May, 2017
No. 102 (5)

Editorials

Review Articles

Articles

Hematopoiesis

Bone marrow mesenchymal stromal cells induce nitric oxide synthase-dependent differentiation of CD11b+ cells that expedite hematopoietic recovery

Cristina Trento, Ilaria Marigo, Alice Pievani, Antonio Galleu, Luigi Dolcetti, Chun-Yin Wang, Marta Serafini, Vincenzo Bronte, Francesco Dazzi

https://doi.org/10.3324/haematol.2016.155390

Red Cell Biology & Its Disorders

Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors

Minyoung Youn, Nan Wang, Corinne LaVasseur, Elena Bibikova, Sharon Kam, Bertil Glader, Kathleen M. Sakamoto, Anupama Narla

https://doi.org/10.3324/haematol.2016.156257

Hemostasis

Obstetric antiphospholipid syndrome: early variations of angiogenic factors are associated with adverse outcomes

Éva Cochery-Nouvellon, Érick Mercier, Sylvie Bouvier, Jean-Pierre Balducchi, Isabelle Quéré, Antonia Perez-Martin, Eve Mousty, Vincent Letouzey, Jean-Christophe Gris

https://doi.org/10.3324/haematol.2016.155184

Chronic Myeloid Leukemia

Increased peroxisome proliferator-activated receptor γ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells

Jueqiong Wang, Liu Lu, Chung H. Kok, Verity A. Saunders, Jarrad M. Goyne, Phuong Dang, Tamara M. Leclercq, Timothy P. Hughes, Deborah L. White

https://doi.org/10.3324/haematol.2016.153270

Acute Myeloid Leukemia

Long-term observation reveals high-frequency engraftment of human acute myeloid leukemia in immunodeficient mice

Anna M. Paczulla, Stephan Dirnhofer, Martina Konantz, Michael Medinger, Helmut R. Salih, Kathrin Rothfelder, Dimitrios A. Tsakiris, Jakob R. Passweg, Pontus Lundberg, Claudia Lengerke

https://doi.org/10.3324/haematol.2016.153528

Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis

Sarah A. Buckley, Brent L. Wood, Megan Othus, Christopher S. Hourigan, Celalettin Ustun, Michael A. Linden, Todd E. DeFor, Michele Malagola, Chloe Anthias, Veronika Valkova, Christopher G. Kanakry, Bernd Gruhn, Francesco Buccisano, Beth Devine, Roland B. Walter

https://doi.org/10.3324/haematol.2016.159343

Chronic Lymphocytic Leukemia

Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia

Mika Shapiro, Yair Herishanu, Ben-Zion Katz, Nili Dezorella, Clare Sun, Sigi Kay, Aaron Polliack, Irit Avivi, Adrian Wiestner, Chava Perry

https://doi.org/10.3324/haematol.2016.148965

Non-Hodgkin Lymphoma

c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells

Amandine David, Nicolas Arnaud, Magali Fradet, Hélène Lascaux, Catherine Ouk-Martin, Nathalie Gachard, Ursula Zimber-Strobl, Jean Feuillard, Nathalie Faumont

https://doi.org/10.3324/haematol.2016.156281

Association between quality of response and outcomes in patients with newly diagnosed mantle cell lymphoma receiving VR-CAP versus R-CHOP in the phase 3 LYM-3002 study

Gregor Verhoef, Tadeusz Robak, Huiqiang Huang, Halyna Pylypenko, Noppadol Siritanaratkul, Juliana Pereira, Johannes Drach, Jiri Mayer, Rumiko Okamoto, Lixia Pei, Brendan Rooney, Andrew Cakana, Helgi van de Velde, Franco Cavalli

https://doi.org/10.3324/haematol.2016.152496

Safety and efficacy of abexinostat, a pan-histone deacetylase inhibitor, in non-Hodgkin lymphoma and chronic lymphocytic leukemia: results of a phase II study

Vincent Ribrag, Won Seog Kim, Reda Bouabdallah, Soon Thye Lim, Bertrand Coiffier, Arpad Illes, Bernard Lemieux, Martin J. S. Dyer, Fritz Offner, Zakia Felloussi, Ioana Kloos, Ying Luan, Remus Vezan, Thorsten Graef, Franck Morschhauser

https://doi.org/10.3324/haematol.2016.154377

Plasma Cell Disorders

A concise revised Myeloma Comorbidity Index as a valid prognostic instrument in a large cohort of 801 multiple myeloma patients

Monika Engelhardt, Anne-Saskia Domm, Sandra Maria Dold, Gabriele Ihorst, Heike Reinhardt, Alexander Zober, Stefanie Hieke, Corine Baayen, Stefan Jürgen Müller, Hermann Einsele, Pieter Sonneveld, Ola Landgren, Martin Schumacher, Ralph Wäsch

https://doi.org/10.3324/haematol.2016.162693

Recovery of polyclonal immunoglobulins one year after autologous stem cell transplantation as a long-term predictor marker of progression and survival in multiple myeloma

Verónica González-Calle, Seila Cerdá, Jorge Labrador, Eduardo Sobejano, Beatriz González-Mena, Carmen Aguilera, Enrique María Ocio, María Belén Vidriales, Noemí Puig, Norma Carmen Gutiérrez, Ramón García-Sanz, José María Alonso, Rosa López, Carlos Aguilar, Alfonso García de Coca, Roberto Hernández, José Mariano Hernández, Fernando Escalante, María-Victoria Mateos

https://doi.org/10.3324/haematol.2016.158345

Cell Therapy & Immunotherapy

Plasma-derived proteomic biomarkers in human leukocyte antigen-haploidentical or human leukocyte antigen-matched bone marrow transplantation using post-transplantation cyclophosphamide

Christopher G. Kanakry, Giorgos Bakoyannis, Susan M. Perkins, Shannon R. McCurdy, Ante Vulic, Edus H. Warren, Etienne Daguindau, Taylor Olmsted, Christen Mumaw, Andrea M.H. Towlerton, Kenneth R. Cooke, Paul V. O’Donnell, Heather J. Symons, Sophie Paczesny, Leo Luznik

https://doi.org/10.3324/haematol.2016.152322

The effect of inter-unit HLA matching in double umbilical cord blood transplantation for acute leukemia

Claudio Brunstein, Mei-Jie Zhang, Juliet Barker, Andrew St. Martin, Asad Bashey, Marcos de Lima, Jason Dehn, Peiman Hematti, Miguel-Angel Perales, Vanderson Rocha, Mary Territo, Daniel Weisdorf, Mary Eapen

https://doi.org/10.3324/haematol.2016.158584

IL-2 promotes early Treg reconstitution after allogeneic hematopoietic cell transplantation

Brian C. Betts, Joseph Pidala, Jongphil Kim, Asmita Mishra, Taiga Nishihori, Lia Perez, Jose Leonel Ochoa-Bayona, Farhad Khimani, Kelly Walton, Ryan Bookout, Michael Nieder, Divis K. Khaira, Marco Davila, Melissa Alsina, Teresa Field, Ernesto Ayala, Frederick L. Locke, Marcie Riches, Mohamed Kharfan-Dabaja, Hugo Fernandez, Claudio Anasetti

https://doi.org/10.3324/haematol.2016.153072

Improved survival after acute graft-versus-host disease diagnosis in the modern era

Hanna J. Khoury, Tao Wang, Michael T. Hemmer, Daniel Couriel, Amin Alousi, Corey Cutler, Mahmoud Aljurf, Joseph H. Antin, Mouhab Ayas, Minoo Battiwalla, Jean-Yves Cahn, Mitchell Cairo, Yi-Bin Chen, Robert Peter Gale, Shahrukh Hashmi, Robert J. Hayashi, Madan Jagasia, Mark Juckett, Rammurti T. Kamble, Mohamed Kharfan-Dabaja, Mark Litzow, Navneet Majhail, Alan Miller, Taiga Nishihori, Muna Qayed, Helene Schoemans, Harry C. Schouten, Gerard Socie, Jan Storek, Leo Verdonck, Ravi Vij, William A. Wood, Lolie Yu, Rodrigo Martino, Matthew Carabasi, Christopher Dandoy, Usama Gergis, Peiman Hematti, Melham Solh, Kareem Jamani, Leslie Lehmann, Bipin Savani, Kirk R. Schultz, Baldeep M. Wirk, Stephen Spellman, Mukta Arora, Joseph Pidala

https://doi.org/10.3324/haematol.2016.156356

Online Only Articles

Prostacyclin-analog therapy in sickle cell pulmonary hypertension

Nargues A. Weir, Rehan Saiyed, Shoaib Alam, Anna Conrey, Himanshu D. Desai, M. Patricia George, Jennifer H. Keeley, Elizabeth S. Klings, Alem Mehari, James G. Taylor, Caterina P. Minniti, Gregory J. Kato

https://doi.org/10.3324/haematol.2015.131227

Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia

Adelina Sergueeva, Galina Miasnikova, Binal N. Shah, Jihyun Song, Ekaterina Lisina, Daniel J. Okhotin, Mehdi Nouraie, Sergei Nekhai, Tatiana Ammosova, Xiao Mei Niu, Josef T. Prchal, Xu Zhang, Victor R. Gordeuk

https://doi.org/10.3324/haematol.2016.158170

Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization

Julia Schanda, Chun-Wei Lee, Katharina Wohlan, Uta Müller-Kuller, Hana Kunkel, Isabell Quagliano-Lo Coco, Stefan Stein, Alexander Metz, Joachim Koch, Jörn Lausen, Uwe Platzbecker, Hind Medyouf, Holger Gohlke, Michael Heuser, Matthias Eder, Manuel Grez, Michaela Scherr, Christian Wichmann

https://doi.org/10.3324/haematol.2016.161570

Hyperlipidemia is a risk factor for osteonecrosis in children and young adults with acute lymphoblastic leukemia

Signe Sloth Mogensen, Kjeld Schmiegelow, Kathrine Grell, Birgitte Klug Albertsen, Peder Skov Wehner, Peter Kampmann, Thomas Leth Frandsen

https://doi.org/10.3324/haematol.2016.160507

Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing

Christoph Bartenhagen, Ute Fischer, Klaus Korn, Stefan M. Pfister, Michael Gombert, Cai Chen, Vera Okpanyi, Julia Hauer, Anna Rinaldi, Jean-Pierre Bourquin, Cornelia Eckert, Jianda Hu, Armin Ensser, Martin Dugas, Arndt Borkhardt

https://doi.org/10.3324/haematol.2016.155382

Hyper-CVAD + epratuzumab as a salvage regimen for younger patients with relapsed/refractory CD22-positive precursor B-cell acute lymphocytic leukemia

Patrice Chevallier, Sylvain Chantepie, Francoise Huguet, Emmanuel Raffoux, Xavier Thomas, Thibaut Leguay, Tony Marchand, Francoise Isnard, Aude Charbonnier, Sébastien Maury, Maria-Pilar Gallego-Hernanz, Nelly Robillard, Thierry Guillaume, Pierre Peterlin, Alice Garnier, Fanny Rialland, Claire Le Houerou, David M. Goldenberg, William A. Wegener, Marie-C. Béné, Hervé Dombret

https://doi.org/10.3324/haematol.2016.159905

BCR-ABL translocation as a favorable prognostic factor in elderly patients with acute lymphoblastic leukemia in the era of potent tyrosine kinase inhibitors

Ja Min Byun, Youngil Koh, Dong-Yeop Shin, Inho Kim, Sung-Soo Yoon, Jeong-Ok Lee, Soo-Mee Bang, Ki Hwan Kim, Sung-Hoon Jung, Won Sik Lee, Yong Park, Jun Ho Jang, Jae Joon Han, Ho-Young Yhim, Dae Sik Kim, Yoo Jin Lee, Hyewon Lee, Yun-Suk Choi, Seok Lee

https://doi.org/10.3324/haematol.2016.159988

The Bruton tyrosine kinase inhibitor ibrutinib abrogates triggering receptor on myeloid cells 1-mediated neutrophil activation

Nicole Stadler, Astrid Hasibeder, Pamela Aranda Lopez, Daniel Teschner, Alexander Desuki, Oliver Kriege, Alexander N. R. Weber, Christoph Schulz, Christian Michel, Georg Heβ, Markus P. Radsak

https://doi.org/10.3324/haematol.2016.152017

Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma

Leo Meriranta, Annika Pasanen, Riku Louhimo, Alejandra Cervera, Amjad Alkodsi, Matias Autio, Minna Taskinen, Ville Rantanen, Marja-Liisa Karjalainen-Lindsberg, Harald Holte, Jan Delabie, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä

https://doi.org/10.3324/haematol.2016.157495

Genetic polymorphism at BCL2 as a predictor for rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone efficacy in patients with diffuse large B-cell lymphoma

Morteza Bashash, Joseph M. Connors, Randy D. Gascoyne, Barbara Meissner, Johanna M. Schuetz, Stephen Leach, Graham W. Slack, Brian R. Berry, Howard Hu, Laurie H. Sehn, Angela R. Brooks-Wilson, John J. Spinelli

https://doi.org/10.3324/haematol.2016.159087

Second-line rituximab, lenalidomide, and bendamustine in mantle cell lymphoma: a phase II clinical trial of the Fondazione Italiana Linfomi

Francesco Zaja, Simone Ferrero, Caterina Stelitano, Angela Ferrari, Flavia Salvi, Annalisa Arcari, Gerardo Musuraca, Barbara Botto, Michele Spina, Claudia Cellini, Caterina Patti, Anna M. Liberati, Claudia Minotto, Stefano A. Pileri, Manuela Ceccarelli, Stefano Volpetti, Antonella Ferranti, Daniela Drandi, Elisa Montechiarello, Marco Ladetto, James Carmichael, Renato Fanin

https://doi.org/10.3324/haematol.2016.154211

Changes in allele frequencies of CSF3R and SETBP1 mutations and evidence of clonal evolution in a chronic neutrophilic leukemia patient treated with ruxolitinib

Zohra Nooruddin, Nicholas Miltgen, Qi Wei, Jeffrey Schowinsky, Zengang Pan, Jennifer Tobin, Enkhtsetseg Purev, Jonathan A. Gutman, William Robinson, Daniel A. Pollyea

https://doi.org/10.3324/haematol.2016.163089

Repeated fecal microbiota transplantations attenuate diarrhea and lead to sustained changes in the fecal microbiota in acute, refractory gastrointestinal graft-versus-host-disease

Walter Spindelboeck, Eduard Schulz, Barbara Uhl, Karl Kashofer, Ariane Aigelsreiter, Wilma Zinke-Cerwenka, Adnan Mulabecirovic, Patrizia K. Kump, Bettina Halwachs, Gregor Gorkiewicz, Heinz Sill, Hildegard Greinix, Christoph Högenauer, Peter Neumeister

https://doi.org/10.3324/haematol.2016.154351