February, 2017
No. 102 (2)

Editorials

Review Articles

Articles

Red Cell Biology & its Disorders

ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease (197 Online Views)

Kyungho Kim, Jing Li, Andrew Barazia, Alan Tseng, Seock-Won Youn, Giovanni Abbadessa, Yi Yu, Brian Schwartz, Robert K. Andrews, Victor R. Gordeuk, Jaehyung Cho

https://doi.org/10.3324/haematol.2016.151159

Iron Metabolism & its Disorders

Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model (262 Online Views)

Sarah Millot, Constance Delaby, Boualem Moulouel, Thibaud Lefebvre, Nathalie Pilard, Nicolas Ducrot, Cécile Ged, Philippe Lettéron, Lucia de Franceschi, Jean Charles Deybach, Carole Beaumont, Laurent Gouya, Hubert De Verneuil, Saïd Lyoumi, Hervé Puy, Zoubida Karim

https://doi.org/10.3324/haematol.2016.151621

Coagulation & its Disorders

The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells (198 Online Views)

Bagirath Gangadharan, Mathieu Ing, Sandrine Delignat, Ivan Peyron, Maud Teyssandier, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2016.148502

Platelet Biology & its Disorders

Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors (320 Online Views)

Marjorie Poggi, Matthias Canault, Marie Favier, Ernest Turro, Paul Saultier, Dorsaf Ghalloussi, Veronique Baccini, Lea Vidal, Anna Mezzapesa, Nadjim Chelghoum, Badreddine Mohand-Oumoussa, Céline Falaise, Rémi Favier, Willem H. Ouwehand, Mathieu Fiore, Franck Peiretti, Pierre Emmanuel Morange, Noémie Saut, Denis Bernot, Andreas Greinacher, NIHR BioResource, Alan T. Nurden, Paquita Nurden, Kathleen Freson, David-Alexandre Trégouët, Hana Raslova, Marie-Christine Alessi

https://doi.org/10.3324/haematol.2016.147694

Bone Marrow Failure

Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice (232 Online Views)

Junping Xin, Peter Breslin, Wei Wei, Jing Li, Rafael Gutierrez, Joseph Cannova, Allen Ni, Grace Ng, Rachel Schmidt, Haiyan Chen, Vamsi Parini, Paul C. Kuo, Ameet R. Kini, Patrick Stiff, Jiang Zhu, Jiwang Zhang

https://doi.org/10.3324/haematol.2016.151514

Myelodysplastic Syndromes

Immunophenotypic analysis of erythroid dysplasia in myelodysplastic syndromes. A report from the IMDSFlow working group (394 Online Views)

Theresia M. Westers, Eline M.P. Cremers, Uta Oelschlaegel, Ulrika Johansson, Peter Bettelheim, Sergio Matarraz, Alberto Orfao, Bijan Moshaver, Lisa Eidenschink Brodersen, Michael R. Loken, Denise A. Wells, Dolores Subirá, Matthew Cullen, Jeroen G. te Marvelde, Vincent H.J. van der Velden, Frank W.M.B. Preijers, Sung-Chao Chu, Jean Feuillard, Estelle Guérin, Katherina Psarra, Anna Porwit, Leonie Saft, Robin Ireland, Timothy Milne, Marie C. Béné, Birgit I. Witte, Matteo G. Della Porta, Wolfgang Kern, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2016.147835

Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes (415 Online Views)

Eline M.P. Cremers, Theresia M. Westers, Canan Alhan, Claudia Cali, Heleen A. Visser-Wisselaar, Dana A. Chitu, Vincent H.J. van der Velden, Jeroen G. te Marvelde, Saskia K. Klein, Petra Muus, Edo Vellenga, Georgina E. de Greef, Marie-Cecile C.J.C. Legdeur, Pierre W. Wijermans, Marian J.P.L. Stevens-Kroef, Pedro da Silva-Coelho, Joop H. Jansen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2016.147843

Myeloproliferative Disorders

Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis (215 Online Views)

John O. Mascarenhas, Moshe Talpaz, Vikas Gupta, Lynda M. Foltz, Michael R. Savona, Ronald Paquette, A. Robert Turner, Paul Coughlin, Elliott Winton, Timothy C. Burn, Peter O’Neill, Jason Clark, Deborah Hunter, Albert Assad, Ronald Hoffman, Srdan Verstovsek

https://doi.org/10.3324/haematol.2016.151126

Acute Myeloid Leukemia

Distinct global binding patterns of the Wilms tumor gene 1 (WT1) −KTS and +KTS isoforms in leukemic cells (172 Online Views)

Tove Ullmark, Linnea Järvstråt, Carl Sandén, Giorgia Montano, Helena Jernmark-Nilsson, Henrik Lilljebjörn, Andreas Lennartsson, Thoas Fioretos, Kristina Drott, Karina Vidovic, Björn Nilsson, Urban Gullberg

https://doi.org/10.3324/haematol.2016.149815

Acute Lymphoblastic Leukemia

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system (213 Online Views)

Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Nele M. Belau, Martin Zimmermann, Tim Wirbelauer, Steffi Spielberg, Michaela Vossen-Gajcy, Gunnar Cario, Martin Schrappe, Denis M. Schewe

https://doi.org/10.3324/haematol.2016.147744

Non-Hodgkin Lymphoma

Early treatment intensification with R-ICE and 90Y-ibritumomab tiuxetan (Zevalin)-BEAM stem cell transplantation in patients with high-risk diffuse large B-cell lymphoma patients and positive interim PET after 4 cycles of R-CHOP-14 (244 Online Views)

Mark Hertzberg, Maher K. Gandhi, Judith Trotman, Belinda Butcher, John Taper, Amanda Johnston, Devinder Gill, Shir-Jing Ho, Gavin Cull, Keith Fay, Geoff Chong, Andrew Grigg, Ian D. Lewis, Sam Milliken, William Renwick, Uwe Hahn, Robin Filshie, George Kannourakis, Anne-Marie Watson, Pauline Warburton, Andrew Wirth, John F. Seymour, Michael S. Hofman, Rodney J. Hicks

https://doi.org/10.3324/haematol.2016.154039

Bone marrow findings in autoimmune lymphoproliferative syndrome with germline FAS mutation (451 Online Views)

Yi Xie, Stefania Pittaluga, Susan Price, Mark Raffeld, Jamie Hahn, Elaine S. Jaffe, V. Koneti Rao, Irina Maric

https://doi.org/10.3324/haematol.2015.138081

Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs (292 Online Views)

Rohit Mathur, Lalit Sehgal, Ondrej Havranek, Stefan Köhrer, Tamer Khashab, Neeraj Jain, Jan A. Burger, Sattva S. Neelapu, R. Eric Davis, Felipe Samaniego

https://doi.org/10.3324/haematol.2016.144964

Plasma Cell Disorders

Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth (341 Online Views)

Renate Burger, Andreas Günther, Katja Klausz, Matthias Staudinger, Matthias Peipp, Eva Maria Murga Penas, Stefan Rose-John, John Wijdenes, Martin Gramatzki

https://doi.org/10.3324/haematol.2016.145060

Cell Therapy & Immunotherapy

Comparable composite endpoints after HLA-matched and HLA-haploidentical transplantation with post-transplantation cyclophosphamide (269 Online Views)

Shannon R. McCurdy, Yvette L. Kasamon, Christopher G. Kanakry, Javier Bolaños-Meade, Hua-Ling Tsai, Margaret M. Showel, Jennifer A. Kanakry, Heather J. Symons, Ivana Gojo, B. Douglas Smith, Maria P. Bettinotti, William H. Matsui, Amy E. Dezern, Carol Ann Huff, Ivan Borrello, Keith W. Pratz, Douglas E. Gladstone, Lode J. Swinnen, Robert A. Brodsky, Mark J. Levis, Richard F. Ambinder, Ephraim J. Fuchs, Gary L. Rosner, Richard J. Jones, Leo Luznik

https://doi.org/10.3324/haematol.2016.144139

Cell Therapy and Immunotherapy

Post-transplant cyclophosphamide versus anti-thymocyte globulin as graft- versus-host disease prophylaxis in haploidentical transplant (405 Online Views)

Annalisa Ruggeri, Yuqian Sun, Myriam Labopin, Andrea Bacigalupo, Francesca Lorentino, William Arcese, Stella Santarone, Zafer Gülbas, Didier Blaise, Giuseppe Messina, Ardeshi Ghavamzadeh, Florent Malard, Benedetto Bruno, Jose Luis Diez-Martin, Yener Koc, Fabio Ciceri, Mohamad Mohty, Arnon Nagler

https://doi.org/10.3324/haematol.2016.151779

Guidelines

Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO) (1116 Online Views)

Francisco-Javier Peñalver, Juan-Manuel Sancho, Adolfo de la Fuente, María-Teresa Olave, Alejandro Martín, Carlos Panizo, Elena Pérez, Antonio Salar, Alberto Orfao

https://doi.org/10.3324/haematol.2016.149120

Online Only Articles

Carboxy-terminal fragment of fibroblast growth factor 23 induces heart hypertrophy in sickle cell disease (98 Online Views)

Marie Courbebaisse, Hind Mehel, Camille Petit-Hoang, Jean-Antoine Ribeil, Laurent Sabbah, Véronique Tuloup-Minguez, David Bergerat, Jean-Benoit Arlet, Aurélie Stanislas, Jean-Claude Souberbielle, Hervé Le Clésiau, Rodolphe Fischmeister, Gérard Friedlander, Dominique Prié

https://doi.org/10.3324/haematol.2016.150987

Decreased numbers of dense granules in fetal and neonatal platelets (91 Online Views)

Denisa Urban, Fred G. Pluthero, Hilary Christensen, Shoma Baidya, Margaret L. Rand, Animitra Das, Prakeshkumar S. Shah, David Chitayat, Victor S. Blanchette, Walter H.A. Kahr

https://doi.org/10.3324/haematol.2016.152421

Response dynamics of pediatric patients with chronic myeloid leukemia on imatinib therapy (206 Online Views)

Rick Proschmann, Christoph Baldow, Tino Rothe, Meinolf Suttorp, Christian Thiede, Josephine T. Tauer, Martin C. Müller, Andreas Hochhaus, Ingo Roeder, Ingmar Glauche

https://doi.org/10.3324/haematol.2016.154138

Association between the TP53 Arg72Pro polymorphism and clinical outcomes in acute myeloid leukemia (109 Online Views)

Matheus F. Bezerra, Juan L Coelho-Silva, Jessica C. Nascimento, Mariana T. Benicio, Cintia R. Rocha, Cintia G. Machado, Eduardo M. Rego, Marcos A. Bezerra, Antonio R. Lucena-Araujo, Eduardo I. Beltrão

https://doi.org/10.3324/haematol.2016.155069

Low-dose clofarabine in combination with a standard remission induction in patients aged 18–60 years with previously untreated intermediate and bad-risk acute myeloid leukemia or high-risk myelodysplastic syndrome: combined phase I/II results of the EORTC/GIMEMA AML-14A trial (66 Online Views)

Dominik Selleslag, Stefan Suciu, Giovanna Meloni, Petra Muus, Constantijn J.M. Halkes, Adriano Venditti, Safaa M. Ramadan, Hans Pruijt, Liv Meert, Marco Vignetti, Jean-Pierre Marie, Sébastian Wittnebel, Theo de Witte, Sergio Amadori, Roelof Willemze, Frédéric Baron

https://doi.org/10.3324/haematol.2016.153130

Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome (223 Online Views)

Christian Klemann, Myrian Esquivel, Aude Magerus-Chatinet, Myriam R. Lorenz, Ilka Fuchs, Nathalie Neveux, Martin Castelle, Jan Rohr, Claudia Bettoni da Cunha, Martin Ebinger, Robin Kobbe, Bernhard Kremens, Florian Kollert, Eleonora Gambineri, Kai Lehmberg, Markus G. Seidel, Kathrin Siepermann, Thomas Voelker, Volker Schuster, Sigune Goldacker, Klaus Schwarz, Carsten Speckmann, Capucine Picard, Alain Fischer, Frederic Rieux-Laucat, Stephan Ehl, Anne Rensing-Ehl, Benedicte Neven

https://doi.org/10.3324/haematol.2016.153411

Comprehensive translocation and clonality detection in lymphoproliferative disorders by next-generation sequencing (251 Online Views)

Dörte Wren, Brian A. Walker, Monika Brüggemann, Mark A. Catherwood, Christiane Pott, Kostas Stamatopoulos, Anton W. Langerak, David Gonzalez

https://doi.org/10.3324/haematol.2016.155424

Higher adherence to the Mediterranean diet is associated with lower levels of D-dimer: findings from the MOLI-SANI study (159 Online Views)

Augusto Di Castelnuovo, Marialaura Bonaccio, Amalia De Curtis, Simona Costanzo, Mariarosaria Persichillo, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello

https://doi.org/10.3324/haematol.2016.156331

Human RAD52 – a novel player in DNA repair in cancer and immunodeficiency (206 Online Views)

Sujal Ghosh, Andrea Hönscheid, Gregor Dückers, Sebastian Ginzel, Holger Gohlke, Michael Gombert, Bettina Kempkes, Wolfram Klapper, Michaela Kuhlen, Hans-Jürgen Laws, René Martin Linka, Roland Meisel, Christian Mielke, Tim Niehues, Detlev Schindler, Dominik Schneider, Friedhelm R Schuster, Carsten Speckmann, Arndt Borkhardt

https://doi.org/10.3324/haematol.2016.155838