March, 2017
No. 102 (3)

Editorials

Review Articles

Is immunotherapy here to stay in multiple myeloma?

Paula Rodríguez-Otero, Bruno Paiva, Monika Engelhardt, Felipe Prósper, Jesús F. San Miguel

https://doi.org/10.3324/haematol.2016.152504

Articles

Hematopoiesis

IFNα-mediated remodeling of endothelial cells in the bone marrow niche

Áine M. Prendergast, Andrea Kuck, Mieke van Essen, Simon Haas, Sandra Blaszkiewicz, Marieke A. G. Essers

https://doi.org/10.3324/haematol.2016.151209

Red Cell Biology & Its Disorders

Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency

Masahiro Kobayashi, Hiroki Kato, Hiroshi Hada, Ari Itoh-Nakadai, Tohru Fujiwara, Akihiko Muto, Yukihiro Inoguchi, Kenji Ichiyanagi, Wataru Hojo, Naohisa Tomosugi, Hiroyuki Sasaki, Hideo Harigae, Kazuhiko Igarashi

https://doi.org/10.3324/haematol.2016.151043

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Xuan Yuan, Eleni Gavriilaki, Jane A. Thanassi, Guangwei Yang, Andrea C. Baines, Steven D. Podos, Yongqing Huang, Mingjun Huang, Robert A. Brodsky

https://doi.org/10.3324/haematol.2016.153312

Blood Transfusion

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes

Hugues Beauchemin, Peiman Shooshtarizadeh, Charles Vadnais, Lothar Vassen, Yves D Pastore, Tarik Möröy

https://doi.org/10.3324/haematol.2016.150375

Myelodysplastic Syndromes

Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations

Christian Scharenberg, Valentina Giai, Andrea Pellagatti, Leonie Saft, Marios Dimitriou, Monika Jansson, Martin Jädersten, Alf Grandien, Iyadh Douagi, Donna S. Neuberg, Katarina LeBlanc, Jacqueline Boultwood, Mohsen Karimi, Sten Eirik W. Jacobsen, Petter S. Woll, Eva Hellström-Lindberg

https://doi.org/10.3324/haematol.2016.152025

Myeloproliferative Disorders

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms

Chih-Cheng Chen, Jie-Yu You, Jrhau Lung, Cih-En Huang, Yi-Yang Chen, Yu-Wei Leu, Hsing-Ying Ho, Chian-Pei Li, Chang-Hsien Lu, Kuan-Der Lee, Chia-Chen Hsu, Jyh-Pyng Gau

https://doi.org/10.3324/haematol.2016.154385

Chronic Myeloid Leukemia

Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia

Jorge Cortes, Moshe Talpaz, Hedy P. Smith, David S. Snyder, Jean Khoury, Kapil N. Bhalla, Javier Pinilla-Ibarz, Richard Larson, David Mitchell, Scott C. Wise, Thomas J. Rutkoski, Bryan D. Smith, Daniel L. Flynn, Hagop M. Kantarjian, Oliver Rosen, Richard A. Van Etten

https://doi.org/10.3324/haematol.2016.152710

Acute Myeloid Leukemia

CEBPA–double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

Francesco Mannelli, Vanessa Ponziani, Sara Bencini, Maria Ida Bonetti, Matteo Benelli, Ilaria Cutini, Giacomo Gianfaldoni, Barbara Scappini, Fabiana Pancani, Matteo Piccini, Tommaso Rondelli, Roberto Caporale, Anna Maria Grazia Gelli, Benedetta Peruzzi, Marco Chiarini, Erika Borlenghi, Orietta Spinelli, Damiano Giupponi, Pamela Zanghì, Renato Bassan, Alessandro Rambaldi, Giuseppe Rossi, Alberto Bosi

https://doi.org/10.3324/haematol.2016.151910

Acute Lymphoblastic Leukemia

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients

Blanca Scheijen, Judith M. Boer, René Marke, Esther Tijchon, Dorette van Ingen Schenau, Esmé Waanders, Liesbeth van Emst, Laurens T. van der Meer, Rob Pieters, Gabriele Escherich, Martin A. Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P. Kuiper, Peter M. Hoogerbrugge, Monique L. den Boer, Frank N. van Leeuwen

https://doi.org/10.3324/haematol.2016.153023

Population pharmacokinetics of intravenous Erwinia asparaginase in pediatric acute lymphoblastic leukemia patients

Sebastiaan D.T. Sassen, Ron A.A. Mathôt, Rob Pieters, Robin Q.H. Kloos, Valérie de Haas, Gertjan J.L. Kaspers, Cor van den Bos, Wim J.E. Tissing, Maroeska te Loo, Marc B. Bierings, Wouter J.W. Kollen, Christian M. Zwaan, Inge M. van der Sluis

https://doi.org/10.3324/haematol.2016.149195

Chronic Lymphocytic Leukemia

T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers

Marzia Palma, Giusy Gentilcore, Kia Heimersson, Fariba Mozaffari, Barbro Näsman-Glaser, Emma Young, Richard Rosenquist, Lotta Hansson, Anders Österborg, Håkan Mellstedt

https://doi.org/10.3324/haematol.2016.151100

Non-Hodgkin Lymphoma

The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells

Martine van Keimpema, Leonie J. Grüneberg, Esther J.M. Schilder-Tol, Monique E.C.M. Oud, Esther A. Beuling, Paul J. Hensbergen, Johann de Jong, Steven T. Pals, Marcel Spaargaren

https://doi.org/10.3324/haematol.2016.156455


Plasma Cell Disorders

Evaluation of the Revised International Staging System in an independent cohort of unselected patients with multiple myeloma

Efstathios Kastritis, Evangelos Terpos, Maria Roussou, Maria Gavriatopoulou, Magdalini Migkou, Evangelos Eleutherakis-Papaiakovou, Despoina Fotiou, Dimitrios Ziogas, Ioannis Panagiotidis, Eftychia Kafantari, Stavroula Giannouli, Athanasios Zomas, Konstantinos Konstantopoulos, Meletios A. Dimopoulos

https://doi.org/10.3324/haematol.2016.145078

Cell Therapy & Immunotherapy

Effect of high-dose plerixafor on CD34+ cell mobilization in healthy stem cell donors: results of a randomized crossover trial

Jeremy Pantin, Enkhtsetseg Purev, Xin Tian, Lisa Cook, Theresa Donohue-Jerussi, Elena Cho, Robert Reger, Matthew Hsieh, Hanh Khuu, Gary Calandra, Nancy L. Geller, Richard W. Childs

https://doi.org/10.3324/haematol.2016.147132

Guidelines

ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients

Frederic Tissot, Samir Agrawal, Livio Pagano, Georgios Petrikkos, Andreas H. Groll, Anna Skiada, Cornelia Lass-Flörl, Thierry Calandra, Claudio Viscoli, Raoul Herbrecht

https://doi.org/10.3324/haematol.2016.152900

Online Only Articles

Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells

Katrin S. Reiners, Olga Shatnyeva, Elena Vasyutina, Teresa Bösl, Hinrich P. Hansen, Michael Hallek, Marco Herling, Elke Pogge von Strandmann

https://doi.org/10.3324/haematol.2016.153197

Invasive fungal infections in chronic lymphoproliferative disorders: a monocentric retrospective study

Maria Chiara Tisi, Stefan Hohaus, Annarosa Cuccaro, Idanna Innocenti, Elena De Carolis, Tommaso Za, Francesco D’Alò, Luca Laurenti, Luana Fianchi, Simona Sica, Maurizio Sanguinetti, Valerio De Stefano, Livio Pagano

https://doi.org/10.3324/haematol.2016.151837

Case Report

Deep and sustained response after venetoclax therapy in a patient with very advanced refractory myeloma with translocation t(11;14)

Cyrille Touzeau, Steven Le Gouill, Béatrice Mahé, Jean Samuel Boudreault, Thomas Gastinne, Nicolas Blin, Hélène Caillon, Christelle Dousset, Martine Amiot, Philippe Moreau

https://doi.org/10.3324/haematol.2016.160408

Comment

Comments

Different clinical characteristics of paroxysmal nocturnal hemoglobinuria in pediatric and adult patients

Álvaro Urbano-Ispizua, Petra Muus, Hubert Schrezenmeier, Antonio M. Almeida, Amanda Wilson, Russell E. Ware

https://doi.org/10.3324/haematol.2016.151852

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

Sachith Mettananda, Christopher A. Fisher, Jackie A. Sloane-Stanley, Stephen Taylor, Udo Oppermann, Richard J. Gibbons, Douglas R. Higgs

https://doi.org/10.3324/haematol.2016.155655

Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model

Mark R. Hanudel, Maxime Rappaport, Victoria Gabayan, Grace Jung, Isidro B. Salusky, Elizabeta Nemeth, Tomas Ganz, Joshua Zaritsky

https://doi.org/10.3324/haematol.2016.150433

Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia

Fumika Ikeda, Kenichi Yoshida, Tsutomu Toki, Tamayo Uechi, Shiori Ishida, Yukari Nakajima, Yoji Sasahara, Yusuke Okuno, Rika Kanezaki, Kiminori Terui, Takuya Kamio, Akie Kobayashi, Takashi Fujita, Aiko Sato-Otsubo, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Hideki Muramatsu, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Naoya Kenmochi, Satoru Miyano, Seishi Ogawa, Etsuro Ito

https://doi.org/10.3324/haematol.2016.153932