April, 2017
No. 102 (4)

Editorials

Review Articles

Articles

Hematopoiesis

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis (435 Online Views)

Salima Benbarche, Catherine Strassel, Catherine Angénieux, Léa Mallo, Monique Freund, Christian Gachet, François Lanza, Henri de la Salle

https://doi.org/10.3324/haematol.2016.143958

Efferocytosis is impaired in Gaucher macrophages (420 Online Views)

Elma Aflaki, Daniel K. Borger, Richard J. Grey, Martha Kirby, Stacie Anderson, Grisel Lopez, Ellen Sidransky

https://doi.org/10.3324/haematol.2016.155093

Red Cell Biology & its Disorders

Associations between environmental factors and hospital admissions for sickle cell disease (692 Online Views)

Frédéric B. Piel, Sanjay Tewari, Valentine Brousse, Antonis Analitis, Anna Font, Stephan Menzel, Subarna Chakravorty, Swee Lay Thein, Baba Inusa, Paul Telfer, Mariane de Montalembert, Gary W. Fuller, Klea Katsouyanni, David C. Rees

https://doi.org/10.3324/haematol.2016.154245

Erythrocyte survival is controlled by microRNA-142 (415 Online Views)

Natalia Rivkin, Elik Chapnik, Alexander Mildner, Gregory Barshtein, Ziv Porat, Elena Kartvelishvily, Tali Dadosh, Yehudit Birger, Gail Amir, Saul Yedgar, Shai Izraeli, Steffen Jung, Eran Hornstein

https://doi.org/10.3324/haematol.2016.156109

Hemostasis

Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking (363 Online Views)

Eduard H.T.M. Ebberink, Eveline A.M. Bouwens, Esther Bloem, Mariëtte Boon-Spijker, Maartje van den Biggelaar, Jan Voorberg, Alexander B. Meijer, Koen Mertens

https://doi.org/10.3324/haematol.2016.153163

Platelet Biology & its Disorders

The transcription factor GATA1 regulates NBEAL2 expression through a long-distance enhancer (538 Online Views)

Anouck Wijgaerts, Christine Wittevrongel, Chantal Thys, Timothy Devos, Kathelijne Peerlinck, Marloes R. Tijssen, Chris Van Geet, Kathleen Freson

https://doi.org/10.3324/haematol.2016.152777

Acute Myeloid Leukemia

CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling (427 Online Views)

Feifei Zhang, Xiaoye Liu, Chiqi Chen, Jun Zhu, Zhuo Yu, Jingjing Xie, Li Xie, Haitao Bai, Yaping Zhang, Xia Fang, Hao Gu, Chun Wang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang, Junke Zheng

https://doi.org/10.3324/haematol.2016.151555

Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia (348 Online Views)

Amir T. Fathi, Seth A. Wander, Traci M. Blonquist, Andrew M. Brunner, Philip C. Amrein, Jeffrey Supko, Nicole M. Hermance, Amity L. Manning, Hossein Sadrzadeh, Karen K. Ballen, Eyal C. Attar, Timothy A. Graubert, Gabriela Hobbs, Christelle Joseph, Ashley M. Perry, Meghan Burke, Regina Silver, Julia Foster, Meghan Bergeron, Aura Y. Ramos, Tina T. Som, Kaitlyn M. Fishman, Kristin L. McGregor, Christine Connolly, Donna S. Neuberg, Yi-Bin Chen

https://doi.org/10.3324/haematol.2016.158394

Lenalidomide combined with intensive chemotherapy in acute myeloid leukemia and higher-risk myelodysplastic syndrome with 5q deletion. Results of a phase II study by the Groupe Francophone Des Myélodysplasies (336 Online Views)

Lionel Ades, Thomas Prebet, Aspasia Stamatoullas, Christian Recher, Romain Guieze, Emmanuel Raffoux, Krimo Bouabdallah, Mathilde Hunault, Eric Wattel, Laure Stalnikiewicz, Andrea Toma, Hervé Dombret, Norbert Vey, Marie Sebert, Claude Gardin, Cendrine Chaffaut, Sylvie Chevret, Pierre Fenaux

https://doi.org/10.3324/haematol.2016.151894

Acute Lymphoblastic Leukemia

Chronic Lymphocytic Leukemia

miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study (350 Online Views)

Anne-Laure Gagez, Isabelle Duroux-Richard, Stéphane Leprêtre, Frédérique Orsini-Piocelle, Rémi Letestu, Sophie De Guibert, Edouard Tuaillon, Véronique Leblond, Olfa Khalifa, Valérie Gouilleux-Gruart, Anne Banos, Olivier Tournilhac, Jehan Dupuis, Christian Jorgensen, Guillaume Cartron, Florence Apparailly

https://doi.org/10.3324/haematol.2016.153189

Non-Hodgkin Lymphoma

Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas (401 Online Views)

Chengfeng Bi, Xuan Zhang, Ting Lu, Xiaoyan Zhang, Xianhuo Wang, Bin Meng, Huilai Zhang, Ping Wang, Julie M. Vose, Wing C. Chan, Timothy W. McKeithan, Kai Fu

https://doi.org/10.3324/haematol.2016.159160

Safety and efficacy of obinutuzumab with CHOP or bendamustine in previously untreated follicular lymphoma (1194 Online Views)

Andrew Grigg, Martin J.S. Dyer, Marcos González Díaz, Martin Dreyling, Simon Rule, Guiyuan Lei, Andrea Knapp, Elisabeth Wassner-Fritsch, Paula Marlton

https://doi.org/10.3324/haematol.2016.152272

Plasma Cell Disorders

IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts (409 Online Views)

Marina Bolzoni, Domenica Ronchetti, Paola Storti, Gaetano Donofrio, Valentina Marchica, Federica Costa, Luca Agnelli, Denise Toscani, Rosanna Vescovini, Katia Todoerti, Sabrina Bonomini, Gabriella Sammarelli, Andrea Vecchi, Daniela Guasco, Fabrizio Accardi, Benedetta Dalla Palma, Barbara Gamberi, Carlo Ferrari, Antonino Neri, Franco Aversa, Nicola Giuliani

https://doi.org/10.3324/haematol.2016.153841

Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients (936 Online Views)

Michael Ghermezi, Mingjie Li, Suzie Vardanyan, Nika Manik Harutyunyan, Jillian Gottlieb, Ariana Berenson, Tanya M. Spektor, Claudia Andreu-Vieyra, Sophia Petraki, Eric Sanchez, Kyle Udd, Cathy S. Wang, Regina A. Swift, Haiming Chen, James R. Berenson

https://doi.org/10.3324/haematol.2016.150896

Cell Therapy & Immunotherapy

Increased age-associated mortality risk in HLA-mismatched hematopoietic stem cell transplantation (315 Online Views)

Daniel Fürst, Dietger Niederwieser, Donald Bunjes, Eva M. Wagner, Martin Gramatzki, Gerald Wulf, Carlheinz R. Müller, Christine Neuchel, Chrysanthi Tsamadou, Hubert Schrezenmeier, Joannis Mytilineos

https://doi.org/10.3324/haematol.2016.151340

Guidelines

Risk factors for mortality in adult patients with sickle cell disease: a meta-analysis of studies in North America and Europe (1509 Online Views)

Poulami Maitra, Melissa Caughey, Laura Robinson, Payal C. Desai, Susan Jones, Mehdi Nouraie, Mark T. Gladwin, Alan Hinderliter, Jianwen Cai, Kenneth I. Ataga

https://doi.org/10.3324/haematol.2016.153791

Online Only Articles

Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced in vivo homing capacity compared to plerixafor alone (354 Online Views)

Maria Rosa Lidonnici, Annamaria Aprile, Marta Claudia Frittoli, Giacomo Mandelli, Ylenia Paleari, Antonello Spinelli, Bernhard Gentner, Matilde Zambelli, Cristina Parisi, Laura Bellio, Elena Cassinerio, Laura Zanaboni, Maria Domenica Cappellini, Fabio Ciceri, Sarah Marktel, Giuliana Ferrari

https://doi.org/10.3324/haematol.2016.154740

Impact of FLT3-ITD diversity on response to induction chemotherapy in patients with acute myeloid leukemia (455 Online Views)

Mike Fischer, Ulf Schnetzke, Bärbel Spies-Weisshart, Mario Walther, Maximilian Fleischmann, Inken Hilgendorf, Andreas Hochhaus, Sebastian Scholl

https://doi.org/10.3324/haematol.2016.157180

Long-term relapse-free survival in a phase 2 study of blinatumomab for the treatment of patients with minimal residual disease in B-lineage acute lymphoblastic leukemia (353 Online Views)

Nicola Gökbuget, Gerhard Zugmaier, Matthias Klinger, Peter Kufer, Matthias Stelljes, Andreas Viardot, Heinz A. Horst, Svenja Neumann, Monika Brüggemann, Oliver G. Ottmann, Thomas Burmeister, Dorothea Wessiepe, Max S. Topp, Ralf Bargou

https://doi.org/10.3324/haematol.2016.153957

Peripheral neuropathies in chronic lymphocytic leukemia: a single center experience on 816 patients (309 Online Views)

Chiara Briani, Andrea Visentin, Alessandro Salvalaggio, Silvia Imbergamo, Francesco Piazza, Mario Cacciavillani, Marta Campagnolo, Federica Frezzato, Gianpietro Semenzato, Livio Trentin

https://doi.org/10.3324/haematol.2016.153064

Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-naïve chronic lymphocytic leukemia (188 Online Views)

Chiara Cavallini, Carlo Visco, Santosh Putta, Davide Rossi, Elda Mimiola, Norman Purvis, Ornella Lovato, Omar Perbellini, Erika Falisi, Monica Facco, Livio Trentin, Maria G. Romanelli, Gianpietro Semenzato, Achille Ambrosetti, Gianluca Gaidano, Giovanni Pizzolo, Alessandra Cesano, Maria T. Scupoli

https://doi.org/10.3324/haematol.2016.154450

Integrative clinicopathological and molecular analyses of angioimmunoblastic T-cell lymphoma and other nodal lymphomas of follicular helper T-cell origin (485 Online Views)

Maria Pamela Dobay, Francois Lemonnier, Edoardo Missiaglia, Christian Bastard, David Vallois, Jean-Philippe Jais, Laurianne Scourzic, Aurélie Dupuy, Virginie Fataccioli, Anais Pujals, Marie Parrens, Fabien Le Bras, Thérèse Rousset, Jean-Michel Picquenot, Nadine Martin, Corinne Haioun, Richard Delarue, Olivier A. Bernard, Mauro Delorenzi, Laurence de Leval, Philippe Gaulard

https://doi.org/10.3324/haematol.2016.158428

Hematopoiesis in patients with mature B-cell malignancies is deregulated even in patients with undetectable bone marrow involvement (156 Online Views)

Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Filipp Savvulidi, Tomas Zikmund, Dana Prukova, Diana Tuskova, Magdalena Klanova, Petra Vockova, Lucie Lateckova, Ludek Sefc, Jan Zivny, Marek Trneny, Pavel Klener

https://doi.org/10.3324/haematol.2016.151571

Efficacy and safety of idelalisib in patients with relapsed, rituximab- and alkylating agent-refractory follicular lymphoma: a subgroup analysis of a phase 2 study (754 Online Views)

Gilles Salles, Stephen J. Schuster, Sven de Vos, Nina D. Wagner-Johnston, Andreas Viardot, Kristie A. Blum, Christopher R. Flowers, Wojciech J. Jurczak, Ian W. Flinn, Brad S. Kahl, Peter Martin, Yeonhee Kim, Sanatan Shreay, Matthias Will, Bess Sorensen, Madlaina Breuleux, Pier Luigi Zinzani, Ajay K. Gopal

https://doi.org/10.3324/haematol.2016.151738