CURRENT ISSUE
October, 2021
No. 106 (10)

About the Cover

Editorials

Review Articles

Articles

Acute Myeloid Leukemia

Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells (1234 Online Views)

Simon Hultmark, Aurélie Baudet, Ludwig Schmiderer, Pavan Prabhala, Sara Palma-Tortosa, Carl Sandén, Thoas Fioretos, Rajkumar Sasidharan, Christer Larsson, Sören Lehmann, Gunnar Juliusson, Fredrik Ek, Mattias Magnusson

https://doi.org/10.3324/haematol.2020.249177

Clinical significance of chromatin-spliceosome acute myeloid leukemia: a report from the Northern Italy Leukemia Group (NILG) randomized trial 02/06 (1439 Online Views)

Chiara Caprioli, Federico Lussana, Silvia Salmoiraghi, Roberta Cavagna, Ksenija Buklijas, Lara Elidi, Pamela Zanghi', Anna Michelato, Federica Delaini, Elena Oldani, Tamara Intermesoli, Anna Grassi, Giacomo Gianfaldoni, Francesco Mannelli, Dario Ferrero, Ernesta Audisio, Elisabetta Terruzzi, Lorella De Paoli, Chiara Cattaneo, Erika Borlenghi, Irene Cavattoni, Monica Tajana, Anna Maria Scattolin, Daniele Mattei, Paolo Corradini, Leonardo Campiotti, Fabio Ciceri, Massimo Bernardi, Elisabetta Todisco, Agostino Cortelezzi, Brunangelo Falini, Chiara Pavoni, Renato Bassan, Orietta Spinelli, Alessandro Rambaldi

https://doi.org/10.3324/haematol.2020.252825

Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells (1426 Online Views)

Brandon Cieniewicz, Molly Javier Uyeda, Ping (Pauline) Chen, Ece Canan Sayitoglu, Jeffrey Mao-Hwa Liu, Grazia Andolfi, Katharine Greenthal, Alice Bertaina, Silvia Gregori, Rosa Bacchetta, Norman James Lacayo, Alma-Martina Cepika, Maria Grazia Roncarolo

https://doi.org/10.3324/haematol.2020.263129

Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines (1123 Online Views)

Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Serena Matis, Maria Cristina Capra, Francesca Puglisi, Paola Luzzi, Simona Pigozzi, Gabriele Gaggero, Antonino Neri, Katia Todoerti, Fortunato Morabito, Adalberto Ibatici, Maurizio Miglino, Micaela Bergamaschi, Silvia Bruno, Gian Mario Sambuceti, Jean Louis Ravetti, Manlio Ferrarini, Franco Fais, Daniela de Totero

https://doi.org/10.3324/haematol.2019.231456

Hematopoiesis

Cell type-specific novel long non-coding RNA and circular RNA in the BLUEPRINT hematopoietic transcriptomes atlas (1223 Online Views)

Luigi Grassi, Osagie G. Izuogu, Natasha A.N. Jorge, Denis Seyres, Mariona Bustamante, Frances Burden, Samantha Farrow, Neda Farahi, Fergal J. Martin, Adam Frankish, Jonathan M. Mudge, Myrto Kostadima, Romina Petersen, John J. Lambourne, Sophia Rowlston, Enca Martin-Rendon, Laura Clarke, Kate Downes, Xavier Estivill, Paul Flicek, Joost H.A. Martens, Marie-Laure Yaspo, Hendrik G. Stunnenberg, Willem H. Ouwehand, Fabio Passetti, Ernest Turro, Mattia Frontini

https://doi.org/10.3324/haematol.2019.238147

Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells (972 Online Views)

Sandra Romero Marquez, Franziska Hettler, Renate Hausinger, Christina Schreck, Theresa Landspersky, Lynette Henkel, Corinne Angerpointner, Ihsan E. Demir, Matthias Schiemann, Florian Bassermann, Katharina S. Götze, Rouzanna Istvánffy, Robert A.J. Oostendorp

https://doi.org/10.3324/haematol.2020.249102

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating β2 integrin clustering (988 Online Views)

Gabriele Zuchtriegel, Bernd Uhl, Robert Pick, Michaela Ramsauer, Julian Dominik, Laura A. Mittmann, Martin Canis, Sandip Kanse, Markus Sperandio, Fritz Krombach, Christoph A. Reichel

https://doi.org/10.3324/haematol.2019.226241

Hodgkin Lymphoma

Evolutionary clonal trajectories in nodular lymphocyte-predominant Hodgkin lymphoma with high risk of transformation (924 Online Views)

Lisa Paschold, Edith Willscher, Julia Bein, Martine Vornanen, Dennis A. Eichenauer, Donjete Simnica, Benjamin Thiele, Claudia Wickenhauser, Andreas Rosenwald, Heinz-Wolfram Bernd, Wolfram Klapper, Alfred C. Feller, German Ott, Falko Fend, Sylvia Hartmann, Mascha Binder

https://doi.org/10.3324/haematol.2021.278427

Non-Hodgkin Lymphoma

Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma (2174 Online Views)

Paolo Strati, Ankur Varma, Sherry Adkins, Loretta J. Nastoupil, Jason Westin, Fredrick B. Hagemeister, Nathan H. Fowler, Hun J. Lee, Luis E. Fayad, Felipe Samaniego, Sairah Ahmed, Yiming Chen, Sandra Horowitz, Sara Arafat, Swapna Johncy, Partow Kebriaei, Victor Eduardo Mulanovich, Ella Ariza Heredia, Sattva S. Neelapu

https://doi.org/10.3324/haematol.2020.254045

Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype (1604 Online Views)

Antonio Vogelsberg, Julia Steinhilber, Barbara Mankel, Birgit Federmann, Janine Schmidt, Ivonne A. Montes-Mojarro, Katrin Hüttl, Maria Rodriguez-Pinilla, Praveen Baskaran, Sven Nahnsen, Miguel A. Piris, German Ott, Leticia Quintanilla-Martinez, Irina Bonzheim, Falko Fend

https://doi.org/10.3324/haematol.2020.254854

MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma (1231 Online Views)

Joan Enric Ramis-Zaldivar, Blanca Gonzalez-Farre, Alina Nicolae, Svetlana Pack, Guillem Clot, Ferran Nadeu, Anja Mottok, Heike Horn, Joo Y. Song, Kai Fu, George Wright, Randy D. Gascoyne, Wing C. Chan, David W. Scott, Andrew L. Feldman, Alexandra Valera, Anna Enjuanes, Rita M. Braziel, Erlend B. Smeland, Louis M. Staudt, Andreas Rosenwald, Lisa M. Rimsza, German Ott, Elaine S. Jaffe, Itziar Salaverria, Elias Campo

https://doi.org/10.3324/haematol.2020.271957

Plasma Cell Disorders

Carfilzomib or bortezomib in combination with cyclophosphamide and dexamethasone followed by carfilzomib maintenance for patients with multiple myeloma after one prior therapy: results from a multicenter, phase II, randomized, controlled trial (MUKfive) (1188 Online Views)

Kwee L. Yong, Samantha Hinsley, Holger W. Auner, Ceri Bygrave, Martin F. Kaiser, Karthik Ramasamy, Ruth M. de Tute, Debbie Sherratt, Louise Flanagan, Mamta Garg, Stephen Hawkins, Catherine Williams, Jamie Cavenagh, Neil K. Rabin, James Croft, Gareth Morgan, Faith Davies, Roger G. Owen, Sarah R. Brown

https://doi.org/10.3324/haematol.2021.278399

Red Cell Biology & its Disorders

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease (1602 Online Views)

Sara El Hoss, Sylvie Cochet, Auria Godard, Hongxia Yan, Michaël Dussiot, Giacomo Frati, Bénédicte Boutonnat-Faucher, Sandrine Laurance, Olivier Renaud, Laure Joseph, Annarita Miccio, Valentine Brousse, Mohandas Narla, Wassim El Nemer

https://doi.org/10.3324/haematol.2020.265462

Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency (999 Online Views)

Birgit van Dooijeweert, Melissa H. Broeks, Nanda M. Verhoeven-Duif, Eduard J. van Beers, Edward E.S. Nieuwenhuis, Wouter W. van Solinge, Marije Bartels, Judith J. Jans, Richard van Wijk

https://doi.org/10.3324/haematol.2020.266957

Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells (728 Online Views)

Angelo D’Alessandro, Ariel Hay, Monika Dzieciatkowska, Benjamin C. Brown, Evan J. Morrison, Kirk C. Hansen, James C. Zimring

https://doi.org/10.3324/haematol.2020.266676

Letters to the Editor

Inclusion of a short hairpin RNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin (635 Online Views)

Silvia Pires Lourenco, Danuta Jarocha; Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella

https://doi.org/10.3324/haematol.2020.276634

Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation? (642 Online Views)

Valentine Brousse, Laurent Holvoet, Rémi Pescarmona, Sebastien Viel, Magali Perret, Benoit Visseaux, Valentine Marie Ferre, Ghislaine Ithier, Caroline Le Van Kim, Malika Benkerrou, Florence Missud, Berengere Koehl

https://doi.org/10.3324/haematol.2021.278573

Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma - a meta-analysis of 2,596 trial patients (956 Online Views)

Niels Weinhold, Hans J. Salwender, David A. Cairns, Marc S. Raab, George Waldron, Igor W. Blau, Uta Bertsch, Thomas Hielscher, Gareth J. Morgan, Anna Jauch, Faith E. Davies, Mathias Hänel, Gordon Cook, Christoph Scheid, Richard Houlston, Hartmut Goldschmidt, Graham Jackson, Martin F. Kaiser

https://doi.org/10.3324/haematol.2021.278888

A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies (352 Online Views)

David H. Vandorpe, Boris E. Shmukler, Yann Ilboudo, Swati Bhasin, Beena Thomas, Alicia Rivera, Jay G. Wohlgemuth, Jeffrey S. Dlott, L. Michael Snyder, Colin Sieff, Manoj Bhasin, Guillaume Lettre, Carlo Brugnara, Seth L. Alper

https://doi.org/10.3324/haematol.2021.278770

Therapeutic potential of ruxolitinib and ponatinib in patients with EPOR-rearranged Philadelphia chromosome-like acute lymphoblastic leukemia (562 Online Views)

Lisa M. Niswander, Joseph P. Loftus, Élodie Lainey, Aurélie Caye-Eude, Morgane Pondrom, David A. Hottman, Ilaria Iacobucci, Charles G. Mullighan, Nitin Jain, Marina Konopleva, Hélène Cavé, André Baruchel, Pierre S. Rohrlich, Sarah K. Tasian

https://doi.org/10.3324/haematol.2021.278697

Single-cell profiling reveals the dynamics of cytomegalovirus-specific T cells in haploidentical hematopoietic stem cell transplantation (406 Online Views)

Jasper J. P. van Beek, Simone Puccio, Alessandra Roberto, Federica De Paoli, Giulia Graziano, Elisa Salviato, Giorgia Alvisi, Veronica Zanon, Alice Scarpa, Elisa Zaghi, Michela Calvi, Clara Di Vito, Rossana Mineri, Barbara Sarina, Chiara De Philippis, Armando Santoro, Jacopo Mariotti, Stefania Bramanti, Francesco Ferrari, Luca Castagna, Domenico Mavilio, Enrico Lugli

https://doi.org/10.3324/haematol.2020.276352

Acalabrutinib for treatment of diffuse large B-cell lymphoma: results from a phase Ib study (850 Online Views)

Paolo Strati, Sven de Vos, Jia Ruan, Kami J. Maddocks, Christopher R. Flowers, Simon Rule, Priti Patel, Yan Xu, Helen Wei, Melanie M. Frigault, Roser Calvo, Martin J.S. Dyer

https://doi.org/10.3324/haematol.2021.278654

Sex-dependent membranopathy in stored human red blood cells (326 Online Views)

Ewa Szczesny-Malysiak, Tasnim Mohaissen, Katarzyna Bulat, Magdalena Kaczmarska, Aleksandra Wajda, Katarzyna M. Marzec

https://doi.org/10.3324/haematol.2021.278895

Case Reports

Successful pregnancies after transplantation of ovarian tissue retrieved and cryopreserved at time of childhood acute lymphoblastic leukemia – A case report (747 Online Views)

Kenny A. Rodriguez-Wallberg, Milan Milenkovic, Kiriaki Papaikonomou, Victoria Keros, Britt Gustafsson, Fotios Sergouniotis, Ida Wikander, Ronak Perot, Birgit Borgström, Per Ljungman, Gisela Barbany

https://doi.org/10.3324/haematol.2021.278828