August, 2023
No. 108 (8)

Landmark papers in Hematology

Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

RNA helicase DHX15 exemplifies a unique dependency in acute leukemia (1391 Online Views)

Hao Guo, Jin Xu, Peiqi Xing, Qilong Li, Donghai Wang, Chao Tang, Bruno Palhais, Juliette Roels, Jiaxu Liu, Sa Pan, Jinyan Huang, Zhaoqi Liu, Ping Zhu, Tom Taghon, Guoliang Qing, Pieter Van Vlierberghe, Hudan Liu

https://doi.org/10.3324/haematol.2022.282066

Acute Myeloid Leukemia

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia (2131 Online Views)

Eline J.M. Bertrums, Jenny L. Smith, Lauren Harmon, Rhonda E. Ries, Yi-Cheng J. Wang, Todd A. Alonzo, Andrew J. Menssen, Karen M. Chisholm, Amanda R. Leonti, Katherine Tarlock, Fabiana Ostronoff, Era L. Pogosova-Agadjanyan, Gertjan J.L. Kaspers, Henrik Hasle, Michael Dworzak, Christiane Walter, Nora Muhlegger, Cristina Morerio, Laura Pardo, Betsy Hirsch, Susana Raimondi, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Jason E. Farrar, Derek Stirewalt, Xiaotu Ma, Tim I. Shaw, Scott N. Furlan, Lisa Eidenschink Brodersen, Michael R. Loken, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Timothy J. Triche, Bianca F. Goemans, Soheil Meshinchi

https://doi.org/10.3324/haematol.2022.281653

Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia (932 Online Views)

Sabine Kayser, David Martínez-Cuadrón, Rebeca Rodriguez-Veiga, Mathias Hänel, Mar Tormo, Kerstin Schäfer-Eckart, Carmen Botella, Friedrich Stölzel, Teresa Bernal del Castillo, Ulrich Keller, Carlos Rodriguez-Medina, Gerhard Held, Maria-Luz Amigo, Christoph Schliemann, Mercedes Colorado, Martin Kaufmann, Manuel Barrios Garcia, Stefan W. Krause, Martin Görner, Edgar Jost, Björn Steffen, Sven Zukunft, Uwe Platzbecker, Anthony D. Ho, Claudia D. Baldus, Hubert Serve, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Pau Montesinos, Christoph Röllig, Richard F. Schlenk

https://doi.org/10.3324/haematol.2022.282127

Cell Therapy & Immunotherapy

Automated production of specific T cells for treatment of refractory viral infections after allogeneic stem cell transplantation (1098 Online Views)

Amadeus T Heinz, Friso G.J. Calkoen, Alexander Derbich, Lea Miltner, Christian Seitz, Michaela Doering, Christiane Braun, Daniel Atar, Michael Schumm, Florian Heubach, Anne-Marie Arendt, Ansgar Schulz, Friedhelm R Schuster, Roland Meisel, Brigitte Strahm, Juergen Finke, Beatrice Heineking, Susanne Stetter, Gerda Silling, Daniel Stachel, Bernd Gruhn, Klaus-Michael Debatin, Juergen Foell, Johannes H Schulte, Wilhelm Woessmann, Christine Mauz-Körholz, Johanna Tischer, Tobias Feuchtinger, Rupert Handgretinger, Peter Lang

https://doi.org/10.3324/haematol.2022.281996

Chronic Lymphocytic Leukemia

High rate of durable responses with undetectable minimal residual disease with front-line venetoclax and rituximab in young, fit patients with chronic lymphocytic leukemia and an adverse biological profile: results of the GIMEMA phase II LLC1518 – VERITAS study (1655 Online Views)

Francesca R. Mauro, Irene Della Starza, Monica Messina, Gianluigi Reda, Livio Trentin, Marta Coscia, Paolo Sportoletti, Lorella Orsucci, Valentina Arena, Gloria Margiotta Casaluci, Roberto Marasca, Roberta Murru, Luca Laurenti, Fiorella Ilariucci, Caterina Stelitano, Donato Mannina, Massimo Massaia, Gian Matteo Rigolin, Lydia Scarfò, Monia Marchetti, Luciano Levato, Monica Tani, Annalisa Arcari, Gerardo Musuraca, Marina Deodato, Piero Galieni, Valeria Belsito Patrizi, Daniela Gottardi, Anna Marina Liberati, Annamaria Giordano, Maria Chiara Molinari, Daniela Pietrasanta, Veronica Mattiello, Andrea Visentin, Candida Vitale, Francesco Albano, Antonino Neri, Lucia Anna De Novi, Maria Stefania De Propris, Mauro Nanni, Ilaria Del Giudice, Anna Guarini, Paola Fazi, Marco Vignetti, Alfonso Piciocchi, Antonio Cuneo, Robin Foà

https://doi.org/10.3324/haematol.2022.282116

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy (1061 Online Views)

Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

https://doi.org/10.3324/haematol.2022.282177

Hematopoiesis

The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia (1159 Online Views)

Kai Zhang, Dingdong Liu, Yafei Li, Zhencan Shi, Jun Guo, Chengjiang Gao, Hu Wang, Zhenyu Ju, Daojun Diao

https://doi.org/10.3324/haematol.2022.281955

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis (1183 Online Views)

Francesca Basso-Valentina, Alessandro Donada, Vladimir T Manchev, Manuel Lisetto, Nathalie Balayn, Jean Edouard Martin, Delphine Muller, Cecilia Paola Marin Oyarzun, Hélène Duparc, Brahim Arkoun, Alessandro Cumin, Lionel Faivre, Nathalie Droin, Ida Biunno, Alessandro Pecci, Alessandra Balduini, Najet Debili, Iléana Antony-Debré, Caroline Marty, William Vainchenker, Isabelle Plo, Remi Favier, Hana Raslova

https://doi.org/10.3324/haematol.2022.282049

Hodgkin Lymphoma

Tislelizumab with gemcitabine and oxaliplatin in patients with relapsed or refractory classic Hodgkin lymphoma: a multicenter phase II trial (2033 Online Views)

Kaiyang Ding, Hailing Liu, Jie Ma, Haiyan Yang, Lei Cao, Huihan Wang, Hongling Peng, Wei Shi, Xiaoli Zhao, Wei Wu, Huayuan Zhu, Jianyong Li, Lei Fan

https://doi.org/10.3324/haematol.2022.282266

Multiple Myeloma

PARP1 and POLD2 as prognostic biomarkers for multiple myeloma in autologous stem cell transplant (1118 Online Views)

Melissa Thomas, Junan Li, Kevan King, Avinash K Persaud, Ernest Duah, Zachary Vangundy, Craig C. Hofmeister, Jatinder K. Lamba, Aik Choon Tan, Brooke L. Fridley, Ming J. Poi, Nathan D. Seligson

https://doi.org/10.3324/haematol.2022.282399

Non-Hodgkin Lymphoma

Low T-cell proportion in the tumor microenvironment is associated with immune escape and poor survival in diffuse large B-cell lymphoma (1469 Online Views)

Joo Y. Song, Mary Nwangwu, Ting-Fang He, Weiwei Zhang, Hany Meawad, Victoria Bedell, Joyce Murata-Collins, Pamela Skrabek, Michel R. Nasr, David Scott, James Godfrey, Peter Lee, Wing C. Chan, Dennis D. Weisenburger, Anamarija M. Perry, Alex F. Herrera

https://doi.org/10.3324/haematol.2022.282265

Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma (2437 Online Views)

Takuro Kameda, Keisuke Kataoka, Ayako Kamiunten, Michihiro Hidaka, Hiroaki Miyoshi, Nobuaki Nakano, Kisato Nosaka, Makoto Yoshimitsu, Jun-ichirou Yasunaga, Yasunori Kogure, Kotaro Shide, Masaharu Miyahara, Takashi Sakamoto, Keiichi Akizuki, Tomonori Hidaka, Yoko Kubuki, Junji Koya, Noriaki Kawano, Kiyoshi Yamashita, Hiroshi Kawano, Takanori Toyama, Kouichi Maeda, Kosuke Marutsuka, Yoshitaka Imaizumi, Koji Kato, Takeshi Sugio, Masahito Tokunaga, Yukie Tashiro, Akifumi Takaori-Kondo, Yasushi Miyazaki, Koichi Akashi, Kenji Ishitsuka, Masao Matsuoka, Koichi Ohshima, Toshiki Watanabe, Akira Kitanaka, Atae Utsunomiya, Seishi Ogawa, Kazuya Shimoda

https://doi.org/10.3324/haematol.2022.281510

Cell Therapy & Immunotherapy

Adjusted comparison of outcomes between patients from CARTITUDE-1 versus multiple myeloma patients with prior exposure to proteasome inhibitors, immunomodulatory drugs and anti-CD38 antibody from the prospective, multinational LocoMMotion study of real-world clinical practice (1909 Online Views)

Maria-Victoria Mateos, Katja Weisel, Thomas Martin, Jesús G. Berdeja, Andrzej Jakubowiak, A. Keith Stewart, Sundar Jagannath, Yi Lin, Joris Diels, Francesca Ghilotti, Pushpike Thilakarathne, Nolen J. Perualila, Jedelyn Cabrieto, Benjamin Haefliger, Nichola Erler-Yates, Clare Hague, Carolyn C. Jackson, Jordan M. Schecter, Vadim Strulev, Tonia Nesheiwat, Lida Pacaud, Hermann Einsele, Philippe Moreau

https://doi.org/10.3324/haematol.2022.280482

Red Cell Biology & its Disorders

CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation (1448 Online Views)

Jian Bai, Fan Fan, Chunchen Gao, Shaohua Li, Wei Li, Tiaoxia Wei, Shilin Cheng, Jinmin Yu, Chao Zheng, Junlong Zhao, Linru Zou, Lei Feng, Jing Yi, Hongyan Qin

https://doi.org/10.3324/haematol.2022.282192

Letters to the Editor

Treatment patterns and real-world effectiveness of rituximab maintenance in older patients with mantle cell lymphoma: a population-based analysis (1708 Online Views)

Mengyang Di, Jessica B. Long, Shalin K. Kothari, Tarsheen Sethi, Amer M. Zeidan, Nikolai A. Podoltsev, Rory M. Shallis, Rong Wang, Xiaomei Ma, Scott F. Huntington

https://doi.org/10.3324/haematol.2022.282252

TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia (748 Online Views)

Clara Bueno, Alba Martínez, Paola Alejandra Romecin, Samanta Romina Zanetti, Ricky Tirtakusuma, Eulalia Genesca, Mireia Camós, Manuel Ramírez-Orellana, Eduardo Anguita, Paola Ballerini, Franco Locatelli, José Luis Fuster, Pablo Menéndez

https://doi.org/10.3324/haematol.2022.282394

Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors (1084 Online Views)

Gregory W. Roloff, Frank Wen, Aubrianna Ramsland, Andrew S. Artz, Satyajit Kosuri, Wendy Stock, Olatoyosi Odenike, Richard A. Larson, Hongtao Liu, Lucy A. Godley, Michael J. Thirman, Anand A. Patel, Christopher K. Daugherty, Adam S. DuVall, Mariam T. Nawas, Emily Dworkin, Geoffrey D. Wool, Sandeep Gurbuxani, Carrie Fitzpatrick, Jeremy P. Segal, Peng Wang, Michael W. Drazer

https://doi.org/10.3324/haematol.2022.282148

Clinical and molecular features of familial chronic lymphocytic leukemia: a pilot monocentric study (633 Online Views)

Giulia Benintende, Idanna Innocenti, Alberto Fresa, Francesco Autore, Annamaria Tomasso, Alfonso Piciocchi, Florenzia Vuono, Luca Stirparo, Antonio Mosca, Andrea Bacigalupo, Valter Gattei, Dimitar Efremov, Eugenio Sangiorgi, Luca Laurenti

https://doi.org/10.3324/haematol.2022.282268

Activity of decitabine combined with all-trans retinoic acid in oligoblastic acute myeloid leukemia: results from a randomized 2x2 phase II trial (DECIDER) (803 Online Views)

Christoph Rummelt, Olga Grishina, Claudia Schmoor, Martina Crysandt, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Konstanze Döhner, Helmut R. Salih, Gerhard Heil, Carsten Müller-Tidow, Wolfram Brugger, Andrea Kündgen, Maike de Wit, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Jürgen Krauter, Gesine Bug, Haifa Kathrin Al-Ali, Ralph Wäsch, Heiko Becker, Annette M. May, Justus Duyster, Björn Hackanson, Arnold Ganser, Hartmut Döhner, Michael Lübbert

https://doi.org/10.3324/haematol.2022.282258

Efficacy, safety, and cost of mobilization strategies in multiple myeloma: a prospective, observational study (932 Online Views)

Binod Dhakal, Mei-Jei Zhang, Linda J. Burns, Xiaoying Tang, Christa Meyer, Lih-Wen Mau, Ajay K. Nooka, Edward Stadtmauer, Ivana N Micallef, Joseph McGuirk, Luciano Costa, Mark B. Juckett, Nina Shah, Richard E. Champlin, Saad Z. Usmani, Sherif S. Farag, Taiga Nishihori, Vivek Roy, Andrew Bodiford, Yvonne J. Barnes, Edward J. Drea, Parameswaran Hari, Mehdi Hamadani

https://doi.org/10.3324/haematol.2022.282269

Case Reports

H syndrome mimicking Erdheim Chester disease: new entity and therapeutic perspectives (868 Online Views)

Hippolyte Lequain, Mathieu Gerfaud-Valentin, Jean-François Emile, Yann-Gaël Gangloff, Guilaine Boursier, Christophe Deligny, Guillaume Le Guenno, Juliet Tantot, Julie Valantin, Lea Savey, Claude Bachmeyer, Yvan Jamilloux, Laurent Schaeffer, Pascal Leblanc, Pascal Sève

https://doi.org/10.3324/haematol.2022.282040