matthias Stelljes, Maximilian Christopeit, Eva Esseling, Christoph Scheid, Jan-Henrik Mikesch, Christina Rautenberg, Paul Jäger, Ron-Patrick Cadeddu, Nadja Drusenheimer, Udo Holtick, Stefan Klein, Rudolf Trenschel, Rainer Haas, Ulrich Germing, Nicolaus Kröger, Guido Kobbe

https://doi.org/10.3324/haematol.2022.282570

Chronic Lymphocytic Leukemia

Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia (1099 Online Views)

Giulia Pagano, Iria Fernandez Botana, Marina Wierz, Philipp M. Roessner, Nikolaos Ioannou, Xiangda Zhou, Gheed Al-Hity, Coralie Borne, Ernesto Gargiulo, Susanne Gonder, Bin Qu, Basile Stamatopoulos, Alan G. Ramsay, Martina Seiffert, Anne Largeot, Etienne Moussay, Jerome Paggetti

https://doi.org/10.3324/haematol.2022.282474

Hodgkin Lymphoma

Effect of cumulative dose of brentuximab vedotin maintenance in relapsed/refractory classical Hodgkin lymphoma after autologous stem cell transplant: an analysis of real-world outcomes (2142 Online Views)

Charlotte B. Wagner, Ken Boucher, Adrienne Nedved, Ivana N. Micallef, Sanjal Desai, Haris Hatic, Gaurav Goyal, Erin Zacholski, Amanda Fegley, Audrey M. Sigmund, David A. Bond, Courtney Samuels, Manali K. Kamdar, Sheeba Ba Aqeel, Pallawi Torka, Kira MacDougall, Azra Borogovac, Sridevi Rajeeve, Suchitra Sundaram, Kalub Fedak, Dipenkumar Modi, Elizabeth Travers, Sabarish Ayyappan, Nitin Chilakamarri, Elizabeth A. Brem, Daniel A. Ermann, Lindsey A. Fitzgerald, Boyu Hu, Deborah M. Stephens, Harsh Shah

https://doi.org/10.3324/haematol.2023.282780

Myelodysplastic Syndromes

Clinical and molecular correlates of somatic and germline DDX41 variants in patients and families with myeloid neoplasms (2045 Online Views)

Talha Badar, Ahmad Nanaa, James M. Foran, David Viswanatha, Aref Al-Kali, Terra Lasho, Christy Finke, Hassan B Alkhateeb, Rong He, Naseema Gangat, Mithun Shah, Ayalew Tefferi, Abhishek A Mangaonkar, Mark R Litzow, Laura J. Ongie, Timothy Chlon, Alejandro Ferrer, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2023.282867

Non-Hodgkin Lymphoma

Characterization and clinical impact of the tumor microenvironment in post-transplant aggressive B-cell lymphomas (954 Online Views)

Suvi-Katri Leivonen, Terhi Friman, Matias Autio, Samuli Vaittinen, Andreas Wind Jensen, Francesco d’Amore, Stephen Jacques Hamilton-Dutoit, Harald Holte, Klaus Beiske, Panu E. Kovanen, Riikka Räty, Sirpa Leppä

https://doi.org/10.3324/haematol.2023.282831

Predictors of SARS-CoV-2 Omicron breakthrough infection after receipt of AZD7442 (tixagevimab-cilgavimab) for pre-exposure prophylaxis among hematologic malignancy patients (2706 Online Views)

Justin C. Laracy, Judy Yan, Samantha N. Steiger, Carrie A. Tan, Nina Cohen, Elizabeth V. Robilotti, Jerome Fender, Sara Cohen, Neha Korde, Melissa Lee-Teh, Ariela Noy, Joseph H. Oved, Lindsey E. Roeker, Gunjan Shah, N. Esther Babady, Mini Kamboj, Susan K. Seo

https://doi.org/10.3324/haematol.2023.283015

Red Cell Biology & its Disorders

Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis (877 Online Views)

Marine Delamare, Amandine Le Roy, Mathilde Pacault, Loïc Schmitt, Céline Garrec, Nada Maaziz, Matti Myllykoski, Antoine Rimbert, Valéna Karaghiannis, Bernard Aral, Mark Catherwood, Fabrice Airaud, Lamisse Mansour-Hendili, David Hoogewijs, Edoardo Peroni, Salam Idriss, Valentine Lesieur, Amandine Caillaud, Karim Si-Tayeb, Caroline Chariau, Anne Gaignerie, Minke Rab, Torsten Haferlach, Manja Meggendorfer, Stéphane Bézieau, Andrea Benetti, Nicole Casadevall, Pierre Hirsch, Christian Rose, Mathieu Wemeau, Frédéric Galacteros, Bruno Cassinat, Beatriz Bellosillo, Celeste Bento, Richard van Wijk, Petro E. Petrides, Maria Luigia Randi, Mary Frances McMullin, Peppi Koivunen, François Girodon, Betty Gardie; ECYT consortium (Collaborative Group)

https://doi.org/10.3324/haematol.2023.282913

Increased retention of functional mitochondria in mature sickle red blood cells is associated with increased sickling tendency, hemolysis and oxidative stress (1052 Online Views)

Sofia Esperti, Elie Nader, Antoine Stier, Camille Boisson, Romain Carin, Muriel Marano, Mélanie Robert, Marie Martin, Françoise Horand, Agnes Cibiel, Céline Renoux, Robin Van Bruggen, Colin Blans, Yesim Dargaud, Philippe Joly, Alexandra Gauthier, Solène Poutrel, Marc Romana, Damien Roussel, Philippe Connes

https://doi.org/10.3324/haematol.2023.282684

Letters to the Editor

TRES, a validated three-factor comorbidity score, is associated with survival in older patients with mantle cell lymphoma (1008 Online Views)

Max J. Gordon, David A. Bond, Adam S. Kittai, Neda Amirmokhtari, Abigail Steinbrunner, Allison Huffman, Victor Orellana-Noia, Geoffrey Shouse, Jonathon B. Cohen, Tycel Phillips, Alexey V. Danilov

https://doi.org/10.3324/haematol.2023.283074

Clinical and molecular features of CBL-mutated juvenile myelomonocytic leukemia (1078 Online Views)

Taro Yoshida, Hideki Muramatsu, Manabu Wakamatsu, Daichi Sajiki, Norihiro Murakami, Hironobu Kitazawa, Yasuhiro Okamoto, Rieko Taniguchi, Shinsuke Kataoka, Atsushi Narita, Asahito Hama, Yusuke Okuno, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2022.282385

Transcriptomic profiling does not refine mastocytosis diagnosis (681 Online Views)

Lars Buschhorn, Dorett I. Odoni, Johanna Geuder, Timo O. Odinius, Celina V. Wagner, Stefanie Jilg, Ulrike Höckendorf, Adam Wahida, Matthias Schlesner, Andreas Reiter, Mohamad Jawhar, Philipp J. Jost

https://doi.org/10.3324/haematol.2022.282617

A proposed predictive mathematical model for efficient T-cell collection by leukapheresis for manufacturing chimeric antigen receptor T cells (596 Online Views)

Xinxin Huang, Gina Pei Ling Gan, Esther Hian Li Chan, Kee Khiang Heng, Susila Perumal, Rohani Salleh, Jessica Mei Ling Teo, Gaoge Xie, Jing Jing Lee, Aloysius Yew Leng Ho, William Ying Khee Hwang, Yeh Ching Linn, Yunxin Chen, Jeffrey Kim Siang Quek, Hein Than, Chandramouli Nagarajan, Francesca Lorraine Wei Inng Lim

https://doi.org/10.3324/haematol.2022.282350

TET2 mutational status affects myelodysplastic syndrome evolution to chronic myelomonocytic leukemia (1397 Online Views)

Violaine Tran Quang, Benjamin Podvin, Christophe Desterke, Sihem Tarfi, Quentin Barathon, Bouchra Badaoui, Nicolas Freynet, Vincent Parinet, Mathieu Leclerc, Sébastien Maury, Eric Solary, Dorothée Selimoglu-Buet, Nicolas Duployez, Orianne Wagner-Ballon, Ivan Sloma

https://doi.org/10.3324/haematol.2022.282528

Examining the impact of age on the prognostic value of ELN-2017 and ELN-2022 acute myeloid leukemia risk stratifications: a report from the SWOG Cancer Research Network (1545 Online Views)

Christina M. Termini, Anna Moseley, Megan Othus, Frederick R. Appelbaum, Thomas R. Chauncey, Harry P. Erba, Min Fang, Stanley C. Lee, Jasmine Naru, Era L. Pogosova-Agadjanyan, Jerald P. Radich, Cheryl L. Willman, Feinan Wu, Soheil Meshinchi, Derek L. Stirewalt

https://doi.org/10.3324/haematol.2023.282733

Risk of relapse after SARS-CoV-2 vaccine in the Milan cohort of thrombotic thrombocytopenic purpura patients (1261 Online Views)

Marco Capecchi, Pasqualina De Leo, Maria Abbattista, Ilaria Mancini, Pasquale Agosti, Marina Biganzoli, Chiara Suffritti, Barbara Ferrari, Anna Lecchi, Silvia La Marca, Lidia Padovan, Erica Scalambrino, Marigrazia Clerici, Armando Tripodi, Andrea Artoni, Roberta Gualtierotti, Flora Peyvandi

https://doi.org/10.3324/haematol.2022.282478

High-risk additional cytogenetic aberrations in a Dutch chronic phase chronic myeloid leukemia patient population (798 Online Views)

Camille C.B. Kockerols, Inge G.P. Geelen, Mark-David Levin, Jeroen J.W.M. Janssen, H. Berna Beveloo, Avinash G. Dinmohamed, Mels Hoogendoorn, Jan J. Cornelissen, Peter E. Westerweel

https://doi.org/10.3324/haematol.2022.282447

Chemotherapy in solitary bone plasmacytoma to prevent evolution to multiple myeloma (794 Online Views)

Sophia Ascione, Stéphanie Harel, Florent L. Besson, Rakiba Belkhir, Julien Henry, Bruno Royer, Bertrand Arnulf, Xavier Mariette, Raphaèle Seror

https://doi.org/10.3324/haematol.2022.282214

The oncogenetic landscape and clinical impact of BCL11B alterations in adult and pediatric T-cell acute lymphoblastic leukemia (880 Online Views)

Marie Emilie Dourthe, Guillaume P. Andrieu, Amandine Potier, Estelle Balducci, Julie Guerder, Mathieu Simonin, Lucien Courtois, Arnaud Petit, Elizabeth Macintyre, Nicolas Boissel, André Baruchel, Vahid Asnafi

https://doi.org/10.3324/haematol.2022.282605

Outcome of patients with acute myeloid leukemia following failure of frontline venetoclax plus hypomethylating agent therapy (1089 Online Views)

Naseema Gangat, Rimal Ilyas, Isla M Johnson, Kristen McCullough, Aref Al-Kali, Hassan B Alkhateeb, Kebede H Begna, Abhishek Mangaonkar, Mark R Litzow, William Hogan, Mithun Shah, Mrinal M Patnaik, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2022.282677

B-lineage acute lymphoblastic leukemia causes cellautonomous defects in long-term hematopoietic stem cell function (1552 Online Views)

Christina T. Jensen, Josefine Åhsberg, Johanna Tingvall-Gustafsson, Rajesh Somasundaram, Stefan Lang, Jonas Ungerbäck, Anna Porwit, Shamit Soneji, Mikael Sigvardsson

https://doi.org/10.3324/haematol.2022.282430

Case Reports

Novel FIP1L1::KIT fusion in a myeloid neoplasm with eosinophilia, T-lymphoblastic transformation, and dasatinib response (748 Online Views)

Aseel Alsouqi, Jeffrey Kleinberger, Taylor S Werner, Rashid Awan, Saurav Chopra, Bryan Rea, Nidhi Aggarwal, Svetlana A. Yatsenko, Rafic Farah, Nathanael G. Bailey

https://doi.org/10.3324/haematol.2022.282636

Spotlight Review