CURRENT ISSUE
October, 2020
No. 105 (10)

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Editorials

Centenary Review

Review Articles

Articles

Hematopoiesis

Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity

Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nithin Mahajan, Daniel Gaston, Troy Lund, David Rittenberg, Graham Dellaire, Clinton J.V. Campbell, Todd Druley, Jason N. Berman

https://doi.org/10.3324/haematol.2019.223040

Iron Metabolism & Its Disorders

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

Tiffany C. Timmer, Rosa de Groot, Judith J.M. Rijnhart, Jeroen Lakerveld, Johannes Brug, Corine W.M. Perenboom, A. Mireille Baart, Femmeke J. Prinsze, Saurabh Zalpuri, C. Ellen van der Schoot, Wim L.A.M. de Kort, Katja van den Hurk

https://doi.org/10.3324/haematol.2019.229450

Red Cell Biology & Its Disorders

Hematologic Neoplasms

The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs

Debora Soncini, Stefania Orecchioni, Samantha Ruberti, Paola Minetto, Claudia Martinuzzi, Luca Agnelli, Katia Todoerti, Antonia Cagnetta, Maurizio Miglino, Marino Clavio, Paola Contini, Riccardo Varaldo, Micaela Bergamaschi, Fabio Guolo, Mario Passalacqua, Alessio Nencioni, Fiammetta Monacelli, Marco Gobbi, Antonino Neri, Giovanni Abbadessa, Sudharshan Eathiraj, Brian Schwartz, Francesco Bertolini, Roberto M. Lemoli, Michele Cea

https://doi.org/10.3324/haematol.2019.224956

Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: a nationwide discovery cohort

Johanne M. Holst, Trine L. Plesner, Martin B. Pedersen, Henrik Frederiksen, Michael B. Møller, Michael R. Clausen, Marcus C. Hansen, Stephen Jacques Hamilton-Dutoit, Peter Nørgaard, Preben Johansen, Tobias Ramm Eberlein, Bo K. Mortensen, Gustav Mathiasen, Andreas Øvlisen, Rui Wang, Chao Wang, Weiwei Zhang, Hans Beier Ommen, Jesper Stentoft, Maja Ludvigsen, Wayne Tam, Wing C. Chan, Giorgio Inghirami, Francesco d'Amore

https://doi.org/10.3324/haematol.2019.225839

Chronic Lymphocytic Leukemia

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1

Eugen Tausch, Philipp Beck, Richard F. Schlenk, Billy J. Jebaraj, Anna Dolnik, Deyan Y. Yosifov, Peter Hillmen, Fritz Offner, Ann Janssens, K. Govind Babu, Sebastian Grosicki, Jiri Mayer, Panagiotis Panagiotidis, Astrid McKeown, Ira V. Gupta, Alexandra Skorupa, Celine Pallaud, Lars Bullinger, Daniel Mertens, Hartmut Döhner, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2019.229161

Plasma Cell Disorders

ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies

Oronza A. Botrugno, Silvia Bianchessi, Desirée Zambroni, Michela Frenquelli, Daniela Belloni, Lucia Bongiovanni, Stefania Girlanda, Simona Di Terlizzi, Marina Ferrarini, Elisabetta Ferrero, Maurilio Ponzoni, Magda Marcatti, Giovanni Tonon

https://doi.org/10.3324/haematol.2018.215210

Platelet Biology & its Disorders

Hemostasis

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner

Nicolas Receveur, Dmitry Nechipurenko, Yannick Knapp, Aleksandra Yakusheva, Eric Maurer, Cécile V. Denis, François Lanza, Mikhail Panteleev, Christian Gachet, Pierre H. Mangin

https://doi.org/10.3324/haematol.2019.235754

Coagulation & Its Disorders

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Susanna H. M. Sluka, Simon F. Stämpfli, Alexander Akhmedov, Tanja Klein-Rodewald, Adrián Sanz-Moreno, Marion Horsch, Paula Grest, Andrea S. Rothmeier, Birgit Rathkolb, Anja Schrewe, Johannes Beckers, Frauke Neff, Eckhard Wolf, Giovanni G. Camici, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Thomas F. Lüscher, Wolfram Ruf, Felix C. Tanner

https://doi.org/10.3324/haematol.2019.218818

Letters to the Editor

Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation

Marini Thian, Birgit Hoeger, Anton Kamnev, Fiona Poyer, Sevgi Köstel Bal, Michael Caldera, Raúl Jiménez-Heredia, Jakob Huemer, Winfried F. Pickl, Miriam Groß, Stephan Ehl, Carrie L. Lucas, Jörg Menche, Caroline Hutter, Andishe Attarbaschi, Loïc Dupré, Kaan Boztug

https://doi.org/10.3324/haematol.2019.231399

Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2

Alessia Pagani, Mariateresa Pettinato, Silvia Colucci, Alessandro Dulja, Martina Rauner, Antonella Nai, Clara Camaschella, Sandro Altamura, Martina U. Muckenthaler, Laura Silvestri

https://doi.org/10.3324/haematol.2019.241984

Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor

Naoya Uchida, Alexis Leonard, David Stroncek, Sandhya R. Panch, Kamille West, Eoghan Molloy, Thomas E. Hughes, Sara Hauffe, Tiffani Taylor, Courtney Fitzhugh, Jane S. Hankins, Megan Wilson, Akshay Sharma, Shengdar Q. Tsai, Mitch J. Weiss, Matthew Hsieh, John F. Tisdale

https://doi.org/10.3324/haematol.2019.236182

High expression of the stem cell marker GPR56 at diagnosis identifies acute myeloid leukemia patients at higher relapse risk after allogeneic stem cell transplantation in context with the CD34+/CD38- population

Madlen Jentzsch, Marius Bill, Juliane Grimm, Julia Schulz, Luba Schuhmann, Dominic Brauer, Karoline Goldmann, Franziska Wilke, Georg-Nikolaus Franke, Gerhard Behre, Wolfram Pönisch, Vladan Vucinic, Dietger Niederwieser, Uwe Platzbecker, Sebastian Schwind

https://doi.org/10.3324/haematol.2019.229260

Brentuximab vedotin in the treatment of elderly Hodgkin lymphoma patients at first relapse or with primary refractory disease: a phase II study of FIL ONLUS

Vittorio Stefoni, Miriam Marangon, Alessandro Re, Arben Lleshi, Maurizio Bonfichi, Antonello Pinto, Nicola Bianchetti, Cinzia Pellegrini, Lisa Argnani, Pier Luigi Zinzani

https://doi.org/10.3324/haematol.2019.243170

High-throughput analysis of the T cell receptor gene repertoire in low-count monoclonal B cell lymphocytosis reveals a distinct profile from chronic lymphocytic leukemia

Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfò, Theodoros Moysiadis, Alessandra Rovida, Elisavet Vlachonikola, Electra Sofou, Fotis Psomopoulos, Anna Vardi, Pamela Ranghetti, Alexandra Siorenta, Alex Galanis, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Paolo Ghia

https://doi.org/10.3324/haematol.2019.221275

Impact of idelalisib on health-related quality of life in patients with relapsed chronic lymphocytic leukemia in a phase III randomized trial

Paolo Ghia, Steven E. Coutre, Bruce D. Cheson, Jacqueline C. Barrientos, Peter Hillmen, Andrew R. Pettitt, Andrew D. Zelenetz, Sanatan Shreay, Michael Hallek, Richard R. Furman

https://doi.org/10.3324/haematol.2019.238808

Validated single-tube multiparameter flow cytometry approach for the assessment of minimal residual disease in multiple myeloma

Sandra Maria Dold, Veronika Riebl, Dagmar Wider, Marie Follo, Milena Pantic, Gabriele Ihorst, Justus Duyster, Robert Zeiser, Ralph Wäsch, Monika Engelhardt

https://doi.org/10.3324/haematol.2019.238394

HLA-DRB1*11 is a strong risk factor for acquired thrombotic thrombocytopenic purpura in children

Bérangère S. Joly, Pascale Loiseau, Michael Darmon, Thierry Leblanc, Hervé Chambost, Fanny Fouyssac, Vincent Guigonis, Jérôme Harambat, Alain Stepanian, Paul Coppo, Agnès Veyradier

https://doi.org/10.3324/haematol.2019.241968

Case Reports

Dramatic presentation of acquired thombotic thrombocytopenic purpura associated with COVID-19

Marco Capecchi, Cristina Mocellin, Chiara Abbruzzese, Ilaria Mancini, Daniele Prati, Flora Peyvandi

https://doi.org/10.3324/haematol.2020.262345

First description of revertant mosaicism in familial platelet disorder with predisposition to acute myelogenous leukemia: correlation with the clinical phenotype

Ana C. Glembotsky, Cecilia P. Marin Oyarzún, Geraldine De Luca, Christophe Marzac, Nathalie Auger, Nora P. Goette, Rosana F. Marta, Hana Raslova, Paula G. Heller

https://doi.org/10.3324/haematol.2020.253070