May, 2015
No. 100 (5)

Editorials

Articles

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells (331 Online Views)

Yiren Xiao, Zhiwu Jiang, Yin Li, Wei Ye, Bei Jia, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Yaoyu Chen, Yingjun Chang, Xiaojun Huang, Hudan Liu, Guoliang Qing, Pentao Liu, Yangqiu Li, Bing Xu, Mei Zhong, Yao Yao, Duanqing Pei, Peng Li

https://doi.org/10.3324/haematol.2014.118612

Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice (399 Online Views)

Stuart T. Fraser, Robyn G. Midwinter, Lucy A. Coupland, Stephanie Kong, Birgit S. Berger, Jia Hao Yeo, Osvaldo Cooley Andrade, Deborah Cromer, Cacang Suarna, Magda Lam, Ghassan J. Maghzal, Beng H. Chong, Christopher R. Parish, Roland Stocker

https://doi.org/10.3324/haematol.2014.116368

Iron Metabolism & its Disorders

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous b1/b2 globin gene deletion) mice (329 Online Views)

Monique P. Gelderman, Jin Hyen Baek, Ayla Yalamanoglu, Michele Puglia, Florence Vallelian, Bo Burla, Jaroslav Vostal, Dominik J. Schaer, Paul W. Buehler

https://doi.org/10.3324/haematol.2014.117325

The impact of category, cytopathology and cytogenetics on development and progression of clonal and malignant myeloid transformation in inherited bone marrow failure syndromes (333 Online Views)

Michaela Cada, Catherin I. Segbefia, Robert Klaassen, Conrad V. Fernandez, Rochelle A. Yanofsky, John Wu, Yves Pastore, Mariana Silva, Jeffrey H. Lipton, Josee Brossard, Bruno Michon, Sharon Abish, MacGregor Steele, Roona Sinha, Mark Belletrutti, Vicky Breakey, Lawrence Jardine, Lisa Goodyear, Lillian Sung, Mary Shago, Joseph Beyene, Preeti Sharma, Bozana Zlateska, Yigal Dror

https://doi.org/10.3324/haematol.2014.117457

Impaired cytotoxicity associated with defective natural killer cell differentiation in myelodysplastic syndromes (282 Online Views)

Maryam Hejazi, Angela R. Manser, Julia Fröbel, Andrea Kündgen, Xiaoyi Zhao, Kathrin Schönberg, Ulrich Germing, Rainer Haas, Norbert Gattermann, Markus Uhrberg

https://doi.org/10.3324/haematol.2014.118679

Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (622 Online Views)

Naval Daver, Deborah Thomas, Farhad Ravandi, Jorge Cortes, Rebecca Garris, Elias Jabbour, Guillermo Garcia-Manero, Gautam Borthakur, Tapan Kadia, Michael Rytting, Marina Konopleva, Hagop Kantarjian, Susan O’Brien

https://doi.org/10.3324/haematol.2014.118588

Efficacy and safety of front-line therapy with fludarabine-cyclophosphamide-rituximab regimen for chronic lymphocytic leukemia outside clinical trials: the Israeli CLL Study Group experience (166 Online Views)

Yair Herishanu, Neta Goldschmidt, Osnat Bairey, Rosa Ruchlemer, Riva Fineman, Naomi Rahimi-Levene, Lev Shvidel, Tamar Tadmor, Aviv Ariel, Andrea Braester, Mika Shapiro, Erel Joffe, Aaron Polliack, on behalf of the Israeli CLL Study Group

https://doi.org/10.3324/haematol.2014.115808

Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma (256 Online Views)

Jesus G. Berdeja, Lowell L. Hart, Joseph R. Mace, Edward R. Arrowsmith, James H. Essell, Rami S. Owera, John D. Hainsworth, Ian W. Flinn

https://doi.org/10.3324/haematol.2014.119735

Extended follow up of high-dose melphalan and autologous stem cell transplantation after vincristine, doxorubicin, dexamethasone induction in amyloid light chain amyloidosis of the prospective phase II HOVON-41 study by the Dutch-Belgian Co-operative Trial Group for Hematology Oncology (244 Online Views)

Bouke P.C. Hazenberg, Alexandra Croockewit, Bronno van der Holt, Sonja Zweegman, Gerard M.J. Bos, Michel Delforge, Reinier A.P. Raymakers, Pieter Sonneveld, Edo Vellenga, Pierre W. Wijermans, Peter A. von dem Borne, Marinus H. van Oers, Okke de Weerdt, Fokje M. Spoelstra, Henk M. Lokhorst, for the Dutch-Belgian Cooperative Trial Group for Hematology Oncology (HOVON)

https://doi.org/10.3324/haematol.2014.119198

The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (145 Online Views)

Marie Thérèse Rubio, Myriam Labopin, Didier Blaise, Gerard Socié, Rafael Rojas Contreras, Patrice Chevallier, Miguel A. Sanz, Stéphane Vigouroux, Anne Huynh, Avichai Shimoni, Claude-Eric Bulabois, Nerea Caminos, Lucía López-Corral, Arnon Nagler, Mohamad Mohty

https://doi.org/10.3324/haematol.2014.119339

Failure-free survival in a prospective cohort of patients with chronic graft-versus-host disease (160 Online Views)

Jeanne Palmer, Xiaoyu Chai, Paul J Martin, Daniel Weisdorf, Yoshihiro Inamoto, Joseph Pidala, Madan Jagasia, Steven Pavletic, Corey Cutler, Georgia Vogelsang, Sally Arai, Mary ED Flowers, Stephanie J Lee

https://doi.org/10.3324/haematol.2014.117283

Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: an EBMT analysis (296 Online Views)

Andrea Bacigalupo, Gerard Socié, Rose Marie Hamladji, Mahmoud Aljurf, Alexei Maschan, Slawomira Kyrcz-Krzemien, Alicja Cybicka, Henrik Sengelov, Ali Unal, Dietrich Beelen, Anna Locasciulli, Carlo Dufour, Jakob R. Passweg, Rosi Oneto, Alessio Signori, Judith C.W. Marsh, for the Aplastic Anemia Working Party of the European Group for Blood Marrow Transplantation (WPSAA-EBMT)

https://doi.org/10.3324/haematol.2014.115345

Online Only Articles

Markedly perturbed hematopoiesis in acid ceramidase deficient mice (99 Online Views)

Shaalee Dworski, Alexandra Berger, Caren Furlonger, Joshua M. Moreau, Makoto Yoshimitsu, Jessa Trentadue, Bryan C.Y. Au, Christopher J. Paige, Jeffrey A. Medin

https://doi.org/10.3324/haematol.2014.108530

Hb S/β+-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the β locus control region (235 Online Views)

Ali Amid, Melina Cheong, Barry Eng, Meredith Hanna, Betty-Ann Hohenadel, Lisa M. Nakamura, Lynda Walker, Isaac Odame, Melanie Kirby-Allen, John S. Waye

https://doi.org/10.3324/haematol.2014.117408

Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and β-thalassemia intermedia (163 Online Views)

Raffaella Origa, Mario Cazzola, Elisabetta Mereu, Fabrice Danjou, Susanna Barella, Nicolina Giagu, Renzo Galanello, Dorine W. Swinkels

https://doi.org/10.3324/haematol.2014.115733

Mutations of ASXL1 and TET2 in aplastic anemia (214 Online Views)

Jinbo Huang, Meili Ge, Shihong Lu, Jun Shi, Xingxin Li, Jizhou Zhang, Min Wang, Wei Yu, Yingqi Shao, Zhendong Huang, Jing Zhang, Neng Nie, Yizhou Zheng

https://doi.org/10.3324/haematol.2014.120931

Endogenous megakaryocytic colonies underline association between megakaryocytes and calreticulin mutations in essential thrombocythemia (67 Online Views)

Julie Mondet, Ji-Hye Park, Audrey Menard, Christophe Marzac, Serge Carillo, Emmanuel Pourcelot, Francois Girodon, Xenia Cabagnols, Laurence Lodé, Nuria Socoro, Martine Chauvet, Claude-Eric Bulabois, Pascale Cony-Makhoul, Selim Corm, Jean-Yves Cahn, Pascal Mossuz

https://doi.org/10.3324/haematol.2014.118927

CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia (132 Online Views)

Eva Barragán, María Carmen Chillón, Remedios Castelló-Cros, Nerea Marcotegui, María Isabel Prieto, Montserrat Hoyos, Raffaella Pippa, Marta Llop, Amaia Etxabe, José Cervera, Gabriela Rodríguez, Ismael Buño, José Rifón, Jorge Sierra, Marcos González, María J. Calasanz, Miguel A. Sanz, María D. Odero

https://doi.org/10.3324/haematol.2014.118117

Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the L.E.A. program (127 Online Views)

Vincent Barlogis, Pascal Auquier, Yves Bertrand, Pascal Chastagner, Dominique Plantaz, Maryline Poiree, Justyna Kanold, Julie Berbis, Claire Oudin, Camille Vercasson, Maya Allouche, Marie-Dominique Tabone, Sandrine Thouvenin-Doulet, Laure Saumet, Hervé Chambost, André Baruchel, Guy Leverger, Gérard Michel

https://doi.org/10.3324/haematol.2014.116574

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition (282 Online Views)

Michael W.M. Kühn, Michael J. Hadler, Scott R. Daigle, Richard P. Koche, Andrei V. Krivtsov, Edward J. Olhava, Michael A. Caligiuri, Gang Huang, James E. Bradner, Roy M. Pollock, Scott A. Armstrong

https://doi.org/10.3324/haematol.2014.115337

BCOR and BCORL1 mutations in pediatric acute myeloid leukemia (247 Online Views)

Jasmijn D.E. de Rooij, Marry M. van den Heuvel-Eibrink, Malou C.H. Hermkens, Lonneke J. Verboon, Susan T.C.J.M. Arentsen-Peters, Maarten Fornerod, Andre Baruchel, Jan Stary, Dirk Reinhardt, Valerie de Haas, Rob Pieters, C. Michel Zwaan

https://doi.org/10.3324/haematol.2014.117796

Impact of additional genetic alterations on the outcome of patients with NPM1-mutated cytogenetically normal acute myeloid leukemia (132 Online Views)

Pierre Peterlin, Aline Renneville, Raouf Ben Abdelali, Olivier Nibourel, Xavier Thomas, Cécile Pautas, Stéphane de Botton, Emmanuel Raffoux, Jean-Michel Cayuela, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Sylvie Castaigne, Claude Preudhomme, Claude Gardin, Hervé Dombret

https://doi.org/10.3324/haematol.2014.115576

Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation (131 Online Views)

Arantza Onaindia, Sagrario Gómez, Miguel Piris-Villaespesa, Carolina Martínez-Laperche, Laura Cereceda, Santiago Montes-Moreno, Ana Batlle, Sonia González de Villambrosia, Marina Pollán, Paloma Martín-Acosta, Julia González-Rincón, Javier Menarguez, Javier Alvés, Socorro M. Rodriguez-Pinilla, Juan F. García, Manuela Mollejo, Máximo Fraga, José A. García-Marco, Miguel A. Piris, Margarita Sánchez-Beato

https://doi.org/10.3324/haematol.2014.117705

Single nucleotide polymorphisms in ABCB1 and CBR1 can predict toxicity to R-CHOP type regimens in patients with diffuse non-Hodgkin lymphoma (79 Online Views)

Lars P. Jordheim, Vincent Ribrag, Hervé Ghesquieres, Sophie Pallardy, Richard Delarue, Hervé Tilly, Corinne Haioun, Fabrice Jardin, Delphine Demangel, Gilles A. Salles, Charles Dumontet

https://doi.org/10.3324/haematol.2014.120113

Subcutaneous versus intravenous bortezomib in patients with relapsed multiple myeloma: subanalysis of patients with renal impairment in the phase III MMY-3021 study (202 Online Views)

Philippe Moreau, Halyna Pylypenko, Sebastian Grosicki, Ievgenii Karamanesht, Xavier Leleu, Grigoriy Rekhtman, Zvenyslava Masliak, Pawel Robak, Dixie-Lee Esseltine, Huaibao Feng, William Deraedt, Helgi van de Velde, Bertrand Arnulf

https://doi.org/10.3324/haematol.2014.118182

On the safety of intravenous iron, evidence trumps conjecture (141 Online Views)

Michael Auerbach, John Adamson, Andreas Bircher, Christian Breymann, Steven Fishbane, Anat Gafter-Gvili, Christoph Gasche, Jeffrey Gilreath, Giuliano Grazzini, David Henry, Giancarlo Liumbruno, Francesco Locatelli, Iain Macdougall, Manuel Munoz, David Rampton, George Rodgers, Aryeh Shander

https://doi.org/10.3324/haematol.2014.121004