September, 2017
No. 102 (9)

Editorials

Review Articles

Articles

Red Cell Biology & its Disorders

Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia (2482 Online Views)

James M. Otto, James O.M. Plumb, Eleri Clissold, Shriya B. Kumar, Denis J. Wakeham, Walter Schmidt, Michael P.W. Grocott, Toby Richards, Hugh E. Montgomery

https://doi.org/10.3324/haematol.2017.169680

Coagulation & its Disorders

Long-term impact of joint bleeds in von Willebrand disease: a nested case-control study (251 Online Views)

Karin P.M. van Galen, Piet de Kleijn, Wouter Foppen, Jeroen Eikenboom, Karina Meijer, Roger E.G. Schutgens, Kathelijn Fischer, Marjon H. Cnossen, Joke de Meris, Karin Fijnvandraat, Johanna G. van der Bom, Britta A.P. Laros-van Gorkom, Frank W.G. Leebeek, Eveline P. Mauser-Bunschoten

https://doi.org/10.3324/haematol.2017.168617

Comparison of risk prediction scores for venous thromboembolism in cancer patients: a prospective cohort study (814 Online Views)

Nick van Es, Marcello Di Nisio, Gabriela Cesarman, Ankie Kleinjan, Hans-Martin Otten, Isabelle Mahé, Ineke T. Wilts, Desirée C. Twint, Ettore Porreca, Oscar Arrieta, Alain Stépanian, Kirsten Smit, Michele De Tursi, Suzanne M. Bleker, Patrick M. Bossuyt, Rienk Nieuwland, Pieter W. Kamphuisen, Harry R. Büller

https://doi.org/10.3324/haematol.2017.169060

Myelodysplastic Syndromes

Myeloproliferative Disorders

Characteristics and clinical significance of cytogenetic abnormalities in polycythemia vera (286 Online Views)

Guilin Tang, Juliana E. Hidalgo Lopez, Sa A. Wang, Shimin Hu, Junsheng Ma, Sherry Pierce, Wenli Zuo, Adrian Alejandro Carballo-Zarate, C. Cameron Yin, Zhenya Tang, Shaoying Li, L. Jeffrey Medeiros, Srdan Verstovsek, Carlos E. Bueso-Ramos

https://doi.org/10.3324/haematol.2017.165795

Chronic Myeloid Leukemia

Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia (226 Online Views)

Karoline V. Gleixner, Mathias Schneeweiss, Gregor Eisenwort, Daniela Berger, Harald Herrmann, Katharina Blatt, Georg Greiner, Konstantin Byrgazov, Gregor Hoermann, Marina Konopleva, Islam Waliul, Abbarna A. Cumaraswamy, Patrick T. Gunning, Hiroshi Maeda, Richard Moriggl, Michael Deininger, Thomas Lion, Michael Andreeff, Peter Valent

https://doi.org/10.3324/haematol.2016.163436

Incidence of second primary malignancies and related mortality in patients with imatinib-treated chronic myeloid leukemia (189 Online Views)

Gabriele Gugliotta, Fausto Castagnetti, Massimo Breccia, Francesco Albano, Alessandra Iurlo, Tamara Intermesoli, Elisabetta Abruzzese, Luciano Levato, Mariella D’Adda, Patrizia Pregno, Francesco Cavazzini, Fabio Stagno, Bruno Martino, Gaetano La Barba, Federica Sorà, Mario Tiribelli, Catia Bigazzi, Gianni Binotto, Massimiliano Bonifacio, Clementina Caracciolo, Simona Soverini, Robin Foà, Michele Cavo, Giovanni Martinelli, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti

https://doi.org/10.3324/haematol.2017.169532

Acute Myeloid Leukemia

High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia (111 Online Views)

Zhihong Zeng, Wenbin Liu, Twee Tsao, YiHua Qiu, Yang Zhao, Ismael Samudio, Dos D. Sarbassov, Steven M. Kornblau, Keith A. Baggerly, Hagop M. Kantarjian, Marina Konopleva, Michael Andreeff

https://doi.org/10.3324/haematol.2016.162230

Acute Lymphoblastic Leukemia

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo (479 Online Views)

Jana Reimer, Sabine Knöß, Maurice Labuhn, Emmanuelle M. Charpentier, Gudrun Göhring, Brigitte Schlegelberger, Jan-Henning Klusmann, Dirk Heckl

https://doi.org/10.3324/haematol.2017.164046

Acute Myeloid Leukemia

Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia (431 Online Views)

Wenwen Wang, Thomas Stiehl, Simon Raffel, Van T. Hoang, Isabel Hoffmann, Laura Poisa-Beiro, Borhan R. Saeed, Rachel Blume, Linda Manta, Volker Eckstein, Tilmann Bochtler, Patrick Wuchter, Marieke Essers, Anna Jauch, Andreas Trumpp, Anna Marciniak-Czochra, Anthony D. Ho, Christoph Lutz

https://doi.org/10.3324/haematol.2016.163584

Acute Lymphoblastic Leukemia

HLA-DRB1*07:01–HLA-DQA1*02:01–HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia (450 Online Views)

Nóra Kutszegi, Xiaoqing Yang, András Gézsi, Géza Schermann, Dániel J. Erdélyi, Ágnes F. Semsei, Krisztina M. Gábor, Judit C. Sági, Gábor T. Kovács, András Falus, Hongyun Zhang, Csaba Szalai

https://doi.org/10.3324/haematol.2017.168211

Chronic Lymphocytic Leukemia

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax (140 Online Views)

Ana M. Cosialls, Helena Pomares, Daniel Iglesias-Serret, José Saura-Esteller, Sonia Núñez-Vázquez, Diana M. González-Gironès, Esmeralda de la Banda, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Eva M. González-Barca, Joan Gil

https://doi.org/10.3324/haematol.2016.162958

Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications (299 Online Views)

Emerence Crompot, Michael Van Damme, Karlien Pieters, Marjorie Vermeersch, David Perez-Morga, Philippe Mineur, Marie Maerevoet, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux, Basile Stamatopoulos

https://doi.org/10.3324/haematol.2016.163337

Non-Hodgkin Lymphoma

Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene (260 Online Views)

Jo-Anne van der Krogt, Marlies Vanden Bempt, Julio Finalet Ferreiro, Nicole Mentens, Kris Jacobs, Ursula Pluys, Kathleen Doms, Ellen Geerdens, Anne Uyttebroeck, Pascal Pierre, Lucienne Michaux, Timothy Devos, Peter Vandenberghe, Thomas Tousseyn, Jan Cools, Iwona Wlodarska

https://doi.org/10.3324/haematol.2016.146571

Plasma Cell Disorders

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma (319 Online Views)

Aneta Mikulasova, Christopher P. Wardell, Alexander Murison, Eileen M. Boyle, Graham H. Jackson, Jan Smetana, Zuzana Kufova, Ludek Pour, Viera Sandecka, Martina Almasi, Pavla Vsianska, Evzen Gregora, Petr Kuglik, Roman Hajek, Faith E. Davies, Gareth J. Morgan, Brian A. Walker

https://doi.org/10.3324/haematol.2017.163766

Online Only Articles

Low-dose methotrexate in myeloproliferative neoplasm models (217 Online Views)

Kavitha Chinnaiya, Michelle A. Lawson, Sally Thomas, Marie-Therese Haider, Jenny Down, Andrew D. Chantry, David Hughes, Antony Green, Jon R. Sayers, John A. Snowden, Martin P. Zeidler

https://doi.org/10.3324/haematol.2017.165738

Center-level variation in accuracy of adverse event reporting in a clinical trial for pediatric acute myeloid leukemia: a report from the Children’s Oncology Group (88 Online Views)

Tamara P. Miller, Yimei Li, Marko Kavcic, Kelly D. Getz, Yuan-Shun V. Huang, Lillian Sung, Todd A. Alonzo, Robert Gerbing, Marla H. Daves, Terzah M. Horton, Michael A. Pulsipher, Jessica Pollard, Rochelle Bagatell, Alix E. Seif, Brian T. Fisher, Selina Luger, Alan S. Gamis, Peter C. Adamson, Richard Aplenc

https://doi.org/10.3324/haematol.2017.168815

Acute myeloid leukemia stem cell function is preserved in the absence of autophagy (196 Online Views)

Amy H. Porter, Lucie Leveque-El Mouttie, Therese Vu, Claudia Bruedigam, Joanne Sutton, Sebastien Jacquelin, Geoffrey R. Hill, Kelli P.A. MacDonald, Steven W. Lane

https://doi.org/10.3324/haematol.2017.166389

Combining flow cytometry and WT1 assessment improves the prognostic value of pre-transplant minimal residual disease in acute myeloid leukemia (177 Online Views)

Fabio Guolo, Paola Minetto, Marino Clavio, Maurizio Miglino, Federica Galaverna, Anna Maria Raiola, Carmen Di Grazia, Nicoletta Colombo, Sarah Pozzi, Adalberto Ibatici, Samuele Bagnasco, Daniela Guardo, Annalisa Kunkl, Filippo Ballerini, Chiara Ghiggi, Roberto M. Lemoli, Marco Gobbi, Andrea Bacigalupo

https://doi.org/10.3324/haematol.2017.167254

Chlorambucil plus rituximab as front-line therapy for elderly and/or unfit chronic lymphocytic leukemia patients: correlation with biologically-based risk stratification (163 Online Views)

Luca Laurenti, Idanna Innocenti, Francesco Autore, Stefania Ciolli, Francesca Romana Mauro, Donato Mannina, Giovanni Del Poeta, Giovanni D’Arena, Massimo Massaia, Marta Coscia, Stefano Molica, Gabriele Pozzato, Dimitar G. Efremov, Barbara Vannata, Roberto Marasca, Pietro Galieni, Antonio Cuneo, Sonia Orlando, Alfonso Piciocchi, Riccardo Boncompagni, Donatella Vincelli, Anna Marina Liberati, Filomena Russo, Robin Foá

https://doi.org/10.3324/haematol.2016.156901

Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3) (148 Online Views)

Stefan Ehrentraut, Stefan Nagel, Claudia Pommerenke, Wilhelm G. Dirks, Hilmar Quentmeier, Maren Kaufmann, Corinna Meyer, Margarete Zaborski, Robert Geffers, Hiroshi Fujiwara, Hans G. Drexler, Roderick A. F. MacLeod

https://doi.org/10.3324/haematol.2017.168203

Improved classification of leukemic B-cell lymphoproliferative disorders using a transcriptional and genetic classifier (596 Online Views)

Alba Navarro, Guillem Clot, Alejandra Martínez-Trillos, Magda Pinyol, Pedro Jares, Blanca González-Farré, Daniel Martínez, Nicola Trim, Verónica Fernández, Neus Villamor, Dolors Colomer, Dolors Costa, Itziar Salaverria, David Martín-Garcia, Wendy Erber, Cristina López, Sandrine Jayne, Reiner Siebert, Martin J. S. Dyer, Adrian Wiestner, Wyndham H. Wilson, Marta Aymerich, Armando López-Guillermo, Àlex Sánchez, Elías Campo, Estella Matutes, Sílvia Beà

https://doi.org/10.3324/haematol.2016.160374

The level of deletion 17p and bi-allelic inactivation of TP53 has a significant impact on clinical outcome in multiple myeloma (173 Online Views)

Sharmilan Thanendrarajan, Erming Tian, Pingping Qu, Pankaj Mathur, Carolina Schinke, Frits van Rhee, Maurizio Zangari, Leo Rasche, Niels Weinhold, Daisy Alapat, William Bellamy, Cody Ashby, Sandra Mattox, Joshua Epstein, Shmuel Yaccoby, Bart Barlogie, Antje Hoering, Michael Bauer, Brian A. Walker, Faith E. Davies, Gareth J. Morgan

https://doi.org/10.3324/haematol.2017.168872

Long-term CD38 saturation by daratumumab interferes with diagnostic myeloma cell detection (224 Online Views)

Anna Oberle, Anna Brandt, Malik Alawi, Claudia Langebrake, Snjezana Janjetovic, Christine Wolschke, Kerstin Schütze, Peter Bannas, Nicolaus Kröger, Friedrich Koch-Nolte, Carsten Bokemeyer, Mascha Binder

https://doi.org/10.3324/haematol.2017.169235

GATA1 erythroid-specific regulation of SEC23B expression and its implication in the pathogenesis of congenital dyserythropoietic anemia type II (133 Online Views)

Roberta Russo, Immacolata Andolfo, Antonella Gambale, Gianluca De Rosa, Francesco Manna, Alessandra Arillo, Farooq Wandroo, Maria Grazia Bisconte, Achille Iolascon

https://doi.org/10.3324/haematol.2016.162966

Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the splice isoform GFI1B-p37 (158 Online Views)

Harald Schulze, Axel Schlagenhauf, Georgi Manukjan, Christine Beham-Schmid, Oliver Andres, Eva Klopocki, Eva-Maria König, Harald Haidl, Simon Panzer, Karina Althaus, Wolfgang E. Muntean, Wolfgang Schwinger, Christian Urban, Andreas Greinacher, Tamam Bakchoul, Markus G. Seidel

https://doi.org/10.3324/haematol.2017.167957