December, 2016
No. 101 (12)

Editorials

Review Articles

The myeloma stem cell concept, revisited: from phenomenology to operational terms

Hans Erik Johnsen, Martin Bøgsted, Alexander Schmitz, Julie Støve Bødker, Tarec Christoffer El-Galaly, Preben Johansen, Peter Valent, Niklas Zojer, Els Van Valckenborgh, Karin Vanderkerken, Mark van Duin, Pieter Sonneveld, Martin Perez-Andres, Alberto Orfao, Karen Dybkær

https://doi.org/10.3324/haematol.2015.138826

‘Trained immunity’: consequences for lymphoid malignancies

Wendy B.C. Stevens, Mihai G. Netea, Arnon P. Kater, Walter J.F.M. van der Velden

https://doi.org/10.3324/haematol.2016.149252

Articles

Hematopoiesis

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

Anita Roy, Larissa Lordier, Catherine Pioche-Durieu, Sylvie Souquere, Lydia Roy, Philippe Rameau, Valérie Lapierre, Eric Le Cam, Isabelle Plo, Najet Debili, Hana Raslova, William Vainchenker

https://doi.org/10.3324/haematol.2016.149914

Revealing eltrombopag’s promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation

Christian A. Di Buduo, Manuela Currao, Alessandro Pecci, David L. Kaplan, Carlo L. Balduini, Alessandra Balduini

https://doi.org/10.3324/haematol.2016.146746

Red Cell Biology & Its Disorders

Unexpected macrophage-independent dyserythropoiesis in Gaucher disease

Nelly Reihani, Jean-Benoit Arlet, Michael Dussiot, Thierry Billette de Villemeur, Nadia Belmatoug, Christian Rose, Yves Colin-Aronovicz, Olivier Hermine, Caroline Le Van Kim, Melanie Franco

https://doi.org/10.3324/haematol.2016.147546

Iron Metabolism & Its Disorders

Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors

Ulrike Baschant, Martina Rauner, Ekaterina Balaian, Heike Weidner, Antonella Roetto, Uwe Platzbecker, Lorenz C. Hofbauer

https://doi.org/10.3324/haematol.2016.144808

Myelodysplastic Syndromes

Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation

Nicolas Waespe, Machiel Van Den Akker, Robert J. Klaassen, Lani Lieberman, Meredith S. Irwin, Salah S. Ali, Mohamed Abdelhaleem, Bozana Zlateska, Mira Liebman, Michaela Cada, Tal Schechter, Yigal Dror

https://doi.org/10.3324/haematol.2016.145821

Acute Myeloid Leukemia

Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance)

Christian Niederwieser, Deedra Nicolet, Andrew J. Carroll, Jonathan E. Kolitz, Bayard L. Powell, Jessica Kohlschmidt, Richard M. Stone, John C. Byrd, Krzysztof Mrózek, Clara D. Bloomfield

https://doi.org/10.3324/haematol.2016.149542

Acute Lymphoblastic Leukemia

International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia

Nicola Gökbuget, Hervè Dombret, Jose-Maria Ribera, Adele K. Fielding, Anjali Advani, Renato Bassan, Victoria Chia, Michael Doubek, Sebastian Giebel, Dieter Hoelzer, Norbert Ifrah, Aaron Katz, Michael Kelsh, Giovanni Martinelli, Mireia Morgades, Susan O’Brien, Jacob M. Rowe, Julia Stieglmaier, Martha Wadleigh, Hagop Kantarjian

https://doi.org/10.3324/haematol.2016.144311

CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia

Benjamin Neveu, Jean-François Spinella, Chantal Richer, Karine Lagacé, Pauline Cassart, Mathieu Lajoie, Silvana Jananji, Simon Drouin, Jasmine Healy, Gilles R.X. Hickson, Daniel Sinnett

https://doi.org/10.3324/haematol.2016.149740

A sequential approach with imatinib, chemotherapy and transplant for adult Ph+ acute lymphoblastic leukemia: final results of the GIMEMA LAL 0904 study

Sabina Chiaretti, Antonella Vitale, Marco Vignetti, Alfonso Piciocchi, Paola Fazi, Loredana Elia, Brunangelo Falini, Francesca Ronco, Felicetto Ferrara, Paolo De Fabritiis, Mario Luppi, Giorgio La Nasa, Alessandra Tedeschi, Catello Califano, Renato Fanin, Fausto Dore, Franco Mandelli, Giovanna Meloni, Robin Foà

https://doi.org/10.3324/haematol.2016.144535

Chronic Lymphocytic Leukemia

Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents

Andishe Attarbaschi, Elisa Carraro, Oussama Abla, Shlomit Barzilai-Birenboim, Simon Bomken, Laurence Brugieres, Eva Bubanska, Birgit Burkhardt, Alan K.S. Chiang, Monika Csoka, Alina Fedorova, Janez Jazbec, Edita Kabickova, Zdenka Krenova, Jelena Lazic, Jan Loeffen, Georg Mann, Felix Niggli, Natalia Miakova, Tomoo Osumi, Leila Ronceray, Anne Uyttebroeck, Denise Williams, Wilhelm Woessmann, Grazyna Wrobel, Marta Pillon

https://doi.org/10.3324/haematol.2016.147116

Stem Cell Trasplantation

Comparison of graft-versus-host disease-free, relapse-free survival according to a variety of graft sources: antithymocyte globulin and single cord blood provide favorable outcomes in some subgroups

Yoshihiro Inamoto, Fumihiko Kimura, Junya Kanda, Junichi Sugita, Kazuhiro Ikegame, Hideki Nakasone, Yasuhito Nannya, Naoyuki Uchida, Takahiro Fukuda, Kosuke Yoshioka, Yukiyasu Ozawa, Ichiro Kawano, Yoshiko Atsuta, Koji Kato, Tatsuo Ichinohe, Masami Inoue, Takanori Teshima

https://doi.org/10.3324/haematol.2016.149427

Complications in Hematology

Metabolic syndrome in long-term survivors of childhood acute leukemia treated without hematopoietic stem cell transplantation: an L.E.A. study

Paul Saultier, Pascal Auquier, Yves Bertrand, Camille Vercasson, Claire Oudin, Audrey Contet, Dominique Plantaz, Marilyne Poirée, Stéphane Ducassou, Justyna Kanold, Marie-Dominique Tabone, Jean-Hugues Dalle, Patrick Lutz, Virginie Gandemer, Nicolas Sirvent, Sandrine Thouvenin, Julie Berbis, Hervé Chambost, André Baruchel, Guy Leverger, Gérard Michel

https://doi.org/10.3324/haematol.2016.148908

Online Only Articles

Nocturnal enuresis and K+ transport in red blood cells from patients with sickle cell anemia

Sanjay Tewari, David C. Rees, Anke Hannemann, Oluwabukola T. Gbotosho, Halima W. M. Al Balushi, John S. Gibson

https://doi.org/10.3324/haematol.2016.149500

Remissions after long-term use of romiplostim for immune thrombocytopenia

Ariela L. Marshall, Roberta Scarpone, Melanie De Greef, Robert Bird, David J. Kuter

https://doi.org/10.3324/haematol.2016.151886

Lack of splice factor and cohesin complex mutations in pediatric myelodysplastic syndrome

Julia C. Obenauer, François G. Kavelaars, Mathijs A. Sanders, Remco M. Hoogenboezem, Andrica C. H. de Vries, Paulina M. H. van Strien, Valerie de Haas, Franco Locatelli, Henrik Hasle, Peter J. M. Valk, Ivo P. Touw, Marry M. van den Heuvel-Eibrink

https://doi.org/10.3324/haematol.2016.151753

The impact of anemia on overall survival in patients with myelofibrosis treated with ruxolitinib in the COMFORT studies

Vikas Gupta, Claire Harrison, Elizabeth O. Hexner, Haifa Kathrin Al-Ali, Lynda Foltz, Michael Montgomery, William Sun, Prashanth Gopalakrishna, Hagop Kantarjian, Srdan Verstovsek

https://doi.org/10.3324/haematol.2016.151449

Peripheral neuropathy associated with subcutaneous or intravenous bortezomib in patients with newly diagnosed myeloma treated within the GMMG MM5 phase III trial

Maximilian Merz, Hans Salwender, Mathias Haenel, Elias K. Mai, Uta Bertsch, Christina Kunz, Thomas Hielscher, Igor W. Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Anna Jauch, Jens Hillengass, Marc S. Raab, Baerbel Schurich, Markus Munder, Peter Brossart, Christian Gerecke, Hans-Walter Lindemann, Matthias Zeis, Katja Weisel, Jan Duerig, Hartmut Goldschmidt

https://doi.org/10.3324/haematol.2016.151266

Comment

Is ruxolitinib a potentially useful drug in hematological malignancies with RAS pathway hyperactivation?

Klaus Geissler, Eva Jäger, Agnes Barna, Thamer Sliwa, Paul Knöbl, Ilse Schwarzinger, Heinz Gisslinger, Peter Valent

https://doi.org/10.3324/haematol.2016.156448