June, 2016
No. 101 (6)

Editorials

Review Articles

Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies

Abdallah Abou Zahr, Mohamed E. Salama, Nicole Carreau, Douglas Tremblay, Srdan Verstovsek, Ruben Mesa, Ronald Hoffman, John Mascarenhas

https://doi.org/10.3324/haematol.2015.141283

Articles

Red Cell Biology & Its Disorders

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)

Angela Rivers, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramasamy Jagadeeswaran, Yogen Saunthararajah, Shuaiying Cui, James D. Engel, Joseph DeSimone, Donald Lavelle

https://doi.org/10.3324/haematol.2015.140749

Platelet Biology & its Disorders

A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia

Shaun M. Flint, Adele Gibson, Geoff Lucas, Raghava Nandigam, Louise Taylor, Drew Provan, Adrian C. Newland, Caroline O. Savage, Robert B. Henderson

https://doi.org/10.3324/haematol.2015.137273

Myelodysplastic Syndromes

Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome

Michaela Nováková, Markéta Žaliová, Martina Suková, Marcin Wlodarski, Aleš Janda, Eva Froňková, Vít Campr, Kateřina Lejhancová, Ondřej Zapletal, Dagmar Pospíšilová, Zdeňka Černá, Tomáš Kuhn, Peter Švec, Vendula Pelková, Zuzana Zemanová, Gitte Kerndrup, Marry van den Heuvel-Eibrink, Vincent van der Velden, Charlotte Niemeyer, Tomáš Kalina, Jan Trka, Jan Starý, Ondřej Hrušák, Ester Mejstříková

https://doi.org/10.3324/haematol.2015.137711

Chronic Myeloid Leukemia

Imatinib withdrawal syndrome and longer duration of imatinib have a close association with a lower molecular relapse after treatment discontinuation: the KID study

Sung-Eun Lee, Soo Young Choi, Hye-Young Song, Soo-Hyun Kim, Mi-Yeon Choi, Joon Seong Park, Hyeoung-Joon Kim, Sung-Hyun Kim, Dae Young Zang, Sukjoong Oh, Hawk Kim, Young Rok Do, Jae-Yong Kwak, Jeong-A Kim, Dae-Young Kim, Yeung-Chul Mun, Won Sik Lee, Myung Hee Chang, Jinny Park, Ji Hyun Kwon, Dong-Wook Kim

https://doi.org/10.3324/haematol.2015.139899

Acute Myeloid Leukemia

Defining the dose of gemtuzumab ozogamicin in combination with induction chemotherapy in acute myeloid leukemia: a comparison of 3 mg/m2 with 6 mg/m2 in the NCRI AML17 Trial

Alan Burnett, Jamie Cavenagh, Nigel Russell, Robert Hills, Jonathan Kell, Gail Jones, Ove Juul Nielsen, Asim Khwaja, Ian Thomas, Richard Clark, on behalf of the UK NCRI AML Study Group

https://doi.org/10.3324/haematol.2016.141937

Acute Lymphoblastic Leukemia

An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study

Jonathan Bond, Tony Marchand, Aurore Touzart, Agata Cieslak, Amélie Trinquand, Laurent Sutton, Isabelle Radford-Weiss, Ludovic Lhermitte, Salvatore Spicuglia, Hervé Dombret, Elizabeth Macintyre, Norbert Ifrah, Jean-François Hamel, Vahid Asnafi

https://doi.org/10.3324/haematol.2015.141218

Risk assessment of relapse by lineage-specific monitoring of chimerism in children undergoing allogeneic stem cell transplantation for acute lymphoblastic leukemia

Sandra Preuner, Christina Peters, Ulrike Pötschger, Helga Daxberger, Gerhard Fritsch, Rene Geyeregger, André Schrauder, Arend von Stackelberg, Martin Schrappe, Peter Bader, Wolfram Ebell, Cornelia Eckert, Peter Lang, Karl-Walter Sykora, Johanna Schrum, Bernhard Kremens, Karoline Ehlert, Michael H. Albert, Roland Meisel, Anita Lawitschka, Georg Mann, Renate Panzer-Grümayer, Tayfun Güngör, Wolfgang Holter, Brigitte Strahm, Bernd Gruhn, Ansgar Schulz, Wilhelm Woessmann, Thomas Lion

https://doi.org/10.3324/haematol.2015.135137

Complications in Hematology

Late thyroid complications in survivors of childhood acute leukemia. An L.E.A. study

Claire Oudin, Pascal Auquier, Yves Bertrand, Philippe Chastagner, Justyna Kanold, Maryline Poirée, Sandrine Thouvenin, Stephane Ducassou, Dominique Plantaz, Marie-Dominique Tabone, Jean-Hugues Dalle, Virginie Gandemer, Patrick Lutz, Anne Sirvent, Virginie Villes, Vincent Barlogis, André Baruchel, Guy Leverger, Julie Berbis, Gérard Michel

https://doi.org/10.3324/haematol.2015.140053

Non-Hodgkin Lymphoma

Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma

Hae Yong Yoo, Pora Kim, Won Seog Kim, Seung Ho Lee, Sangok Kim, So Young Kang, Hye Yoon Jang, Jong-Eun Lee, Jaesang Kim, Seok Jin Kim, Young Hyeh Ko, Sanghyuk Lee

https://doi.org/10.3324/haematol.2015.139253

Stem Cell Transplantation

Improved graft-versus-host disease-free, relapse-free survival associated with bone marrow as the stem cell source in adults

Rohtesh S. Mehta, Regis Peffault de Latour, Todd E DeFor, Marie Robin, Aleksandr Lazaryan, Aliénor Xhaard, Nelli Bejanyan, Flore Sicre de Fontbrune, Mukta Arora, Claudio G. Brunstein, Bruce R. Blazar, Daniel J. Weisdorf, Margaret L. MacMillan, Gerard Socie, Shernan G. Holtan

https://doi.org/10.3324/haematol.2015.138990

Expanding transplant options to patients over 50 years. Improved outcome after reduced intensity conditioning mismatched-unrelated donor transplantation for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the EBMT

Bipin N. Savani, Myriam Labopin, Nicolaus Kröger, Jürgen Finke, Gerhard Ehninger, Dietger Niederwieser, Rainer Schwerdtfeger, Donald Bunjes, Bertram Glass, Gerard Socié, Per Ljungman, Charles Craddock, Frédéric Baron, Fabio Ciceri, Norbert Claude Gorin, Jordi Esteve, Christoph Schmid, Sebastian Giebel, Mohamad Mohty, Arnon Nagler

https://doi.org/10.3324/haematol.2015.138180

Quality of Life

Prospective international validation of the Quality of Life in Myelodysplasia Scale (QUALMS)

Gregory A. Abel, Fabio Efficace, Rena J. Buckstein, Sara Tinsley, Joseph G. Jurcic, Yolanda Martins, David. P Steensma, Corey D. Watts, Azra Raza, Stephanie J. Lee, Alan F. List, Robert J. Klaassen

https://doi.org/10.3324/haematol.2015.140335

Online Only Articles

Efficient CRISPR-Cas9 mediated gene disruption in primary erythroid progenitor cells

Hojun Li, Jiahai Shi, Nai-Jia Huang, Novalia Pishesha, Anirudh Natarajan, Jennifer C. Eng, Harvey F. Lodish

https://doi.org/10.3324/haematol.2015.135723

Bio-engineered and native red blood cells from cord blood exhibit the same metabolomic profile

Dhouha Darghouth, Marie-Catherine Giarratana, Lydie Oliveira, Séverine Jolly, Tiffany Marie, Samia Boudah, Nathalie Mario, Christophe Junot, Luc Douay, Paul-Henri Romeo

https://doi.org/10.3324/haematol.2015.141465

The efficacy of current prognostic models in predicting outcome of patients with myelodysplastic syndromes at the time of hypomethylating agent failure

Aziz Nazha, Rami S. Komrokji, Guillermo Garcia-Manero, John Barnard, Gail J. Roboz, David P. Steensma, Amy E. DeZern, Katrina Zell, Cassie Zimmerman, Najla Al Ali, Elias Jabbour, Molly D. Greenberg, Hagop M. Kantarjian, Jaroslaw P. Maciejewski, Alan F. List, Mikkael A. Sekeres

https://doi.org/10.3324/haematol.2015.140962

Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms

Angela Stoddart, Zhijian Qian, Anthony A. Fernald, Rachel J. Bergerson, Jianghong Wang, Theodore Karrison, John Anastasi, Elizabeth T. Bartom, Aaron L. Sarver, Megan E. McNerney, David A. Largaespada, Michelle M. Le Beau

https://doi.org/10.3324/haematol.2015.139527

Genetic analysis of five children with essential thrombocytosis identified mutations in cancer-associated genes with roles in transcriptional regulation

Nicole Kucine, Aaron D. Viny, Raajit Rampal, Michael Berger, Nicholas Socci, Agnes Viale, James B. Bussel, Ross L. Levine, Franck Rapaport

https://doi.org/10.3324/haematol.2016.142935

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty H. Helsmoortel, Barbara De Moerloose, Tim Pieters, Farzaneh Ghazavi, Silvia Bresolin, Hélène Cavé, Andrica de Vries, Valerie de Haas, Christian Flotho, Veerle Labarque, Charlotte Niemeyer, Pascale De Paepe, Nadine Van Roy, Jan Stary, Marry M. van den Heuvel-Eibrink, Yves Benoit, Johannes Schulte, Steven Goossens, Geert Berx, Jody J. Haigh, Frank Speleman, Pieter Van Vlierberghe, Tim Lammens

https://doi.org/10.3324/haematol.2016.143818

Mutations of TP53 gene in adult acute lymphoblastic leukemia at diagnosis do not affect the achievement of hematologic response but correlate with early relapse and very poor survival

Silvia Salmoiraghi, Marie Lorena Guinea Montalvo, Greta Ubiali, Manuela Tosi, Barbara Peruta, Pamela Zanghi, Elena Oldani, Cristina Boschini, Alexander Kohlmann, Silvia Bungaro, Tamara Intermesoli, Elisabetta Terruzzi, Emanuele Angelucci, Irene Cavattoni, Fabio Ciceri, Renato Bassan, Alessandro Rambaldi, Orietta Spinelli

https://doi.org/10.3324/haematol.2015.137059

Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling

Katharina Filarsky, Angela Garding, Natalia Becker, Christine Wolf, Manuela Zucknick, Rainer Claus, Dieter Weichenhan, Christoph Plass, Hartmut Döhner, Stephan Stilgenbauer, Peter Lichter, Daniel Mertens

https://doi.org/10.3324/haematol.2015.138172

Autoimmune cytopenias in patients with chronic lymphocytic leukemia treated with ibrutinib

Candida Vitale, Inhye E. Ahn, Mariela Sivina, Alessandra Ferrajoli, William G. Wierda, Zeev Estrov, Sergej N. Konoplev, Nitin Jain, Susan O’Brien, Mohammed Farooqui, Michael J. Keating, Adrian Wiestner, Jan A. Burger

https://doi.org/10.3324/haematol.2015.138289

Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma

Monika Szczepanowski, Neus Masqué-Soler, Matthias Schlesner, Andrea Haake, Julia Richter, Rabea Wagener, Birgit Burkhardt, Markus Kreuz, Reiner Siebert, ICGC MMML-Seq Consortium, Wolfram Klapper

https://doi.org/10.3324/haematol.2015.138701

Allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning regimen for elderly patients (60 years and older) with hematologic malignancies using unrelated donors: a retrospective study from the French society for stem cell transplantation (SFGM-TC)

Jean El Cheikh, Patrick Sfumato, Mohamad Sobh, Nathalie Fegueux, Mohamad Mohty, Stephane Vigouroux, Yves Beguin, Ibrahim Yakoub-Agha, Gerard Socié, Jerome Cornillon, Melanie Mercier, Jacques Olivier Bay, Didier Blaise, Mauricette Michallet, Regis Peffault de Latour

https://doi.org/10.3324/haematol.2015.139345

Efficacy and safety of second-line ponatinib after failure of a single previous tyrosine kinase inhibitor for chronic myeloid leukemia patients in chronic phase

Massimo Breccia, Elisabetta Abruzzese, Alessandra Iurlo, Antonella Gozzini, Alessandro Isidori, Domenica Gangemi, Patrizia Pregno, Giuliana Alimena

https://doi.org/10.3324/haematol.2016.145623