March, 2018
No. 103 (3)

Editorials

Review Articles

Articles

Hematopoiesis

Red Cell Biology & its Disorders

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia (389 Online Views)

Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu

https://doi.org/10.3324/haematol.2017.177394

Bone Marrow Failure

Hypomorphic FANCA mutations correlate with mild mitochondrial and clinical phenotype in Fanconi anemia (314 Online Views)

Roberta Bottega, Elena Nicchia, Enrico Cappelli, Silvia Ravera, Daniela De Rocco, Michela Faleschini, Fabio Corsolini, Filomena Pierri, Michaela Calvillo, Giovanna Russo, Gabriella Casazza, Ugo Ramenghi, Piero Farruggia, Carlo Dufour, Anna Savoia

https://doi.org/10.3324/haematol.2017.176131

Myelodysplastic Syndromes

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7 (1171 Online Views)

Victor B. Pastor, Sushree S. Sahoo, Jessica Boklan, Georg C. Schwabe, Ebru Saribeyoglu, Brigitte Strahm, Dirk Lebrecht, Matthias Voss, Yenan T. Bryceson, Miriam Erlacher, Gerhard Ehninger, Marena Niewisch, Brigitte Schlegelberger, Irith Baumann, John C. Achermann, Akiko Shimamura, Jochen Hochrein, Ulf Tedgård, Lars Nilsson, Henrik Hasle, Melanie Boerries, Hauke Busch, Charlotte M. Niemeyer, Marcin W. Wlodarski

https://doi.org/10.3324/haematol.2017.180778

Myeloproliferative Neoplasms

Benefits and pitfalls of pegylated interferon-α2a therapy in patients with myeloproliferative neoplasm-associated myelofibrosis: a French Intergroup of Myeloproliferative neoplasms (FIM) study (1570 Online Views)

Jean-Christophe Ianotto, Aurélie Chauveau, Françoise Boyer-Perrard, Emmanuel Gyan, Kamel Laribi, Pascale Cony-Makhoul, Jean-Loup Demory, Benoit de Renzis, Christine Dosquet, Jerome Rey, Lydia Roy, Brigitte Dupriez, Laurent Knoops, Laurence Legros, Mohamed Malou, Pascal Hutin, Dana Ranta, Omar Benbrahim, Valérie Ugo, Eric Lippert, Jean-Jacques Kiladjian

https://doi.org/10.3324/haematol.2017.181297

Chronic Myeloid Leukemia

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting (485 Online Views)

Niklas Landberg, Sofia von Palffy, Maria Askmyr, Henrik Lilljebjörn, Carl Sandén, Marianne Rissler, Satu Mustjoki, Henrik Hjorth-Hansen, Johan Richter, Helena Ågerstam, Marcus Järås, Thoas Fioretos

https://doi.org/10.3324/haematol.2017.169946

Acute Myeloid Leukemia

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia (575 Online Views)

Tobias Herold, Vindi Jurinovic, Aarif M. N. Batcha, Stefanos A. Bamopoulos, Maja Rothenberg-Thurley, Bianka Ksienzyk, Luise Hartmann, Philipp A. Greif, Julia Phillippou-Massier, Stefan Krebs, Helmut Blum, Susanne Amler, Stephanie Schneider, Nikola Konstandin, Maria Cristina Sauerland, Dennis Görlich, Wolfgang E. Berdel, Bernhard J. Wörmann, Johanna Tischer, Marion Subklewe, Stefan K. Bohlander, Jan Braess, Wolfgang Hiddemann, Klaus H. Metzeler, Ulrich Mansmann, Karsten Spiekermann

https://doi.org/10.3324/haematol.2017.178442

Non-Hodgkin Lymphoma

Chronic Lymphocytic Leukemia

In vitro and in vivo evidence for uncoupling of B-cell receptor internalization and signaling in chronic lymphocytic leukemia (511 Online Views)

Eve M. Coulter, Andrea Pepper, Silvia Mele, Najeem’deen Folarin, William Townsend, Kirsty Cuthill, Elizabeth H. Phillips, Piers E. M. Patten, Stephen Devereux

https://doi.org/10.3324/haematol.2017.176164

Plasma Cell Disorders

Outcome and survival of myeloma patients diagnosed 2008–2015. Real-world data on 4904 patients from the Swedish Myeloma Registry (1434 Online Views)

Cecilie Hveding Blimark, Ingemar Turesson, Anna Genell, Lucia Ahlberg, Bo Björkstrand, Kristina Carlson, Karin Forsberg, Gunnar Juliusson, Olle Linder, Ulf-Henrik Mellqvist, Hareth Nahi, Sigurdur Y. Kristinsson, for the Swedish Myeloma Registry

https://doi.org/10.3324/haematol.2017.178103

Melphalan 140 mg/m2 or 200 mg/m2 for autologous transplantation in myeloma: results from the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT Chronic Malignancies Working Party (2167 Online Views)

Holger W. Auner, Simona Iacobelli, Giulia Sbianchi, Cora Knol-Bout, Didier Blaise, Nigel H. Russell, Jane F. Apperley, David Pohlreich, Paul V. Browne, Guido Kobbe, Cecilia Isaksson, Stig Lenhoff, Christof Scheid, Cyrille Touzeau, Esa Jantunen, Achilles Anagnostopoulos, Ibrahim Yakoub-Agha, Alina Tanase, Nicolaas Schaap, Wieslaw Wiktor-Jedrzejczak, Marta Krejci, Stefan O. Schönland, Curly Morris, Laurent Garderet, Nicolaus Kröger

https://doi.org/10.3324/haematol.2017.181339

Stem Cell Transplantation

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: randomized phase II results (302 Online Views)

John Koreth, Haesook T. Kim, Paulina B. Lange, Samuel J. Poryanda, Carol G. Reynolds, Sharmila Chamling Rai, Philippe Armand, Corey S. Cutler, Vincent T. Ho, Brett Glotzbecker, Rushdia Yusuf, Sarah Nikiforow, Yi-Bin Chen, Bimalangshu Dey, Malgorzata McMasters, Jerome Ritz, Bruce R. Blazar, Robert J. Soiffer, Joseph H. Antin, Edwin P. Alyea

https://doi.org/10.3324/haematol.2017.176859

Cell Therapy & Immunotherapy

In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation (415 Online Views)

Joseph Pidala, Francisca Beato, Jongphil Kim, Brian Betts, Heather Jim, Elizabeth Sagatys, John E. Levine, James L.M. Ferrara, Umut Ozbek, Ernesto Ayala, Marco Davila, Hugo F. Fernandez, Teresa Field, Mohamed A. Kharfan-Dabaja, Divis Khaira, Farhad Khimani, Frederick L. Locke, Asmita Mishra, Michael Nieder, Taiga Nishihori, Lia Perez, Marcie Riches, Claudio Anasetti

https://doi.org/10.3324/haematol.2017.171199

Platelet Biology & its Disorders

Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies (254 Online Views)

Magdolna Nagy, Tom G. Mastenbroek, Nadine J.A. Mattheij, Susanne de Witt, Kenneth J. Clemetson, Janbernd Kirschner, Ansgar S. Schulz, Thomas Vraetz, Carsten Speckmann, Attila Braun, Judith M.E.M. Cosemans, Barbara Zieger, Johan W.M. Heemskerk

https://doi.org/10.3324/haematol.2017.176974

Coagulation and its Disorders

Desmopressin in moderate hemophilia A patients: a treatment worth considering (805 Online Views)

Janneke I. Loomans, Marieke J.H.A. Kruip, Manuel Carcao, Shannon Jackson, Alice S. van Velzen, Marjolein Peters, Elena Santagostino, Helen Platokouki, Erik Beckers, Jan Voorberg, Johanna G. van der Bom, Karin Fijnvandraat, for the RISE consortium

https://doi.org/10.3324/haematol.2017.180059

Online Only Articles

Hematopoietic stem cell transplantation for patients with paroxysmal nocturnal hemoglobinuria previously treated with eculizumab: a retrospective study of 21 patients from SFGM-TC centers (167 Online Views)

Nicolas Vallet, Flore Sicre de Fontbrune, Michaël Loschi, Deborah Desmier, Alban Villate, Fiorenza Barraco, Patrice Chevallier, Louis Terriou, Ibrahim Yakoub-Agha, Annalisa Ruggeri, Mohamad Mohty, Natacha Maillard, Pierre-Simon Rohrlich, Patrice Ceballos, Stéphanie Nguyen, Xavier Poiré, Gaëlle Guillerm, Reza Tabrizi, Jonathan Farhi, Raynier Devillier, Marie-Thérèse Rubio, Gérard Socié, Régis Peffault de Latour

https://doi.org/10.3324/haematol.2017.182360

Unsatisfactory efficacy in randomized study of reduced-dose CPX-351 for medically less fit adults with newly diagnosed acute myeloid leukemia or other high-grade myeloid neoplasm (224 Online Views)

Roland B. Walter, Megan Othus, Kaysey F. Orlowski, Emily N. McDaniel, Bart L. Scott, Pamela S. Becker, Mary-Elizabeth M. Percival, Paul C. Hendrie, Bruno C. Medeiros, Michael T. Chiarella, Arthur C. Louie, Elihu H. Estey

https://doi.org/10.3324/haematol.2017.182642

High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments (249 Online Views)

Jack Bartram, Nick Goulden, Gary Wright, Stuart Adams, Tony Brooks, Darren Edwards, Sarah Inglott, Yasar Yousafzai, Mike Hubank, Christina Halsey

https://doi.org/10.3324/haematol.2017.174987

Loss of 5-hydroxymethylcytosine is a frequent event in peripheral T-cell lymphomas (154 Online Views)

François Lemonnier, Elsa Poullot, Aurélie Dupuy, Lucile Couronné, Nadine Martin, Laurianne Scourzic, Virginie Fataccioli, Julie Bruneau, Rob A Cairns, Tak W. Mak, Olivier A. Bernard, Laurence de Leval, Philippe Gaulard

https://doi.org/10.3324/haematol.2017.167973

Expression of programmed death-1 on lymphocytes in myeloma patients is lowered during lenalidomide maintenance (217 Online Views)

Sophia Danhof, Martin Schreder, Stefan Knop, Leo Rasche, Susanne Strifler, Claudia Löffler, Tea Gogishvili, Hermann Einsele, Michael Hudecek

https://doi.org/10.3324/haematol.2017.178947

Comment

Comment on “MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma” (164 Online Views)

Sophie Voruz, Filipe Martins, Anne Cairoli, Olaia Naveiras, Krisztian Homicsko, Edoardo Missiaglia, Laurence de Leval, Bettina Bisig, Olivier Michielin, Sabine Blum

https://doi.org/10.3324/haematol.2017.186932

Acquired thrombotic thrombocytopenic purpura in a child: rituximab to prevent relapse. A pediatric report and literature review (312 Online Views)

Sabrina Mariani, Silvia M. Trisolini, Saveria Capria, Maria L. Moleti, Marta Chisini, Giancarlo Ferrazza, Mahnaz Shafii Bafti, Maria A. Limongiello, Eleonora Miulli, Flora Peyvandi, Robin Foà, Anna M. Testi

https://doi.org/10.3324/haematol.2017.185363

PIEZO1-R1864H rare variant accounts for a genetic phenotype-modifier role in dehydrated hereditary stomatocytosis (155 Online Views)

Immacolata Andolfo, Francesco Manna, Gianluca De Rosa, Barbara Eleni Rosato, Antonella Gambale, Giovanna Tomaiuolo, Antonio Carciati, Roberta Marra, Lucia De Franceschi, Achille Iolascon, Roberta Russo

https://doi.org/10.3324/haematol.2017.180687

Macrocytosis and dysplastic anemia is associated with the cyclin-dependent kinase 4/6 inhibitor palbociclib in metastatic breast cancer (611 Online Views)

Jesus Anampa, Tamanna Haque, Irina Murakhovskaya, Yanhua Wang, Kimo Bachiashvili, Cristian Papazoglu, Kith Pradhan, Ulrich G. Steidl, Joseph A. Sparano, Amit Verma

https://doi.org/10.3324/haematol.2017.181941