Vol. 104 No. 10 (2019): October, 2019

Hendrika A. van Dorland, Magnus Mansouri Taleghani, Kazuya Sakai, Kenneth D. Friedman, James N. George, Ingrid Hrachovinova, Paul N. Knöbl, Anne Sophie von Krogh, Reinhard Schneppenheim, Isabella Aebi-Huber, Lukas Bütikofer, Carlo R. Largiadèr, Zuzana Cermakova, Koichi Kokame, Toshiyuki Miyata, Hideo Yagi, Deirdra R. Terrell, Sara K. Vesely, Masanori Matsumoto, Bernhard Lämmle, Yoshihiro Fujimura, Johanna A. Kremer Hovinga

https://doi.org/10.3324/haematol.2019.216796

Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia (1641 Online Views)

Ai Gao, Yuemin Gong, Caiying Zhu, Wanzhu Yang, Qing Li, Mei Zhao, Shihui Ma, Jianyong Li, Sha Hao, Hui Cheng, Tao Cheng

https://doi.org/10.3324/haematol.2018.214593

Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients (2762 Online Views)

Minako Mori, Asuka Hira, Kenichi Yoshida, Hideki Muramatsu, Yusuke Okuno, Yuichi Shiraishi, Michiko Anmae, Jun Yasuda, Shu Tadaka, Kengo Kinoshita, Tomoo Osumi, Yasushi Noguchi, Souichi Adachi, Ryoji Kobayashi, Hiroshi Kawabata, Kohsuke Imai, Tomohiro Morio, Kazuo Tamura, Akifumi Takaori-Kondo, Masayuki Yamamoto, Satoru Miyano, Seiji Kojima, Etsuro Ito, Seishi Ogawa, Keitaro Matsuo, Hiromasa Yabe, Miharu Yabe, Minoru Takata

https://doi.org/10.3324/haematol.2018.207241

Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study (4711 Online Views)

Zora R. Rogers, Taizo A. Nakano, Timothy S. Olson, Alison A. Bertuch, Winfred Wang, Alfred Gillio, Thomas D. Coates, Anjulika Chawla, Paul Castillo, Peter Kurre, Christopher Gamper, Carolyn M. Bennett, Sarita Joshi, Amy E. Geddis, Jessica Boklan, Grzegorz Nalepa, Jennifer A. Rothman, James N. Huang, Gary M. Kupfer, Michaela Cada, Bertil Glader, Kelly J. Walkovich, Alexis A. Thompson, Rabi Hanna, Adrianna Vlachos, Maggie Malsch, Edie A. Weller, David A. Williams, Akiko Shimamura

https://doi.org/10.3324/haematol.2018.206540

Deletion of a flippase subunit Tmem30a in hematopoietic cells impairs mouse fetal liver erythropoiesis (1751 Online Views)

Fan Yang, Yumin Huang, Xianda Chen, Lu Liu, Dandan Liao, Huan Zhang, Gang Huang, Wenjing Liu, Xianjun Zhu, Wengong Wang, Cheryl A. Lobo, Karina Yazdanbakhsh, Xiuli An, Zhenyu Ju

https://doi.org/10.3324/haematol.2018.203992

Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis (1211 Online Views)

Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Shin Aizawa

https://doi.org/10.3324/haematol.2018.209551

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells (1458 Online Views)

Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås

https://doi.org/10.3324/haematol.2018.192062

Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5-and hypoxia-dependent upregulation of AXL (2478 Online Views)

Pierre-Yves Dumas, Cécile Naudin, Séverine Martin-Lannerée, Brigitte Izac, Luana Casetti, Olivier Mansier, Benoît Rousseau, Alexandre Artus, Mélody Dufossée, Alban Giese, Pierre Dubus, Arnaud Pigneux, Vincent Praloran, Audrey Bidet, Arnaud Villacreces, Amélie Guitart, Noël Milpied, Olivier Kosmider, Isabelle Vigon, Vanessa Desplat, Isabelle Dusanter-Fourt, Jean-Max Pasquet

https://doi.org/10.3324/haematol.2018.205385

A systematic literature review and meta-analysis of minimal residual disease as a prognostic indicator in adult B-cell acute lymphoblastic leukemia (4137 Online Views)

Renato Bassan, Monika Brüggemann, Hoi-Shen Radcliffe, Elizabeth Hartfield, Georg Kreuzbauer, Sally Wetten

https://doi.org/10.3324/haematol.2018.201053

p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape (1350 Online Views)

Laura Patrussi, Nagaja Capitani, Cristina Ulivieri, Noemi Manganaro, Massimo Granai, Francesca Cattaneo, Anna Kabanova, Lucia Mundo, Stefania Gobessi, Federica Frezzato, Andrea Visentin, Francesca Finetti, Pier Giuseppe Pelicci, Mario M. D’Elios, Livio Trentin, Gianpietro Semenzato, Lorenzo Leoncini, Dimitar G. Efremov, Cosima T. Baldari

https://doi.org/10.3324/haematol.2018.209981

Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia (1943 Online Views)

Michael Steurer, Marco Montillo, Lydia Scarfò, Francesca R. Mauro, Johannes Andel, Sophie Wildner, Livio Trentin, Ann Janssens, Sonja Burgstaller, Anna Frömming, Thomas Dümmler, Kai Riecke, Matthias Baumann, Diana Beyer, Stéphanie Vauléon, Paolo Ghia, Robin Foà, Federico Caligaris-Cappio, Marco Gobbi

https://doi.org/10.3324/haematol.2018.205930

Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma (2386 Online Views)

Vijay G. Ramakrishnan, Kevin C. Miller, Elaine P. Macon, Teresa K. Kimlinger, Jessica Haug, Sanjay Kumar, Wilson I. Gonsalves, S. Vincent Rajkumar, Shaji K. Kumar

https://doi.org/10.3324/haematol.2018.211110

Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood (1722 Online Views)

Seema Bhatlekar, Indranil Basak, Leonard C. Edelstein, Robert A. Campbell, Cory R. Lindsey, Joseph E. Italiano, Andrew S. Weyrich, Jesse W. Rowley, Matthew T. Rondina, Martha Sola-Visner, Paul F. Bray

https://doi.org/10.3324/haematol.2018.204685

Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects (1260 Online Views)

Marcin M. Gorski, Anna Lecchi, Eti A. Femia, Silvia La Marca, Andrea Cairo, Emanuela Pappalardo, Luca A. Lotta, Andrea Artoni, Flora Peyvandi

https://doi.org/10.3324/haematol.2018.204990

Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells (1285 Online Views)

Ellie Karampini, Maaike Schillemans, Menno Hofman, Floris van Alphen, Martin de Boer, Taco W. Kuijpers, Maartje van den Biggelaar, Jan Voorberg, Ruben Bierings

https://doi.org/10.3324/haematol.2018.207787

Mode of delivery in hemophilia: vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds (2199 Online Views)

Nadine G. Andersson, Elizabeth A. Chalmers, Gili Kenet, Rolf Ljung, Anne Mäkipernaa, Hervé Chambost

https://doi.org/10.3324/haematol.2018.209619

Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population (747 Online Views)

Gabrielle deVeber, Fenella Kirkham, Kelsey Shannon, Leonardo Brandão, Ronald Sträter, Gili Kenet, Hartmut Clausnizer, Mahendranath Moharir, Martina Kausch, Rand Askalan, Daune MacGregor, Monika Stoll, Antje Torge, Nomazulu Dlamini, Vijeja Ganesan, Mara Prengler, Jaspal Singh, Ulrike Nowak-Göttl

https://doi.org/10.3324/haematol.2019.234666

Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions (14231 Online Views)

Peter Valent, Attilio Orazi, Michael R. Savona, Mrinal M. Patnaik, Francesco Onida, Arjan A. van de Loosdrecht, Detlef Haase, Torsten Haferlach, Chiara Elena, Lisa Pleyer, Wolfgang Kern, Tea Pemovska, Gregory I. Vladimer, Julie Schanz, Alexandra Keller, Michael Lübbert, Thomas Lion, Karl Sotlar, Andreas Reiter, Theo De Witte, Michael Pfeilstöcker, Klaus Geissler, Eric Padron, Michael Deininger, Alberto Orfao, Hans-Peter Horny, Peter L. Greenberg, Daniel A. Arber, Luca Malcovati, John M. Bennett

https://doi.org/10.3324/haematol.2019.222059

Apoptotic mesenchymal stromal cells induce prostaglandin E2 in monocytes: implications for the monitoring of mesenchymal stromal cell activity (1646 Online Views)

Tik Shing Cheung, Antonio Galleu, Malte von Bonin, Martin Bornhäuser, Francesco Dazzi

https://doi.org/10.3324/haematol.2018.214767

Genetic loss of Tmprss6 alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia (682 Online Views)

David B. Stagg, Rebecca L. Whittlesey, Xiuqi Li, Larisa Lozovatsky, Sara Gardenghi, Stefano Rivella, Karin E. Finberg

https://doi.org/10.3324/haematol.2018.213371

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia (912 Online Views)

Mahmoud I. Elbadry, Hiroki Mizumaki, Kohei Hosokawa, J. Luis Espinoza, Noriharu Nakagawa, Kazuhisa Chonabayashi, Yoshinori Yoshida, Takamasa Katagiri, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Tatsuya Imi, Mai Anh Thi Nguyen, Youichi Fujii, Atsushi Tajima, Seishi Ogawa, Katsuto Takenaka, Koichi Akashi, Shinji Nakao

https://doi.org/10.3324/haematol.2018.210856

Red cell autoimmunization and alloimmunization in myelodysplastic syndromes: prevalence, characteristic and significance (889 Online Views)

Rakchha Chhetri, Li Yan A. Wee, Romi Sinha, Monika M. Kutyna, Anh Pham, Helen Stathopoulos, Lakshmi Nath, Shriram V. Nath, Nicholas Wickham, Tim Hughes, Deepak Singhal, David J. Roxby, Devendra K. Hiwase

https://doi.org/10.3324/haematol.2018.215087

NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2 (2069 Online Views)

Femke M. Hormann, Alex Q. Hoogkamer, H. Berna Beverloo, Aurélie Boeree, Ilse Dingjan, Moniek M. Wattel, Ronald W. Stam, Gabriele Escherich, Rob Pieters, Monique L. den Boer, Judith M. Boer

https://doi.org/10.3324/haematol.2018.206961

A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy (1344 Online Views)

Chloé B. Steen, Ellen Leich, June H. Myklebust, Sandra Lockmer, Jillian F. Wise, Björn E. Wahlin, Bjørn Østenstad, Knut Liestøl, Eva Kimby, Andreas Rosenwald, Erlend B. Smeland, Harald Holte, Ole Christian Lingjærde, Marianne Brodtkorb

https://doi.org/10.3324/haematol.2018.209080

The transcriptomic profile of CD138+ cells from patients with early progression from smoldering to active multiple myeloma remains substantially unchanged (1068 Online Views)

Paola Storti, Luca Agnelli, Benedetta dalla Palma, Katia Todoerti, Valentina Marchica, Fabrizio Accardi, Gabriella Sammarelli, Federica Deluca, Denise Toscani, Federica Costa, Emanuela Vicario, Giannalisa Todaro, Eugenia Martella, Antonino Neri, Nicola Giuliani

https://doi.org/10.3324/haematol.2018.209999

Bone marrow characteristics predict outcome in a multicenter cohort of primary immune thrombocytopenia patients treated with thrombopoietin analogs (758 Online Views)

Bruno Fattizzo, Raffaella Pasquale, Monica Carpenedo, Silvia Cantoni, Giuseppe Auteri, Doriana Gramegna, Mariella D’Adda, Mariasanta Napolitano, Dario Consonni, Marco Ruggeri, Sergio Siragusa, Giuseppe Rossi, Nicola Vianelli, Wilma Barcellini

https://doi.org/10.3324/haematol.2019.216804

Extended anticoagulant therapy in venous thromboembolism: a balanced, fractional factorial, clinical vignette-based study (581 Online Views)

Vincent ten Cate, Anthonie W.A. Lensing, Jeffrey I. Weitz, Jan Beyer-Westendorf, Philip S. Wells, Patrick Mismetti, Paolo Prandoni, Alexander T. Cohen, Bruce L. Davidson, Martin H. Prins

https://doi.org/10.3324/haematol.2018.209924

T-cell replete haploidentical bone marrow transplantation and post-transplant cyclophosphamide for patients with inborn errors (1450 Online Views)

Mathias Kurzay, Fabian Hauck, Irene Schmid, Volker Wiebking, Anna Eichinger, Eva Jung, Ann Boekstegers, Tobias Feuchtinger, Christoph Klein, Michael H. Albert

https://doi.org/10.3324/haematol.2018.215285

Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ (1468 Online Views)

David J. Swan, Dominik Aschenbrenner, Christopher A. Lamb, Krishnendu Chakraborty, Jonathan Clark, Sumeet Pandey, Karin R. Engelhardt, Rui Chen, Athena Cavounidis, Yuchun Ding, Natalio Krasnogor, Christopher D. Carey, Meghan Acres, Stephanie Needham, Andrew J. Cant, Peter D. Arkwright, Anita Chandra, Klaus Okkenhaug, Holm H. Uhlig, Sophie Hambleton

https://doi.org/10.3324/haematol.2018.208397